Detailed information for compound 1574968

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 488.58 | Formula: C24H36N6O5
  • H donors: 2 H acceptors: 5 LogP: 0.33 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@@H](N1C[C@H](C)[C@@H](OCc2n(CCCC1=O)nnc2)CN(C(=O)Nc1ccccc1OC)C)C
  • InChi: 1S/C24H36N6O5/c1-17-13-29(18(2)15-31)23(32)10-7-11-30-19(12-25-27-30)16-35-22(17)14-28(3)24(33)26-20-8-5-6-9-21(20)34-4/h5-6,8-9,12,17-18,22,31H,7,10-11,13-16H2,1-4H3,(H,26,33)/t17-,18-,22-/m0/s1
  • InChiKey: LJFLDXJAOYTNMN-SPEDKVCISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0052 0.0466 0.065
Echinococcus multilocularis nAChR subunit 0.0018 0.0094 0.0094
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0098 0.0981 0.0981
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.135 0.9353
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0514 0.3783
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0337 0.3632
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0038 0.0314 0.2163
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0169 0.0204
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.001 0.0006 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0094 0.0131
Trichomonas vaginalis proliferating cell nuclear antigen, putative 0.0063 0.0589 0.0718
Echinococcus granulosus ecdysone induced protein 78C 0.0098 0.0981 0.0981
Loa Loa (eye worm) hypothetical protein 0.0013 0.0031 0.0044
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0014 0.0087
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0058 0.0401
Loa Loa (eye worm) hypothetical protein 0.0018 0.0094 0.0131
Loa Loa (eye worm) hypothetical protein 0.0046 0.0405 0.0564
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0337 0.2325
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0105
Echinococcus multilocularis lamin dm0 0.0084 0.0833 0.0833
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.001 0.0006 0.0027
Schistosoma mansoni apoferritin-2 0.001 0.0002 0.0002
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.014 0.014
Echinococcus granulosus axis inhibition protein axin 0.0025 0.0169 0.0169
Echinococcus granulosus expressed protein 0.0385 0.4195 0.4195
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0918 0.128
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0047 0.0047
Brugia malayi hypothetical protein 0.0054 0.0497 0.0693
Schistosoma mansoni nuclear receptor 0.0046 0.0405 0.0405
Echinococcus granulosus nmda type glutamate receptor 0.0053 0.0479 0.0479
Echinococcus granulosus regulator of G protein signaling 3 0.0025 0.0169 0.0169
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0918 0.0918
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0094 0.0094
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.001 0.0006 0.0027
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0098 0.0981 0.0981
Schistosoma mansoni lamin 0.0084 0.0833 0.0833
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0058 0.008
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0006 0.0008
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0918 0.0918
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0941 0.0941
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0098 0.0981 0.0981
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0341 0.0751
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.001 0.0006 0.0027
Loa Loa (eye worm) cytochrome P450 0.001 0.0006 0.0008
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0094 0.0094
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0038 0.0314 0.2163
Brugia malayi steroid hormone receptor 0.0098 0.0981 0.1367
Loa Loa (eye worm) nuclear receptor NHR-67 0.0046 0.0405 0.0564
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0018 0.0094 0.0131
Plasmodium vivax SET domain protein, putative 0.0094 0.0941 1
Schistosoma mansoni jumonji domain containing protein 0.0145 0.1515 0.1515
Schistosoma mansoni lamin 0.0084 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0098 0.0981 0.1367
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0312 0.3376 0.3376
Schistosoma mansoni steroid hormone receptor ad4bp 0.0098 0.0981 0.0981
Loa Loa (eye worm) acetyltransferase 0.0312 0.3376 0.4706
Loa Loa (eye worm) hypothetical protein 0.0046 0.0405 0.0564
Entamoeba histolytica proliferating cell nuclear antigen, putative 0.0063 0.0589 0.188
Brugia malayi Raf kinase 0.0049 0.0435 0.0606
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.1444 1
Trichomonas vaginalis proliferating cell nuclear antigen, putative 0.0063 0.0589 0.0718
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0025 0.0169 0.0169
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0105 0.0912
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0098 0.0981 0.1367
Onchocerca volvulus 0.0098 0.0981 0.1148
Echinococcus multilocularis expressed protein 0.0385 0.4195 0.4195
Schistosoma mansoni lozenge 0.0054 0.0495 0.0495
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0018 0.0094 0.0131
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.001 0.0006 0.0027
Schistosoma mansoni nuclear hormone receptor 0.0046 0.0405 0.0405
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.001 0.0006 0.0027
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0341 0.3869
Echinococcus multilocularis NMDA receptor 0.0015 0.0056 0.0056
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0621 0.0866
Loa Loa (eye worm) LGC-31 protein 0.0018 0.0094 0.0131
Onchocerca volvulus 0.0054 0.0497 0.0554
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0098 0.0981 0.1367
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0028 0.0201 0.0201
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0058 0.0058
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0341 0.1106
Brugia malayi excitatory GABA receptor EXP-1A 0.0018 0.0094 0.0131
Schistosoma mansoni protein phosphatase 2C 0.0026 0.0183 0.0183
Trypanosoma brucei DNA polymerase eta, putative 0.0014 0.0048 0.046
Echinococcus granulosus cpg binding protein 0.003 0.0221 0.0221
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0094 0.0131
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0094 0.0094
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0156 0.1631 0.1631
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0054 0.0497 0.0497
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.001 0.0006 0.0027
Trypanosoma cruzi MFS transporter, putative 0.0054 0.0497 0.5385
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0228 0.2441
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0094 0.0941 0.6954
Chlamydia trachomatis glutamine binding protein 0.0038 0.0314 1
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0018 0.0094 0.0094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0098 0.0981 0.1367
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0038 0.0314 0.1017
Loa Loa (eye worm) hypothetical protein 0.0098 0.0981 0.1367
Loa Loa (eye worm) hypothetical protein 0.0015 0.0058 0.008
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0038 0.0314 1
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0265 0.2845
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0015 0.0058 0.008
Brugia malayi Nuclear hormone receptor E75 0.0046 0.0405 0.0564
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0015 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0018 0.0094 0.0131
Echinococcus multilocularis GPCR, family 2 0.0065 0.0621 0.0621
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0025 0.0169 0.0169
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.014 0.014
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0094 0.0094
Echinococcus multilocularis neuropeptide s receptor 0.0454 0.4965 0.4965
Brugia malayi Steroid receptor seven-up type 2 0.0098 0.0981 0.1367
Loa Loa (eye worm) RGS-3 protein 0.0025 0.0169 0.0235
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0018 0.0094 0.0131
