TDR Targets

Basic information

Technical information

TDR Targets ID: 157465
Name: 1-[(3,4-dimethoxyphenyl)methyl]-6-propyl-2,3, 4,9-tetrahydro-1H-pyrido[3,4-b]indole
MW: 364.481 | Formula: C23H28N2O2
H donors: 2 H acceptors: 0 LogP: 4.76 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCCc1ccc2c(c1)c1CCNC(c1[nH]2)Cc1ccc(c(c1)OC)OC
InChi: 1S/C23H28N2O2/c1-4-5-15-6-8-19-18(12-15)17-10-11-24-20(23(17)25-19)13-16-7-9-21(26-2)22(14-16)27-3/h6-9,12,14,20,24-25H,4-5,10-11,13H2,1-3H3
InChiKey: ALCNGWSUVIHDOX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-propyl-1-veratryl-2,3,4,9-tetrahydro-1H-$b-carboline
1-(3,4-dimethoxybenzyl)-6-propyl-2,3,4,9-tetrahydro-1H-$b-carboline

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0441	0.3092	0.295
Echinococcus multilocularis	lamin dm0	0.0059	0.0236	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0441	0.3092	0.3092
Toxoplasma gondii	proteasome subunit alpha type, putative	0.0054	0.0202	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0441	0.3092	0.3092
Leishmania major	proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative)	0.0054	0.0202	0.0034
Schistosoma mansoni	notch	0.0441	0.3092	0.3034
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0234	0.0118
Brugia malayi	Muscle positioning protein 4	0.0441	0.3092	0.3071
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0054	0.0202	0.0194
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0054	0.0202	0.0034
Echinococcus granulosus	protein jagged 1	0.0441	0.3092	0.3087
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0054	0.0202	0.0118
Echinococcus multilocularis	neurogenic locus notch protein	0.0441	0.3092	0.3087
Echinococcus granulosus	delta-like protein 1	0.0441	0.3092	0.3087
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0054	0.0202	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0441	0.3092	0.3092
Brugia malayi	EGF-like domain containing protein	0.0441	0.3092	0.3071
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0162	0.1008	0.2954
Schistosoma mansoni	notch	0.0441	0.3092	0.3034
Schistosoma mansoni	hypothetical protein	0.0441	0.3092	0.3034
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0234	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0441	0.3092	0.3092
Brugia malayi	EGF-like domain containing protein	0.0441	0.3092	0.3071
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.0054	0.0202	0.0034
Toxoplasma gondii	proteasome subunit alpha1, putative	0.0054	0.0202	0.0033
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0054	0.0202	0.0194
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0234	0.0152
Plasmodium vivax	proteasome subunit beta type-6, putative	0.0054	0.0202	0.0034
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.0054	0.0202	0.0034
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0054	0.0202	0.0034
Onchocerca volvulus	Dual oxidase homolog	0.1365	1	1
Loa Loa (eye worm)	hypothetical protein	0.0441	0.3092	0.3092
Schistosoma mansoni	septate junction protein	0.0441	0.3092	0.3034
Loa Loa (eye worm)	hypothetical protein	0.1365	1	1
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0054	0.0202	0.0118
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0422	0.2953	1
Brugia malayi	Proteasome A-type and B-type family protein	0.0422	0.2953	0.2931
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.0054	0.0202	0.0034
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0107	0.0597	0.0517
Leishmania major	proteasome alpha 2 subunit, putative	0.0054	0.0202	0.0034
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0142	0.086	0.0852
Plasmodium falciparum	proteasome subunit beta type-7, putative	0.0054	0.0202	0.0034
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0054	0.0202	0.0034
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0422	0.2953	1
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.0054	0.0202	0.0034
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0107	0.0597	0.0597
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0054	0.0202	0.0118
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.0054	0.0202	0.0034
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0054	0.0202	0.0194
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.0218	0.0187
Onchocerca volvulus	Chorion peroxidase homolog	0.1365	1	1
Brugia malayi	hypothetical protein	0.0034	0.0052	0.002
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0054	0.0202	0.0034
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0422	0.2953	1
Leishmania major	proteasome alpha 3 subunit, putative	0.0054	0.0202	0.0034
