Detailed information for compound 1574949

Basic information

Technical information
  • TDR Targets ID: 1574949
  • Name: 2-[2-[(3-fluorophenyl)methylsulfanyl]imidazo[ 5,4-b]pyridin-3-yl]-N,N-dipropylacetamide
  • MW: 400.513 | Formula: C21H25FN4OS
  • H donors: 0 H acceptors: 3 LogP: 4.56 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN(C(=O)Cn1c(SCc2cccc(c2)F)nc2c1nccc2)CCC
  • InChi: 1S/C21H25FN4OS/c1-3-11-25(12-4-2)19(27)14-26-20-18(9-6-10-23-20)24-21(26)28-15-16-7-5-8-17(22)13-16/h5-10,13H,3-4,11-12,14-15H2,1-2H3
  • InChiKey: QCQKTQVFNGMMND-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[2-[(3-fluorophenyl)methylsulfanyl]imidazo[5,4-b]pyridin-3-yl]-N,N-dipropyl-acetamide
  • 2-[2-[(3-fluorophenyl)methylthio]-3-imidazo[5,4-b]pyridinyl]-N,N-dipropylacetamide
  • 2-[2-[(3-fluorobenzyl)thio]imidazo[5,4-b]pyridin-3-yl]-N,N-dipropyl-acetamide
  • 2-[2-[(3-fluorophenyl)methylsulfanyl]imidazo[5,4-b]pyridin-3-yl]-N,N-dipropyl-ethanamide
  • E643-0851
  • NCGC00124002-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0023
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Echinococcus multilocularis abhydrolase domain containing 3 0.0019 0.0023 0.0023
Brugia malayi G-protein coupled receptor 0.0092 0.067 0.067
Echinococcus granulosus tm gpcr rhodopsin 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0029 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Echinococcus granulosus transient receptor potential cation channel 0.0029 0.0113 0.0113
Plasmodium falciparum exported lipase 2 0.0019 0.0023 0.0086
Schistosoma mansoni biogenic amine receptor 0.0092 0.067 0.067
Brugia malayi cation channel family protein 0.0027 0.0095 0.0095
Echinococcus granulosus neuropeptide receptor A26 0.0092 0.067 0.067
Echinococcus granulosus neuropeptide s receptor 0.0092 0.067 0.067
Plasmodium falciparum exported lipase 1 0.0019 0.0023 0.0086
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0092 0.067 0.067
Schistosoma mansoni neuropeptide F-like receptor 0.0092 0.067 0.067
Schistosoma mansoni neuropeptide f receptor 76f 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0019 0.0023 0.0086
Onchocerca volvulus 0.0092 0.067 0.3192
Echinococcus multilocularis neuropeptide FF receptor 2 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Schistosoma mansoni hypothetical protein 0.0092 0.067 0.067
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0019 0.0023 0.0545
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0027 0.0095 0.0095
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0027 0.0095 0.0352
Schistosoma mansoni neuropeptide receptor 0.0092 0.067 0.067
Echinococcus multilocularis rhodopsin orphan GPCR 0.0092 0.067 0.067
Trypanosoma cruzi monoglyceride lipase, putative 0.032 0.2702 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0426 0.1522
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0019 0.0023 0.0086
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0027 0.0095 0.0095
Trypanosoma brucei hypothetical protein, conserved 0.0047 0.0277 0.0966
Brugia malayi hypothetical protein 0.0092 0.067 0.067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0406 0.1447
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0027 0.0095 0.0095
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0095 0.0095
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0018 0.0066
Echinococcus granulosus abhydrolase domain containing 3 0.0019 0.0023 0.0023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0406 0.1447
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0018 0.0066
Plasmodium falciparum esterase, putative 0.032 0.2702 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0406 0.1447
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Brugia malayi hypothetical protein 0.0092 0.067 0.067
Brugia malayi neuropeptide F receptor 0.0092 0.067 0.067
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0138 0.1079 0.3955
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0406 0.1447
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Plasmodium vivax PST-A protein 0.0019 0.0023 0.0086
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Echinococcus granulosus two pore calcium channel protein 1 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Echinococcus granulosus two pore calcium channel protein 2 0.0027 0.0095 0.0095
Echinococcus multilocularis L aminoadipate semialdehyde 0.0169 0.1355 0.1355
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0136 0.0136
Onchocerca volvulus 0.0092 0.067 0.3192
Echinococcus granulosus fmrfamide receptor 0.0092 0.067 0.067
Schistosoma mansoni amidase 0.1142 1 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0027 0.0095 0.0095
Brugia malayi voltage-dependent calcium channel 0.0027 0.0095 0.0095
Trypanosoma brucei monoglyceride lipase, putative 0.032 0.2702 1
Echinococcus granulosus tm gpcr rhodopsin 0.0092 0.067 0.067
Onchocerca volvulus 0.0092 0.067 0.3192
Echinococcus multilocularis rhodopsin orphan GPCR 0.0092 0.067 0.067
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0023 0.002
Schistosoma mansoni voltage-gated cation channel 0.0027 0.0095 0.0095
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0092 0.067 0.067
Echinococcus granulosus transient receptor potential cation channel 0.0027 0.0095 0.0095
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Schistosoma mansoni hypothetical protein 0.0092 0.067 0.067
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0426 0.0426
Echinococcus multilocularis transient receptor potential cation channel 0.0027 0.0095 0.0095
Plasmodium falciparum lysophospholipase, putative 0.032 0.2702 1
Brugia malayi ORL1-like opioid receptor 0.0092 0.067 0.067