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.0268 0.0268
Onchocerca volvulus 0.0018 0.0094 0.0058
Schistosoma mansoni phosphatidylserine receptor 0.0026 0.0183 0.0183
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0918 0.112
Echinococcus granulosus neuropeptide s receptor 0.0454 0.4965 0.4965
Schistosoma mansoni ferritin light chain 0.001 0.0002 0.0002
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.014 0.014
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0018 0.0094 0.0131
Loa Loa (eye worm) hypothetical protein 0.0046 0.0405 0.0564
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.0305 0.0424
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0337 0.041
Echinococcus granulosus regulator of G protein signaling 7 0.0025 0.0169 0.0169
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0337 0.3632
Brugia malayi sodium-independent organic anion transporter family protein 0.0086 0.0847 0.1181
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0018 0.0094 0.0131
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0048 0.0067
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0058 0.0058
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0514 0.3555
Brugia malayi Glutamate receptor 1 precursor 0.0015 0.0056 0.0077
Echinococcus multilocularis lamin 0.0084 0.0833 0.0833
Brugia malayi nuclear hormone receptor family member nhr-6 0.0046 0.0405 0.0564
Loa Loa (eye worm) hypothetical protein 0.0098 0.0981 0.1367
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0014 0.0048 0.0048
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0047 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0169 0.0204
Echinococcus multilocularis sodium and chloride dependent glycine 0.0015 0.0058 0.0058
Schistosoma mansoni nAChR subunit 0.0018 0.0094 0.0094
Brugia malayi hypothetical protein 0.0019 0.0105 0.0146
Schistosoma mansoni z-protein (S1r protein) 0.0025 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0018 0.0094 0.0131
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0094 0.0941 0.0941
Echinococcus multilocularis ecdysone induced protein 78C 0.0098 0.0981 0.0981
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0046 0.0405 0.0564
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0014 0.0093
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.001 0.0006 0.0027
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0025 0.0172 0.024
Onchocerca volvulus 0.0028 0.0203 0.0192
Loa Loa (eye worm) hypothetical protein 0.0026 0.0183 0.0256
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.0305 0.0424
Echinococcus multilocularis cpg binding protein 0.003 0.0221 0.0221
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0268 0.0373
Brugia malayi Calcitonin receptor-like protein seb-1 0.0207 0.2201 0.3068
Schistosoma mansoni regulator of G protein signaling 0.0025 0.0169 0.0169
Echinococcus granulosus Nuclear hormone receptor HR96 0.0046 0.0405 0.0405
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0183 0.1947
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.001 0.0006 0.0027
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0037 0.0305 0.0424
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0014 0.0048 0.0048
Onchocerca volvulus 0.0431 0.471 0.5732
Loa Loa (eye worm) raf kinase 0.0049 0.0435 0.0606
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.001 0.0006 0.0027
Schistosoma mansoni hypothetical protein 0.0065 0.0621 0.0621
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0018 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0018 0.0094 0.0131
Onchocerca volvulus Alhambra homolog 0.0034 0.0268 0.0272
Brugia malayi cytoplasmic intermediate filament protein 0.0045 0.0395 0.0551
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0337 0.3632
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0156 0.1631 0.1631
Brugia malayi Nuclear hormone receptor-like 1 0.0574 0.6302 0.8785
Brugia malayi Cation transporter family protein 0.0018 0.0094 0.0131
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0048 0.0067
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0098 0.0981 0.0981
Leishmania major hypothetical protein, conserved 0.0026 0.0183 0.1321
Schistosoma mansoni phd/f-box containing protein 0.0026 0.0183 0.0183
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.001 0.0006 0.0027
Schistosoma mansoni nAChR subunit 0.0018 0.0094 0.0094
Brugia malayi hypothetical protein 0.0046 0.0405 0.0564
Trypanosoma cruzi proliferative cell nuclear antigen (PCNA), putative 0.0063 0.0589 0.6392
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0399 0.0486
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0025 0.0172 0.024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0094 0.0131
Loa Loa (eye worm) hypothetical protein 0.0207 0.2201 0.3068
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0094 0.0094
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0047 0.0047
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0047 0.0047
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0405 0.0405
Echinococcus granulosus axis inhibition protein axin 0.0025 0.0169 0.0169
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0374 0.407 0.407
Brugia malayi Cation transporter family protein 0.0018 0.0094 0.0131
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0046 0.0405 0.0405
Echinococcus multilocularis 0.001 0.0006 0.0006
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.2462 0.3432
Echinococcus granulosus nAChR subunit 0.0018 0.0094 0.0094
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.0305 0.2222
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0514 0.0717
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0094 0.0094
Echinococcus multilocularis glutamate receptor 2 0.0022 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0094 0.0131
Echinococcus granulosus ferritin 0.001 0.0002 0.0002
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0026 0.0183 0.1947
Echinococcus multilocularis G protein signaling modulator 2 0.0014 0.0043 0.0043
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0025 0.0169 0.0169
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0228 0.2441
Loa Loa (eye worm) CYP4Cod1 0.001 0.0006 0.0008
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0094 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0169 0.0204
Loa Loa (eye worm) hypothetical protein 0.0046 0.0405 0.0564
Loa Loa (eye worm) hypothetical protein 0.0026 0.0183 0.0256
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0792 0.8743 0.8743
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0046 0.0405 0.044
Schistosoma mansoni hypothetical protein 0.0065 0.0621 0.0621
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.307 0.3752
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0098 0.0981 0.0981
Brugia malayi acetyltransferase, GNAT family protein 0.0312 0.3376 0.4706
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0094 0.0094
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0099 0.0996 0.0996
Toxoplasma gondii proliferating cell nuclear antigen PCNA2 0.0033 0.0264 0.192
Brugia malayi nuclear receptor RXR 0.0052 0.0466 0.065
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0337 0.3632
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.001 0.0006 0.0027
Loa Loa (eye worm) hypothetical protein 0.0034 0.0268 0.0373
Schistosoma mansoni hypothetical protein 0.0065 0.0621 0.0621
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0018 0.0094 0.0131
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0058 0.008
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0341 0.3676
Echinococcus granulosus histone lysine methyltransferase setb 0.0094 0.0941 0.0941
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0094 0.0131
Brugia malayi PHD-finger family protein 0.0013 0.0031 0.0044
Plasmodium falciparum proliferating cell nuclear antigen 2 0.0033 0.0264 0.29