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0054	0.0202	0.0118
Echinococcus multilocularis	musashi	0.0059	0.0236	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0236	0.0236
Plasmodium falciparum	proteasome subunit alpha type-1, putative	0.0054	0.0202	0.0034
Loa Loa (eye worm)	hypothetical protein	0.1365	1	1
Echinococcus multilocularis	neurogenic locus protein delta	0.0441	0.3092	0.3087
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0054	0.0202	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0441	0.3092	0.3092
Loa Loa (eye worm)	hypothetical protein	0.1365	1	1
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0107	0.0597	0.1467
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0441	0.3092	0.3087
Onchocerca volvulus	Peroxidase homolog	0.1365	1	1
Echinococcus granulosus	neurogenic locus notch protein	0.0441	0.3092	0.3087
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.0054	0.0202	0.0034
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.0054	0.0202	0.0034
Trypanosoma brucei	proteasome beta 7 subunit	0.0054	0.0202	0.0034
Toxoplasma gondii	proteasome beta subunit	0.0054	0.0202	0.0033
Toxoplasma gondii	proteasome subunit	0.0054	0.0202	0.0033
Brugia malayi	Cadherin domain containing protein	0.0441	0.3092	0.3071
Loa Loa (eye worm)	hypothetical protein	0.1365	1	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0234	0.0118
Echinococcus granulosus	lamin dm0	0.0059	0.0236	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0441	0.3092	0.3092
Loa Loa (eye worm)	hypothetical protein	0.0441	0.3092	0.3092
Brugia malayi	proteasome subunit alpha type 3	0.0054	0.0202	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0441	0.3092	0.3092
Brugia malayi	MH2 domain containing protein	0.0135	0.0807	0.0778
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0107	0.0597	0.0517
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0422	0.2953	1
Schistosoma mansoni	cellular tumor antigen P53	0.0056	0.0215	0.0131
Schistosoma mansoni	peroxidasin	0.1365	1	1
Toxoplasma gondii	proteasome subunit alpha type 5-2, putative	0.0054	0.0202	0.0033
Plasmodium falciparum	proteasome subunit alpha type-2, putative	0.0054	0.0202	0.0034
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0054	0.0202	0.0194
Echinococcus granulosus	neurogenic locus protein delta	0.0441	0.3092	0.3087
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0234	0.0151
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0054	0.0202	0.0034
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0422	0.2953	0.2953
Brugia malayi	Peroxidasin	0.1365	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0142	0.086	0.0852
Leishmania major	proteasome alpha 1 subunit, putative	0.0054	0.0202	0.0034
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.0054	0.0202	0.0034
Loa Loa (eye worm)	Notch2	0.0441	0.3092	0.3092
Loa Loa (eye worm)	intermediate filament protein	0.0059	0.0236	0.0236
Echinococcus multilocularis	notch	0.0441	0.3092	0.3087
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0054	0.0202	0.0118
Onchocerca volvulus		0.0441	0.3092	0.295
Toxoplasma gondii	proteasome subunit alpha type 1, putative	0.0054	0.0202	0.0033
Echinococcus multilocularis	protein jagged 1	0.0441	0.3092	0.3087
Plasmodium falciparum	proteasome subunit alpha type-4, putative	0.0054	0.0202	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0228	0.0228
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0054	0.0202	0.0194
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.0054	0.0202	0.0034
Onchocerca volvulus	Peroxidase homolog	0.1365	1	1
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0054	0.0202	0.0118
Trypanosoma brucei	proteasome alpha 7 subunit	0.0054	0.0202	0.0034
Echinococcus granulosus	notch	0.0441	0.3092	0.3087
Schistosoma mansoni	hypothetical protein	0.0441	0.3092	0.3034
Loa Loa (eye worm)	hypothetical protein	0.0441	0.3092	0.3092
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.0218	0.0218
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0054	0.0202	0.0034
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.0054	0.0202	0.0034
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0054	0.0202	0.0118
Echinococcus granulosus	proteasome subunit beta type 6	0.0054	0.0202	0.0194
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0054	0.0202	0.0034
Echinococcus granulosus	proteasome subunit alpha type 6	0.0054	0.0202	0.0194
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.0218	0.0187
Plasmodium vivax	proteasome subunit beta type-4, putative	0.0054	0.0202	0.0034
Trypanosoma cruzi	20S proteasome subunit	0.0107	0.0597	0.1467