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0092 0.067 0.067
Plasmodium vivax lysophospholipase, putative 0.0019 0.0023 0.0086
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0019 0.0023 0.0023
Echinococcus multilocularis conserved hypothetical protein 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0027 0.0095 0.0095
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0095 0.0095
Echinococcus granulosus voltage gated potassium channel 0.0027 0.0095 0.0095
Brugia malayi olfactory channel protein osm-9 0.0029 0.0113 0.0113
Brugia malayi hypothetical protein 0.0092 0.067 0.067
Echinococcus multilocularis g-protein coupled receptor 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Plasmodium vivax PST-A protein 0.0019 0.0023 0.0086
Toxoplasma gondii protein c14orf29, putative 0.0019 0.0023 0.0545
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0092 0.067 0.067
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0027 0.0095 0.0095
Brugia malayi hypothetical protein 0.0092 0.067 0.067
Echinococcus granulosus 7tm_1 domain containing protein 0.0092 0.067 0.067
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0095 0.0095
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0019 0.0023 0.002
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0027 0.0095 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.032 0.2702 1
Echinococcus multilocularis voltage dependent calcium channel 0.0027 0.0095 0.0095
Onchocerca volvulus 0.0092 0.067 0.3192
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0019 0.0023 0.0086
Brugia malayi G protein-coupled receptor 0.0092 0.067 0.067
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0023 0.0086
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0426 0.1578
Schistosoma mansoni myosin xvIII 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Loa Loa (eye worm) voltage-gated potassium channel 0.0027 0.0095 0.0095
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0138 0.1079 0.3955
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0047 0.0277 0.0966
Mycobacterium ulcerans peptide amidase, GatA 0.0138 0.1079 0.3955
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0426 0.1522
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0138 0.1079 0.1079
Brugia malayi putative amidase 0.0138 0.1079 0.1079
Schistosoma mansoni neuropeptide receptor 0.0092 0.067 0.067
Schistosoma mansoni two-pore calcium channel 0.0027 0.0095 0.0095
Brugia malayi hypothetical protein 0.0092 0.067 0.067
Schistosoma mansoni opsin-like receptor 0.0092 0.067 0.067
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0092 0.067 0.067
Schistosoma mansoni opsin-like receptor 0.0092 0.067 0.067
Brugia malayi Melatonin receptor type 1A 0.0092 0.067 0.067
Brugia malayi Transient-receptor-potential like protein 0.0027 0.0095 0.0095
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Leishmania major hypothetical protein, conserved 0.0138 0.1079 0.3994
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0027 0.0095 0.0095
Plasmodium falciparum BEM46-like protein, putative 0.0019 0.0023 0.0086
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0027 0.0095 0.0095
Schistosoma mansoni fatty-acid amide hydrolase 0.1142 1 1
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0027 0.0095 0.0095
Schistosoma mansoni neuropeptide receptor 0.0092 0.067 0.067
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0018 0.0018
Onchocerca volvulus 0.0092 0.067 0.3192
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0047 0.0277 0.2444
Echinococcus granulosus neuropeptide FF receptor 2 0.0092 0.067 0.067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0092 0.067 0.067
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0047 0.0277 0.2444
Echinococcus multilocularis serotonin receptor 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0095 0.2233
Echinococcus granulosus rhodopsin orphan GPCR 0.0092 0.067 0.067
Echinococcus multilocularis potassium voltage gated channel protein 0.0027 0.0095 0.0095
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0027 0.0095 0.0095
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0092 0.067 0.067
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0092 0.067 0.067
Echinococcus multilocularis neuropeptides capa receptor 0.0092 0.067 0.067
Onchocerca volvulus 0.0253 0.2101 1
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0138 0.1079 0.1079
Echinococcus multilocularis dro:myosuppressin receptor 0.0092 0.067 0.067
Brugia malayi RE15519p 0.0092 0.067 0.067
Schistosoma mansoni transient receptor potential channel 4 0.0027 0.0095 0.0095
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0027 0.0095 0.0095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0406 0.1447
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0027 0.0095 0.0095
Brugia malayi Protein C20orf22 0.0019 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Echinococcus multilocularis neuropeptide Y receptor 0.0092 0.067 0.067
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0426 0.0426
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0027 0.0095 0.0288
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0092 0.067 0.067
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0027 0.0095 0.0095
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0092 0.067 0.067
Echinococcus granulosus transient receptor potential cation channel 0.0027 0.0095 0.0095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0092 0.067 0.067
Brugia malayi G-protein coupled receptor 0.0092 0.067 0.067
Plasmodium falciparum alpha/beta hydrolase, putative 0.0019 0.0023 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0023 0.0086
