Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | geminin | 0.0205 | 0.8639 | 1 |
Onchocerca volvulus | 0.0028 | 0.0496 | 1 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2738 | 0.3169 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0496 | 0.0496 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2738 | 0.2738 |
Onchocerca volvulus | 0.0028 | 0.0496 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0496 | 0.0496 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2738 | 0.2738 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2738 | 0.2739 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2738 | 0.3169 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.8629 | 0.8632 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2738 | 0.2739 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.8639 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2738 | 0.2738 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.0234 | 0.9996 | 1 |
Echinococcus multilocularis | MAM | 0.0028 | 0.0496 | 0.0414 |
Echinococcus granulosus | geminin | 0.0205 | 0.8639 | 1 |
Echinococcus granulosus | MAM | 0.0028 | 0.0496 | 0.0414 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2738 | 0.3169 |
Loa Loa (eye worm) | plexin A | 0.002 | 0.0144 | 0.0144 |
Brugia malayi | plexin A | 0.002 | 0.0144 | 0.0144 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.2738 | 0.3053 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2738 | 0.2739 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2738 | 0.3169 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0496 | 0.0574 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0496 | 0.0496 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.2738 | 0.3053 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0496 | 0.0574 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.8639 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2738 | 0.3169 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0496 | 0.0496 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.1095 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.