Echinococcus multilocularis	neural cadherin	0.0441	0.3092	0.3087
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0422	0.2953	0.2893
Echinococcus multilocularis	neurogenic locus protein delta	0.0441	0.3092	0.3087
Toxoplasma gondii	20S proteasome subunit beta 7, putative	0.0054	0.0202	0.0033
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0054	0.0202	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0441	0.3092	0.3092
Onchocerca volvulus		0.0059	0.0236	0.0035
Brugia malayi	EGF-like domain containing protein	0.0441	0.3092	0.3071
Loa Loa (eye worm)	hypothetical protein	0.1365	1	1
Echinococcus multilocularis	peroxidasin	0.1365	1	1
Echinococcus granulosus	tumor protein p63	0.0383	0.2659	0.2654
Schistosoma mansoni	peroxidasin	0.1365	1	1
Schistosoma mansoni	microtubule-associated protein tau	0.0667	0.478	0.4736
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0107	0.0597	0.1438
Echinococcus granulosus	intermediate filament protein	0.0059	0.0236	0.0228
Plasmodium falciparum	proteasome subunit beta type-6, putative	0.0054	0.0202	0.0034
Echinococcus granulosus	Proteasome subunit alpha beta	0.0054	0.0202	0.0194
Toxoplasma gondii	heat shock protein hslv, putative	0.0054	0.0202	0.0033
Schistosoma mansoni	intermediate filament proteins	0.0059	0.0236	0.0153
Brugia malayi	Proteasome A-type and B-type family protein	0.0054	0.0202	0.0171
Brugia malayi	Calcium binding EGF domain containing protein	0.0441	0.3092	0.3071
Onchocerca volvulus		0.0441	0.3092	0.295
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0422	0.2953	1
Echinococcus granulosus	microtubule associated protein 2	0.0667	0.478	0.4776
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.0054	0.0202	0.0034
Loa Loa (eye worm)	animal heme peroxidase	0.1365	1	1
Leishmania major	proteasome alpha 1 subunit, putative	0.0054	0.0202	0.0034
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0162	0.1008	0.2954
Schistosoma mansoni	notch	0.0441	0.3092	0.3034
Loa Loa (eye worm)	hypothetical protein	0.0441	0.3092	0.3092
Plasmodium falciparum	proteasome subunit beta type-3, putative	0.0054	0.0202	0.0034
Plasmodium falciparum	proteasome subunit beta type-5	0.0422	0.2953	1
Leishmania major	proteasome beta 7 subunit, putative	0.0054	0.0202	0.0034
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0054	0.0202	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0441	0.3092	0.3092
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0107	0.0597	0.1467
Loa Loa (eye worm)	hypothetical protein	0.1365	1	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0215	0.0215
Schistosoma mansoni	laminin gamma-3 chain	0.0441	0.3092	0.3034
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.0054	0.0202	0.0034
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0054	0.0202	0.0194
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0422	0.2953	0.9517
Echinococcus granulosus	proteasome subunit alpha type 2	0.0054	0.0202	0.0194
Plasmodium falciparum	proteasome subunit alpha type-3, putative	0.0054	0.0202	0.0034
Echinococcus granulosus	proteasome subunit beta type 7	0.0054	0.0202	0.0194
Echinococcus granulosus	neurogenic locus notch protein 4	0.0441	0.3092	0.3087
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0054	0.0202	0.0194
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0234	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0441	0.3092	0.3092
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0054	0.0202	0.0202
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.0054	0.0202	0.0034
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0162	0.1008	0.2954
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0054	0.0202	0.0034
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0054	0.0202	0.0202
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0107	0.0597	0.1397
Echinococcus granulosus	proteasome subunit beta t family	0.0054	0.0202	0.0194
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0107	0.0597	0.1467
Brugia malayi	Animal haem peroxidase family protein	0.1365	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0142	0.086	0.0852
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.0054	0.0202	0.0034
Echinococcus granulosus	proteasome prosome macropain	0.0422	0.2953	0.2947
Schistosoma mansoni	hypothetical protein	0.0441	0.3092	0.3034
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0054	0.0202	0.0034
Toxoplasma gondii	proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative	0.0054	0.0202	0.0033
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0162	0.1008	0.2954
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0054	0.0202	0.0194