Schistosoma mansoni histamine h1 receptor 0.0092 0.067 0.067
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0092 0.067 0.067
Echinococcus multilocularis rhodopsin orphan GPCR 0.0092 0.067 0.067
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0092 0.067 0.067
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0027 0.0095 0.0095
Echinococcus multilocularis potassium large conductance calcium activated 0.0027 0.0095 0.0095
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0092 0.067 0.067
Echinococcus multilocularis transient receptor potential cation channel 0.0029 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0019 0.0023 0.0086
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0095 0.0095
Toxoplasma gondii peptidase S15, putative 0.0019 0.0023 0.0545
Brugia malayi hypothetical protein 0.0092 0.067 0.067
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0092 0.067 0.3192
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0092 0.067 0.067
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0027 0.0095 0.0288
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0019 0.0023 0.0545
Echinococcus granulosus hypothetical protein 0.0092 0.067 0.067
Schistosoma mansoni biogenic amine receptor 0.0092 0.067 0.067
Echinococcus multilocularis transient receptor potential cation channel 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0095 0.0095
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0027 0.0095 0.0095
Onchocerca volvulus 0.0092 0.067 0.3192
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0092 0.067 0.067
Echinococcus granulosus potassium voltage gated channel protein 0.0027 0.0095 0.0095
Plasmodium vivax PST-A protein 0.0019 0.0023 0.0086
Loa Loa (eye worm) ion channel NompC 0.0027 0.0095 0.0095
Brugia malayi Cyclic-nucleotide gated cation channel 0.0027 0.0095 0.0095
Echinococcus granulosus rhodopsin orphan GPCR 0.0092 0.067 0.067
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Brugia malayi Amidase family protein 0.0138 0.1079 0.1079
Echinococcus granulosus rhodopsin orphan GPCR 0.0092 0.067 0.067
Echinococcus granulosus potassium voltage gated channel protein 0.0027 0.0095 0.0095
Echinococcus multilocularis orexin receptor type 2 0.0092 0.067 0.067
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0027 0.0095 0.0095
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0047 0.0277 0.0966
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0027 0.0095 0.0095
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0095 0.0095
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0027 0.0095 0.0095
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0027 0.0095 0.0095
Echinococcus granulosus TRP transient receptor potential channel 0.0027 0.0095 0.0095
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0019 0.0023 0.002
Toxoplasma gondii transporter, cation channel family protein 0.0027 0.0095 0.2233
Loa Loa (eye worm) amidase 0.0138 0.1079 0.1079
Echinococcus granulosus g protein coupled receptor 0.0092 0.067 0.067
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0027 0.0095 0.0453
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0019 0.0023 0.0023
Entamoeba histolytica hypothetical protein 0.0019 0.0023 0.0086
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0138 0.1079 1
Trypanosoma brucei monoglyceride lipase, putative 0.032 0.2702 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Schistosoma mansoni biogenic amine receptor 0.0092 0.067 0.067
Entamoeba histolytica ;Alias 0.0019 0.0023 0.0086
Plasmodium falciparum esterase, putative 0.0019 0.0023 0.0086
Brugia malayi hypothetical protein 0.0092 0.067 0.067
Onchocerca volvulus 0.0092 0.067 0.3192
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0019 0.0023 0.0086
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0023
Onchocerca volvulus 0.0092 0.067 0.3192
Echinococcus granulosus fatty acid amide hydrolase 1 0.0138 0.1079 0.1079
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Echinococcus granulosus rhodopsin orphan GPCR 0.0092 0.067 0.067
Onchocerca volvulus 0.0092 0.067 0.3192
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0095 0.0095
Toxoplasma gondii transporter, cation channel family protein 0.0027 0.0095 0.2233
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Brugia malayi hypothetical protein 0.0092 0.067 0.067
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0092 0.067 0.067
Schistosoma mansoni transient receptor potential channel 0.0029 0.0113 0.0113
Echinococcus multilocularis transient receptor potential cation channel 0.0027 0.0095 0.0095
Echinococcus granulosus 7TM GPCR rhodopsin 0.0092 0.067 0.067
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0027 0.0095 0.0095
Onchocerca volvulus 0.0092 0.067 0.3192
Mycobacterium ulcerans hypothetical protein 0.032 0.2702 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0092 0.067 0.067
Echinococcus granulosus dro:myosuppressin receptor 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Schistosoma mansoni amine GPCR 0.0092 0.067 0.067
Schistosoma mansoni amine GPCR 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Toxoplasma gondii transporter, cation channel family protein 0.0027 0.0095 0.2233
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0136 0.0136
Schistosoma mansoni amine GPCR 0.0092 0.067 0.067
Schistosoma mansoni hypothetical protein 0.0027 0.0095 0.0095
Echinococcus multilocularis potassium voltage gated channel protein 0.0027 0.0095 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0023 0.0086
Brugia malayi Pre-SET motif family protein 0.0032 0.0136 0.0136
