Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | aldehyde dehydrogenase | 0.0049 | 0.2626 | 0.2671 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.00148236 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.012 | 0.9832 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.00148236 | 0 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0049 | 0.2626 | 0.2671 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.00148236 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.00148236 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.00148236 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00148236 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.00148236 | 0 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0049 | 0.2626 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0049 | 0.2626 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00148236 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0049 | 0.2626 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0108 | 0.8602 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0111747 | 1 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0103916 | 0.919204 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.00148236 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.012 | 0.9832 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.00148236 | 0 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0049 | 0.2626 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.00148236 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.00148236 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.00148236 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0111747 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.00148236 | 0 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.00148236 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.00148236 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.00148236 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00148236 | 0 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.00148236 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.00148236 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.00148236 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.00148236 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00148236 | 0 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0049 | 0.2626 | 0.3053 |
Loa Loa (eye worm) | hypothetical protein | 0.00148236 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00148236 | 0 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0049 | 0.2626 | 0.2671 |
Onchocerca volvulus | 0.0122 | 1 | 1 | |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.00148236 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.00148236 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.00148236 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.00148236 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00148236 | 0 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.00148236 | 0 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.00148236 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.00148236 | 0 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.00148236 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.00148236 | 0 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.00148236 | 0 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.00148236 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00148236 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0049 | 0.2626 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.00148236 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0049 | 0.2626 | 0.5 |
Onchocerca volvulus | 0.00148236 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cytotoxicity (ADMET) | = 0 % | Cytotoxicity upon MRC-5 cells (diploid embryonic lung cell line) at 6.3 microM | ChEMBL. | 11495593 |
Cytotoxicity (ADMET) | = 0 % | Cytotoxicity upon MRC-5 cells (diploid embryonic lung cell line) at 1.6 uM conc. | ChEMBL. | 11495593 |
Cytotoxicity (ADMET) | = 0 % | Cytotoxicity upon MRC-5 cells (diploid embryonic lung cell line) at 6.3 microM | ChEMBL. | 11495593 |
Cytotoxicity (ADMET) | = 0 % | Cytotoxicity upon MRC-5 cells (diploid embryonic lung cell line) at 1.6 uM conc. | ChEMBL. | 11495593 |
Cytotoxicity (ADMET) | = 90 % | Cytotoxicity upon MRC-5 cells (diploid embryonic lung cell line) at 25 uM conc. | ChEMBL. | 11495593 |
Cytotoxicity (ADMET) | = 90 % | Cytotoxicity upon MRC-5 cells (diploid embryonic lung cell line) at 25 uM conc. | ChEMBL. | 11495593 |
IC50 (functional) | = 78.3 nM | Inhibitory activity against chloroquine resistant P. falciparum FcB1R strain | ChEMBL. | 11495593 |
IC50 (functional) | = 78.3 nM | Inhibitory activity against chloroquine resistant P. falciparum FcB1R strain | ChEMBL. | 11495593 |
IC50 (functional) | = 78.9 nM | Antimalarial activity after 24 hrs against chloroquine-resistant Plasmodium falciparum FcB1R/Colombia by [3H]hypoxanthine uptake | ChEMBL. | 18226428 |
NT (ADMET) | 0 | Cytotoxicity upon MPMs (mouse peritoneal macrophages) at 12.5 uM conc.;NT=No Toxicity | ChEMBL. | 11495593 |
NT (ADMET) | 0 | Cytotoxicity upon MPMs (mouse peritoneal macrophages) at 6.3 microM | ChEMBL. | 11495593 |
NT (ADMET) | 0 | Cytotoxicity upon MPMs (mouse peritoneal macrophages) at 2 microM | ChEMBL. | 11495593 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 11495593 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.