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.0054	0.0202	0.0034
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0441	0.3092	0.3071
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0162	0.1008	0.2954
Echinococcus multilocularis	microtubule associated protein 2	0.0667	0.478	0.4776
Leishmania major	proteasome beta 5 subunit, putative	0.0422	0.2953	1
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0054	0.0202	0.0194
Brugia malayi	Proteasome subunit alpha type 1	0.0054	0.0202	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0441	0.3092	0.3092
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0054	0.0202	0.0034
Echinococcus granulosus	peroxidasin	0.1365	1	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0234	0.0144
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0422	0.2953	1
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0054	0.0202	0.0118
Schistosoma mansoni	slit	0.0441	0.3092	0.3034
Loa Loa (eye worm)	hypothetical protein	0.0441	0.3092	0.3092
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0107	0.0597	0.059
Echinococcus multilocularis	proteasome subunit beta type 6	0.0054	0.0202	0.0194
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0054	0.0202	0.0194
Echinococcus granulosus	fibropellin Ia	0.0441	0.3092	0.3087
Schistosoma mansoni	notch	0.0441	0.3092	0.3034
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0054	0.0202	0.0202
Brugia malayi	Serotonin receptor	0.0561	0.3993	0.3974
Plasmodium falciparum	proteasome subunit alpha type-7, putative	0.0054	0.0202	0.0034
Toxoplasma gondii	EGF family domain-containing protein	0.0441	0.3092	1
Schistosoma mansoni	lamin	0.0059	0.0236	0.0153
Loa Loa (eye worm)	hypothetical protein	0.1365	1	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0218	0.0218
Plasmodium falciparum	proteasome subunit alpha type-5, putative	0.0054	0.0202	0.0034
Schistosoma mansoni	hypothetical protein	0.0441	0.3092	0.3034
Brugia malayi	proteasome subunit alpha type 1	0.0054	0.0202	0.0171
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0054	0.0202	0.0034
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.0054	0.0202	0.0034
Brugia malayi	hypothetical protein	0.0053	0.0192	0.0161
Onchocerca volvulus	Slit protein homolog	0.0441	0.3092	0.295
Brugia malayi	Animal haem peroxidase family protein	0.1365	1	1
Brugia malayi	Proteasome subunit alpha type 7-1	0.0054	0.0202	0.0171
Leishmania major	proteasome beta 2 subunit, putative	0.0054	0.0202	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0441	0.3092	0.3092
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0054	0.0202	0.0202
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0054	0.0202	0.0118
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0162	0.1008	0.2812
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0054	0.0202	0.0034
Loa Loa (eye worm)	hypothetical protein	0.1365	1	1
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0054	0.0202	0.0194
Brugia malayi	Cadherin domain containing protein	0.0441	0.3092	0.3071
Brugia malayi	intermediate filament protein	0.0059	0.0236	0.0205
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0054	0.0202	0.0118
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0054	0.0202	0.0194
Plasmodium vivax	proteasome subunit beta type-7, putative	0.0054	0.0202	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0441	0.3092	0.3092
Echinococcus multilocularis	protein jagged 1	0.0441	0.3092	0.3087
Onchocerca volvulus		0.0059	0.0236	0.0035
Schistosoma mansoni	hypothetical protein	0.0441	0.3092	0.3034
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0054	0.0202	0.0118
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0054	0.0202	0.0202
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0422	0.2953	1
Brugia malayi	EGF-like domain containing protein	0.0441	0.3092	0.3071
Plasmodium vivax	proteasome subunit beta type-3, putative	0.0054	0.0202	0.0034
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0234	0.0226
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0142	0.086	0.0782
Echinococcus granulosus	slit 2 protein	0.0441	0.3092	0.3087
Brugia malayi	Animal haem peroxidase family protein	0.1365	1	1
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.0054	0.0202	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0441	0.3092	0.3092
Loa Loa (eye worm)	animal heme peroxidase	0.1365	1	1
Loa Loa (eye worm)	hypothetical protein	0.1365	1	1
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.0054	0.0202	0.0034
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0054	0.0202	0.0118
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0234	0.0118