Schistosoma mansoni rab6-interacting 0.0019 0.0105 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0098 0.0981 0.1367
Loa Loa (eye worm) hypothetical protein 0.0065 0.0621 0.0866
Treponema pallidum sodium- and chloride- dependent transporter 0.0015 0.0058 0.0182
Echinococcus granulosus RUN 0.0019 0.0105 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0098 0.0981 0.1367
Loa Loa (eye worm) hypothetical protein 0.0037 0.0305 0.0424
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0018 0.0094 0.0131
Brugia malayi Nuclear hormone receptor E75 0.0046 0.0405 0.0564
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0098 0.0981 0.1367
Onchocerca volvulus 0.0018 0.0094 0.0058
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0038 0.0314 0.1017
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.0305 0.0424
Echinococcus multilocularis nuclear receptor nhr 48 0.0046 0.0405 0.0405
Plasmodium vivax proliferating cell nuclear antigen, putative 0.0063 0.0589 0.6174
Loa Loa (eye worm) hypothetical protein 0.0098 0.0981 0.1367
Loa Loa (eye worm) hypothetical protein 0.0037 0.0305 0.0424
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0918 0.0918
Schistosoma mansoni ferritin 0.001 0.0002 0.0002
Onchocerca volvulus 0.0015 0.0058 0.0014
Loa Loa (eye worm) hypothetical protein 0.0015 0.0058 0.008
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0918 0.2957
Loa Loa (eye worm) RecQ helicase 0.0021 0.0122 0.0171
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0374 0.407 0.407
Loa Loa (eye worm) hypothetical protein 0.0015 0.0058 0.008
Toxoplasma gondii hypothetical protein 0.0015 0.0058 0.0386
Brugia malayi PXA domain containing protein 0.0025 0.0169 0.0235
Echinococcus multilocularis dna polymerase kappa 0.004 0.0337 0.0337
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0918 0.128
Echinococcus granulosus dnaJ subfamily B 0.0398 0.4341 0.4341
Brugia malayi Death domain containing protein 0.0014 0.0047 0.0065
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0183 0.0256
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0399 0.0486
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0099 0.0996 0.0996
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0105 0.0105
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0098 0.0981 0.0981
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0207 0.2201 0.3068
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0018 0.0094 0.0094
Echinococcus granulosus jumonji domain containing 1A 0.0026 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0086 0.0847 0.1181
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0025 0.0035
Schistosoma mansoni regulator of G protein signaling 0.0025 0.0169 0.0169
Loa Loa (eye worm) nuclear hormone receptor 0.0046 0.0405 0.0564
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0094 0.0094
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0025 0.0169 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0169 0.0204
Echinococcus granulosus proliferating cell nuclear antigen 0.0063 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0025 0.0169 0.0235
Echinococcus granulosus lysine specific demethylase 6a 0.0026 0.0183 0.0183
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0514 0.0514
Echinococcus granulosus regulator of G protein signaling 7 0.0025 0.0169 0.0169
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0168 0.1769 0.1769
Brugia malayi orphan nuclear receptor NR2E1 0.0046 0.0405 0.0564
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0094 0.0094
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0094 0.0094
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0094 0.0094
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0054 0.0497 0.0693
Loa Loa (eye worm) hypothetical protein 0.003 0.0228 0.0318
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0022 0.014 0.014
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0098 0.0981 0.0981
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.307 0.3752
Trypanosoma brucei polo-like protein kinase 0.0092 0.0918 1
Onchocerca volvulus 0.0742 0.8181 1
Brugia malayi sodium-independent organic anion transporter family protein 0.0086 0.0847 0.1181
Echinococcus granulosus thyroid hormone receptor alpha 0.0046 0.0405 0.0405
Brugia malayi Glutamate receptor 2 precursor 0.0015 0.0056 0.0077
Brugia malayi hypothetical protein 0.0025 0.0169 0.0235
Onchocerca volvulus Putative organic anion transporter 0.0054 0.0497 0.0554
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0094 0.0131
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0014 0.0048 0.0048
Leishmania major proliferative cell nuclear antigen (PCNA), putative 0.0063 0.0589 0.4336
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0156 0.1631 0.1631
Schistosoma mansoni ferritin 0.001 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0098 0.0981 0.1367
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0058 0.0058
Schistosoma mansoni DNA polymerase eta 0.0014 0.0048 0.0048
Echinococcus granulosus beta-adrenergic receptor kinase 0.0025 0.0172 0.0172
Plasmodium falciparum phd finger protein, putative 0.0034 0.0268 0.295
Onchocerca volvulus 0.0046 0.0405 0.044
Echinococcus granulosus lamin dm0 0.0084 0.0833 0.0833
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0046 0.0405 0.0405
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0015 0.0056 0.0056
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0053 0.0479 0.0479
Echinococcus multilocularis axis inhibition protein axin 0.0025 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0015 0.0058 0.008
Schistosoma mansoni hypothetical protein 0.0014 0.0047 0.0047
Brugia malayi hypothetical protein 0.0019 0.0105 0.0146
Brugia malayi Regulator of G protein signaling domain containing protein 0.0025 0.0169 0.0235
Loa Loa (eye worm) hypothetical protein 0.0098 0.0981 0.1367
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0341 0.0415
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0098 0.0981 0.0981
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.001 0.0006 0.0027
Toxoplasma gondii transporter, major facilitator family protein 0.0054 0.0497 0.3653
Echinococcus granulosus bloom syndrome protein 0.0021 0.0122 0.0122
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0491 0.0491
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0018 0.0094 0.0094
Echinococcus granulosus death domain containing protein 0.0014 0.0047 0.0047
Onchocerca volvulus 0.0084 0.0833 0.0967
Loa Loa (eye worm) hypothetical protein 0.0099 0.0996 0.1389
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0435 0.0435
Schistosoma mansoni netrin receptor unc5 0.0014 0.0047 0.0047
Echinococcus granulosus cytochrome P450 2K1 0.001 0.0006 0.0006
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0045 0.0295
Brugia malayi regulator of G-protein signaling egl-10 0.0025 0.0169 0.0235
Onchocerca volvulus 0.0084 0.0833 0.0967
Giardia lamblia Fructose-bisphosphate aldolase 0.0285 0.307 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0014 0.0093
Loa Loa (eye worm) steroid hormone receptor 0.0098 0.0981 0.1367
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0337 0.3632
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0015 0.0056 0.0056
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0098 0.0981 0.0981
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0074 0.0074
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0015 0.0058 0.0058
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0015 0.0058 0.008
Giardia lamblia Histone acetyltransferase GCN5 0.0084 0.083 0.2407
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0094 0.0094
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0094 0.0131
Echinococcus multilocularis regulator of G protein signaling 7 0.0025 0.0169 0.0169
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0098 0.0981 0.0981
Brugia malayi hypothetical protein 0.0052 0.0466 0.065
Entamoeba histolytica hypothetical protein 0.0025 0.0169 0.0505
