TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 356.201 | Formula: C16H15Cl2NO4
H donors: 1 H acceptors: 3 LogP: 3.23 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)Cn1ccc(c(c1=O)Cc1ccc(cc1Cl)Cl)O
InChi: 1S/C16H15Cl2NO4/c1-2-23-15(21)9-19-6-5-14(20)12(16(19)22)7-10-3-4-11(17)8-13(10)18/h3-6,8,20H,2,7,9H2,1H3
InChiKey: AOLWLLVYCTZIKP-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	g protein coupled receptor	0.0051	0.0395	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Toxoplasma gondii	hypothetical protein	0.0022	0.0095	0.4056
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0395	0.0333
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0019	0.0064	0.0174
Echinococcus granulosus	neuropeptide s receptor	0.0051	0.0395	0.0395
Toxoplasma gondii	hypothetical protein	0.0022	0.0095	0.4056
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0395	0.0395
Echinococcus multilocularis	serotonin receptor	0.0051	0.0395	0.0333
Trypanosoma brucei	Serine peptidase, Clan SC, Family S09X	0.0022	0.0095	0.002
Loa Loa (eye worm)	G-protein coupled receptor	0.0051	0.0395	0.0395
Echinococcus multilocularis	g protein coupled receptor	0.0051	0.0395	0.0333
Leishmania major	cathepsin L-like protease	0.0071	0.0605	0.1503
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Plasmodium falciparum	alpha/beta hydrolase fold domain containing protein, putative	0.0022	0.0095	0.0086
Echinococcus multilocularis	fmrfamide receptor	0.0051	0.0395	0.0333
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0395	0.0395
Echinococcus granulosus	fmrfamide receptor	0.0051	0.0395	0.0395
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0051	0.0395	0.0395
Brugia malayi	Protein C20orf22	0.0022	0.0095	0.0095
Brugia malayi	Melatonin receptor type 1A	0.0051	0.0395	0.0395
Onchocerca volvulus		0.0019	0.0064	0.077
Schistosoma mansoni	neuropeptide F-like receptor	0.0051	0.0395	0.0395
Plasmodium falciparum	lysophospholipase, putative	0.0367	0.3665	1
Plasmodium falciparum	exported lipase 2	0.0022	0.0095	0.0086
Echinococcus granulosus	neuropeptide FF receptor 2	0.0051	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Leishmania major	phosphopantetheinyl transferase-like protein	0.0026	0.014	0.0212
Onchocerca volvulus		0.0051	0.0395	0.4773
Mycobacterium leprae	PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A)	0.0118	0.1093	0.2703
Toxoplasma gondii	protein c14orf29, putative	0.0022	0.0095	0.4056
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0022	0.0095	0.0086
Onchocerca volvulus		0.0051	0.0395	0.4773
Schistosoma mansoni	biogenic amine receptor	0.0051	0.0395	0.0395
Plasmodium falciparum	lysophospholipase, putative	0.0022	0.0095	0.0086
Onchocerca volvulus		0.0051	0.0395	0.4773
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0095	0.0258
Schistosoma mansoni	adenoreceptor	0.0051	0.0395	0.0395
Schistosoma mansoni	histamine h1 receptor	0.0051	0.0395	0.0395
Brugia malayi	Amidase family protein	0.0118	0.1093	0.1093
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0605	0.1447
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0395	0.0395
Mycobacterium ulcerans	lysophospholipase	0.0367	0.3665	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0051	0.0395	0.0395
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0051	0.0395	0.0395
Trypanosoma cruzi	amidase, putative	0.0118	0.1093	0.2858
Brugia malayi	Dopamine receptor protein 2	0.0051	0.0395	0.0395
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0064	0.0174
Echinococcus granulosus	neuropeptide receptor	0.0051	0.0395	0.0395
Loa Loa (eye worm)	fibroinase	0.0019	0.0064	0.0064
Schistosoma mansoni	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0118	0.1093	0.1093
Brugia malayi	Serotonin receptor	0.0051	0.0395	0.0395
Trypanosoma cruzi	serine peptidase, putative	0.0022	0.0095	0.0086
Trypanosoma brucei	fatty-acid amide hydrolase, putative	0.0118	0.1093	0.281
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0026	0.014	0.0455
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0064	0.0064
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0605	0.1447
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0051	0.0395	0.0395
Mycobacterium ulcerans	amidase	0.0118	0.1093	0.281
Echinococcus multilocularis	neuropeptide receptor	0.0051	0.0395	0.0333
Mycobacterium tuberculosis	Probable amidase AmiB2 (aminohydrolase)	0.0118	0.1093	0.281
Mycobacterium tuberculosis	Possible amidase (aminohydrolase)	0.0118	0.1093	0.281
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0395	0.0333
Plasmodium vivax	hypothetical protein, conserved	0.0022	0.0095	0.0086
Onchocerca volvulus		0.0051	0.0395	0.4773
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0051	0.0395	0.0333
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0095	0.0258
Schistosoma mansoni	family S9 unassigned peptidase (S09 family)	0.0022	0.0095	0.0095