Brugia malayi	notch-like transmembrane receptor	0.0441	0.3092	0.3071
Mycobacterium ulcerans	proteasome PrcB	0.0422	0.2953	1
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0162	0.1008	0.1008
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0054	0.0202	0.0034
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0422	0.2953	1
Brugia malayi	proteasome subunit alpha type 6	0.0054	0.0202	0.0171
Brugia malayi	proteasome subunit beta type 3	0.0054	0.0202	0.0171
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0054	0.0202	0.0202
Schistosoma mansoni	hypothetical protein	0.0441	0.3092	0.3034
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0142	0.086	0.0782
Loa Loa (eye worm)	hypothetical protein	0.1365	1	1
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0441	0.3092	0.295
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0192	0.0192
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0162	0.1008	0.293
Echinococcus granulosus	lamin	0.0059	0.0236	0.0228
Schistosoma mansoni	notch	0.0441	0.3092	0.3034
Leishmania major	proteasome alpha 7 subunit, putative	0.0054	0.0202	0.0034
Onchocerca volvulus		0.0441	0.3092	0.295
Loa Loa (eye worm)	hypothetical protein	0.0441	0.3092	0.3092
Onchocerca volvulus		0.1365	1	1
Loa Loa (eye worm)	hypothetical protein	0.0441	0.3092	0.3092
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0084	0.0053
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0054	0.0202	0.0034
Loa Loa (eye worm)	hypothetical protein	0.1365	1	1
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0107	0.0597	0.1467
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0054	0.0202	0.0202
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0059	0.0236	0.0236
Brugia malayi	proteasome subunit alpha type 2	0.0054	0.0202	0.0171
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0054	0.0202	0.0118
Schistosoma mansoni	cell polarity protein	0.0441	0.3092	0.3034
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.0054	0.0202	0.0034
Loa Loa (eye worm)	MH2 domain-containing protein	0.0135	0.0807	0.0807
Echinococcus multilocularis	neurogenic locus notch protein	0.0441	0.3092	0.3087
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0054	0.0202	0.0034
Onchocerca volvulus	Putative cubilin	0.0441	0.3092	0.295
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0054	0.0202	0.0034
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0054	0.0202	0.0194
Echinococcus multilocularis	proteasome subunit beta type 7	0.0054	0.0202	0.0194
Plasmodium falciparum	proteasome subunit alpha type-6, putative	0.0054	0.0202	0.0034
Onchocerca volvulus		0.0441	0.3092	0.295
Leishmania major	proteasome beta 2 subunit, putative	0.0107	0.0597	0.1467
Loa Loa (eye worm)	animal heme peroxidase	0.1365	1	1
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0054	0.0202	0.0194
Brugia malayi	Proteasome A-type and B-type family protein	0.0054	0.0202	0.0171
Brugia malayi	Blistered cuticle protein 3	0.1365	1	1
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0054	0.0202	0.0194
Leishmania major	proteasome beta-1 subunit, putative	0.0054	0.0202	0.0034
Plasmodium falciparum	proteasome subunit beta type-4	0.0054	0.0202	0.0034
Brugia malayi	Intermediate filament tail domain containing protein	0.0059	0.0236	0.0205
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.0054	0.0202	0.0034
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0142	0.086	0.0831
Loa Loa (eye worm)	transcription factor SMAD2	0.0135	0.0807	0.0807
Onchocerca volvulus		0.1365	1	1
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0054	0.0202	0.0202
Toxoplasma gondii	peptidase, T1 family protein	0.0054	0.0202	0.0033
Echinococcus multilocularis	fibropellin Ia	0.0441	0.3092	0.3087
Onchocerca volvulus	Peroxidasin homolog	0.1365	1	1
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0162	0.1008	0.0931
Brugia malayi	GCC2 and GCC3 family protein	0.0441	0.3092	0.3071
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0054	0.0202	0.0202
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0162	0.1008	0.1
Plasmodium falciparum	ATP-dependent protease subunit ClpQ	0.0054	0.0202	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0441	0.3092	0.3092
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0054	0.0202	0.0034
Brugia malayi	20S proteasome alpha5 subunit	0.0054	0.0202	0.0171
Brugia malayi	Calcium binding EGF domain containing protein	0.0441	0.3092	0.3071
Toxoplasma gondii	proteasome subunit beta type 7 precursor, putative	0.0054	0.0202	0.0033
Echinococcus granulosus	neurogenic locus notch protein	0.0441	0.3092	0.3087
