Detailed information for compound 1574703

Basic information

Technical information
  • TDR Targets ID: 1574703
  • Name: 3-bromo-1-[5-(3-bromopyridin-1-ium-1-yl)hexan -2-yl]pyridin-1-ium
  • MW: 400.151 | Formula: C16H20Br2N2++
  • H donors: 0 H acceptors: 0 LogP: 4.51 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc[n+](c1)C(CCC([n+]1cccc(c1)Br)C)C
  • InChi: 1S/C16H20Br2N2/c1-13(19-9-3-5-15(17)11-19)7-8-14(2)20-10-4-6-16(18)12-20/h3-6,9-14H,7-8H2,1-2H3/q+2
  • InChiKey: TULMUCDXOPUSJN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-bromo-1-[4-(3-bromopyridin-1-ium-1-yl)-1-methyl-pentyl]pyridin-1-ium
  • 3-bromo-1-[4-(3-bromo-1-pyridin-1-iumyl)-1-methylpentyl]pyridin-1-ium

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0037 0.002 0.5
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0088 0.0367 0.0439
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0921 0.2667
Loa Loa (eye worm) hypothetical protein 0.1496 1 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0088 0.0367 0.0439
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0206 0.1177 0.3423
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0037 0.002 0.5
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0088 0.0367 0.0439
Loa Loa (eye worm) subtilase 0.0037 0.002 0.002
Echinococcus granulosus G protein coupled receptor kinase 1 0.0081 0.0318 0.0377
Echinococcus granulosus Furin 1 0.0206 0.1177 0.1461
Echinococcus granulosus neuroendocrine convertase 2 0.0549 0.3523 0.4422
Onchocerca volvulus 0.0088 0.0367 0.318
Schistosoma mansoni biogenic amine receptor 0.0088 0.0367 0.0547
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0112 0.0529 0.051
Schistosoma mansoni biogenic amine (5HT) receptor 0.0088 0.0367 0.0547
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0088 0.0367 0.0348
Echinococcus multilocularis neuropeptide FF receptor 2 0.0088 0.0367 0.0439
Echinococcus granulosus sex peptide receptor 0.0088 0.0367 0.0439
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Schistosoma mansoni biogenic amine receptor 0.0088 0.0367 0.0547
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0053 0.013 0.0139
Onchocerca volvulus 0.0088 0.0367 0.318
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.0367 0.0547
Loa Loa (eye worm) hypothetical protein 0.0053 0.013 0.013
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0088 0.0367 0.0439
Schistosoma mansoni histamine h1 receptor 0.0088 0.0367 0.0547
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Brugia malayi putative neuropeptide receptor NPR1 0.0088 0.0367 0.0348
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0382 0.057
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.0367 0.0439
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Schistosoma mansoni growth hormone secretagogue receptor 0.0088 0.0367 0.0547
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0088 0.0367 0.0348
Brugia malayi follicle stimulating hormone receptor 0.0088 0.0367 0.0348
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0088 0.0367 0.0348
Loa Loa (eye worm) hypothetical protein 0.0139 0.0717 0.0717
Echinococcus granulosus biogenic amine 5HT receptor 0.0088 0.0367 0.0439
Loa Loa (eye worm) G-protein coupled receptor 0.0088 0.0367 0.0367
Plasmodium vivax apical membrane antigen 1 0.0289 0.1741 1
Brugia malayi endoprotease bli-4 precursor 0.0874 0.5745 0.5737
Echinococcus granulosus g protein coupled receptor 0.0088 0.0367 0.0439
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0531 0.3399 0.4267
Brugia malayi hypothetical protein 0.0088 0.0367 0.0348
Onchocerca volvulus 0.0088 0.0367 0.318
Echinococcus multilocularis G-protein coupled receptor, putative 0.0088 0.0367 0.0439
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0088 0.0367 0.0547
Schistosoma mansoni neuropeptide F-like receptor 0.0088 0.0367 0.0547
Echinococcus multilocularis serotonin receptor 0.0088 0.0367 0.0439
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0088 0.0367 0.0547
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0037 0.002 0.0029
Echinococcus multilocularis serotonin receptor 0.0088 0.0367 0.0439
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Trichomonas vaginalis hypothetical protein 0.0169 0.0921 0.2667
