Detailed information for compound 1574855

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 407.441 | Formula: C18H21N3O6S
  • H donors: 1 H acceptors: 4 LogP: 3.03 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)N1C(=S)N=C(/C(=C(\OC(C)C)/O)/[C@@H]1c1cccc(c1)[N+](=O)[O-])C
  • InChi: 1S/C18H21N3O6S/c1-5-26-18(23)20-15(12-7-6-8-13(9-12)21(24)25)14(11(4)19-17(20)28)16(22)27-10(2)3/h6-10,15,22H,5H2,1-4H3/b16-14+/t15-/m0/s1
  • InChiKey: MNQUJICKNQOWHX-IDTYTIONSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens calcium channel, voltage-dependent, L type, alpha 1F subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni high voltage-activated calcium channel Cav1 Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum expressed protein Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni high voltage-activated calcium channel Cav2A Get druggable targets OG5_126791 All targets in OG5_126791
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type D subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent L type calcium channel subunit Get druggable targets OG5_126791 All targets in OG5_126791
Neospora caninum hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum expressed protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni voltage-gated cation channel Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) voltage-dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type A subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Toxoplasma gondii transporter, cation channel family protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel type d subunit Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Muscle calcium channel subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type A subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04850 calcium channel, voltage-dependent, L type, alpha 1C subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent L type calcium channel subunit Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04853 calcium channel, voltage-dependent, L type, alpha 1F subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma brucei gambiense calcium channel protein, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type D subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent N-type calcium channel subunit alpha-1B, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Probable voltage-dependent R-type calcium channel subunit alpha-1E, putative Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel type d subunit Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04344 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04849 calcium channel, voltage-dependent, N type, alpha 1B subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma congolense Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0446 0.1503 0.1503
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0061 0.0067
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0428 0.1443 0.1594
Giardia lamblia Replication factor C, subunit 1 0.001 0.0004 0.0149
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2559 0.878 0.878
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0091 0.0091
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0109 0.4574
Loa Loa (eye worm) hypothetical protein 0.0146 0.0472 0.0522
Schistosoma mansoni ubiquitin-specific peptidase 24 (C19 family) 0.0009 0.0001 0.0001
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0054 0.2266
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0004 0.0122
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0036 0.0035
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0091 0.009
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0008 0.0007
Leishmania major DNA polymerase kappa, putative 0.002 0.0039 0.1627
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0039 0.1627
Schistosoma mansoni hypothetical protein 0.2914 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.0372 0.2255
Mycobacterium ulcerans DNA polymerase IV 0.0065 0.0194 0.1267
Echinococcus multilocularis Smad4 0.0016 0.0025 0.0024
Entamoeba histolytica HEAT repeat domain containing protein 0.0012 0.0012 0.0289
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0495 0.1674 1
Echinococcus multilocularis voltage dependent calcium channel 0.0093 0.0289 0.0288
Trypanosoma brucei DNA polymerase eta, putative 0.0065 0.0194 0.8185
Brugia malayi RNA, U transporter 1 0.0183 0.0601 0.0664
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.0152
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0047 0.0047
Brugia malayi hypothetical protein 0.001 0.0004 0.0004
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0054 0.2799
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Echinococcus multilocularis transportin 1 0.0012 0.0012 0.0011
Echinococcus granulosus zinc finger protein 0.004 0.0109 0.0108
Schistosoma mansoni hypothetical protein 0.0011 0.0008 0.0008
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0047 0.0052
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0047 0.1976
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0065 0.0194 0.8185
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0047 0.013 0.013
Schistosoma mansoni ubiquitin-specific peptidase 7 (C19 family) 0.0009 0.0001 0.0001
