Detailed information for compound 1574374

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 461.427 | Formula: C23H19N5O6
  • H donors: 0 H acceptors: 5 LogP: 4.12 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1cc(C)c2c(o1)cc(cc2)OCC(=O)n1nc(c(c1C)/N=N/c1ccc(cc1)[N+](=O)[O-])C
  • InChi: 1S/C23H19N5O6/c1-13-10-22(30)34-20-11-18(8-9-19(13)20)33-12-21(29)27-15(3)23(14(2)26-27)25-24-16-4-6-17(7-5-16)28(31)32/h4-11H,12H2,1-3H3/b25-24+
  • InChiKey: JRCXYUHSRMDRBG-OCOZRVBESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus acetylcholinesterase 0.0282 0.3447 0.3871
Loa Loa (eye worm) beta-lactamase 0.0036 0.0332 0.0366
Echinococcus granulosus FTZ F1 alpha 0.001 0.0006 0.0007
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0043 0.0422 0.1685
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0332 0.0669
Entamoeba histolytica acyl-CoA synthetase, putative 0.0147 0.1732 1
Onchocerca volvulus 0.0048 0.048 0.0774
Plasmodium vivax acetyl-CoA synthetase, putative 0.0043 0.0422 0.3339
Leishmania major 4-coumarate:coa ligase-like protein 0.0147 0.1732 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0405 0.0448
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0043 0.0422 0.1685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0104 0.1188 0.3926
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0006 0.0007
Mycobacterium ulcerans beta-lactamase 0.0036 0.0332 0.1114
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0422 0.1011
Loa Loa (eye worm) hypothetical protein 0.011 0.1263 0.1413
Onchocerca volvulus 0.0495 0.6136 1
Schistosoma mansoni survival motor neuron protein 0.0146 0.1719 0.2004
Toxoplasma gondii propionate-CoA ligase 0.0043 0.0422 0.6335
Echinococcus multilocularis acetylcholinesterase 0.0282 0.3447 0.3447
Schistosoma mansoni microtubule-associated protein tau 0.0688 0.8577 1
Brugia malayi beta-lactamase family protein 0.0036 0.0332 0.0366
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0147 0.1732 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0147 0.1732 1
Brugia malayi Carboxylesterase family protein 0.0048 0.048 0.0533
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0043 0.0422 0.6335
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0332 0.0387
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0006 0.0007
Onchocerca volvulus 0.0043 0.0422 0.0678
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0043 0.0422 0.1011
Loa Loa (eye worm) hypothetical protein 0.0298 0.3647 0.4092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0666 0.0776
Schistosoma mansoni gliotactin 0.0048 0.048 0.056
Brugia malayi Carboxylesterase family protein 0.0048 0.048 0.0533
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.004 0.0387 0.1462
Loa Loa (eye worm) hypothetical protein 0.0097 0.1106 0.1236
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0332 0.0541
Loa Loa (eye worm) hypothetical protein 0.0043 0.0422 0.0467
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0043 0.0422 0.0467
Brugia malayi Carboxylesterase family protein 0.0048 0.048 0.0533
Plasmodium vivax acyl-CoA synthetase, putative 0.011 0.1263 1
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0422 0.0467
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0006 0.0007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0137 0.1605 0.1796
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0043 0.0422 0.0467
Trichomonas vaginalis esterase, putative 0.0036 0.0332 0.0541
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0043 0.0422 0.1685
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0332 0.0669
Loa Loa (eye worm) cytochrome P450 family protein 0.0081 0.0896 0.1
Entamoeba histolytica hypothetical protein 0.0035 0.0326 0.1883
Brugia malayi AMP-binding enzyme family protein 0.0147 0.1732 0.194
Echinococcus multilocularis protein patched 0.0042 0.0405 0.0405
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0048 0.048 0.056
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0147 0.1732 1
Mycobacterium ulcerans hypothetical protein 0.0036 0.0332 0.1114
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0043 0.0422 1
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0332 0.0669
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0422 0.1685
Schistosoma mansoni nuclear hormone receptor 0.001 0.0006 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0104 0.1188 0.3926
Loa Loa (eye worm) hypothetical protein 0.0062 0.0666 0.0741
Brugia malayi Pre-SET motif family protein 0.0062 0.0666 0.0741
Onchocerca volvulus 0.0036 0.0332 0.0531
Mycobacterium ulcerans acyl-CoA synthetase 0.0147 0.1732 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.1605 0.1871
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0332 0.6615
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0104 0.1188 0.3926
Trichomonas vaginalis antibiotic synthetase, putative 0.0043 0.0422 0.0687
Echinococcus multilocularis survival motor neuron protein 1 0.0713 0.8906 0.8906
Schistosoma mansoni hypothetical protein 0.004 0.0386 0.0449
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0006 0.0007
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.1106 0.6385
Loa Loa (eye worm) hypothetical protein 0.0036 0.0332 0.0366
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0147 0.1732 0.6
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0006 0.0007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0048 0.048 0.0533
Echinococcus granulosus acetylcholinesterase 0.0282 0.3447 0.3871
Mycobacterium tuberculosis Conserved protein 0.0036 0.0332 0.0669