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0138 0.1079 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Echinococcus multilocularis two pore calcium channel protein 1 0.0027 0.0095 0.0095
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0092 0.067 0.067
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0169 0.1355 0.1355
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0019 0.0023 0.0086
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0023
Brugia malayi hypothetical protein 0.0092 0.067 0.067
Plasmodium vivax PST-A protein 0.0019 0.0023 0.0086
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Loa Loa (eye worm) neuropeptide F receptor 0.0092 0.067 0.067
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Plasmodium vivax lysophospholipase, putative 0.0019 0.0023 0.0086
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1142 1 1
Leishmania major phosphopantetheinyl transferase-like protein 0.0047 0.0277 0.1026
Echinococcus multilocularis Phospholipase carboxylesterase 0.0019 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0023 0.0086
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0092 0.067 0.067
Mycobacterium ulcerans amidase 0.0138 0.1079 0.3955
Brugia malayi Dopamine receptor protein 2 0.0092 0.067 0.067
Echinococcus granulosus orexin receptor type 2 0.0092 0.067 0.067
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1142 1 1
Plasmodium falciparum lysophospholipase, putative 0.0019 0.0023 0.0086
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0027 0.0095 0.0095
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0019 0.0023 0.0545
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0138 0.1079 0.3955
Echinococcus granulosus voltage dependent calcium channel 0.0027 0.0095 0.0095
Echinococcus multilocularis transient receptor potential cation channel 0.0029 0.0113 0.0113
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0027 0.0095 0.0095
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0138 0.1079 1
Echinococcus multilocularis fmrfamide receptor 0.0092 0.067 0.067
Echinococcus granulosus potassium voltage gated channel protein 0.0027 0.0095 0.0095
Loa Loa (eye worm) voltage-gated calcium channel 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0406 0.1447
Echinococcus granulosus voltage gated hydrogen channel 1 0.0027 0.0095 0.0095
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0047 0.0277 0.1026
Echinococcus multilocularis g protein coupled receptor 0.0092 0.067 0.067
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0027 0.0095 0.0095
Echinococcus granulosus neuropeptide Y receptor 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Brugia malayi MGC83647 protein 0.0019 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0019 0.0023 0.0086
Schistosoma mansoni 60S ribosomal protein L21 0.0027 0.0095 0.0095
Toxoplasma gondii hypothetical protein 0.0027 0.0095 0.2233
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0027 0.0095 0.0095
Loa Loa (eye worm) neuropeptide F receptor 0.0092 0.067 0.067
Loa Loa (eye worm) amidase 0.0138 0.1079 0.1079
Brugia malayi GnHR receptor homolog 0.0092 0.067 0.067
Brugia malayi Dopamine receptor 0.0092 0.067 0.067
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0027 0.0095 0.0095
Brugia malayi Tachykinin-like peptides receptor 99D 0.0092 0.067 0.067
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0092 0.067 0.067
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0095 0.2233
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Echinococcus granulosus shaker cognate 0.0027 0.0095 0.0095
Leishmania major cathepsin L-like protease 0.0062 0.0406 0.1503
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0023 0.0086
Echinococcus multilocularis neuropeptide receptor 0.0092 0.067 0.067
Echinococcus multilocularis voltage gated potassium channel 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Echinococcus multilocularis neuropeptide Y receptor 0.0092 0.067 0.067
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0027 0.0095 0.0095
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0027 0.0095 0.0095
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.032 0.2702 1
Echinococcus granulosus neuropeptides capa receptor 0.0092 0.067 0.067
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0027 0.0095 0.0095
Echinococcus granulosus tachykinin peptides receptor 99D 0.0092 0.067 0.067
Toxoplasma gondii hypothetical protein 0.0019 0.0023 0.0545
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0288 0.1067
Plasmodium vivax SET domain protein, putative 0.0032 0.0136 0.0504
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0092 0.067 0.067
Echinococcus multilocularis calcium activated potassium channel 0.0027 0.0095 0.0095
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0018 0.0066
Echinococcus granulosus transient receptor potential cation channel 0.0027 0.0095 0.0095
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0092 0.067 0.067
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0018 0.0018
Loa Loa (eye worm) voltage-dependent calcium channel 0.0027 0.0095 0.0095
Loa Loa (eye worm) voltage-gated potassium channel 0.0027 0.0095 0.0095
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0095 0.0095
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.032 0.2702 1
Schistosoma mansoni ap endonuclease 0.0018 0.0018 0.0018
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0092 0.067 0.067
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0023 0.0086
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0027 0.0095 0.0095
Echinococcus granulosus rhodopsin orphan GPCR 0.0092 0.067 0.067
Onchocerca volvulus 0.0092 0.067 0.3192