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0009 0.0001 0.0001
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0036 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0194 0.8185
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0138 0.0137
Brugia malayi polk-prov protein 0.002 0.0039 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0194 0.8185
Brugia malayi PHD-finger family protein 0.0051 0.0147 0.0162
Loa Loa (eye worm) MH2 domain-containing protein 0.0235 0.0777 0.0859
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0091 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0004 0.0017
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0061 0.0067
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0047 0.0047
Brugia malayi hypothetical protein 0.001 0.0004 0.0004
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.2637 0.9047 0.9047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0154 0.0499 0.0552
Echinococcus multilocularis importin 5 0.0012 0.0012 0.0011
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0039 0.1627
Echinococcus multilocularis translational activator gcn1 0.0012 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0084 0.0259 0.0286
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0236 0.0817
Schistosoma mansoni acetylcholinesterase 0.0446 0.1503 0.1503
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0214
Schistosoma mansoni hypothetical protein 0.0106 0.0333 0.0333
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0004 0.0017
Echinococcus multilocularis voltage dependent calcium channel 0.0093 0.0289 0.0288
Schistosoma mansoni calpain-7 (C02 family) 0.0009 0.0001 0.0001
Entamoeba histolytica deoxycytidyl transferase, putative 0.0065 0.0194 0.5163
Schistosoma mansoni ubiquitin-specific peptidase 22 (C19 family) 0.0009 0.0001 0.0001
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0093 0.0289 0.0288
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.0374 0.0374
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0052 0.015 0.0904
Leishmania major DNA damage repair protein, putative 0.002 0.0039 0.1627
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0156 0.0155
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0053 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Schistosoma mansoni importin-beta 2 0.0012 0.0012 0.0012
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0004 0.0122
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0109 0.0108
Trypanosoma brucei importin beta-1 subunit, putative 0.0064 0.0192 0.8098
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0116 0.0116
Schistosoma mansoni hypothetical protein 0.0049 0.0138 0.0138
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0109 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0181 0.018
Entamoeba histolytica Ran family GTPase 0.0023 0.0047 0.1246
Entamoeba histolytica protein kinase, putative 0.0118 0.0374 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0.0001 0.0001
Loa Loa (eye worm) carboxylesterase 0.0446 0.1503 0.1662
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0054 0.2266
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Loa Loa (eye worm) carboxylesterase 0.2637 0.9047 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0236 0.0261
Loa Loa (eye worm) nuclear factor I 0.0009 0.0000041609 0.0000045992
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0097 0.0302 0.0302
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0039 0.1627
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 46 0.0009 0.0001 0.0001
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0014 0.0013
Loa Loa (eye worm) transcription factor SMAD2 0.0235 0.0777 0.0859
Onchocerca volvulus 0.0077 0.0236 0.1432
Schistosoma mansoni ubiquitin-specific peptidase 48 (C19 family) 0.0009 0.0001 0.0001
Schistosoma mansoni importin beta-1 0.0064 0.0192 0.0192
Brugia malayi ImpB/MucB/SamB family protein 0.0065 0.0194 0.0214
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0688 0.2339 0.2585
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0004 0.0151
Echinococcus granulosus acetylcholinesterase 0.2637 0.9047 0.9047
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0039 0.1627
Echinococcus multilocularis zinc finger protein 0.004 0.0109 0.0108
Schistosoma mansoni ubiquitin-specific peptidase 45 (C19 family) 0.0009 0.0001 0.0001
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0236 1
Schistosoma mansoni rab6-interacting 0.0019 0.0036 0.0036
Plasmodium vivax transportin, putative 0.0012 0.0012 0.0458
Schistosoma mansoni voltage-gated cation channel 0.0093 0.0289 0.0289
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0236 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0065 0.0194 0.0194
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0036 0.0035
Trypanosoma brucei importin beta-1 subunit, putative 0.0064 0.0192 0.8098
Onchocerca volvulus 0.0027 0.0061 0.0366
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0446 0.1503 0.1503
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0004 0.0004
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0004 0.0122
Mycobacterium tuberculosis Conserved hypothetical protein 0.0065 0.0194 0.0543
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.0155 0.0502 0.0555
Entamoeba histolytica protein kinase, putative 0.0118 0.0374 1
