Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, nicotinic, alpha 4 (neuronal) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0198 | 0.1582 | 0.1582 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.1582 | 0.1582 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0198 | 0.1582 | 0.1582 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0101 | 0.0738 | 0.0738 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0198 | 0.1582 | 0.5 |
Onchocerca volvulus | 0.0198 | 0.1582 | 1 | |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0101 | 0.0738 | 0.0738 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0198 | 0.1582 | 0.1582 |
Onchocerca volvulus | 0.0198 | 0.1582 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.1582 | 0.1582 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0198 | 0.1582 | 0.1582 |
Brugia malayi | Carboxylesterase family protein | 0.1174 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.1582 | 0.1582 |
Brugia malayi | Carboxylesterase family protein | 0.0198 | 0.1582 | 0.1582 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0198 | 0.1582 | 0.1582 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0198 | 0.1582 | 0.1582 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0101 | 0.0738 | 0.0738 |
Onchocerca volvulus | 0.0198 | 0.1582 | 1 | |
Brugia malayi | hypothetical protein | 0.0198 | 0.1582 | 0.1582 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0198 | 0.1582 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0198 | 0.1582 | 0.1582 |
Echinococcus granulosus | neuroligin | 0.0198 | 0.1582 | 0.1582 |
Schistosoma mansoni | gliotactin | 0.0198 | 0.1582 | 0.1582 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0198 | 0.1582 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.1582 | 0.1582 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.1582 | 0.1582 |
Loa Loa (eye worm) | carboxylesterase | 0.0198 | 0.1582 | 0.1582 |
Onchocerca volvulus | 0.0198 | 0.1582 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.1582 | 0.1582 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1174 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0198 | 0.1582 | 0.1582 |
Brugia malayi | Carboxylesterase family protein | 0.0198 | 0.1582 | 0.1582 |
Onchocerca volvulus | 0.0198 | 0.1582 | 1 | |
Echinococcus granulosus | BC026374 protein S09 family | 0.0198 | 0.1582 | 0.1582 |
Loa Loa (eye worm) | carboxylesterase | 0.1174 | 1 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0101 | 0.0738 | 0.0738 |
Echinococcus multilocularis | acetylcholinesterase | 0.1174 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0198 | 0.1582 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1174 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1174 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.1174 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0198 | 0.1582 | 0.1582 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0101 | 0.0738 | 0.0738 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0101 | 0.0738 | 0.0738 |
Onchocerca volvulus | Putative nachr subunit | 0.0101 | 0.0738 | 0.4664 |
Echinococcus multilocularis | acetylcholinesterase | 0.1174 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0198 | 0.1582 | 0.1582 |
Schistosoma mansoni | acetylcholinesterase | 0.0198 | 0.1582 | 0.1582 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.1582 | 0.1582 |
Echinococcus multilocularis | neuroligin | 0.0198 | 0.1582 | 0.1582 |
Loa Loa (eye worm) | hypothetical protein | 0.1174 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1174 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0198 | 0.1582 | 0.1582 |
Echinococcus granulosus | acetylcholinesterase | 0.1174 | 1 | 1 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0101 | 0.0738 | 0.0738 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0101 | 0.0738 | 0.0738 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0198 | 0.1582 | 0.1582 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0738 | 0.0738 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0198 | 0.1582 | 0.1582 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0198 | 0.1582 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1174 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0198 | 0.1582 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 110 nM | Potency to displace [3H]-Nicotine binding to Nicotinic acetylcholine receptor alpha4-beta2 immuno-isolated from M10 cells | ChEMBL. | 12061885 |
Ki (binding) | = 110 nM | Potency to displace [3H]-Nicotine binding to Nicotinic acetylcholine receptor alpha4-beta2 immuno-isolated from M10 cells | ChEMBL. | 12061885 |
Ki (binding) | = 3200 nM | Potency to displace [3H]-IMI binding to Nicotinic acetylcholine receptor from Drosophila head membranes | ChEMBL. | 12061885 |
Selectivity (binding) | = 29 | Selectivity ratio of Ki of Nicotinic acetylcholine receptor of Drosophila to Nicotinic acetylcholine receptor alpha4-beta2 | ChEMBL. | 12061885 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.