Brugia malayi	G-protein coupled receptor	0.0051	0.0395	0.0395
Schistosoma mansoni	ap endonuclease	0.0021	0.0087	0.0087
Plasmodium vivax	PST-A protein	0.0022	0.0095	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0051	0.0395	0.0333
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0026	0.014	0.0147
Plasmodium vivax	PST-A protein	0.0022	0.0095	0.0086
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0051	0.0395	0.0395
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.0064	0.0064
Mycobacterium ulcerans	peptide amidase, GatA	0.0118	0.1093	0.281
Onchocerca volvulus	Cathepsin L homolog	0.0019	0.0064	0.077
Schistosoma mansoni	amine GPCR	0.0051	0.0395	0.0395
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0026	0.014	0.0524
Schistosoma mansoni	opsin-like receptor	0.0051	0.0395	0.0395
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0051	0.0395	0.0395
Echinococcus granulosus	abhydrolase domain containing 3	0.0022	0.0095	0.0095
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0064	0.0174
Toxoplasma gondii	hypothetical protein	0.0022	0.0095	0.4056
Onchocerca volvulus		0.0092	0.0828	1
Plasmodium vivax	alpha/beta hydrolase, putative	0.0022	0.0095	0.0086
Entamoeba histolytica	hypothetical protein	0.0022	0.0095	0.0258
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0051	0.0395	0.0333
Echinococcus multilocularis	dro:myosuppressin receptor	0.0051	0.0395	0.0333
Brugia malayi	neuropeptide F receptor	0.0051	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0064	0.0174
Echinococcus multilocularis	allatostatin A receptor	0.0051	0.0395	0.0333
Loa Loa (eye worm)	TYRA-2 protein	0.0051	0.0395	0.0395
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0051	0.0395	0.0333
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0095	0.0258
Echinococcus granulosus	glutamyl tRNAGln amidotransferase subunit A	0.0118	0.1093	0.1093
Schistosoma mansoni	hypothetical protein	0.0051	0.0395	0.0395
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0064	0.0174
Schistosoma mansoni	peptidase	0.0022	0.0095	0.0095
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0022	0.0095	0.0086
Leishmania major	hypothetical protein, conserved	0.0118	0.1093	0.2858
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0051	0.0395	0.0333
Brugia malayi	sulfakinin receptor protein	0.0051	0.0395	0.0395
Trypanosoma brucei	Alpha/beta hydrolase family, putative	0.0022	0.0095	0.002
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0051	0.0395	0.0395
Schistosoma mansoni	neuropeptide F-like receptor	0.0051	0.0395	0.0395
Schistosoma mansoni	neuropeptide receptor	0.0051	0.0395	0.0395
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0979	1	1
Echinococcus granulosus	abhydrolase domain containing protein 13	0.0022	0.0095	0.0095
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0051	0.0395	0.0395
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0022	0.0095	0.0258
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0022	0.0095	0.0258
Plasmodium vivax	hypothetical protein, conserved	0.0022	0.0095	0.0086
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0395	0.0333
Loa Loa (eye worm)	G-protein coupled receptor	0.0051	0.0395	0.0395
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0064	0.0174
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0064	0.0174
Brugia malayi	follicle stimulating hormone receptor	0.0051	0.0395	0.0395
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0395	0.0395
Schistosoma mansoni	neuropeptide receptor	0.0051	0.0395	0.0395
Echinococcus granulosus	g-protein coupled receptor	0.0051	0.0395	0.0395
Echinococcus granulosus	dro:myosuppressin receptor	0.0051	0.0395	0.0395
Echinococcus granulosus	cathepsin l1	0.0019	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Brugia malayi	neuropeptide F receptor	0.0051	0.0395	0.0395
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0605	0.1447
Mycobacterium tuberculosis	Possible lysophospholipase	0.0367	0.3665	1
Loa Loa (eye worm)	amidase	0.0118	0.1093	0.1093
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0367	0.3665	1
Brugia malayi	larval opioid receptor	0.0051	0.0395	0.0395
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0051	0.0395	0.0333
Plasmodium falciparum	esterase, putative	0.0022	0.0095	0.0086
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0092	0.0828	0.0828
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0118	0.1093	0.1036
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0087	0.0066
Echinococcus multilocularis	fmrfamide receptor	0.0051	0.0395	0.0333
Brugia malayi	Serotonin receptor	0.0051	0.0395	0.0395
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0605	0.1447
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0051	0.0395	0.0395
Toxoplasma gondii	peptidase S15, putative	0.0022	0.0095	0.4056