Schistosoma mansoni ap endonuclease 0.004 0.0109 0.0109
Echinococcus granulosus translational activator gcn1 0.0012 0.0012 0.0011
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0036 0.1858
Schistosoma mansoni ap endonuclease 0.004 0.0109 0.0109
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0138 0.0152
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0093 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Echinococcus granulosus intermediate filament protein 0.0027 0.0061 0.006
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0116 0.4877
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0047 0.013 0.0129
Brugia malayi Carboxylesterase family protein 0.0446 0.1503 0.1662
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0109 0.0699
Schistosoma mansoni smad1 5 8 and 0.0016 0.0025 0.0025
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0103 0.0102
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0199 0.0199
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0446 0.1503 0.1503
Trichomonas vaginalis DNA polymerase eta, putative 0.0065 0.0194 0.1172
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0116 0.0115
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0.0001 0.0001
Toxoplasma gondii hypothetical protein 0.0017 0.0028 0.1174
Echinococcus granulosus smad 0.0016 0.0025 0.0024
Trypanosoma brucei ISWI complex protein 0.0032 0.0078 0.3291
Brugia malayi hypothetical protein 0.0016 0.0024 0.0027
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0009 0.0001 0.0001
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0009 0.0001 0.0001
Trichomonas vaginalis esterase, putative 0.0077 0.0236 0.1432
Entamoeba histolytica hypothetical protein 0.0111 0.0353 0.9426
Echinococcus multilocularis carboxylesterase 5A 0.2637 0.9047 0.9047
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0036 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0194 0.8185
Trichomonas vaginalis serine threonine-protein kinase, putative 0.0117 0.0372 0.2255
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0047 0.2414
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0039 0.1627
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0053 0.0151 0.6381
Schistosoma mansoni ubiquitin-specific peptidase 46 (C19 family) 0.0009 0.0001 0.0001
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0009 0.0001 0.0001
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0053 0.0151 0.6381
Echinococcus granulosus acetylcholinesterase 0.2637 0.9047 0.9047
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0039 0.1627
Brugia malayi ImpB/MucB/SamB family protein 0.0065 0.0194 0.0214
Brugia malayi beta-lactamase family protein 0.0077 0.0236 0.0261
Schistosoma mansoni hypothetical protein 0.0049 0.0138 0.0138
Onchocerca volvulus 0.0446 0.1503 0.9133
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0236 0.1432
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0109 0.4574
Echinococcus multilocularis serine:threonine protein kinase:endoribonuclease 0.0118 0.0374 0.0373
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0236 0.0817
Echinococcus granulosus dna polymerase eta 0.0065 0.0194 0.0193
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Schistosoma mansoni intermediate filament proteins 0.0027 0.0061 0.0061
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0004 0.0004
Brugia malayi Bromodomain containing protein 0.0155 0.0503 0.0556
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0199 0.0199
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0004 0.0077
Toxoplasma gondii exonuclease III APE 0.004 0.0109 0.4574
Echinococcus granulosus BC026374 protein S09 family 0.0446 0.1503 0.1503
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0004 0.0122
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0194 0.8185
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0065 0.0194 0.0214
Schistosoma mansoni rab6-interacting 0.0019 0.0036 0.0036
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0053 0.0151 0.4025
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0093 0.0289 0.0288
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0446 0.1503 0.1503
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0009 0.0001 0.0001
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0093 0.0289 0.0288
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0009 0.0001 0.0001
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0116 0.3076
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.0095 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0116 0.0698
Schistosoma mansoni ran 0.0023 0.0047 0.0047
Giardia lamblia DNA damage repair protein 0.002 0.0039 0.1988
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0009 0.0001 0.0001
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0053 0.0151 0.0914
Loa Loa (eye worm) importin-beta domain-containing protein 0.0012 0.0012 0.0013
Brugia malayi T-complex protein 1, beta subunit 0.0053 0.0151 0.0167
Brugia malayi Ribonuclease 2-5A family protein 0.0118 0.0374 0.0414
Loa Loa (eye worm) carboxylesterase 0.0446 0.1503 0.1662
Onchocerca volvulus 0.0027 0.0061 0.0366
Brugia malayi Pre-SET motif family protein 0.0428 0.1443 0.1594
Entamoeba histolytica hypothetical protein 0.0111 0.0353 0.9426
Trichomonas vaginalis chaperonin, putative 0.0053 0.0151 0.0914
