Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.1062 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0054 | 1 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.1062 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.3135 | 0.3135 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.1062 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.1062 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.3135 | 0.2319 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.3135 | 0.2319 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.1062 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.3135 | 0.5 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0.1062 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.1062 | 0.1062 |
Leishmania major | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.3135 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0054 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.3135 | 0.2319 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.1062 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.3135 | 0.2319 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.3135 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.1062 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0054 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0038 | 0.533 | 0.4775 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0.533 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0038 | 0.533 | 0.4775 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.3135 | 0.2319 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.15 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.