Onchocerca volvulus 0.0018 0.0094 0.0058
Entamoeba histolytica hypothetical protein 0.0025 0.0169 0.0505
Brugia malayi jmjC domain containing protein 0.0026 0.0183 0.0256
Giardia lamblia PcnA 0.0063 0.0589 0.1591
Echinococcus granulosus glutamate NMDA receptor subunit 0.0015 0.0056 0.0056
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.0268 0.0268
Brugia malayi photoreceptor-specific nuclear receptor 0.0098 0.0981 0.1367
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0918 0.112
Loa Loa (eye worm) hypothetical protein 0.0018 0.0094 0.0131
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0092 0.0915 0.6764
Echinococcus multilocularis regulator of G protein signaling 0.0025 0.0169 0.0169
Toxoplasma gondii exonuclease III APE 0.004 0.0341 0.2494
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.001 0.0006 0.0027
Schistosoma mansoni terminal deoxycytidyl transferase 0.0014 0.0048 0.0048
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0015 0.0056 0.0056
Echinococcus granulosus expressed protein 0.001 0.0002 0.0002
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0094 0.0131
Echinococcus granulosus Ankyrin 0.0014 0.0048 0.0048
Plasmodium falciparum histone acetyltransferase GCN5 0.0084 0.083 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0094 0.0131
Loa Loa (eye worm) hypothetical protein 0.0054 0.0497 0.0693
Schistosoma mansoni nuclear receptor 0.0046 0.0405 0.0405
Echinococcus granulosus follistatin 0.0037 0.0305 0.0305
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.001 0.0006 0.0027
Toxoplasma gondii hypothetical protein 0.0015 0.0058 0.0386
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0086 0.0847 0.0847
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0168 0.1769 0.1769
Echinococcus multilocularis axis inhibition protein axin 0.0025 0.0169 0.0169
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0058 0.0386
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0047 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0098 0.0981 0.1367
Onchocerca volvulus 0.0054 0.0497 0.0554
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0025 0.0169 0.0204
Brugia malayi hypothetical protein 0.0025 0.0169 0.0235
Brugia malayi SPARC precursor 0.0037 0.0305 0.0424
Loa Loa (eye worm) hypothetical protein 0.0039 0.0328 0.0457
Schistosoma mansoni polycystin 1-related 0.0019 0.0105 0.0105
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0337 0.3632
Schistosoma mansoni RAR-like nuclear receptor 0.0098 0.0981 0.0981
Loa Loa (eye worm) hypothetical protein 0.0522 0.5726 0.7982
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0052 0.0466 0.0466
Schistosoma mansoni loxhd1 0.0019 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0018 0.0094 0.0131
Treponema pallidum fructose-bisphosphate aldolase 0.0285 0.307 1
Brugia malayi secreted modular calcium-binding protein 1 0.0037 0.0305 0.0424
Loa Loa (eye worm) runx1 0.0054 0.0495 0.069
Schistosoma mansoni axis inhibition protein axin 0.0025 0.0169 0.0169
Onchocerca volvulus 0.0018 0.0094 0.0058
Leishmania major DNA polymerase eta, putative 0.0014 0.0048 0.0312
Loa Loa (eye worm) hypothetical protein 0.0046 0.0405 0.0564
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.0416 0.0416
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0268 0.1949
Brugia malayi hypothetical protein 0.0431 0.471 0.6565
Brugia malayi Intermediate filament tail domain containing protein 0.0084 0.0833 0.1161
Schistosoma mansoni hypothetical protein 0.005 0.0453 0.0453
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0621 0.0621
Schistosoma mansoni proliferating cell nuclear antigen 0.0063 0.0589 0.0589
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0098 0.0981 0.1367
Loa Loa (eye worm) solute carrier family 6 member 4 0.0015 0.0058 0.008
Schistosoma mansoni glutamate receptor kainate 0.0015 0.0056 0.0056
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.009 0.0896 0.0896
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0052 0.0466 0.0466
Echinococcus granulosus FTZ F1 alpha 0.0098 0.0981 0.0981
Brugia malayi ecdysteroid receptor 0.0098 0.0981 0.1367
Brugia malayi tailless protein 0.0046 0.0405 0.0564
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0652 0.7174 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0026 0.0183 0.1321
Mycobacterium ulcerans hypothetical protein 0.0106 0.1072 0.742
Schistosoma mansoni rab6-interacting 0.0019 0.0105 0.0105
Toxoplasma gondii protease inhibitor PI2 0.0037 0.0305 0.2222
Onchocerca volvulus 0.0015 0.0058 0.0014
Brugia malayi sodium-independent organic anion transporter family protein 0.0054 0.0497 0.0693
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0213 0.0297
Loa Loa (eye worm) hypothetical protein 0.0018 0.0094 0.0131
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0341 0.3676
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0941 0.0941
Echinococcus granulosus Solute carrier organic anion transporter family 0.0054 0.0497 0.0497
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0098 0.0981 0.0981
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.001 0.0006 0.0027
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0061 0.0061
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0405 0.0405
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0058 0.008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.307 0.3752
Schistosoma mansoni intermediate filament proteins 0.0084 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0142 0.1477 0.2059
Schistosoma mansoni jumonji/arid domain-containing protein 0.01 0.1007 0.1007
Echinococcus granulosus dna polymerase eta 0.0014 0.0048 0.0048
Brugia malayi intermediate filament protein 0.0084 0.0833 0.1161
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.067 0.0934
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0059
Echinococcus multilocularis proliferating cell nuclear antigen 0.0063 0.0589 0.0589
Brugia malayi proliferating cell nuclear antigen (PCNA) 0.0063 0.0589 0.0821
Loa Loa (eye worm) hypothetical protein 0.0015 0.0058 0.008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.307 0.3752
Onchocerca volvulus 0.0019 0.0105 0.0071
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.001 0.0006 0.0027
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0341 0.2353
Brugia malayi Cation transporter family protein 0.0018 0.0094 0.0131
Brugia malayi GoLoco motif family protein 0.0014 0.0043 0.0059
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0014 0.0015
Echinococcus multilocularis agrin 0.0037 0.0305 0.0305
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0203 0.0283
Plasmodium falciparum amino acid transporter, putative 0.0015 0.0058 0.0314
Plasmodium falciparum JmjC domain-containing protein, putative 0.0026 0.0183 0.189
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0337 0.3632
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.001 0.0006 0.0027
Brugia malayi jmjC domain containing protein 0.0168 0.1769 0.2466
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.001 0.0006 0.0027
Schistosoma mansoni ferritin light chain 0.001 0.0002 0.0002
Plasmodium vivax amine transporter, putative 0.0015 0.0058 0.0401
Loa Loa (eye worm) hypothetical protein 0.0046 0.0405 0.0564
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0025 0.0169 0.0169
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.001 0.0006 0.0027
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0099 0.0996 0.0996
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.065
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0015 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0098 0.0981 0.1367
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.012 0.0816
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0337 0.3632
Schistosoma mansoni hypothetical protein 0.0065 0.0621 0.0621
Echinococcus multilocularis ferritin 0.001 0.0002 0.0002