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.032 0.2702 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0092 0.067 0.067
Echinococcus granulosus abhydrolase domain containing protein 13 0.0019 0.0023 0.0023
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0138 0.1079 0.3994
Plasmodium falciparum lysophospholipase, putative 0.032 0.2702 1
Plasmodium falciparum esterase, putative 0.0019 0.0023 0.0086
Echinococcus multilocularis neuropeptide s receptor 0.0092 0.067 0.067
Brugia malayi follicle stimulating hormone receptor 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Brugia malayi Dopamine receptor protein 1 0.0092 0.067 0.067
Echinococcus multilocularis hyperpolarization activated cyclic 0.0027 0.0095 0.0095
Onchocerca volvulus Neuropeptide F receptor homolog 0.0092 0.067 0.3192
Mycobacterium ulcerans amidase 0.0138 0.1079 0.3955
Plasmodium falciparum alpha/beta hydrolase, putative 0.0019 0.0023 0.0086
Echinococcus multilocularis G-protein coupled receptor, putative 0.0092 0.067 0.067
Entamoeba histolytica hypothetical protein 0.0019 0.0023 0.0086
Echinococcus multilocularis sex peptide receptor 0.0092 0.067 0.067
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0136 0.0136
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0092 0.067 0.067
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0027 0.0095 0.0095
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0092 0.067 0.067
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0027 0.0095 0.0095
Echinococcus multilocularis neuropeptide receptor 0.0092 0.067 0.067
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0092 0.067 0.067
Echinococcus granulosus Phospholipase carboxylesterase 0.0019 0.0023 0.0023
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0018 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0023 0.0086
Schistosoma mansoni voltage-dependent calcium channel 0.0027 0.0095 0.0095
Schistosoma mansoni growth hormone secretagogue receptor 0.0092 0.067 0.067
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0027 0.0095 0.0095
Echinococcus granulosus G protein coupled receptor 139 0.0092 0.067 0.067
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0138 0.1079 0.3308
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Brugia malayi larval opioid receptor 0.0092 0.067 0.067
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0426 0.0426
Echinococcus granulosus potassium voltage gated channel protein 0.0027 0.0095 0.0095
Toxoplasma gondii hypothetical protein 0.0019 0.0023 0.0545
Schistosoma mansoni fatty-acid amide hydrolase 0.0138 0.1079 0.1079
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0138 0.1079 0.3955
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0023 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.032 0.2702 1
Onchocerca volvulus 0.0092 0.067 0.3192
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0019 0.0023 0.0086
Trichomonas vaginalis valacyclovir hydrolase, putative 0.032 0.2702 1
Plasmodium falciparum lysophospholipase, putative 0.0019 0.0023 0.0086
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0092 0.067 0.067
Plasmodium falciparum epoxide hydrolase 2 0.0019 0.0023 0.0086
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0169 0.1355 0.1355
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0138 0.1079 0.1079
Echinococcus granulosus hyperpolarization activated cyclic 0.0027 0.0095 0.0095
Mycobacterium ulcerans hypothetical protein 0.0019 0.0023 0.002
Echinococcus multilocularis fmrfamide receptor 0.0092 0.067 0.067
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0027 0.0095 0.0352
Echinococcus granulosus transient receptor potential gamma protein 0.0027 0.0095 0.0095
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0095 0.0095
Toxoplasma gondii phospholipase 0.0019 0.0023 0.0545
Echinococcus granulosus voltage dependent calcium channel 0.0027 0.0095 0.0095
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.032 0.2702 1
Trypanosoma cruzi serine peptidase, putative 0.0019 0.0023 0.0086
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0027 0.0095 0.0095
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0027 0.0095 0.0352
Echinococcus granulosus sodium leak channel non selective protein 0.0027 0.0095 0.0095
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0019 0.0023 0.0086
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0027 0.0095 0.0095
Mycobacterium tuberculosis Possible lysophospholipase 0.032 0.2702 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0136 0.3193
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0092 0.067 0.067
Plasmodium vivax alpha/beta hydrolase, putative 0.0019 0.0023 0.0086
Schistosoma mansoni amine GPCR 0.0092 0.067 0.067
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0027 0.0095 0.0095
Mycobacterium ulcerans amidase 0.0138 0.1079 0.3955
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0027 0.0095 0.0095
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0138 0.1079 0.1079
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0426 0.0426
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0047 0.0277 0.1026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0406 0.1447
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0019 0.0023 0.0086
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0019 0.0023 0.0086
Loa Loa (eye worm) melatonin receptor type 1A 0.0092 0.067 0.067
Echinococcus granulosus neuropeptide Y receptor 0.0092 0.067 0.067
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0018 0.0066
Echinococcus granulosus ryanodine receptor 44f 0.0027 0.0095 0.0095
Plasmodium vivax alpha/beta hydrolase, putative 0.0019 0.0023 0.0086
Onchocerca volvulus 0.0092 0.067 0.3192