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0019	0.0064	0.0064
Echinococcus granulosus	7tm_1 domain containing protein	0.0051	0.0395	0.0395
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0051	0.0395	0.0333
Plasmodium vivax	glutamyl-tRNA(Gln) amidotransferase subunit A, putative	0.0118	0.1093	0.2858
Schistosoma mansoni	amine GPCR	0.0051	0.0395	0.0395
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0087	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0064	0.0174
Echinococcus granulosus	7TM GPCR rhodopsin	0.0051	0.0395	0.0395
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0051	0.0395	0.0395
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0395	0.0395
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0367	0.3665	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0605	0.1447
Leishmania major	monoglyceride lipase, putative	0.0367	0.3665	1
Toxoplasma gondii	exonuclease III APE	0.0021	0.0087	0.3107
Plasmodium vivax	lysophospholipase, putative	0.0022	0.0095	0.0086
Onchocerca volvulus		0.0019	0.0064	0.077
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Trypanosoma cruzi	monoglyceride lipase, putative	0.0367	0.3665	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0095	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Schistosoma mansoni	ap endonuclease	0.0021	0.0087	0.0087
Plasmodium falciparum	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0118	0.1093	0.2858
Schistosoma mansoni	opsin-like receptor	0.0051	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Echinococcus granulosus	tm gpcr rhodopsin	0.0051	0.0395	0.0395
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0051	0.0395	0.4773
Brugia malayi	hypothetical protein	0.0051	0.0395	0.0395
Schistosoma mansoni	family S9 unassigned peptidase (S09 family)	0.0022	0.0095	0.0095
Entamoeba histolytica	hypothetical protein	0.0026	0.014	0.0382
Echinococcus granulosus	sex peptide receptor	0.0051	0.0395	0.0395
Loa Loa (eye worm)	cysteine protease	0.0019	0.0064	0.0064
Echinococcus granulosus	G protein coupled receptor 139	0.0051	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0019	0.0064	0.0174
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.0087	0.0066
Schistosoma mansoni	biogenic amine receptor	0.0051	0.0395	0.0395
Echinococcus granulosus	monoacylglycerol lipase abhd12	0.0022	0.0095	0.0095
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0051	0.0395	0.0395
Trypanosoma brucei	monoglyceride lipase, putative	0.0367	0.3665	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0395	0.0333
Plasmodium falciparum	exported lipase 1	0.0022	0.0095	0.0086
Loa Loa (eye worm)	neuropeptide F receptor	0.0051	0.0395	0.0395
Toxoplasma gondii	phospholipase	0.0022	0.0095	0.4056
Leishmania major	cathepsin L-like protease	0.0071	0.0605	0.1503
Plasmodium vivax	PST-A protein	0.0367	0.3665	1
Trichomonas vaginalis	conserved hypothetical protein	0.0367	0.3665	1
Brugia malayi	hypothetical protein	0.0051	0.0395	0.0395
Mycobacterium ulcerans	amidase	0.0118	0.1093	0.281
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0051	0.0395	0.0395
Onchocerca volvulus		0.0051	0.0395	0.4773
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0021	0.0087	0.0239
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0979	1	1
Brugia malayi	G protein-coupled receptor	0.0051	0.0395	0.0395
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0064	0.0064
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0064	0.0174
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0095	0.0258
Wolbachia endosymbiont of Brugia malayi	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0118	0.1093	1
Leishmania major	Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X	0.0022	0.0095	0.0086
Echinococcus granulosus	Phospholipase carboxylesterase	0.0022	0.0095	0.0095
Onchocerca volvulus		0.0019	0.0064	0.077
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0051	0.0395	0.0395
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0026	0.014	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0095	0.0095
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0051	0.0395	0.0395
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0087	0.0087
Trichomonas vaginalis	conserved hypothetical protein	0.0367	0.3665	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0051	0.0395	0.0395
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0022	0.0095	0.0258
Echinococcus granulosus	neuropeptide receptor	0.0051	0.0395	0.0395
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0019	0.0064	0.0064
Mycobacterium ulcerans	hypothetical protein	0.0022	0.0095	0.002
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0051	0.0395	0.0333
Leishmania major	hypothetical protein, conserved	0.0022	0.0095	0.0086
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.0367	0.3665	1
Echinococcus granulosus	somatostatin receptor	0.0051	0.0395	0.0395