Echinococcus granulosus Nuclear hormone receptor HR96 0.0046 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0025 0.0169 0.0235
Echinococcus granulosus G protein signaling modulator 2 0.0014 0.0043 0.0043
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0047 0.0047
Brugia malayi Cytochrome P450 family protein 0.001 0.0006 0.0008
Schistosoma mansoni glutamate receptor NMDA 0.0015 0.0056 0.0056
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0122 0.0147
Loa Loa (eye worm) hypothetical protein 0.0018 0.0094 0.0131
Schistosoma mansoni jumonji/arid domain-containing protein 0.01 0.1007 0.1007
Loa Loa (eye worm) hypothetical protein 0.0018 0.0094 0.0131
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0341 0.0475
Loa Loa (eye worm) hypothetical protein 0.0019 0.0105 0.0146
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0098 0.0981 0.0981
Echinococcus granulosus dna polymerase kappa 0.004 0.0337 0.0337
Onchocerca volvulus 0.0018 0.0094 0.0058
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.0305 0.2222
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.0431 0.471 0.6565
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0098 0.0981 0.1367
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0341 0.0475
Schistosoma mansoni glutamate receptor kainate 0.0015 0.0056 0.0056
Brugia malayi Nuclear hormone receptor-like 1 0.0528 0.5788 0.8068
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.0094 0.0131
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.001 0.0006 0.0027
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0015 0.0056 0.0056
Onchocerca volvulus Huntingtin homolog 0.0142 0.1477 0.1758
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0094 0.0772
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0098 0.0981 0.1367
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0092 0.0915 0.9722
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0094 0.0131
Schistosoma mansoni thyroid hormone receptor 0.0472 0.516 0.516
Brugia malayi follicle stimulating hormone receptor 0.023 0.2462 0.3432
Schistosoma mansoni nAChR subunit 0.0018 0.0094 0.0094
Echinococcus multilocularis serotonin transporter 0.0015 0.0058 0.0058
Giardia lamblia Kinase, PLK 0.0092 0.0918 0.2706
Schistosoma mansoni glutamate receptor kainate 0.0015 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0142 0.1477 0.2059
Trichomonas vaginalis set domain proteins, putative 0.0742 0.818 1
Brugia malayi Cytochrome P450 family protein 0.001 0.0006 0.0008
Brugia malayi nuclear hormone receptor family member odr-7 0.0046 0.0405 0.0564
Echinococcus multilocularis expressed protein 0.001 0.0002 0.0002
Brugia malayi jmjC domain containing protein 0.0026 0.0183 0.0256
Brugia malayi Pre-SET motif family protein 0.0094 0.0941 0.1311
Loa Loa (eye worm) hypothetical protein 0.0054 0.0497 0.0693
Brugia malayi jmjC domain containing protein 0.01 0.1007 0.1404
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0045 0.0395 0.0551
Echinococcus multilocularis regulator of G protein signaling 3 0.0025 0.0169 0.0169
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0098 0.0981 0.0981
Schistosoma mansoni hypothetical protein 0.0905 1 1
Giardia lamblia PHD finger protein 15 0.0034 0.0268 0.0503
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.065
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.001 0.0006 0.0027
Trypanosoma brucei unspecified product 0.0034 0.0265 0.2845
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0098 0.0981 0.0981
Schistosoma mansoni glutamate receptor AMPA 0.0015 0.0056 0.0056
Brugia malayi PHD-finger family protein 0.0034 0.0268 0.0373
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0337 0.3632
Schistosoma mansoni organic anion transporter 0.0086 0.0847 0.0847
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0026 0.0183 0.1321
Echinococcus multilocularis regulator of G protein signaling 3 0.0025 0.0169 0.0169
Echinococcus multilocularis dna polymerase eta 0.0014 0.0048 0.0048
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.1444 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.001 0.0006 0.0027
Toxoplasma gondii proliferating cell nuclear antigen PCNA1 0.0063 0.0589 0.4336
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.1444 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0156 0.1631 0.2274
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0098 0.0981 0.0981
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0094 0.0094
Trypanosoma cruzi DNA polymerase eta, putative 0.0014 0.0048 0.046
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0014 0.0047 0.0065
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0058 0.0386
Echinococcus granulosus Regulator of G protein signaling 20 0.0025 0.0169 0.0169
Schistosoma mansoni nuclear hormone receptor 0.0098 0.0981 0.0981
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0341 0.1069
Echinococcus multilocularis RUN 0.0019 0.0105 0.0105
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0098 0.0981 0.1367
Onchocerca volvulus Huntingtin homolog 0.0142 0.1477 0.1758
Schistosoma mansoni nuclear hormone receptor 0.0046 0.0405 0.0405
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0046 0.0405 0.0405
Schistosoma mansoni proliferating cell nuclear antigen 0.0063 0.0589 0.0589
Echinococcus granulosus lamin 0.0084 0.0833 0.0833
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0025 0.0025
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0046 0.0405 0.0405
Echinococcus granulosus GPCR family 2 0.0065 0.0621 0.0621
Schistosoma mansoni hypothetical protein 0.0398 0.4341 0.4341
Loa Loa (eye worm) agrin synaptic family protein 0.0037 0.0305 0.0424
Loa Loa (eye worm) hypothetical protein 0.0037 0.0305 0.0424
Onchocerca volvulus 0.0094 0.0941 0.1099
Schistosoma mansoni nAChR subunit 0.0018 0.0094 0.0094
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0098 0.0981 0.0981
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0183 0.0256
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0105 0.0105
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0941 0.0941
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0312 0.3376 0.3376
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.0305 0.2222
Loa Loa (eye worm) hypothetical protein 0.0018 0.0094 0.0131
Onchocerca volvulus Putative organic anion transporter 0.0054 0.0497 0.0554
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0094 0.0941 0.0941
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0018 0.0094 0.0131
Brugia malayi hypothetical protein 0.0054 0.0497 0.0693
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0094 0.0094
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0054 0.0497 0.0693
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0098 0.0981 0.1367
Brugia malayi Bromodomain containing protein 0.0041 0.0353 0.0492
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0918 1
Schistosoma mansoni hypothetical protein 0.0905 1 1
Brugia malayi nuclear hormone receptor 0.0098 0.0981 0.1367
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0169 0.0204
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.065
Loa Loa (eye worm) hypothetical protein 0.0083 0.0816 0.1137
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0052 0.0466 0.0466
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0018 0.0094 0.0094
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0692 0.0692
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.001 0.0006 0.0027
Loa Loa (eye worm) hypothetical protein 0.0025 0.0169 0.0235
Echinococcus multilocularis follistatin 0.0037 0.0305 0.0305
Schistosoma mansoni ATP-binding cassette transporter 0.0015 0.0056 0.0056
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0341 0.3481
Schistosoma mansoni hypothetical protein 0.0374 0.407 0.407
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0122 0.0122
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0098 0.0981 0.0981