Plasmodium falciparum lysophospholipase, putative 0.032 0.2702 1
Echinococcus granulosus transient receptor potential cation channel 0.0027 0.0095 0.0095
Trypanosoma cruzi amidase, putative 0.0138 0.1079 0.3994
Plasmodium vivax PST-A protein 0.032 0.2702 1
Echinococcus multilocularis g protein coupled receptor 0.0092 0.067 0.067
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0136 0.0136
Schistosoma mansoni hypothetical protein 0.0092 0.067 0.067
Schistosoma mansoni transient receptor potential channel 0.0027 0.0095 0.0095
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0136 0.0136
Echinococcus multilocularis two pore calcium channel protein 2 0.0027 0.0095 0.0095
Toxoplasma gondii exonuclease III APE 0.0018 0.0018 0.0418
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0027 0.0095 0.0095
Trypanosoma cruzi serine peptidase, putative 0.0019 0.0023 0.0086
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0426 1
Mycobacterium ulcerans hydrolase 0.0019 0.0023 0.002
Loa Loa (eye worm) G-protein coupled receptor 0.0092 0.067 0.067
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0095 0.0095
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0092 0.067 0.067
Echinococcus granulosus neuropeptide receptor 0.0092 0.067 0.067
Echinococcus granulosus biogenic amine 5HT receptor 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Echinococcus granulosus fatty acid amide hydrolase 1 0.1142 1 1
Echinococcus granulosus voltage gated potassium channel 0.0027 0.0095 0.0095
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0019 0.0023 0.0086
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0027 0.0095 0.0352
Echinococcus granulosus sex peptide receptor 0.0092 0.067 0.067
Echinococcus granulosus g-protein coupled receptor 0.0092 0.067 0.067
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0092 0.067 0.067
Schistosoma mansoni hypothetical protein 0.0092 0.067 0.067
Echinococcus multilocularis potassium voltage gated channel protein 0.0027 0.0095 0.0095
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0027 0.0095 0.0095
Echinococcus granulosus g protein coupled receptor 0.0092 0.067 0.067
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.032 0.2702 1
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0027 0.0095 0.0095
Echinococcus granulosus neuropeptide receptor 0.0092 0.067 0.067
Schistosoma mansoni opsin-like receptor 0.0092 0.067 0.067
Plasmodium vivax unspecified product 0.0019 0.0023 0.0086
Plasmodium falciparum alpha/beta hydrolase, putative 0.0019 0.0023 0.0086
Echinococcus multilocularis voltage gated potassium channel 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Mycobacterium ulcerans lysophospholipase 0.032 0.2702 1
Brugia malayi AKH receptor 0.0092 0.067 0.067
Schistosoma mansoni neuropeptide receptor 0.0092 0.067 0.067
Echinococcus multilocularis sodium leak channel non selective protein 0.0027 0.0095 0.0095
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0092 0.067 0.067
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0047 0.0277 0.2405
Schistosoma mansoni voltage-gated ion channel 0.0027 0.0095 0.0095
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0018 0.0066
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0027 0.0095 0.0095
Echinococcus multilocularis short transient receptor potential channel 6 0.0029 0.0113 0.0113
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0406 0.1447
Leishmania major cathepsin L-like protease 0.0062 0.0406 0.1503
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0019 0.0023 0.0086
Echinococcus granulosus sodium channel protein 0.0027 0.0095 0.0095
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0095 0.0095
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0138 0.1079 0.3955
Echinococcus granulosus short transient receptor potential channel 6 0.0027 0.0095 0.0095
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0027 0.0095 0.0095
Plasmodium vivax unspecified product 0.0019 0.0023 0.0086
Echinococcus multilocularis g protein coupled receptor 0.0092 0.067 0.067
Echinococcus granulosus potassium large conductance calcium activated 0.0027 0.0095 0.0095
Loa Loa (eye worm) G-protein coupled receptor 0.0092 0.067 0.067
Brugia malayi neuropeptide F receptor 0.0092 0.067 0.067
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0095 0.0095
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0027 0.0095 0.0352
Onchocerca volvulus 0.0092 0.067 0.3192
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0023 0.0086
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.0019 0.0023 0.0086
Schistosoma mansoni calcium-activated potassium channel 0.0027 0.0095 0.0095
Echinococcus granulosus somatostatin receptor 0.0092 0.067 0.067
Trichomonas vaginalis set domain proteins, putative 0.0251 0.2082 0.7708
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0406 0.1503
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Echinococcus granulosus fatty acid amide hydrolase 1 0.1142 1 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.032 0.2702 1
Echinococcus granulosus hypothetical protein 0.0027 0.0095 0.0095
Leishmania major monoglyceride lipase, putative 0.032 0.2702 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0027 0.0095 0.0095
Schistosoma mansoni ryanodine receptor related 0.0027 0.0095 0.0095
Echinococcus multilocularis somatostatin receptor 0.0092 0.067 0.067
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0406 0.1503
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0019 0.0023 0.0086
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0426 0.1522
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0027 0.0095 0.0095