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0087	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Echinococcus multilocularis	neuropeptides capa receptor	0.0051	0.0395	0.0333
Echinococcus granulosus	g protein coupled receptor	0.0051	0.0395	0.0395
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0064	0.0174
Schistosoma mansoni	biogenic amine receptor	0.0051	0.0395	0.0395
Echinococcus multilocularis	neuropeptide Y receptor	0.0051	0.0395	0.0333
Mycobacterium ulcerans	hypothetical protein	0.0022	0.0095	0.002
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0395	0.0395
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0026	0.014	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0064	0.0174
Trypanosoma cruzi	cysteine peptidase, putative	0.0071	0.0605	0.1503
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0021	0.0087	0.0066
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0064	0.0174
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0051	0.0395	0.0395
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0367	0.3665	1
Brugia malayi	putative amidase	0.0118	0.1093	0.1093
Brugia malayi	hypothetical protein	0.0051	0.0395	0.0395
Onchocerca volvulus	Cathepsin F homolog	0.0019	0.0064	0.077
Toxoplasma gondii	hydrolase, alpha/beta fold family protein	0.0022	0.0095	0.4056
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0605	0.1447
Toxoplasma gondii	phospholipase/carboxylesterase	0.0022	0.0095	0.4056
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0979	1	1
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0022	0.0095	0.0258
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0395	0.0333
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0051	0.0395	0.0395
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0051	0.0395	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Echinococcus multilocularis	G protein coupled receptor 139	0.0051	0.0395	0.0333
Echinococcus granulosus	g protein coupled receptor	0.0051	0.0395	0.0395
Echinococcus multilocularis	neuropeptide Y receptor	0.0051	0.0395	0.0333
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0367	0.3665	1
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0022	0.0095	0.0086
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0051	0.0395	0.0333
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0019	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0367	0.3665	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0087	0.0087
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0064	0.0174
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0605	0.1447
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0395	0.0395
Brugia malayi	hypothetical protein	0.0051	0.0395	0.0395
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0064	0.0064
Plasmodium falciparum	esterase, putative	0.0367	0.3665	1
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0064	0.0174
Mycobacterium ulcerans	amidase	0.0118	0.1093	0.281
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0395	0.0395
Mycobacterium tuberculosis	Probable amidase AmiA2 (aminohydrolase)	0.0118	0.1093	0.281
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0095	0.0095
Brugia malayi	AKH receptor	0.0051	0.0395	0.0395
Plasmodium vivax	lysophospholipase, putative	0.0022	0.0095	0.0086
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0051	0.0395	0.0395
Echinococcus granulosus	biogenic amine 5HT receptor	0.0051	0.0395	0.0395
Brugia malayi	hypothetical protein	0.0051	0.0395	0.0395
Brugia malayi	hypothetical protein	0.0051	0.0395	0.0395
Onchocerca volvulus		0.0051	0.0395	0.4773
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0019	0.0064	0.0064
Brugia malayi	hypothetical protein	0.0051	0.0395	0.0395
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0064	0.0174
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0051	0.0395	0.0395
Brugia malayi	Amidase family protein	0.0118	0.1093	0.1093
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0095	0.0258
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0064	0.0064
Entamoeba histolytica	;Alias	0.0022	0.0095	0.0258
Plasmodium falciparum	alpha/beta-hydrolase, putative	0.0022	0.0095	0.0086
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0064	0.0064
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0064	0.0174
Plasmodium falciparum	BEM46-like protein, putative	0.0022	0.0095	0.0086
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0118	0.1093	0.1093
Echinococcus granulosus	neuropeptides capa receptor	0.0051	0.0395	0.0395
Schistosoma mansoni	hypothetical protein	0.0051	0.0395	0.0395
Plasmodium falciparum	lysophospholipase, putative	0.0367	0.3665	1
Chlamydia trachomatis	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0118	0.1093	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0051	0.0395	0.0333