Echinococcus granulosus sodium and chloride dependent glycine 0.0015 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0098 0.0981 0.1367
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0122 0.0171
Schistosoma mansoni lipoxygenase 0.0054 0.0491 0.0491
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0047 0.0065
Echinococcus multilocularis musashi 0.0084 0.0833 0.0833
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.001 0.0006 0.0027
Leishmania major DNA polymerase kappa, putative 0.0021 0.012 0.0846
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0015 0.0056 0.0056
Schistosoma mansoni kinase 0.0047 0.0413 0.0413
Echinococcus granulosus serotonin transporter 0.0015 0.0058 0.0058
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.0305 0.0424
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0046 0.0405 0.044
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0098 0.0981 0.0981
Schistosoma mansoni glutamate receptor NMDA 0.0022 0.014 0.014
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.012 0.1247
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0099 0.0996 0.0996
Echinococcus multilocularis thyroid hormone receptor alpha 0.0472 0.516 0.516
Echinococcus multilocularis expressed protein 0.0037 0.0305 0.0305
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0918 0.112
Echinococcus granulosus glutamate receptor subunit protein glur 0.0015 0.0056 0.0056
Brugia malayi Cytochrome P450 family protein 0.001 0.0006 0.0008
Trypanosoma cruzi proliferative cell nuclear antigen (PCNA), putative 0.0063 0.0589 0.6392
Schistosoma mansoni ap endonuclease 0.004 0.0341 0.0341
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.135 0.9353
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0341 0.2353
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.001 0.0006 0.0027
Schistosoma mansoni cytochrome P450 0.001 0.0006 0.0006
Echinococcus granulosus glutamate receptor 2 0.0022 0.014 0.014
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.014 0.014
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0015 0.0058 0.0058
Trypanosoma brucei proliferative cell nuclear antigen (PCNA), putative 0.0063 0.0589 0.6392
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0337 0.3632
Brugia malayi Pre-SET motif family protein 0.0652 0.7174 1
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0105 0.0146
Trichomonas vaginalis bromodomain-containing protein, putative 0.0092 0.0915 0.1117
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0514 0.3555
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0098 0.0981 0.1367
Schistosoma mansoni coup transcription factor 0.0098 0.0981 0.0981
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.307 0.3752
Echinococcus granulosus raf serine:threonine protein kinase 0.0049 0.0435 0.0435
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.014 0.014
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0131 0.135 0.135
Loa Loa (eye worm) norepinephrine transporter 0.0015 0.0058 0.008
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0014 0.0048 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0098 0.0981 0.1367
Echinococcus multilocularis Regulator of G protein signaling 20 0.0025 0.0169 0.0169
Schistosoma mansoni ferritin 0.001 0.0002 0.0002
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0092 0.0915 0.1117
Brugia malayi PXA domain containing protein 0.0025 0.0169 0.0235
Loa Loa (eye worm) hypothetical protein 0.0046 0.0405 0.0564
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0058 0.0058
Schistosoma mansoni jumonji domain containing protein 0.0026 0.0183 0.0183
Brugia malayi hypothetical protein 0.0142 0.1477 0.2059
Loa Loa (eye worm) hypothetical protein 0.0094 0.0941 0.1311
Echinococcus granulosus phd:f box containing protein 0.0026 0.0183 0.0183
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.001 0.0006 0.0027
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0094 0.0131
Brugia malayi ecdysone receptor 0.0046 0.0405 0.0564
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0018 0.0094 0.0094
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0105 0.0904
Schistosoma mansoni hypothetical protein 0.0011 0.0014 0.0014
Onchocerca volvulus 0.0015 0.0058 0.0014
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.4341 0.4341
Onchocerca volvulus 0.0086 0.0847 0.0984
Loa Loa (eye worm) hypothetical protein 0.0025 0.0169 0.0235
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.001 0.0006 0.0027
Mycobacterium leprae Conserved hypothetical protein 0.001 0.0006 0.0027
Loa Loa (eye worm) hypothetical protein 0.0037 0.0305 0.0424
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0918 0.112
Schistosoma mansoni hypothetical protein 0.0015 0.0056 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0098 0.0981 0.1367
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.307 0.3752
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.001 0.0006 0.0027
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0606 0.4464
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0022 0.014 0.014
Onchocerca volvulus Protein ultraspiracle homolog 0.0098 0.0981 0.1148
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.065
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0046 0.0405 0.0564
Loa Loa (eye worm) hypothetical protein 0.0052 0.0466 0.065
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0041 0.0345 0.0481
Schistosoma mansoni regulator of G protein signaling 0.0025 0.0169 0.0169
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0621 0.0866
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0337 0.3632
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0028 0.0201 0.0201
Echinococcus multilocularis sodium and chloride dependent glycine 0.0015 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0018 0.0094 0.0131
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0011 0.0014 0.0059
Schistosoma mansoni nAChR subunit 0.0018 0.0094 0.0094
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0131 0.135 0.135
Brugia malayi hypothetical protein 0.0015 0.0058 0.008
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0621 0.0621
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0156 0.1631 0.2274
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0058 0.0058
Echinococcus granulosus nuclear receptor nhr 48 0.0046 0.0405 0.0405
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.307 1
Loa Loa (eye worm) proliferating cell nuclear antigen 0.0063 0.0589 0.0821
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0047 0.0287
Echinococcus granulosus lysine specific demethylase 5A 0.01 0.1007 0.1007
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0341 0.3676
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0337 0.2325
Brugia malayi prostaglandin transporter 0.0054 0.0497 0.0693
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.135 0.135
Entamoeba histolytica acetyltransferase, GNAT family 0.0084 0.083 0.2669
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0148 0.0206
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.001 0.0006 0.0027
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0086 0.0847 0.1181
Plasmodium falciparum transporter, putative 0.0015 0.0058 0.0314
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.014 0.014
Loa Loa (eye worm) GoLoco domain-containing protein family protein 0.0014 0.0043 0.0059
Schistosoma mansoni hypothetical protein 0.001 0.0006 0.0006
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0094 0.0131
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0337 0.3632
Loa Loa (eye worm) hypothetical protein 0.0084 0.0833 0.1161
Schistosoma mansoni cpg binding protein 0.003 0.0221 0.0221
Loa Loa (eye worm) jmjC domain-containing protein 0.01 0.1007 0.1404
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0491 0.0491
Schistosoma mansoni hypothetical protein 0.0034 0.0268 0.0268