Schistosoma mansoni ran 0.0023 0.0047 0.0047
Schistosoma mansoni DNA polymerase IV / kappa 0.002 0.0039 0.0039
Echinococcus multilocularis importin subunit beta 1 0.0064 0.0192 0.0191
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Trypanosoma brucei unspecified product 0.0045 0.0124 0.5234
Loa Loa (eye worm) IRE protein kinase 0.0118 0.0374 0.0414
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0194 0.8185
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0.0001 0.0001
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0014 0.0013
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0047 0.1976
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0065 0.0194 0.1172
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0025 0.0024
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.0353 0.0353
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.014 0.0155
Echinococcus granulosus serine:threonine protein kinase:endoribonuclease 0.0118 0.0374 0.0373
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0236 0.0817
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0194 0.8185
Onchocerca volvulus 0.0154 0.0499 0.303
Schistosoma mansoni lamin 0.0027 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0004 0.0017
Trypanosoma cruzi importin beta-1 subunit, putative 0.0052 0.015 0.6316
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0015
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0116 0.4877
Loa Loa (eye worm) hypothetical protein 0.0446 0.1503 0.1662
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0111 0.0353 0.9426
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0043
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0077 0.0236 0.0261
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0036 0.0035
Loa Loa (eye worm) Smad1 0.0016 0.0025 0.0027
Echinococcus multilocularis smad 0.0016 0.0025 0.0024
Brugia malayi beta-lactamase 0.0077 0.0236 0.0261
Onchocerca volvulus 0.0487 0.1646 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.004
Echinococcus multilocularis acetylcholinesterase 0.2637 0.9047 0.9047
Loa Loa (eye worm) hypothetical protein 0.0077 0.0236 0.0261
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.0502 0.0555
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0199 0.022
Echinococcus granulosus carboxylesterase 5A 0.2637 0.9047 0.9047
Onchocerca volvulus 0.0446 0.1503 0.9133
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.0502 0.0554
Loa Loa (eye worm) acetylcholinesterase 1 0.2637 0.9047 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0194 0.8185
Loa Loa (eye worm) hypothetical protein 0.0025 0.0054 0.006
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0138 0.0137
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0225 0.0224
Schistosoma mansoni topbp1 0.001 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0111 0.0353 0.0353
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0.0001 0.0001
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0054 0.2266
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0116 0.0115
Brugia malayi MH2 domain containing protein 0.0016 0.0025 0.0027
Mycobacterium tuberculosis Conserved protein 0.0077 0.0236 0.0817
Echinococcus multilocularis geminin 0.2914 1 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0025 0.0025
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0025 0.0024
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0236 1
Trypanosoma brucei unspecified product 0.0065 0.0194 0.8185
Leishmania major GTP-binding protein, putative 0.0023 0.0047 0.1976
Schistosoma mansoni peptidase 0.001 0.0003 0.0003
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0009 0.0001 0.0001
Brugia malayi Carboxylesterase family protein 0.0446 0.1503 0.1662
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0123 0.0394 0.0393
Plasmodium falciparum T-complex protein 1 subunit beta 0.0053 0.0151 0.788
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0123 0.0394 0.0393
Brugia malayi Bromodomain containing protein 0.0079 0.0242 0.0267
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0009 0.0001 0.0001
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0093 0.0289 0.032
Plasmodium vivax DNA repair protein REV1, putative 0.002 0.0039 0.1627
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0236 0.0817
Echinococcus multilocularis lamin dm0 0.0027 0.0061 0.006
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.0502 0.0554
Trypanosoma cruzi ISWI complex protein 0.0032 0.0078 0.3291
Leishmania major DNA polymerase kappa, putative 0.0065 0.0194 0.8185
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0053 0.0151 0.015
Echinococcus granulosus Smad4 0.0016 0.0025 0.0024
Brugia malayi MH1 domain containing protein 0.0016 0.0025 0.0027
Schistosoma mansoni neuroligin 3 (S09 family) 0.0446 0.1503 0.1503
Brugia malayi intermediate filament protein 0.0027 0.0061 0.0067
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0053 0.0151 0.015
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0199 0.532
Loa Loa (eye worm) hypothetical protein 0.0093 0.0289 0.032
Entamoeba histolytica hypothetical protein 0.001 0.0004 0.0077
Schistosoma mansoni polycystin 1-related 0.0019 0.0036 0.0036
Echinococcus multilocularis BC026374 protein (S09 family) 0.0446 0.1503 0.1503
