Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0.533 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.3135 | 0.2319 |
Brugia malayi | hypothetical protein | 0.003 | 0.3135 | 0.3135 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.3135 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.3135 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 1 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0054 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0038 | 0.533 | 0.4775 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.3135 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.1062 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.3135 | 0.2319 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.3135 | 0.2319 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0.1062 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.1062 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.3135 | 0.2319 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.1062 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.1062 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0054 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0038 | 0.533 | 0.4775 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.1062 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.1062 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.1062 | 0.1062 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.1062 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0054 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.3135 | 0.2319 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.15 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.