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0006 0.0006
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.011 0.1263 0.4215
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0332 0.0366
Brugia malayi AMP-binding enzyme family protein 0.0147 0.1732 0.194
Echinococcus multilocularis BC026374 protein (S09 family) 0.0048 0.048 0.048
Loa Loa (eye worm) hypothetical protein 0.0147 0.1732 0.194
Schistosoma mansoni patched 1 0.0042 0.0405 0.0472
Loa Loa (eye worm) hypothetical protein 0.0051 0.0523 0.0581
Loa Loa (eye worm) CYP4Cod1 0.004 0.0387 0.0428
Loa Loa (eye worm) cytochrome P450 0.0022 0.0156 0.0169
Loa Loa (eye worm) hypothetical protein 0.0282 0.3447 0.3866
Trichomonas vaginalis spcc417.12 protein, putative 0.0048 0.048 0.0783
Echinococcus multilocularis para nitrobenzyl esterase 0.0048 0.048 0.048
Loa Loa (eye worm) carboxylesterase 0.0048 0.048 0.0533
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0332 0.0541
Loa Loa (eye worm) hypothetical protein 0.011 0.1263 0.1413
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.1634 0.1834
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0332 0.1114
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0104 0.1188 0.3926
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0332 0.0541
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0043 0.0422 0.1685
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0043 0.0422 0.1011
Onchocerca volvulus 0.0043 0.0422 0.0678
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0422 0.1011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.1605 0.1605
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0422 0.1685
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0422 0.0467
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0006 0.0007
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0048 0.048 0.0783
Echinococcus granulosus survival motor neuron protein 1 0.0713 0.8906 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0043 0.0422 0.0467
Brugia malayi Cytochrome P450 family protein 0.0081 0.0896 0.1
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0043 0.0422 0.1685
Mycobacterium ulcerans fatty-acid-CoA ligase 0.011 0.1263 0.7024
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0043 0.0422 0.1685
Brugia malayi Carboxylesterase family protein 0.0282 0.3447 0.3866
Brugia malayi Pre-SET motif family protein 0.0435 0.5376 0.6034
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0422 0.1685
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0405 0.0454
Loa Loa (eye worm) carboxylesterase 0.0282 0.3447 0.3866
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0405 0.0659
Loa Loa (eye worm) hypothetical protein 0.011 0.1263 0.1413
Echinococcus granulosus microtubule associated protein 2 0.0688 0.8577 0.9631
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0043 0.0422 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0048 0.048 0.056
Leishmania major 4-coumarate:coa ligase-like protein 0.0147 0.1732 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0043 0.0422 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0006 0.0007
Echinococcus multilocularis muscleblind protein 1 0.0298 0.3647 0.3647
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0422 0.1011
Schistosoma mansoni thyroid hormone receptor 0.001 0.0006 0.0007
Mycobacterium ulcerans lipase LipD 0.0036 0.0332 0.1114
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0666 0.0666
Loa Loa (eye worm) hypothetical protein 0.0048 0.048 0.0533
Echinococcus granulosus expressed conserved protein 0.0091 0.1032 0.1158
Schistosoma mansoni coup transcription factor 0.001 0.0006 0.0007
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0048 0.048 0.1233
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0422 0.1685
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0332 0.0373
Schistosoma mansoni hypothetical protein 0.0035 0.0326 0.038
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0043 0.0422 0.1685
Echinococcus multilocularis carboxylesterase 5A 0.0282 0.3447 0.3447
Loa Loa (eye worm) hypothetical protein 0.0048 0.048 0.0533
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0637 0.0715
Echinococcus multilocularis neuroligin 0.0048 0.048 0.048
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.2783 1
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0332 0.2627
Schistosoma mansoni thyroid hormone receptor 0.001 0.0006 0.0007
Leishmania major cytochrome p450-like protein 0.004 0.0387 0.1462
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0043 0.0422 0.0474
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0048 0.048 0.1233
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0326 0.0366
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0332 0.1114
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0666 0.0748
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0006 0.0007
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0043 0.0422 0.1011
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0332 0.0541
Mycobacterium tuberculosis Carboxylesterase LipT 0.0048 0.048 0.1233
Echinococcus multilocularis acetylcholinesterase 0.0282 0.3447 0.3447
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0006 0.0007
Mycobacterium tuberculosis Conserved protein 0.0036 0.0332 0.0669
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0037 0.0346 0.0723
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0006 0.0006
Onchocerca volvulus 0.0048 0.048 0.0774
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0332 0.0669