Toxoplasma gondii aldehyde dehydrogenase 0.0131 0.135 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0098 0.0981 0.0981
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0918 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0014 0.0048 0.0109
Brugia malayi latrophilin 2 splice variant baaae 0.0141 0.147 0.2049
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0018 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0046 0.0405 0.0564
Echinococcus granulosus JmjC domain containing protein 4 0.0026 0.0183 0.0183
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.001 0.0006 0.0027
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0514 0.3555
Plasmodium vivax proliferating cell nuclear antigen, putative 0.0033 0.0264 0.2642
Loa Loa (eye worm) hypothetical protein 0.0014 0.0048 0.0067
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0156 0.1631 0.1631
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0472 0.0658
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0094 0.0094
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0621 0.0866
Echinococcus multilocularis regulator of G protein signaling 7 0.0025 0.0169 0.0169
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.001 0.0006 0.0027
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0591 0.0591
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0026 0.0183 0.0183
Brugia malayi hypothetical protein 0.0046 0.0405 0.0564
Loa Loa (eye worm) hypothetical protein 0.0025 0.0169 0.0235
Echinococcus multilocularis Ankyrin 0.0014 0.0048 0.0048
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0018 0.0094 0.0094
Loa Loa (eye worm) serotonin transporter b 0.0015 0.0058 0.008
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0052 0.0466 0.0466
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0084 0.0833 0.1161
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0018 0.0094 0.0131
Loa Loa (eye worm) hypothetical protein 0.0054 0.0497 0.0693
Schistosoma mansoni nAChR subunit 0.0018 0.0094 0.0094
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0094 0.0131
Loa Loa (eye worm) hypothetical protein 0.0046 0.0405 0.0564
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0015 0.0056 0.0056
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.012 0.0846
Schistosoma mansoni lipoxygenase 0.0019 0.0105 0.0105
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0621 0.0621
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.135 0.135
Echinococcus multilocularis peregrin 0.0041 0.0353 0.0353
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.307 0.3752
Loa Loa (eye worm) hypothetical protein 0.0025 0.0169 0.0235
Echinococcus granulosus peregrin 0.0041 0.0353 0.0353
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0014 0.0063
Brugia malayi nuclear receptor NHR-88 0.0098 0.0981 0.1367
Loa Loa (eye worm) hypothetical protein 0.0018 0.0094 0.0131
Schistosoma mansoni thyroid hormone receptor 0.0472 0.516 0.516
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.013 0.013
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.001 0.0006 0.0027
Schistosoma mansoni regulator of G protein signaling 0.0025 0.0169 0.0169
Schistosoma mansoni ap endonuclease 0.004 0.0341 0.0341
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0099 0.0996 0.0996
Brugia malayi Protein kinase domain containing protein 0.0014 0.005 0.007
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0105 0.0105
Schistosoma mansoni cpg binding protein 0.003 0.0221 0.0221
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0058 0.008
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1501 0.2092
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0025 0.0172 0.024
Toxoplasma gondii PHD-finger domain-containing protein 0.0011 0.0014 0.0059
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0692 0.0692
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.001 0.0006 0.0027
Schistosoma mansoni retinoic acid receptor RXR 0.0098 0.0981 0.0981
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0918 0.112
Brugia malayi Nuclear hormone receptor-like 1 0.0528 0.5788 0.8068
Echinococcus multilocularis JmjC domain containing protein 4 0.0026 0.0183 0.0183
Echinococcus granulosus neuropeptide receptor A26 0.0454 0.4965 0.4965
Loa Loa (eye worm) hypothetical protein 0.0014 0.0048 0.0067
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0341 0.2494
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0046 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0018 0.0094 0.0131
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.001 0.0006 0.0027
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0098 0.0981 0.1367
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0122 0.0147
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.001 0.0006 0.0027
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0337 0.041
Brugia malayi CXXC zinc finger family protein 0.0028 0.0203 0.0283
Loa Loa (eye worm) hypothetical protein 0.0098 0.0981 0.1367
Loa Loa (eye worm) hypothetical protein 0.0018 0.0094 0.0131
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0098 0.0981 0.1367
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0918 0.1071
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0071 0.0711
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.0305 0.2222
Loa Loa (eye worm) hypothetical protein 0.0073 0.0709 0.0988
Brugia malayi nuclear hormone receptor 0.0046 0.0405 0.0564
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.001 0.0006 0.0027
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0183 0.0256
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0156 0.1631 0.1631
Loa Loa (eye worm) hypothetical protein 0.0019 0.0105 0.0146
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0015 0.0056 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0918 0.112
Echinococcus multilocularis beta adrenergic receptor kinase 0.0025 0.0172 0.0172
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0014 0.0087
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.135 0.9353
Brugia malayi jmjC domain containing protein 0.0026 0.0183 0.0256
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1501 0.2092
Echinococcus granulosus jumonji domain containing protein 0.0047 0.0416 0.0416
Brugia malayi polk-prov protein 0.003 0.0228 0.0318
Loa Loa (eye worm) hypothetical protein 0.0046 0.0405 0.0564
Schistosoma mansoni follistatin 0.0037 0.0305 0.0305
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0018 0.0094 0.0094
Echinococcus multilocularis Protein lozenge 0.0054 0.0495 0.0495
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.001 0.0006 0.0027
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0048 0.0048
Echinococcus multilocularis lysine specific demethylase 5A 0.0098 0.0989 0.0989
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0018 0.0094 0.0131
Brugia malayi Regulator of G protein signaling domain containing protein 0.0025 0.0169 0.0235
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0071 0.0711
Brugia malayi nuclear receptor NHR-88 0.0046 0.0405 0.0564
Echinococcus multilocularis raf serine:threonine protein kinase 0.0049 0.0435 0.0435
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0006 0.0008
Onchocerca volvulus 0.0054 0.0497 0.0554
Echinococcus granulosus histone acetyltransferase KAT2B 0.0303 0.3278 0.3278
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0268 0.2685
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0046 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0046 0.0405 0.0564
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.307 0.3752
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0094 0.0941 0.0941
Brugia malayi Uncoordinated protein 44 0.0014 0.0047 0.0065
Echinococcus granulosus regulator of G protein signaling 3 0.0025 0.0169 0.0169
Loa Loa (eye worm) intermediate filament protein 0.0084 0.0833 0.1161
Brugia malayi GoLoco motif family protein 0.0014 0.0043 0.0059