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0027 0.0095 0.0095
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0019 0.0023 0.0023
Echinococcus multilocularis sodium channel protein 0.0027 0.0095 0.0095
Echinococcus multilocularis hyperpolarization activated cyclic 0.0027 0.0095 0.0095
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0169 0.1355 0.1355
Schistosoma mansoni peptidase 0.0019 0.0023 0.0023
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0138 0.1079 0.3994
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0095 0.0095
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0018 0.0066
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Echinococcus multilocularis transient receptor potential gamma protein 0.0027 0.0095 0.0095
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0092 0.067 0.067
Echinococcus granulosus rhodopsin orphan GPCR 0.0092 0.067 0.067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0092 0.067 0.067
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0095 0.0095
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.1812 0.1812
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0138 0.1079 0.3308
Echinococcus multilocularis rhodopsin orphan GPCR 0.0092 0.067 0.067
Toxoplasma gondii hypothetical protein 0.0019 0.0023 0.0545
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0027 0.0095 0.0095
Echinococcus multilocularis voltage dependent calcium channel 0.0027 0.0095 0.0095
Brugia malayi putative neuropeptide receptor NPR1 0.0092 0.067 0.067
Echinococcus multilocularis rhodopsin orphan GPCR 0.0092 0.067 0.067
Brugia malayi MGC79044 protein 0.0019 0.0023 0.0023
Plasmodium falciparum alpha/beta hydrolase, putative 0.0019 0.0023 0.0086
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0019 0.0023 0.002
Echinococcus multilocularis allatostatin A receptor 0.0092 0.067 0.067
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0019 0.0023 0.0023
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0027 0.0095 0.0095
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0092 0.067 0.067
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0095 0.0095
Onchocerca volvulus 0.0092 0.067 0.3192
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0027 0.0095 0.0095
Schistosoma mansoni biogenic amine (5HT) receptor 0.0092 0.067 0.067
Loa Loa (eye worm) calcium channel 0.0027 0.0095 0.0095
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0138 0.1079 0.3955
Mycobacterium ulcerans amidase 0.0138 0.1079 0.3955
Echinococcus multilocularis neuropeptide receptor A26 0.0092 0.067 0.067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0406 0.1447
Brugia malayi Amidase family protein 0.0138 0.1079 0.1079
Schistosoma mansoni amine GPCR 0.0092 0.067 0.067
Brugia malayi sulfakinin receptor protein 0.0092 0.067 0.067
Schistosoma mansoni neuropeptide F-like receptor 0.0092 0.067 0.067
Brugia malayi Pre-SET motif family protein 0.022 0.1812 0.1812
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0092 0.067 0.067
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.032 0.2702 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0092 0.067 0.067
Plasmodium vivax lysophospholipase, putative 0.0019 0.0023 0.0086
Echinococcus granulosus rhodopsin orphan GPCR 0.0092 0.067 0.067
Toxoplasma gondii hypothetical protein 0.0019 0.0023 0.0545
Echinococcus granulosus biogenic amine 5HT receptor 0.0092 0.067 0.067
Echinococcus granulosus potassium voltage gated channel protein 0.0027 0.0095 0.0095
Schistosoma mansoni biogenic amine (5HT) receptor 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Echinococcus granulosus short transient receptor potential channel 6 0.0029 0.0113 0.0113
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0027 0.0095 0.0095
Leishmania major cathepsin L-like protease 0.0062 0.0406 0.1503
Echinococcus granulosus serotonin receptor 0.0092 0.067 0.067
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0019 0.0023 0.0086
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0027 0.0095 0.0095
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0047 0.0277 0.0966
Plasmodium vivax PST-A protein 0.0019 0.0023 0.0086
Mycobacterium ulcerans amidase 0.0138 0.1079 0.3955
Loa Loa (eye worm) hypothetical protein 0.0032 0.0136 0.0136
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0092 0.067 0.067
Brugia malayi Serotonin receptor 0.0092 0.067 0.067
Echinococcus multilocularis short transient receptor potential channel 6 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Leishmania major hypothetical protein, conserved 0.0019 0.0023 0.0086
Entamoeba histolytica hypothetical protein 0.0047 0.0277 0.1026
Leishmania major hypothetical protein, conserved 0.0027 0.0095 0.0352
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.032 0.2702 1
Brugia malayi hypothetical protein 0.0092 0.067 0.067
Schistosoma mansoni alpha-1 adrenergic receptor 0.0092 0.067 0.067
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0092 0.067 0.067
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0047 0.0277 0.6501
Echinococcus granulosus calcium activated potassium channel 0.0027 0.0095 0.0095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0406 0.1447
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0092 0.067 0.067
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0136 0.0136
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0023 0.0086
Echinococcus granulosus alpha 1A adrenergic receptor 0.0092 0.067 0.067
Echinococcus granulosus neuropeptides capa receptor 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0027 0.0095 0.0095
Onchocerca volvulus 0.0032 0.0136 0.0648