Loa Loa (eye worm)	hypothetical protein	0.1365	1	1
Onchocerca volvulus	Peroxidasin homolog	0.1365	1	1
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0441	0.3092	0.3087
Brugia malayi	EGF-like domain containing protein	0.0441	0.3092	0.3071
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0234	0.0118
Onchocerca volvulus		0.0056	0.0215	0.0013
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0054	0.0202	0.0118
Giardia lamblia	High cysteine protein	0.0441	0.3092	1
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0054	0.0202	0.0034
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0054	0.0202	0.0118
Echinococcus multilocularis	slit 2 protein	0.0441	0.3092	0.3087
Leishmania major	proteasome alpha 7 subunit, putative	0.0054	0.0202	0.0034
Brugia malayi	Calcium binding EGF domain containing protein	0.0441	0.3092	0.3071
Echinococcus granulosus	neural cadherin	0.0441	0.3092	0.3087
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0054	0.0202	0.0034
Echinococcus granulosus	protein jagged 2	0.0441	0.3092	0.3087
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.0054	0.0202	0.0034
Loa Loa (eye worm)	animal heme peroxidase	0.1365	1	1
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.0054	0.0202	0.0034
Brugia malayi	EGF-like domain containing protein	0.0441	0.3092	0.3071
Echinococcus multilocularis	protein jagged 2	0.0441	0.3092	0.3087
Brugia malayi	proteasome subunit beta type 2	0.0107	0.0597	0.0568
Giardia lamblia	Proteasome subunit beta type 1	0.0162	0.1008	0.2789
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0054	0.0202	0.0034
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0142	0.086	0.086
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0032	0.0031	0.0031
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0142	0.086	0.0782
Schistosoma mansoni	notch	0.0441	0.3092	0.3034
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0142	0.086	0.0852
Brugia malayi	EGF-like domain containing protein	0.0441	0.3092	0.3071
Brugia malayi	proteasome subunit alpha type 4	0.0054	0.0202	0.0171
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0162	0.1008	0.1
Brugia malayi	Proteasome A-type and B-type family protein	0.0054	0.0202	0.0171
Brugia malayi	Delta serrate ligand family protein	0.0441	0.3092	0.3071
Brugia malayi	Animal haem peroxidase family protein	0.1365	1	1
Brugia malayi	proteasome subunit beta type 1	0.0162	0.1008	0.0979
Echinococcus multilocularis	lamin	0.0059	0.0236	0.0228
Onchocerca volvulus		0.1365	1	1
Echinococcus multilocularis	tumor protein p63	0.0383	0.2659	0.2654
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0008	0.0008
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0162	0.1008	0.293
Echinococcus granulosus	protein jagged 2	0.0441	0.3092	0.3087
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0107	0.0597	0.059
Brugia malayi	Animal haem peroxidase family protein	0.1365	1	1
Loa Loa (eye worm)	blistered cuticle protein 3	0.1365	1	1
Loa Loa (eye worm)	hypothetical protein	0.1365	1	1
Leishmania major	proteasome beta 3 subunit, putative	0.0054	0.0202	0.0034
Giardia lamblia	Proteasome subunit beta type 2	0.0107	0.0597	0.1369
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0084	0.0084
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.0054	0.0202	0.0034
Loa Loa (eye worm)	hypothetical protein	0.1365	1	1
Echinococcus granulosus	protein jagged 1	0.0441	0.3092	0.3087
Schistosoma mansoni	lamin	0.0059	0.0236	0.0153
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0107	0.0597	0.1438
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0422	0.2953	0.2947
Loa Loa (eye worm)	notch protein	0.0441	0.3092	0.3092
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0107	0.0597	0.1438
Schistosoma mansoni	hypothetical protein	0.0441	0.3092	0.3034
Onchocerca volvulus	Neurogenic locus notch homolog	0.0441	0.3092	0.295
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0441	0.3092	0.3034
Leishmania major	hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B	0.0054	0.0202	0.0034
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0054	0.0202	0.5
Trypanosoma brucei	proteasome beta 6 subunit	0.0162	0.1008	0.2954
Toxoplasma gondii	proteasome subunit beta type, putative	0.0422	0.2953	0.9519
Loa Loa (eye worm)	PAS-3 protein	0.0054	0.0202	0.0202

Activities

Activity type	Activity value	Assay description	Source	Reference
-Log KB (binding)	= 8.64	Binding affinity analysed for 5-HT 2B receptor in rat stomach fundus	ChEMBL.	8709108

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 10713831

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 157465