Mycobacterium ulcerans beta-lactamase 0.0077 0.0236 0.1552
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.014 0.0155
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0124 0.5234
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0199 0.8435
Schistosoma mansoni hypothetical protein 0.0049 0.0138 0.0138
Onchocerca volvulus 0.0061 0.0181 0.1095
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0236 0.1432
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0047 0.1976
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0004 0.0004
Brugia malayi Importin beta-1 subunit 0.0064 0.0192 0.0212
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0116 0.0116
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0065 0.0194 0.0543
Schistosoma mansoni hypothetical protein 0.2914 1 1
Echinococcus granulosus voltage dependent calcium channel 0.0093 0.0289 0.0288
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0116 0.4877
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0181 0.7644
Schistosoma mansoni family C19 unassigned peptidase (C19 family) 0.0009 0.0001 0.0001
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0446 0.1503 0.9133
Onchocerca volvulus 0.0019 0.0036 0.0215
Mycobacterium ulcerans hypothetical protein 0.002 0.0039 0.0236
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0093 0.0289 0.0288
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0097 0.0302 0.0334
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0049 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0064 0.0192 0.0212
Schistosoma mansoni ubiquitin-specific peptidase 30 (C19 family) 0.0009 0.0001 0.0001
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0109 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0199 0.8435
Chlamydia trachomatis DNA ligase 0.001 0.0004 0.5
Brugia malayi MH1 domain containing protein 0.0016 0.0025 0.0027
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0236 0.1432
Mycobacterium ulcerans DNA polymerase IV 0.0065 0.0194 0.1267
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0047 0.1976
Plasmodium falciparum importin beta, putative 0.0064 0.0192 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.014 0.014
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0091 0.009
Brugia malayi hypothetical protein 0.0019 0.0036 0.004
Brugia malayi Carboxylesterase family protein 0.0446 0.1503 0.1662
Leishmania major DNA polymerase eta, putative 0.0065 0.0194 0.8185
Schistosoma mansoni ubiquitin-specific peptidase 14 (C19 family) 0.0009 0.0001 0.0001
Echinococcus granulosus histone lysine methyltransferase setb 0.0097 0.0302 0.0301
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0025 0.0024
Schistosoma mansoni lipoxygenase 0.0019 0.0036 0.0036
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0004 0.0017
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0138 0.0137
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0.0001 0.0001
Echinococcus multilocularis acetylcholinesterase 0.2637 0.9047 0.9047
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0039 0.1627
Loa Loa (eye worm) beta-lactamase 0.0077 0.0236 0.0261
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0116 0.0128
Onchocerca volvulus 0.0446 0.1503 0.9133
Brugia malayi hypothetical protein 0.0019 0.0036 0.004
Brugia malayi ubiquitin carboxyl-terminal hydrolase 46 0.0009 0.0001 0.0001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0138 0.0137
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0109 0.012
Echinococcus granulosus lamin dm0 0.0027 0.0061 0.006
Trichomonas vaginalis set domain proteins, putative 0.0487 0.1646 1
Brugia malayi MH2 domain containing protein 0.0016 0.0025 0.0027
Schistosoma mansoni terminal deoxycytidyl transferase 0.0065 0.0194 0.0194
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0053 0.0151 0.0151
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0236 0.0817
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0156 0.0155
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0116 0.0698
Echinococcus granulosus dna polymerase kappa 0.0065 0.0194 0.0193
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0236 0.1552
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0236 0.0261
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0116 0.0115
Brugia malayi hypothetical protein 0.0111 0.0353 0.039
Loa Loa (eye worm) hypothetical protein 0.2637 0.9047 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0109 0.5588
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0004 0.0122
Loa Loa (eye worm) PHD-finger family protein 0.0043 0.0116 0.0128
Echinococcus multilocularis RUN 0.0019 0.0036 0.0035
Plasmodium falciparum transportin 0.0012 0.0012 0.0565
Echinococcus granulosus fetal alzheimer antigen falz 0.0047 0.013 0.0129
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0199 0.022
Toxoplasma gondii ImpB/MucB/SamB family protein 0.002 0.0039 0.1627
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0236 0.0261
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0446 0.1503 0.891
Trypanosoma cruzi DNA polymerase eta, putative 0.0065 0.0194 0.8185
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0103 0.0102
Entamoeba histolytica hypothetical protein 0.0111 0.0353 0.9426
Brugia malayi hypothetical protein 0.0154 0.0499 0.0552
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0065 0.0194 0.0193