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.0367 0.0547
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0169 0.0921 0.2667
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Plasmodium falciparum apical membrane antigen 1 0.0289 0.1741 1
Loa Loa (eye worm) TYRA-2 protein 0.0088 0.0367 0.0367
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0088 0.0367 0.0439
Schistosoma mansoni amine GPCR 0.0088 0.0367 0.0547
Schistosoma mansoni integrin beta subunit 0.0179 0.099 0.1475
Echinococcus multilocularis fmrfamide receptor 0.0088 0.0367 0.0439
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0081 0.0318 0.0377
Brugia malayi proprotein convertase 2 0.0549 0.3523 0.351
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0088 0.0367 0.0439
Echinococcus multilocularis protein will die slowly 0.0131 0.0662 0.0811
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0088 0.0367 0.0367
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0088 0.0367 0.0547
Schistosoma mansoni neuropeptide f receptor 76f 0.0088 0.0367 0.0547
Echinococcus granulosus neuropeptide FF receptor 2 0.0088 0.0367 0.0439
Schistosoma mansoni hypothetical protein 0.0139 0.0717 0.1069
Echinococcus granulosus neuropeptide s receptor 0.0555 0.356 0.447
Loa Loa (eye worm) hypothetical protein 0.0874 0.5745 0.5745
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0139 0.0717 0.0699
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0088 0.0367 0.0439
Brugia malayi Will die slowly protein 0.0131 0.0662 0.0644
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.0367 0.0439
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.0367 0.0439
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0037 0.002 0.5
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0037 0.002 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0921 0.2667
Echinococcus granulosus neuropeptide Y receptor 0.0088 0.0367 0.0439
Brugia malayi hypothetical protein 0.0088 0.0367 0.0348
Echinococcus multilocularis g protein coupled receptor 0.0088 0.0367 0.0439
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.0367 0.0547
Loa Loa (eye worm) hypothetical protein 0.0301 0.1823 0.1823
Brugia malayi Tachykinin-like peptides receptor 99D 0.0088 0.0367 0.0348
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0088 0.0367 0.0439
Echinococcus multilocularis neuropeptide receptor 0.0088 0.0367 0.0439
Echinococcus multilocularis neuropeptides capa receptor 0.0088 0.0367 0.0439
Echinococcus granulosus neuropeptide receptor 0.0088 0.0367 0.0439
Schistosoma mansoni integrin alpha-ps 0.0066 0.0217 0.0324
Schistosoma mansoni apoptosis regulator bax 0.0053 0.013 0.0193
Schistosoma mansoni hypothetical protein 0.0053 0.013 0.0193
Onchocerca volvulus 0.0088 0.0367 0.318
Schistosoma mansoni hypothetical protein 0.0301 0.1823 0.2718
Echinococcus multilocularis neuropeptide receptor A26 0.0555 0.356 0.447
Echinococcus multilocularis beta adrenergic receptor kinase 0.009 0.0382 0.0458
Brugia malayi Dopamine receptor protein 1 0.0088 0.0367 0.0348
Schistosoma mansoni neuropeptide receptor 0.0088 0.0367 0.0547
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0088 0.0367 0.0348
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0921 0.2667
Echinococcus multilocularis g-protein coupled receptor 0.0088 0.0367 0.0439
Loa Loa (eye worm) neuropeptide F receptor 0.0088 0.0367 0.0367
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0921 0.2667
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.1195 0.7941 1
Toxoplasma gondii apical membrane antigen 1 protein 0.0068 0.0231 0.1228
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0206 0.1177 0.3423
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.0367 0.0439
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.0367 0.0547
Echinococcus granulosus neuropeptide receptor 0.1015 0.671 0.8446
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0139 0.0717 0.0881
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.0367 0.0547
Brugia malayi neuropeptide F receptor 0.0088 0.0367 0.0348
Schistosoma mansoni alpha-1 adrenergic receptor 0.0088 0.0367 0.0547
Echinococcus multilocularis 0.0705 0.4588 0.5768
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.0367 0.0439