Loa Loa (eye worm) hypothetical protein 0.0713 0.8906 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0043 0.0422 0.1685
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0043 0.0422 0.1011
Onchocerca volvulus 0.0043 0.0422 0.0678
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0332 0.0669
Brugia malayi Carboxylesterase family protein 0.0282 0.3447 0.3866
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0006 0.0007
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0036 0.0332 0.0366
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0147 0.1732 1
Mycobacterium ulcerans acetyl-CoA synthetase 0.0043 0.0422 0.1685
Onchocerca volvulus 0.0048 0.048 0.0774
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0043 0.0422 0.0467
Schistosoma mansoni cytochrome P450 0.0022 0.0156 0.0182
Echinococcus granulosus neuroligin 0.0048 0.048 0.0539
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0332 0.0669
Entamoeba histolytica hypothetical protein 0.0035 0.0326 0.1883
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.1605 0.1802
Loa Loa (eye worm) hypothetical protein 0.011 0.1263 0.1413
Echinococcus granulosus para nitrobenzyl esterase 0.0048 0.048 0.0539
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0387 0.8679
Loa Loa (eye worm) acetylcholinesterase 1 0.0282 0.3447 0.3866
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0006 0.0006
Trichomonas vaginalis antibiotic synthetase, putative 0.0043 0.0422 0.0687
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0156 0.0176
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0043 0.0422 0.1685
Loa Loa (eye worm) hypothetical protein 0.0036 0.0332 0.0366
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0332 0.0669
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0387 0.8679
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0006 0.0006
Brugia malayi Muscleblind-like protein 0.0298 0.3647 0.4092
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0043 0.0422 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.048 0.0533
Loa Loa (eye worm) hypothetical protein 0.0282 0.3447 0.3866
Loa Loa (eye worm) hypothetical protein 0.0048 0.048 0.0533
Entamoeba histolytica hypothetical protein 0.0035 0.0326 0.1883
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0666 1
Brugia malayi hypothetical protein 0.0035 0.0326 0.036
Schistosoma mansoni hypothetical protein 0.0022 0.0156 0.0182
Brugia malayi AMP-binding enzyme family protein 0.0147 0.1732 0.194
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.1605 0.1605
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0006 0.0006
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.1106 0.1106
Leishmania major acetyl-CoA synthetase, putative 0.0043 0.0422 0.1685
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0405 0.0448
Brugia malayi hypothetical protein 0.0713 0.8906 1
Schistosoma mansoni hypothetical protein 0.0146 0.1719 0.2004
Onchocerca volvulus 0.0147 0.1732 0.2816
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.1605 0.1871
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0043 0.0422 0.1011
Schistosoma mansoni acetylcholinesterase 0.0048 0.048 0.056
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0043 0.0422 0.3339
Echinococcus multilocularis 0.0022 0.0156 0.0156
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.011 0.1263 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0387 0.0428
Loa Loa (eye worm) hypothetical protein 0.0298 0.3647 0.4092
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0048 0.048 0.056
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0006 0.0006
Brugia malayi CHE-14 protein 0.0042 0.0405 0.0448
Plasmodium vivax SET domain protein, putative 0.0062 0.0666 0.5271
Loa Loa (eye worm) hypothetical protein 0.0048 0.048 0.0533
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0043 0.0422 0.2435
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0666 0.0666
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0332 0.0541
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.1106 0.1236
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0048 0.048 0.0539
Leishmania major hypothetical protein, conserved 0.0036 0.0332 0.1114
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0048 0.048 0.048
Plasmodium falciparum acyl-CoA synthetase 0.011 0.1263 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0332 0.0366
Mycobacterium ulcerans acyl-CoA synthetase 0.0147 0.1732 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0146 0.1719 0.1924
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0422 0.0467
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0332 0.6615
Trypanosoma brucei cytochrome P450, putative 0.004 0.0387 0.8679
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0666 0.0776
Loa Loa (eye worm) hypothetical protein 0.011 0.1263 0.1413
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0405 0.0454
Mycobacterium ulcerans hypothetical protein 0.0147 0.1732 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.1605 0.1802
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0435 0.5376 0.6034
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0147 0.1732 0.6
Loa Loa (eye worm) hypothetical protein 0.0036 0.0332 0.0366
Toxoplasma gondii ABC1 family protein 0.0036 0.0332 0.4985
Leishmania major acetyl-CoA synthetase, putative 0.0043 0.0422 0.1685
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0006 0.0007
Echinococcus multilocularis expressed conserved protein 0.0091 0.1032 0.1032