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0181 0.0181
Leishmania major T-complex protein 1, beta subunit, putative 0.0053 0.0151 0.6381
Brugia malayi T-complex protein 1, beta subunit 0.0053 0.0151 0.0167
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0446 0.1503 0.891
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0039 0.1627
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0025 0.0027
Toxoplasma gondii HEAT repeat-containing protein 0.0012 0.0012 0.0458
Echinococcus granulosus replication factor c subunit 1 0.001 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0446 0.1503 0.1662
Trypanosoma brucei chrX additional, unordered contigs 0.002 0.0039 0.1627
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0004 0.0017
Echinococcus granulosus lamin 0.0027 0.0061 0.006
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0116 0.5958
Loa Loa (eye worm) hypothetical protein 0.0106 0.0333 0.0368
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0.0001 0.0001
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0236 0.1432
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0181 0.0181
Leishmania major DNA polymerase eta, putative 0.002 0.0039 0.1627
Echinococcus multilocularis sodium channel protein 0.0039 0.0105 0.0104
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0009 0.0001 0.0001
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0109 0.0655
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0053 0.0151 0.0151
Onchocerca volvulus 0.0019 0.0036 0.0215
Mycobacterium ulcerans hypothetical protein 0.0077 0.0236 0.1552
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0194 0.8185
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Echinococcus multilocularis dna polymerase kappa 0.0065 0.0194 0.0193
Loa Loa (eye worm) hypothetical protein 0.0446 0.1503 0.1662
Loa Loa (eye worm) hypothetical protein 0.0009 0.0000041609 0.0000045992
Loa Loa (eye worm) hypothetical protein 0.0446 0.1503 0.1662
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0194 0.8185
Toxoplasma gondii ImpB/MucB/SamB family protein 0.002 0.0039 0.1627
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0109 0.4574
Schistosoma mansoni topbp1 0.001 0.0004 0.0004
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0097 0.0302 0.0301
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0236 0.0817
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0065 0.0194 0.0193
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0004 0.0003
Brugia malayi DKFZp564C0469 protein 0.001 0.0004 0.0004
Schistosoma mansoni BC026374 protein (S09 family) 0.0446 0.1503 0.1503
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0109 0.5648
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0004 0.0017
Echinococcus granulosus nibrin 0.001 0.0004 0.0003
Leishmania major importin beta-1 subunit, putative 0.0052 0.015 0.6316
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0004 0.0122
Entamoeba histolytica hypothetical protein 0.0052 0.015 0.3984
Mycobacterium ulcerans carboxylesterase, LipT 0.0446 0.1503 1
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0039 0.0105 0.0104
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0138 0.0152
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.2637 0.9047 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0194 0.8185
Mycobacterium tuberculosis Carboxylesterase LipT 0.0446 0.1503 0.891
Loa Loa (eye worm) hypothetical protein 0.0077 0.0236 0.0261
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0.0001 0.0001
Schistosoma mansoni lamin 0.0027 0.0061 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0194 0.8185
Echinococcus multilocularis GPCR, family 2 0.0049 0.0138 0.0137
Brugia malayi topoisomerase 0.001 0.0004 0.0004
Echinococcus granulosus neuroligin 0.0446 0.1503 0.1503
Giardia lamblia TCP-1 chaperonin subunit beta 0.0053 0.0151 0.7796
Loa Loa (eye worm) hypothetical protein 0.0079 0.0242 0.0268
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0.0001 0.0001
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0025 0.0027
Schistosoma mansoni zinc finger protein 0.004 0.0109 0.0109
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0061 0.0067
Giardia lamblia DINP protein human, muc B family 0.0065 0.0194 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0116 0.0115
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Brugia malayi hypothetical protein 0.0009 0.0001 0.0001
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0236 0.0236
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0039 0.1627
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0236 0.0817
Trypanosoma brucei unspecified product 0.0045 0.0124 0.5234
Echinococcus granulosus GPCR family 2 0.0049 0.0138 0.0137
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0.0001 0.0001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.0353 0.0352
Plasmodium vivax importin-beta 2, putative 0.0064 0.0192 0.8098
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0109 0.0655
Schistosoma mansoni calpain-7 (C02 family) 0.0009 0.0001 0.0001
Brugia malayi Carboxylesterase family protein 0.0446 0.1503 0.1662
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0194 0.8185
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0093 0.0289 0.0288
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0047 0.244