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0022	0.0095	0.0086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0064	0.0174
Mycobacterium leprae	PROBABLE AMIDASE AMIC (AMINOHYDROLASE)	0.0118	0.1093	0.2703
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0095	0.0258
Trypanosoma cruzi	major cysteine proteinase, putative	0.0056	0.0448	0.1067
Plasmodium falciparum	esterase, putative	0.0022	0.0095	0.0086
Echinococcus granulosus	allatostatin A receptor	0.0051	0.0395	0.0395
Onchocerca volvulus		0.0051	0.0395	0.4773
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Trypanosoma cruzi	cruzipain precursor, putative	0.0071	0.0605	0.1503
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0395	0.0333
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0051	0.0395	0.0333
Giardia lamblia	Cgi67 serine protease precursor-like protein	0.0022	0.0095	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0064	0.0174
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0051	0.0395	0.0395
Schistosoma mansoni	amine GPCR	0.0051	0.0395	0.0395
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0051	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0064
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.0064	0.0064
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0051	0.0395	0.0395
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0395	0.0395
Brugia malayi	G protein-coupled receptor F59B2.13	0.0051	0.0395	0.0395
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0051	0.0395	0.0395
Onchocerca volvulus		0.0051	0.0395	0.4773
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0095	0.0258
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0064	0.0174
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0051	0.0395	0.0395
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0051	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Schistosoma mansoni	myosin xvIII	0.0051	0.0395	0.0395
Schistosoma mansoni	hypothetical protein	0.0051	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Schistosoma mansoni	neuropeptide receptor	0.0051	0.0395	0.0395
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0087	0.0087
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0095	0.0258
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0395	0.0395
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0022	0.0095	0.0086
Echinococcus multilocularis	g protein coupled receptor	0.0051	0.0395	0.0333
Schistosoma mansoni	opsin-like receptor	0.0051	0.0395	0.0395
Echinococcus granulosus	orexin receptor type 2	0.0051	0.0395	0.0395
Echinococcus multilocularis	somatostatin receptor	0.0051	0.0395	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0395	0.0395
Trypanosoma cruzi	amidase, putative	0.0118	0.1093	0.2858
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0087	0.0066
Brugia malayi	Dopamine receptor protein 1	0.0051	0.0395	0.0395
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0051	0.0395	0.0395
Echinococcus multilocularis	neuropeptides capa receptor	0.0051	0.0395	0.0333
Loa Loa (eye worm)	ctsf protein	0.0019	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0095	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0979	1	1
Toxoplasma gondii	hydrolase, alpha/beta fold family protein	0.0022	0.0095	0.4056
Mycobacterium tuberculosis	Probable amidase AmiD (acylamidase) (acylase)	0.0118	0.1093	0.281
Echinococcus multilocularis	neuropeptide receptor A26	0.0051	0.0395	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Schistosoma mansoni	amidase	0.0979	1	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0051	0.0395	0.4773
Onchocerca volvulus		0.0051	0.0395	0.4773
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Plasmodium vivax	lysophospholipase, putative	0.0022	0.0095	0.0086
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0022	0.0095	0.002
Onchocerca volvulus		0.0051	0.0395	0.4773
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0026	0.014	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0095	0.0095
Echinococcus multilocularis	abhydrolase domain containing 3	0.0022	0.0095	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0828	0.0828
Onchocerca volvulus		0.0019	0.0064	0.077
Echinococcus granulosus	tm gpcr rhodopsin	0.0051	0.0395	0.0395
Echinococcus multilocularis	glutamyl tRNA(Gln) amidotransferase subunit A	0.0118	0.1093	0.1036
Brugia malayi	putative neuropeptide receptor NPR1	0.0051	0.0395	0.0395
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0022	0.0095	0.0258
Plasmodium falciparum	lysophospholipase, putative	0.0022	0.0095	0.0086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0605	0.1447
Plasmodium vivax	unspecified product	0.0022	0.0095	0.0086
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0064	0.0174
Plasmodium falciparum	epoxide hydrolase 2	0.0022	0.0095	0.0086
