Detailed information for compound 1575479

Basic information

Technical information
  • TDR Targets ID: 1575479
  • Name: 1-bromo-2,3-di(phenyl)indolizine-7-carbonitri le
  • MW: 373.245 | Formula: C21H13BrN2
  • H donors: 0 H acceptors: 1 LogP: 6.2 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccn2c(c1)c(Br)c(c2c1ccccc1)c1ccccc1
  • InChi: 1S/C21H13BrN2/c22-20-18-13-15(14-23)11-12-24(18)21(17-9-5-2-6-10-17)19(20)16-7-3-1-4-8-16/h1-13H
  • InChiKey: MWMIFUSNERWPBU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-bromo-2,3-di(phenyl)-7-indolizinecarbonitrile
  • 7-Indolizinecarbonitrile, 1-bromo-2,3-diphenyl-
  • AIDS-118440
  • AIDS118440

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cytochrome P450 family protein 0.0012 0.0209 0.0343
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0737 0.0737
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0131 0.3919 0.7641
Loa Loa (eye worm) hypothetical protein 0.001 0.0143 0.0235
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.065 0.1067
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0143 0.0143
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0131 0.3919 0.5512
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) 0.0166 0.5004 1
Mycobacterium ulcerans adenosine deaminase 0.0166 0.5004 1
Onchocerca volvulus 0.0026 0.065 0.081
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0209 0.0343
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0143 0.0143
Trypanosoma cruzi AMP deaminase, putative 0.0054 0.1522 0.3585
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0737 0.1473
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0143 0.0071
Plasmodium vivax adenosine deaminase, putative 0.0166 0.5004 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0405 0.0329
Leishmania major AMP deaminase, putative,adenosine monophosphate deaminase-like protein 0.0054 0.1522 0.2908
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0041 0.1103 0.2465
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0131 0.3919 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0182 0.0179
Trypanosoma cruzi cytidine deaminase-like protein 0.0052 0.1453 0.3401
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0131 0.3919 0.775
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0143 0.0235
Loa Loa (eye worm) hypothetical protein 0.0012 0.0216 0.0354
Echinococcus granulosus lamin dm0 0.0026 0.065 0.065
Echinococcus granulosus FTZ F1 alpha 0.001 0.0143 0.0143
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0131 0.3919 0.5
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0131 0.3919 0.5512
Leishmania major cytochrome p450-like protein 0.0012 0.0209 0.0234
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0405 0.0633
Treponema pallidum adenosine deaminase 0.0166 0.5004 1
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0086 0.2512 0.412
Leishmania major hypothetical protein, conserved 0.0054 0.1522 0.2908
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0143 0.0143
Schistosoma mansoni lamin 0.0026 0.065 0.13
Brugia malayi Pre-SET motif family protein 0.0202 0.6098 1
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0209 0.0072
Loa Loa (eye worm) globin family protein 0.0008 0.0094 0.0155
Trypanosoma cruzi AMP deaminase 2, putative 0.0054 0.1522 0.3585
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0143 0.0143
Leishmania major AMP deaminase, putative,amp deaminase-like protein 0.0054 0.1522 0.2908
Schistosoma mansoni nuclear hormone receptor 0.001 0.0143 0.0286
Loa Loa (eye worm) hypothetical protein 0.001 0.0143 0.0235
Trypanosoma cruzi AMP deaminase, putative 0.0054 0.1522 0.3585
Loa Loa (eye worm) hypothetical protein 0.0112 0.3322 0.5448
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0131 0.3919 0.775
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0143 0.0286
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0131 0.3919 1
Mycobacterium ulcerans cytidine deaminase 0.0052 0.1453 0.2768
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0143 0.0235
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0131 0.3919 0.7786
Schistosoma mansoni hypothetical protein 0.0008 0.0094 0.0188
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0143 0.0286
Schistosoma mansoni lamin 0.0026 0.065 0.13
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0143 0.0286
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0131 0.3919 0.779
Echinococcus granulosus bloom syndrome protein 0.0021 0.0481 0.0481
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0481 0.0441
Loa Loa (eye worm) hypothetical protein 0.0029 0.0737 0.1209
Loa Loa (eye worm) hypothetical protein 0.0086 0.2512 0.412
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0737 0.1473
Brugia malayi adenosine monophosphate deaminase 0.0054 0.1522 0.2496
Trypanosoma brucei AMP deaminase, putative 0.0054 0.1522 0.3585
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0143 0.0071
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0346 0.0692
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0131 0.3919 0.779
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0737 0.0737
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0143 0.0235
Plasmodium vivax adenosine/AMP deaminase, putative 0.0054 0.1522 0.2639
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0104 0.0104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0143 0.0235
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0131 0.3919 1
Brugia malayi Globin family protein 0.0008 0.0094 0.0155
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0166 0.5004 1
Schistosoma mansoni myoglobin 1 0.0008 0.0094 0.0188
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0405 0.0633
Toxoplasma gondii exonuclease III APE 0.0018 0.0405 0.0614
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0041 0.1103 0.1809
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0086 0.2512 0.412
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0166 0.5004 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0143 0.0235
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0268 0.0334
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0131 0.3919 0.775
Echinococcus multilocularis lamin dm0 0.0026 0.065 0.065
Brugia malayi steroid hormone receptor 0.001 0.0143 0.0235
Loa Loa (eye worm) hypothetical protein 0.0166 0.5004 0.8207
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0405 0.0596
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0086 0.2512 0.3437
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.065 0.1067
Schistosoma mansoni adenosine deaminase 0.0166 0.5004 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0131 0.3919 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0143 0.0235
Onchocerca volvulus 0.0026 0.065 0.081
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0737 0.1473