Onchocerca volvulus Neuropeptide F receptor homolog 0.0088 0.0367 0.318
Echinococcus granulosus g-protein coupled receptor 0.0088 0.0367 0.0439
Brugia malayi AKH receptor 0.0088 0.0367 0.0348
Loa Loa (eye worm) neuropeptide F receptor 0.0088 0.0367 0.0367
Echinococcus multilocularis neuropeptide s receptor 0.0555 0.356 0.447
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.009 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0206 0.1177 0.1754
Echinococcus multilocularis beta catenin 0.0198 0.1122 0.1391
Echinococcus multilocularis neuropeptides capa receptor 0.0088 0.0367 0.0439
Echinococcus multilocularis integrin alpha ps 0.0066 0.0217 0.0249
Brugia malayi Serotonin receptor 0.0088 0.0367 0.0348
Onchocerca volvulus 0.0088 0.0367 0.318
Echinococcus granulosus tm gpcr rhodopsin 0.0088 0.0367 0.0439
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0669 0.4341 0.5455
Echinococcus multilocularis integrin beta 2 0.0225 0.1306 0.1624
Schistosoma mansoni neuropeptide receptor 0.0088 0.0367 0.0547
Echinococcus multilocularis integrin alpha 3 0.0113 0.0539 0.0655
Onchocerca volvulus 0.0088 0.0367 0.318
Onchocerca volvulus 0.0088 0.0367 0.318
Echinococcus granulosus integrin alpha 3 0.0113 0.0539 0.0655
Schistosoma mansoni beta-catenin 0.0198 0.1122 0.1672
Brugia malayi GnHR receptor homolog 0.0088 0.0367 0.0348
Echinococcus granulosus alpha 1A adrenergic receptor 0.0088 0.0367 0.0439
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0088 0.0367 0.0439
Plasmodium vivax merozoite adhesive erythrocytic binding protein 0.0068 0.0231 0.1228
Schistosoma mansoni opsin-like receptor 0.0088 0.0367 0.0547
Schistosoma mansoni hypothetical protein 0.0131 0.0662 0.0987
Brugia malayi hypothetical protein 0.0088 0.0367 0.0348
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Schistosoma mansoni amine GPCR 0.0088 0.0367 0.0547
Echinococcus granulosus GPCR family 2 0.0139 0.0717 0.0881
Brugia malayi Melatonin receptor type 1A 0.0088 0.0367 0.0348
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0037 0.002 0.5
Brugia malayi Integrin beta pat-3 precursor 0.0304 0.1846 0.1829
Brugia malayi G-protein coupled receptor 0.0088 0.0367 0.0348
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0053 0.013 0.0139
Loa Loa (eye worm) proprotein convertase 2 0.0206 0.1177 0.1177
Brugia malayi RE15519p 0.0088 0.0367 0.0348
Echinococcus granulosus tm gpcr rhodopsin 0.0088 0.0367 0.0439
Trypanosoma cruzi subtilisin peptidase 0.0037 0.002 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0088 0.0367 0.0439
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.1195 0.7941 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Echinococcus granulosus g protein coupled receptor 0.0088 0.0367 0.0439
Schistosoma mansoni furin-1 (S08 family) 0.038 0.2366 0.3526
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0088 0.0367 0.0439
Brugia malayi G-protein coupled receptor 0.0088 0.0367 0.0348
Schistosoma mansoni hypothetical protein 0.0053 0.013 0.0193
Echinococcus granulosus beta catenin 0.0198 0.1122 0.1391
Brugia malayi sulfakinin receptor protein 0.0088 0.0367 0.0348
Brugia malayi hypothetical protein 0.0088 0.0367 0.0348
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Schistosoma mansoni hypothetical protein 0.0139 0.0717 0.1069
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0139 0.0717 0.0881
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0088 0.0367 0.0367
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0921 0.2667
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0088 0.0367 0.0367
Loa Loa (eye worm) integrin alpha pat-2 0.0228 0.1322 0.1322
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0088 0.0367 0.0439
Echinococcus granulosus hypothetical protein 0.0088 0.0367 0.0439
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0874 0.5745 0.8563
Loa Loa (eye worm) pigment dispersing factor receptor c 0.044 0.2777 0.2777
Brugia malayi hypothetical protein 0.0046 0.008 0.0061
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0046 0.008 0.008
Echinococcus granulosus integrin alpha ps 0.0066 0.0217 0.0249
Loa Loa (eye worm) WD40 repeat protein 0.0131 0.0662 0.0662
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0037 0.002 0.0029
Echinococcus granulosus neuropeptides capa receptor 0.0088 0.0367 0.0439