Onchocerca volvulus		0.0051	0.0395	0.4773
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0051	0.0395	0.0395
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0092	0.0828	0.0828
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0605	0.1447
Brugia malayi	hypothetical protein	0.0051	0.0395	0.0395
Plasmodium vivax	PST-A protein	0.0022	0.0095	0.0086
Brugia malayi	G-protein coupled receptor	0.0051	0.0395	0.0395
Mycobacterium ulcerans	amidase	0.0118	0.1093	0.281
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Brugia malayi	hypothetical protein	0.0051	0.0395	0.0395
Entamoeba histolytica	hypothetical protein	0.0022	0.0095	0.0258
Echinococcus multilocularis	Phospholipase carboxylesterase	0.0022	0.0095	0.0031
Echinococcus granulosus	neuropeptide Y receptor	0.0051	0.0395	0.0395
Echinococcus granulosus	hypothetical protein	0.0051	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Echinococcus granulosus	neuropeptide Y receptor	0.0051	0.0395	0.0395
Onchocerca volvulus		0.0051	0.0395	0.4773
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0064	0.0064
Echinococcus multilocularis	serotonin receptor	0.0051	0.0395	0.0333
Trypanosoma brucei	monoglyceride lipase, putative	0.0367	0.3665	1
Schistosoma mansoni	neuropeptide receptor	0.0051	0.0395	0.0395
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0051	0.0395	0.0395
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0605	0.1447
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0051	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Toxoplasma gondii	hypothetical protein	0.0022	0.0095	0.4056
Brugia malayi	Dopamine receptor	0.0051	0.0395	0.0395
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0979	1	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Onchocerca volvulus		0.0019	0.0064	0.077
Mycobacterium ulcerans	hypothetical protein	0.0367	0.3665	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0064	0.0174
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0051	0.0395	0.0395
Schistosoma mansoni	hypothetical protein	0.0051	0.0395	0.0395
Echinococcus granulosus	biogenic amine 5HT receptor	0.0051	0.0395	0.0395
Trypanosoma cruzi	hydrolase, alpha/beta fold family, putative	0.0022	0.0095	0.0086
Trypanosoma brucei	hypothetical protein, conserved	0.0026	0.014	0.0147
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.0367	0.3665	1
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0026	0.014	0.0147
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0051	0.0395	0.0395
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0022	0.0095	0.0086
Echinococcus multilocularis	g-protein coupled receptor	0.0051	0.0395	0.0333
Echinococcus granulosus	neuropeptide receptor A26	0.0051	0.0395	0.0395
Treponema pallidum	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0118	0.1093	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0395	0.0333
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0051	0.0395	0.0333
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0026	0.014	0.0147
Loa Loa (eye worm)	neuropeptide F receptor	0.0051	0.0395	0.0395
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0092	0.0828	0.0769
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0026	0.014	0.0524
Echinococcus multilocularis	neuropeptide receptor	0.0051	0.0395	0.0333
Echinococcus granulosus	neuropeptides capa receptor	0.0051	0.0395	0.0395
Onchocerca volvulus		0.0051	0.0395	0.4773
Trypanosoma cruzi	Serine peptidase, Clan SC, Family S09X, putative	0.0022	0.0095	0.0086
Trypanosoma brucei	Alpha/beta hydrolase family, putative	0.0022	0.0095	0.002
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0051	0.0395	0.0395
Schistosoma mansoni	amine GPCR	0.0051	0.0395	0.0395
Trypanosoma cruzi	serine peptidase, putative	0.0022	0.0095	0.0086
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0022	0.0095	0.0258
Plasmodium falciparum	prodrug activation and resistance esterase	0.0022	0.0095	0.0086
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	0.0022	0.0095	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0064	0.0174
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0051	0.0395	0.0395
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0367	0.3665	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0395	0.0395
Trypanosoma cruzi	Alpha/beta hydrolase family, putative	0.0022	0.0095	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Brugia malayi	RE15519p	0.0051	0.0395	0.0395
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0051	0.0395	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Plasmodium vivax	PST-A protein	0.0022	0.0095	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Onchocerca volvulus		0.0051	0.0395	0.4773
Leishmania major	hypothetical protein, conserved	0.0022	0.0095	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Brugia malayi	MGC83647 protein	0.0022	0.0095	0.0095