Trichomonas vaginalis set domain proteins, putative 0.0495 0.6136 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0422 0.1685
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0422 0.1685
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0006 0.0007
Brugia malayi hypothetical protein 0.0048 0.048 0.0533
Mycobacterium leprae Probable lipase LipE 0.0036 0.0332 0.1114
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0422 0.1011
Onchocerca volvulus 0.0043 0.0422 0.0678
Loa Loa (eye worm) hypothetical protein 0.0018 0.0108 0.0114
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0326 0.038
Toxoplasma gondii cytochrome p450 superfamily protein 0.0022 0.0156 0.2347
Schistosoma mansoni acetyl-CoA synthetase 0.0043 0.0422 0.0492
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0282 0.3447 0.4019
Echinococcus multilocularis microtubule associated protein 2 0.0688 0.8577 0.8577
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0043 0.0422 0.1685
Echinococcus multilocularis muscleblind protein 0.0298 0.3647 0.3647
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0422 0.1685
Loa Loa (eye worm) hypothetical protein 0.0147 0.1732 0.194
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0043 0.0422 0.0422
Loa Loa (eye worm) carboxylesterase 0.0048 0.048 0.0533
Brugia malayi Carboxylesterase family protein 0.0048 0.048 0.0533
Onchocerca volvulus 0.0146 0.1719 0.2794
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0332 0.0387
Loa Loa (eye worm) hypothetical protein 0.0036 0.0332 0.0366
Echinococcus granulosus muscleblind protein 0.0298 0.3647 0.4096
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0332 0.0366
Loa Loa (eye worm) hypothetical protein 0.0043 0.0422 0.0467
Loa Loa (eye worm) hypothetical protein 0.0147 0.1732 0.194
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0422 0.1685
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0332 0.6615
Entamoeba histolytica hypothetical protein 0.0035 0.0326 0.1883
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0137 0.1605 0.1796
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0666 0.0776
Leishmania major 4-coumarate:coa ligase-like protein 0.0147 0.1732 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0666 0.0776
Brugia malayi Cytochrome P450 family protein 0.004 0.0387 0.0428
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0006 0.0006
Echinococcus granulosus carboxylesterase 5A 0.0282 0.3447 0.3871
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0043 0.0422 0.1685
Onchocerca volvulus 0.0036 0.0332 0.0531
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.1125 0.1312
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0043 0.0422 0.1011
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0147 0.1732 1
Echinococcus multilocularis protein dispatched 1 0.0048 0.0479 0.0479
Brugia malayi cytochrome P450 0.0022 0.0156 0.0169
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0422 0.0467
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0332 0.0332
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0332 0.1114
Mycobacterium tuberculosis Conserved protein 0.0036 0.0332 0.0669
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0147 0.1732 1
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0043 0.0422 0.6335
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0043 0.0422 1
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0387 0.0428
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0006 0.0007
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0043 0.0422 0.1685
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0043 0.0422 0.1011
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0147 0.1732 1
Brugia malayi beta-lactamase family protein 0.0036 0.0332 0.0366
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0006 0.0007
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0006 0.0007
Onchocerca volvulus 0.0048 0.048 0.0774
Entamoeba histolytica acyl-CoA synthetase, putative 0.0147 0.1732 1
Schistosoma mansoni hypothetical protein 0.004 0.0386 0.0449
Echinococcus granulosus BC026374 protein S09 family 0.0048 0.048 0.0539
Schistosoma mansoni hypothetical protein 0.004 0.0386 0.0449
Mycobacterium ulcerans acyl-CoA synthetase 0.0147 0.1732 1
Mycobacterium ulcerans carboxylesterase, LipT 0.0048 0.048 0.2056
Brugia malayi Cytochrome P450 family protein 0.0022 0.0156 0.0169
Onchocerca volvulus 0.0062 0.0666 0.1076
Brugia malayi Cytochrome P450 family protein 0.004 0.0387 0.0428
Brugia malayi beta-lactamase 0.0036 0.0332 0.0366
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0006 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.1605 0.1871
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0006 0.0006
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.1106 0.1242
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0326 0.0326
Giardia lamblia Replication factor C, subunit 1 0.001 0 0.5
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0043 0.0422 1
Onchocerca volvulus 0.0048 0.048 0.0774
Schistosoma mansoni BC026374 protein (S09 family) 0.0048 0.048 0.056
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0006 0.0007
Schistosoma mansoni hypothetical protein 0.004 0.0386 0.0449
Loa Loa (eye worm) oxidoreductase 0.0043 0.0422 0.0467
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.1634 0.1634
Loa Loa (eye worm) hypothetical protein 0.0048 0.048 0.0533
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0048 0.048 0.056
Onchocerca volvulus 0.0036 0.0332 0.0531

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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