Echinococcus granulosus peptide allatostatin:somatostatin 0.0092 0.067 0.067
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0095 0.0095
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0027 0.0095 0.0095
Schistosoma mansoni ap endonuclease 0.0018 0.0018 0.0018
Brugia malayi G protein-coupled receptor F59B2.13 0.0092 0.067 0.067
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0023 0.0086
Schistosoma mansoni adenoreceptor 0.0092 0.067 0.067
Echinococcus granulosus g protein coupled receptor 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Loa Loa (eye worm) TYRA-2 protein 0.0092 0.067 0.067
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0027 0.0095 0.0095
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0027 0.0095 0.0095
Brugia malayi Serotonin receptor 0.0092 0.067 0.067
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0092 0.067 0.067
Brugia malayi hypothetical protein 0.0027 0.0095 0.0095
Plasmodium falciparum prodrug activation and resistance esterase 0.0019 0.0023 0.0086
Echinococcus granulosus transient receptor potential cation channel 0.0027 0.0095 0.0095
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0023 0.0086
Schistosoma mansoni vesicular amine transporter 0.0027 0.0095 0.0095
Echinococcus multilocularis serotonin receptor 0.0092 0.067 0.067
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0027 0.0095 0.0095
Mycobacterium ulcerans hypothetical protein 0.0019 0.0023 0.002
Onchocerca volvulus 0.0092 0.067 0.3192
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0406 0.1503
Echinococcus multilocularis G protein coupled receptor 139 0.0092 0.067 0.067
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0092 0.067 0.067
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0019 0.0023 1
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0027 0.0095 0.0095
Plasmodium falciparum alpha/beta hydrolase, putative 0.0019 0.0023 0.0086
Brugia malayi cation channel family protein 0.0027 0.0095 0.0095
Loa Loa (eye worm) ryanodine receptor 0.0027 0.0095 0.0095
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0027 0.0095 0.0095
Echinococcus multilocularis rhodopsin orphan GPCR 0.0092 0.067 0.067
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0027 0.0095 0.0095
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0018 0.0066
Loa Loa (eye worm) hypothetical protein 0.1142 1 1
Toxoplasma gondii hypothetical protein 0.0027 0.0095 0.2233
Echinococcus multilocularis transfer RNA-Gly 0.0027 0.0095 0.0095
Onchocerca volvulus 0.0092 0.067 0.3192
Echinococcus multilocularis potassium voltage gated channel protein 0.0027 0.0095 0.0095
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0027 0.0095 0.0095
Echinococcus granulosus tm gpcr rhodopsin 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0092 0.067 0.067
Trypanosoma cruzi amidase, putative 0.0138 0.1079 0.3994
Echinococcus multilocularis shaker cognate 0.0027 0.0095 0.0095
Brugia malayi putative neuropeptide receptor 0.0092 0.067 0.067
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0092 0.067 0.067
Echinococcus granulosus allatostatin A receptor 0.0092 0.067 0.067
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0027 0.0095 0.0095
Echinococcus multilocularis neuropeptides capa receptor 0.0092 0.067 0.067
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0027 0.0095 0.0095
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0027 0.0095 0.0453
Brugia malayi ion channel NompC 0.0027 0.0095 0.0095
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0027 0.0095 0.0095
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0138 0.1079 0.3955
Leishmania major hypothetical protein, unknown function 0.0027 0.0095 0.0352
Toxoplasma gondii phospholipase/carboxylesterase 0.0019 0.0023 0.0545
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0358 0.1326
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Echinococcus multilocularis rhodopsin orphan GPCR 0.0092 0.067 0.067
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0406 0.1503
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0027 0.0095 0.0095
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0047 0.0277 0.6501
Plasmodium falciparum alpha/beta-hydrolase, putative 0.0019 0.0023 0.0086
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0092 0.067 0.067
Onchocerca volvulus 0.0169 0.1355 0.6449
Onchocerca volvulus 0.0027 0.0095 0.0453
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0092 0.067 0.067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Leishmania major hypothetical protein, conserved 0.0019 0.0023 0.0086
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0019 0.0023 0.0086
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0095 0.0095
Echinococcus multilocularis ryanodine receptor 44f 0.0027 0.0095 0.0095
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0092 0.067 0.067
Schistosoma mansoni transient receptor potential channel 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Echinococcus multilocularis transient receptor potential cation channel 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0092 0.067 0.067
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0406 0.1447
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0426 0.1522
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0023
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0018 0.0066
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0095 0.0095
Echinococcus granulosus L aminoadipate semialdehyde 0.0169 0.1355 0.1355
Echinococcus granulosus hyperpolarization activated cyclic 0.0027 0.0095 0.0095

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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