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0093 0.0289 0.0288
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0194 0.8185
Onchocerca volvulus 0.0077 0.0236 0.1432
Schistosoma mansoni hypothetical protein 0.0009 0.0001 0.0001
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0116 0.0115
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0009 0.0001 0.0001
Schistosoma mansoni ubiquitin carboxyl-terminal hydrolase of the cysteine proteinase fold 0.0009 0.0001 0.0001
Toxoplasma gondii t-complex protein beta subunit 0.0053 0.0151 0.6381
Schistosoma mansoni DNA ligase IV 0.001 0.0004 0.0004
Echinococcus granulosus importin subunit beta 1 0.0064 0.0192 0.0191
Schistosoma mansoni hypothetical protein 0.0032 0.0078 0.0078
Mycobacterium leprae Probable lipase LipE 0.0077 0.0236 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0199 0.8435
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0054 0.2799
Onchocerca volvulus 0.0077 0.0236 0.1432
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0004 0.0122
Toxoplasma gondii HEAT repeat-containing protein 0.0012 0.0012 0.0458
Brugia malayi Smad1 0.0016 0.0025 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0004 0.0017
Loa Loa (eye worm) hypothetical protein 0.0446 0.1503 0.1662
Echinococcus granulosus importin 5 0.0012 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0028 0.0031
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0004 0.0122
Echinococcus multilocularis musashi 0.0027 0.0061 0.006
Echinococcus granulosus snurportin 1 0.0688 0.2339 0.2338
Schistosoma mansoni Smad4 0.0016 0.0025 0.0025
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0116 0.4877
Brugia malayi Pre-SET motif family protein 0.0061 0.0181 0.02
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0025 0.0024
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0054 0.2266
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0047 0.0052
Schistosoma mansoni gliotactin 0.0446 0.1503 0.1503
Brugia malayi Carboxylesterase family protein 0.2637 0.9047 1
Brugia malayi kap beta 3 protein 0.0012 0.0012 0.0013
Loa Loa (eye worm) kap beta 3 protein 0.0012 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.0077 0.0236 0.0261
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0053 0.0151 0.6381
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0109 0.0108
Schistosoma mansoni ubiquitin-specific peptidase 42 (C19 family) 0.0009 0.0001 0.0001
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0109 0.4574
Onchocerca volvulus 0.0446 0.1503 0.9133
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0109 0.4574
Schistosoma mansoni ubiquitin-specific peptidase 4 (C19 family) 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0026 0.0059 0.0066
Trichomonas vaginalis spcc417.12 protein, putative 0.0446 0.1503 0.9133
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.004
Onchocerca volvulus 0.0446 0.1503 0.9133
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.014 0.0139
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0009 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.0012 0.0012 0.0458
Brugia malayi ubiquitin specific protease 14 0.0009 0.0001 0.0001
Trichomonas vaginalis hypothetical protein 0.0012 0.0012 0.0066
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0.0001 0.0001
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0008 0.0007
Echinococcus multilocularis lamin 0.0027 0.0061 0.006
Brugia malayi Carboxylesterase family protein 0.2637 0.9047 1
Leishmania major hypothetical protein, conserved 0.0032 0.0078 0.3291
Plasmodium vivax SET domain protein, putative 0.0061 0.0181 0.7644
Toxoplasma gondii ABC1 family protein 0.0077 0.0236 1
Echinococcus multilocularis neuroligin 0.0446 0.1503 0.1503
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0446 0.1503 0.1503
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0116 0.0115
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0019 0.0021
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.0333 0.0368
Trichomonas vaginalis ran, putative 0.0023 0.0047 0.0283
Schistosoma mansoni smad 0.0016 0.0025 0.0025
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0039 0.1627
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0056 0.0164 0.6929
Leishmania major hypothetical protein, conserved 0.0077 0.0236 1
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0019 0.002
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0236 1
Schistosoma mansoni lipoxygenase 0.0054 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0017 0.0028 0.0031
Loa Loa (eye worm) hypothetical protein 0.0027 0.0061 0.0067
Mycobacterium ulcerans lipase LipD 0.0077 0.0236 0.1552
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0036 0.1505
Echinococcus granulosus RUN 0.0019 0.0036 0.0035
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0042 0.0116 0.0128
Loa Loa (eye worm) calcium channel 0.0093 0.0289 0.032
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.0353 0.0352
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.002 0.0039 0.1627
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.014 0.0139
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.004
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Mycobacterium tuberculosis Conserved protein 0.0077 0.0236 0.0817