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0037 0.002 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0921 0.2667
Echinococcus granulosus allatostatin A receptor 0.0088 0.0367 0.0439
Schistosoma mansoni adenoreceptor 0.0088 0.0367 0.0547
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Loa Loa (eye worm) endoprotease bli-4 0.0874 0.5745 0.5745
Onchocerca volvulus 0.0088 0.0367 0.318
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0037 0.002 0.5
Echinococcus multilocularis G protein coupled receptor 139 0.1015 0.671 0.8446
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0088 0.0367 0.0547
Echinococcus multilocularis orexin receptor type 2 0.0088 0.0367 0.0439
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.0367 0.0547
Schistosoma mansoni hypothetical protein 0.0053 0.013 0.0193
Schistosoma mansoni neuropeptide receptor 0.1015 0.671 1
Loa Loa (eye worm) hypothetical protein 0.0343 0.211 0.211
Brugia malayi ORL1-like opioid receptor 0.0088 0.0367 0.0348
Onchocerca volvulus 0.0088 0.0367 0.318
Schistosoma mansoni opsin-like receptor 0.0088 0.0367 0.0547
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Echinococcus granulosus g protein coupled receptor 0.0088 0.0367 0.0439
Loa Loa (eye worm) HMP-2 protein 0.0198 0.1122 0.1122
Echinococcus granulosus neuropeptide receptor A26 0.0555 0.356 0.447
Brugia malayi Dopamine receptor protein 2 0.0088 0.0367 0.0348
Echinococcus granulosus protein will die slowly 0.0131 0.0662 0.0811
Brugia malayi Armadillo/beta-catenin-like repeat family protein 0.0198 0.1122 0.1104
Echinococcus granulosus 7tm_1 domain containing protein 0.0088 0.0367 0.0439
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0053 0.013 0.0193
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.0367 0.0547
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0531 0.3399 0.4267
Onchocerca volvulus 0.0088 0.0367 0.318
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.0367 0.0439
Loa Loa (eye worm) G-protein coupled receptor 0.0088 0.0367 0.0367
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Brugia malayi hypothetical protein 0.0088 0.0367 0.0348
Echinococcus multilocularis neuroendocrine convertase 2 0.0549 0.3523 0.4422
Echinococcus granulosus beta-adrenergic receptor kinase 0.009 0.0382 0.0458
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0382 0.057
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0921 0.2667
Echinococcus granulosus tachykinin peptides receptor 99D 0.0088 0.0367 0.0439
Brugia malayi Kelch motif family protein 0.0046 0.008 0.0061
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0088 0.0367 0.0547
Schistosoma mansoni amine GPCR 0.0088 0.0367 0.0547
Schistosoma mansoni hypothetical protein 0.0088 0.0367 0.0547
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0088 0.0367 0.0547
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.0367 0.0439
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.0367 0.0439
Echinococcus granulosus serotonin receptor 0.0088 0.0367 0.0439
Brugia malayi latrophilin 2 splice variant baaae 0.0301 0.1823 0.1807
Schistosoma mansoni biogenic amine (5HT) receptor 0.0088 0.0367 0.0547
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0169 0.0921 0.2667
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0669 0.4341 0.5455
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0088 0.0367 0.0439
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0088 0.0367 0.0547
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0088 0.0367 0.0348
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0531 0.3399 1
Brugia malayi hypothetical protein 0.0088 0.0367 0.0348
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0531 0.3399 1
Brugia malayi neuropeptide F receptor 0.0088 0.0367 0.0348
Schistosoma mansoni amine GPCR 0.0088 0.0367 0.0547
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0921 0.2667
Mycobacterium leprae Possible secreted protease 0.0037 0.002 0.5
Onchocerca volvulus 0.0088 0.0367 0.318
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Schistosoma mansoni hypothetical protein 0.0169 0.0921 0.1373
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0206 0.1177 0.3423
Echinococcus multilocularis integrin alpha ps 0.0066 0.0217 0.0249