Echinococcus multilocularis nmda type glutamate receptor 0.0053 0.0479 0.0479
Echinococcus granulosus sodium and chloride dependent glycine 0.0015 0.0058 0.0058
Onchocerca volvulus 0.0015 0.0058 0.0014
Brugia malayi regulator of G-protein signaling rgs-7 0.0025 0.0169 0.0235
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0268 0.1949
Schistosoma mansoni agrin 0.0037 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0015 0.0058 0.008
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0015 0.0058 0.008
Onchocerca volvulus 0.0046 0.0405 0.044
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0156 0.1631 0.1631
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.307 1
Brugia malayi Doublecortin family protein 0.0019 0.0105 0.0146
Schistosoma mansoni axis inhibition protein axin 0.0025 0.0169 0.0169
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0046 0.0405 0.0405
Echinococcus multilocularis neuropeptide receptor A26 0.0454 0.4965 0.4965
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0006 0.0006
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0015 0.0058 0.0058
Schistosoma mansoni hypothetical protein 0.0141 0.147 0.147
Schistosoma mansoni zinc finger protein 0.0046 0.0405 0.0405
Onchocerca volvulus 0.0019 0.0105 0.0071
Echinococcus multilocularis phd:f box containing protein 0.0026 0.0183 0.0183
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0025 0.0169 0.0169
Brugia malayi conserved hypotetical protein 0.0046 0.0405 0.0564
Echinococcus multilocularis lysine specific demethylase 6a 0.0026 0.0183 0.0183
Onchocerca volvulus 0.0037 0.0305 0.0317
Brugia malayi nuclear receptor RXR 0.0046 0.0405 0.0564
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0337 0.3632
Onchocerca volvulus 0.0018 0.0094 0.0058
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0341 1
Echinococcus multilocularis geminin 0.0905 1 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.001 0.0006 0.0027
Echinococcus granulosus agrin 0.0037 0.0305 0.0305
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0131 0.135 0.9353
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0918 0.112
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0006 0.0006
Schistosoma mansoni regulator of G protein signaling 0.0026 0.0181 0.0181
Echinococcus multilocularis FTZ F1 alpha 0.0098 0.0981 0.0981
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0094 0.0094
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0431 0.471 0.6565
Echinococcus multilocularis glutamate receptor 2 0.0015 0.0056 0.0056
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0092 0.0915 0.6764
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0058 0.0058
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.001 0.0006 0.0027
Brugia malayi MH2 domain containing protein 0.0144 0.1501 0.2092
Schistosoma mansoni organic anion transporter 0.0054 0.0497 0.0497
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0341 0.0415
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0094 0.0131
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0183 0.1947
Plasmodium vivax JmjC domain containing protein 0.0026 0.0183 0.1766
Schistosoma mansoni hypothetical protein 0.0014 0.0043 0.0043
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0172 0.0172
Schistosoma mansoni nuclear receptor nhr-48 0.0046 0.0405 0.0405
Schistosoma mansoni nAChR subunit 0.0018 0.0094 0.0094
Loa Loa (eye worm) glutamate receptor 2 0.0015 0.0056 0.0077
Onchocerca volvulus Putative nachr subunit 0.0018 0.0094 0.0058
Brugia malayi nuclear receptor NHR-67 0.0046 0.0405 0.0564
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0018 0.0094 0.0131
Echinococcus multilocularis jumonji domain containing 1A 0.0026 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0018 0.0094 0.0131
Echinococcus granulosus intermediate filament protein 0.0084 0.0833 0.0833
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0058 0.0058
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0345 0.0345
Schistosoma mansoni sodium-dependent amino acid transporter 0.0015 0.0058 0.0058
Schistosoma mansoni glutamate receptor AMPA 0.0015 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0015 0.0058 0.008
Loa Loa (eye worm) hypothetical protein 0.0054 0.0497 0.0693
Brugia malayi A-kinase anchor protein 10, precursor 0.0025 0.0169 0.0235
Schistosoma mansoni hypothetical protein 0.0019 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0039 0.0328 0.0457
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0918 0.6784
Brugia malayi AF-10 protein 0.0011 0.0014 0.0019
Onchocerca volvulus Putative organic anion transporter 0.0054 0.0497 0.0554
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0341 0.0341
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0018 0.0094 0.0094
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0105 0.0105
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0514 0.0514
Echinococcus granulosus histone acetyltransferase KAT2B 0.0092 0.0915 0.0915
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0018 0.0094 0.0131
Loa Loa (eye worm) glutamate receptor 1 0.0015 0.0056 0.0077
Loa Loa (eye worm) DR-78 0.0046 0.0405 0.0564
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0156 0.1631 0.1631
Loa Loa (eye worm) hypothetical protein 0.0015 0.0058 0.008
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0172 0.0172
Schistosoma mansoni ferritin 0.001 0.0002 0.0002
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0058 0.0058
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0018 0.0094 0.0131
Loa Loa (eye worm) hypothetical protein 0.0046 0.0405 0.0564
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0011 0.0011 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0071 0.0711
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0337 0.3632
Mycobacterium leprae putative cytochrome p450 0.001 0.0006 0.0027
Brugia malayi jmjC domain containing protein 0.0026 0.0183 0.0256
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0528 0.5788 0.8068
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0337 0.3632
Loa Loa (eye worm) hypothetical protein 0.0141 0.147 0.2049
Brugia malayi Cytochrome P450 family protein 0.0029 0.0213 0.0297
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0514 0.0514
Schistosoma mansoni cpg binding protein 0.0028 0.0203 0.0203
Onchocerca volvulus Bile acid receptor homolog 0.0098 0.0981 0.1148
Schistosoma mansoni apoferritin-2 0.001 0.0002 0.0002
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0058 0.0386
Brugia malayi cytochrome P450 0.001 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0098 0.0981 0.1367
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0207 0.2201 0.3068
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0099 0.0996 0.1389
Loa Loa (eye worm) PXA domain-containing protein 0.0025 0.0169 0.0235
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0086 0.0847 0.0847
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0169 0.0204
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0098 0.0981 0.1148
Onchocerca volvulus 0.0086 0.0847 0.0984
Mycobacterium tuberculosis Conserved hypothetical protein 0.0014 0.0048 0.0318
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.001 0.0006 0.0027
Entamoeba histolytica hypothetical protein 0.0025 0.0169 0.0505
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0098 0.0981 0.1367
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0094 0.0094
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0033 0.0129
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0018 0.0094 0.0094
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0131 0.135 1
Plasmodium falciparum proliferating cell nuclear antigen 1 0.0063 0.0589 0.6977
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0018 0.0094 0.0094
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0341 0.0341

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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