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0064	0.0064
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0051	0.0395	0.0333
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0051	0.0395	0.0333
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0395	0.0395
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0022	0.0095	0.0258
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0087	0.0239
Loa Loa (eye worm)	amidase	0.0118	0.1093	0.1093
Mycobacterium ulcerans	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0118	0.1093	0.281
Trypanosoma cruzi	cysteine peptidase, putative	0.0071	0.0605	0.1503
Echinococcus granulosus	rhodopsin orphan GPCR	0.0051	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Brugia malayi	ORL1-like opioid receptor	0.0051	0.0395	0.0395
Plasmodium falciparum	alpha/beta hydrolase, putative	0.0022	0.0095	0.0086
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0064	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Plasmodium vivax	alpha/beta hydrolase, putative	0.0022	0.0095	0.0086
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0051	0.0395	0.0395
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0395	0.0395
Schistosoma mansoni	amine GPCR	0.0051	0.0395	0.0395
Onchocerca volvulus		0.0019	0.0064	0.077
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0064	0.0174
Brugia malayi	MGC79044 protein	0.0022	0.0095	0.0095
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0026	0.014	0.0212
Echinococcus granulosus	L aminoadipate semialdehyde	0.0092	0.0828	0.0828
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0022	0.0095	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Echinococcus granulosus	g protein coupled receptor	0.0051	0.0395	0.0395
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0065	0.0541	0.1326
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0051	0.0395	0.0395
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0051	0.0395	0.0395
Toxoplasma gondii	esterase/lipase/thioesterase domain-containing protein	0.0022	0.0095	0.4056
Onchocerca volvulus		0.0051	0.0395	0.4773
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Leishmania major	cathepsin L-like protease	0.0071	0.0605	0.1503
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Schistosoma mansoni	fatty-acid amide hydrolase	0.0979	1	1
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0022	0.0095	0.0258
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0605	0.1447
Plasmodium vivax	PST-A protein	0.0022	0.0095	0.0086
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0367	0.3665	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0051	0.0395	0.0395
Schistosoma mansoni	neuropeptide f receptor 76f	0.0051	0.0395	0.0395
Brugia malayi	GnHR receptor homolog	0.0051	0.0395	0.0395
Loa Loa (eye worm)	melatonin receptor type 1A	0.0051	0.0395	0.0395
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0095	0.0258
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0087	0.0239
Echinococcus multilocularis	neuropeptide s receptor	0.0051	0.0395	0.0333
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0064	0.0174
Brugia malayi	putative neuropeptide receptor	0.0051	0.0395	0.0395
Onchocerca volvulus		0.0019	0.0064	0.077
Echinococcus granulosus	serotonin receptor	0.0051	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0395	0.0395
Onchocerca volvulus	Cathepsin L homolog	0.0019	0.0064	0.077
Trypanosoma cruzi	cysteine peptidase, putative	0.0071	0.0605	0.1503
Mycobacterium ulcerans	hydrolase	0.0022	0.0095	0.002
Schistosoma mansoni	fatty-acid amide hydrolase	0.0118	0.1093	0.1093
Mycobacterium tuberculosis	Probable amidase AmiC (aminohydrolase)	0.0118	0.1093	0.281
Mycobacterium ulcerans	amidase	0.0118	0.1093	0.281
Schistosoma mansoni	growth hormone secretagogue receptor	0.0051	0.0395	0.0395
Echinococcus multilocularis	orexin receptor type 2	0.0051	0.0395	0.0333
Plasmodium vivax	hypothetical protein, conserved	0.0022	0.0095	0.0086
Plasmodium vivax	unspecified product	0.0022	0.0095	0.0086
Plasmodium falciparum	lysophospholipase, putative	0.0367	0.3665	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0051	0.0395	0.0395
Onchocerca volvulus		0.0051	0.0395	0.4773
Echinococcus multilocularis	sex peptide receptor	0.0051	0.0395	0.0333
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0051	0.0395	0.0333
Brugia malayi	hypothetical protein	0.0051	0.0395	0.0395
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0064	0.0174
Onchocerca volvulus		0.0051	0.0395	0.4773
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0064	0.0174
Echinococcus multilocularis	monoacylglycerol lipase abhd12	0.0022	0.0095	0.0031

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	8.2753 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1898168

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1574978