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0206 0.1177 0.3423
Brugia malayi G protein-coupled receptor F59B2.13 0.0088 0.0367 0.0348
Onchocerca volvulus 0.0088 0.0367 0.318
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Schistosoma mansoni serine-type protease inhibitor 0.0458 0.2896 0.4316
Echinococcus granulosus fmrfamide receptor 0.0088 0.0367 0.0439
Schistosoma mansoni hypothetical protein 0.0088 0.0367 0.0547
Echinococcus granulosus integrin beta 2 0.0225 0.1306 0.1624
Loa Loa (eye worm) hypothetical protein 0.0037 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0088 0.0367 0.0547
Loa Loa (eye worm) melatonin receptor type 1A 0.0088 0.0367 0.0367
Brugia malayi hypothetical protein 0.0088 0.0367 0.0348
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0921 0.2667
Echinococcus granulosus tm gpcr rhodopsin 0.0088 0.0367 0.0439
Loa Loa (eye worm) hypothetical protein 0.0082 0.0322 0.0322
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0088 0.0367 0.0439
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0053 0.013 0.011
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Brugia malayi Latrophilin receptor protein 2 0.0139 0.0717 0.0699
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Onchocerca volvulus 0.0088 0.0367 0.318
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0037 0.002 0.5
Brugia malayi putative neuropeptide receptor 0.0088 0.0367 0.0348
Echinococcus granulosus neuropeptides capa receptor 0.0088 0.0367 0.0439
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0206 0.1177 0.3423
Echinococcus granulosus furin 0.0874 0.5745 0.7228
Giardia lamblia High cysteine membrane protein Group 2 0.0325 0.1987 1
Brugia malayi hypothetical protein 0.0088 0.0367 0.0348
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0921 0.2667
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.0921 0.2667
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0088 0.0367 0.0547
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Onchocerca volvulus 0.0088 0.0367 0.318
Echinococcus granulosus orexin receptor type 2 0.0088 0.0367 0.0439
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0169 0.0921 0.2667
Loa Loa (eye worm) hypothetical protein 0.0116 0.0558 0.0558
Loa Loa (eye worm) integrin beta-2 0.0304 0.1846 0.1846
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0088 0.0367 0.318
Brugia malayi neuroendocrine convertase 1 precursor 0.0549 0.3523 0.351
Echinococcus multilocularis GPCR, family 2 0.0139 0.0717 0.0881
Brugia malayi hypothetical protein 0.0088 0.0367 0.0348
Brugia malayi Dopamine receptor 0.0088 0.0367 0.0348
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0088 0.0367 0.0547
Toxoplasma gondii apical membrane antigen 1 domain-containing protein 0.0289 0.1741 1
Schistosoma mansoni hypothetical protein 0.0139 0.0717 0.1069
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.0367 0.0439
Loa Loa (eye worm) latrophilin receptor protein 2 0.0139 0.0717 0.0717
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0037 0.002 0.5
Trypanosoma brucei subtilisin peptidase 0.0037 0.002 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0088 0.0367 0.0439
Plasmodium falciparum membrane associated erythrocyte binding-like protein 0.0068 0.0231 0.1228
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0206 0.1177 0.3423
Echinococcus granulosus biogenic amine 5HT receptor 0.0088 0.0367 0.0439
Echinococcus granulosus G protein coupled receptor 139 0.0088 0.0367 0.0439
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0088 0.0367 0.0547
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Echinococcus multilocularis dro:myosuppressin receptor 0.0088 0.0367 0.0439
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Schistosoma mansoni hypothetical protein 0.0139 0.0717 0.1069
Schistosoma mansoni myosin xvIII 0.0088 0.0367 0.0547
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.0367 0.0439
Brugia malayi hypothetical protein 0.0088 0.0367 0.0348
Echinococcus multilocularis somatostatin receptor 0.0088 0.0367 0.0439
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.0367 0.0439
Brugia malayi larval opioid receptor 0.0088 0.0367 0.0348
Schistosoma mansoni amine GPCR 0.0088 0.0367 0.0547