Loa Loa (eye worm) T-complex protein 1 0.0053 0.0151 0.0167
Brugia malayi hypothetical protein 0.0025 0.0054 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0194 0.8185
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0039 0.1627
Brugia malayi hypothetical protein 0.0446 0.1503 0.1662
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0009 0.0001 0.0001
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0.0001 0.0001
Schistosoma mansoni DNA polymerase eta 0.0065 0.0194 0.0194
Leishmania major hypothetical protein, conserved 0.0025 0.0054 0.2266
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0124 0.5234
Schistosoma mansoni ubiquitin-specific peptidase 10 (C19 family) 0.0009 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0043 0.0116 0.0116
Echinococcus multilocularis dna polymerase eta 0.0065 0.0194 0.0193
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0194 0.8185
Brugia malayi beta-lactamase family protein 0.0077 0.0236 0.0261
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0199 0.0199
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0225 0.0224
Mycobacterium tuberculosis Conserved protein 0.0077 0.0236 0.0817
Plasmodium falciparum DNA repair protein REV1, putative 0.002 0.0039 0.2009
Toxoplasma gondii transporter, cation channel family protein 0.0019 0.0037 0.1517
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0236 0.0236
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0236 0.1552
Brugia malayi MH2 domain containing protein 0.0235 0.0777 0.0859
Schistosoma mansoni zinc finger protein 0.0032 0.0078 0.0078
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0093 0.0289 0.0289
Toxoplasma gondii HEAT repeat-containing protein 0.0064 0.0192 0.8098
Loa Loa (eye worm) hypothetical protein 0.0446 0.1503 0.1662
Echinococcus multilocularis para nitrobenzyl esterase 0.0446 0.1503 0.1503
Loa Loa (eye worm) hypothetical protein 0.0088 0.0273 0.0301
Trichomonas vaginalis importin beta-1, putative 0.0052 0.015 0.0904
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0109 0.012
Schistosoma mansoni bromodomain containing protein 0.0131 0.0419 0.0419
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0116 0.0698
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0052 0.015 0.0904
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0236 0.1432
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0093 0.0289 0.0288
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0004 0.0017
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0109 0.2885
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.014 0.0139
Echinococcus granulosus para nitrobenzyl esterase 0.0446 0.1503 0.1503
Loa Loa (eye worm) voltage-dependent calcium channel 0.0019 0.0037 0.004
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0056 0.0164 0.6929
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0012 0.0012 0.0458
Loa Loa (eye worm) hypothetical protein 0.0077 0.0236 0.0261
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.014 0.0139
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0036 0.0035
Echinococcus granulosus transportin 1 0.0012 0.0012 0.0011
Onchocerca volvulus 0.001 0.0004 0.0017
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0138 0.0152
Loa Loa (eye worm) hypothetical protein 0.0446 0.1503 0.1662
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0013 0.0014 0.0563
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0124 0.5234
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0199 0.8435
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0036 0.0035
Brugia malayi Doublecortin family protein 0.0019 0.0036 0.004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0236 0.0236
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0097 0.0302 0.0302
Schistosoma mansoni hypothetical protein 0.0019 0.0036 0.0036
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0025 0.0025
Trypanosoma cruzi ISWI complex protein 0.0032 0.0078 0.3291
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0004 0.0017
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0173 0.0172
Schistosoma mansoni ubiquitin-specific peptidase 16 (C19 family) 0.0009 0.0001 0.0001
Echinococcus multilocularis snurportin 1 0.0688 0.2339 0.2338
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0004 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0236 1
Echinococcus multilocularis nibrin 0.001 0.0004 0.0003
Schistosoma mansoni smad1 5 8 and 0.0016 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0194 0.8185
Schistosoma mansoni hypothetical protein 0.0688 0.2339 0.2339
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0.0001 0.0001
Schistosoma mansoni loxhd1 0.0019 0.0036 0.0036
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0047 0.1976
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0054 0.2266
Echinococcus granulosus voltage dependent calcium channel 0.0019 0.0037 0.0036
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0194 0.8185
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.014 0.014

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1500 nM In vitro vasorelaxant activity (voltage-gated calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aorta ChEMBL. 2391701

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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