Toxoplasma gondii apical membrane antigen AMA1 0.0068 0.0231 0.1228
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0088 0.0367 0.0547
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0088 0.0367 0.0439
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0088 0.0367 0.0367
Schistosoma mansoni neuropeptide F-like receptor 0.0088 0.0367 0.0547
Echinococcus granulosus dro:myosuppressin receptor 0.0088 0.0367 0.0439
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0037 0.002 0.5
Schistosoma mansoni integrin alpha 0.0148 0.0775 0.1155
Echinococcus multilocularis g protein coupled receptor 0.0088 0.0367 0.0439
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.0367 0.0547
Schistosoma mansoni hypothetical protein 0.0088 0.0367 0.0547
Echinococcus multilocularis g protein coupled receptor 0.0088 0.0367 0.0439
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0088 0.0367 0.0439
Schistosoma mansoni biogenic amine receptor 0.0088 0.0367 0.0547
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0088 0.0367 0.0439
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0088 0.0367 0.0547
Loa Loa (eye worm) hypothetical protein 0.0112 0.0529 0.0529
Echinococcus multilocularis fmrfamide receptor 0.0088 0.0367 0.0439
Echinococcus multilocularis rhodopsin orphan GPCR 0.0088 0.0367 0.0439
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0037 0.002 0.5
Schistosoma mansoni hypothetical protein 0.0088 0.0367 0.0547
Brugia malayi Calcitonin receptor-like protein seb-1 0.044 0.2777 0.2762
Loa Loa (eye worm) apoptosis regulator protein 0.0053 0.013 0.013
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0088 0.0367 0.0439
Echinococcus granulosus 7TM GPCR rhodopsin 0.0088 0.0367 0.0439
Onchocerca volvulus 0.0088 0.0367 0.318
Brugia malayi Serotonin receptor 0.0088 0.0367 0.0348
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0088 0.0367 0.0547
Schistosoma mansoni site-1 peptidase (S08 family) 0.0037 0.002 0.0029
Echinococcus multilocularis neuropeptide receptor 0.1015 0.671 0.8446
Brugia malayi Integrin alpha pat-2 precursor 0.0148 0.0775 0.0757
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.0367 0.0439
Echinococcus multilocularis sex peptide receptor 0.0088 0.0367 0.0439
Schistosoma mansoni opsin-like receptor 0.0088 0.0367 0.0547
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0088 0.0367 0.0367
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.0367 0.0439
Brugia malayi celfurPC protein 0.0705 0.4588 0.4578
Echinococcus granulosus peptide allatostatin:somatostatin 0.0088 0.0367 0.0439
Onchocerca volvulus 0.0088 0.0367 0.318
Schistosoma mansoni neuropeptide receptor 0.0088 0.0367 0.0547
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0088 0.0367 0.0439
Schistosoma mansoni site-1 peptidase (S08 family) 0.0037 0.002 0.0029
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0037 0.002 0.5
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0088 0.0367 0.0439
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0037 0.002 0.5
Onchocerca volvulus 0.0131 0.0662 0.5879
Onchocerca volvulus Cirhin homolog 0.0197 0.1113 1
Echinococcus multilocularis Furin 1 0.0206 0.1177 0.1461
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Echinococcus multilocularis neuropeptide Y receptor 0.0088 0.0367 0.0439
Echinococcus granulosus somatostatin receptor 0.0088 0.0367 0.0439
Onchocerca volvulus 0.0088 0.0367 0.318
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367
Trichomonas vaginalis WD repeat domain, putative 0.0131 0.0662 0.1901
Echinococcus granulosus rhodopsin orphan GPCR 0.0088 0.0367 0.0439
Schistosoma mansoni serine-type protease inhibitor 0.0458 0.2896 0.4316
Leishmania major subtilisin-like serine peptidase 0.0037 0.002 0.5
Plasmodium falciparum membrane associated erythrocyte binding-like protein 0.0068 0.0231 0.1228
Echinococcus multilocularis allatostatin A receptor 0.0088 0.0367 0.0439
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0088 0.0367 0.0439
Brugia malayi G protein-coupled receptor 0.0088 0.0367 0.0348
Loa Loa (eye worm) hypothetical protein 0.0046 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0088 0.0367 0.0367

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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