Toxoplasma gondii AMP deaminase 0.0054 0.1522 0.2893
Trypanosoma brucei AMP deaminase, putative 0.0054 0.1522 0.3585
Trypanosoma cruzi adenosine monophosphate deaminase-like protein, putative 0.0054 0.1522 0.3585
Loa Loa (eye worm) hypothetical protein 0.0008 0.0094 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0143 0.0235
Echinococcus multilocularis cytidine deaminase 0.0052 0.1453 0.1453
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0143 0.0143
Trypanosoma cruzi AMP deaminase, putative 0.0054 0.1522 0.3585
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0086 0.251 0.6229
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0131 0.3919 1
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0143 0.0143
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0131 0.3919 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0104 0.0104
Trichomonas vaginalis cytidine deaminase, putative 0.0052 0.1453 0.1875
Loa Loa (eye worm) hypothetical protein 0.0048 0.1327 0.2176
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0131 0.3919 0.3919
Trypanosoma cruzi cytidine deaminase-like protein, putative 0.0052 0.1453 0.3401
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0131 0.3919 0.6427
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0143 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0143 0.0235
Schistosoma mansoni AMP deaminase 0.0054 0.1522 0.3041
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0086 0.251 0.6229
Schistosoma mansoni coup transcription factor 0.001 0.0143 0.0286
Plasmodium falciparum AMP deaminase, putative 0.0054 0.1522 0.2893
Loa Loa (eye worm) hypothetical protein 0.0026 0.0636 0.1042
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0091 0.2655 0.4355
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0481 0.0441
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0481 0.0481
Trichomonas vaginalis set domain proteins, putative 0.0229 0.6962 1
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.1327 0.2651
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0405 0.0596
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0405 0.0462
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0143 0.0235
Echinococcus granulosus intermediate filament protein 0.0026 0.065 0.065
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0405 0.0329
Leishmania major cytidine deaminase-like protein 0.0052 0.1453 0.2768
Loa Loa (eye worm) RecQ helicase 0.0021 0.0481 0.0789
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0131 0.3919 1
Brugia malayi Globin family protein 0.0008 0.0094 0.0155
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0143 0.0286
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0143 0.0235
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0405 0.0664
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0405 0.0278
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0143 0.0286
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0131 0.3919 0.7832
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0045 0.1248 0.2351
Loa Loa (eye worm) hypothetical protein 0.0112 0.3322 0.5448
Schistosoma mansoni DNA helicase recq5 0.0009 0.0104 0.0208
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0086 0.2512 0.2512
Echinococcus multilocularis AMP deaminase 2 0.0054 0.1522 0.1522
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0143 0.0143
Schistosoma mansoni globin X 0.0008 0.0094 0.0188
Brugia malayi intermediate filament protein 0.0026 0.065 0.1067
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0209 0.0343
Onchocerca volvulus 0.001 0.0143 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0143 0.0235
Onchocerca volvulus AMP deaminase 2 homolog 0.0054 0.1522 0.2079
Mycobacterium tuberculosis Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) 0.0052 0.1453 0.2768
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0131 0.3919 0.7786
Onchocerca volvulus 0.0048 0.1327 0.1794
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0104 0.0171
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0403 0.061
Plasmodium falciparum adenosine deaminase 0.0166 0.5004 1
Echinococcus multilocularis tumor protein p63 0.0327 1 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0274 0.0449
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0143 0.0143
Trichomonas vaginalis cytidine deaminase, putative 0.0052 0.1453 0.1875
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0143 0.0235
Trichomonas vaginalis adenosine deaminase, putative 0.0166 0.5004 0.7112
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0143 0.0235
Loa Loa (eye worm) hypothetical protein 0.0008 0.0094 0.0155
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0405 0.0664
Entamoeba histolytica AMP deaminase, putative 0.0054 0.1522 0.2778
Brugia malayi hypothetical protein 0.0008 0.0094 0.0155
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0143 0.0235
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0045 0.1246 0.2044
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0041 0.1103 0.2465
Brugia malayi nuclear hormone receptor 0.001 0.0143 0.0235
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0104 0.0171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0143 0.0235
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0131 0.3919 0.779
Onchocerca volvulus 0.0229 0.6962 1
Trypanosoma cruzi adenosine monophosphate deaminase, putative 0.0054 0.1522 0.3585
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0209 0.0343
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0143 0.0143
Echinococcus multilocularis adenosine deaminase 0.0166 0.5004 0.5004
Brugia malayi hypothetical protein 0.0008 0.0094 0.0155
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0086 0.2512 0.2512
Loa Loa (eye worm) hypothetical protein 0.0112 0.3322 0.5448
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0131 0.3919 0.3919
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0737 0.0737
Loa Loa (eye worm) hypothetical protein 0.0013 0.0231 0.0379
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0405 0.0596
Loa Loa (eye worm) hypothetical protein 0.001 0.0143 0.0235
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0143 0.0286
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0704 0.0704
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0143 0.0143
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0209 0.0072
Loa Loa (eye worm) hypothetical protein 0.0008 0.0094 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0143 0.0235
Entamoeba histolytica adenosine deaminase, putative 0.0166 0.5004 1
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0131 0.3919 0.3919
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0086 0.2512 0.3437
Schistosoma mansoni DNA helicase recq1 0.0009 0.0104 0.0208
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0104 0.00000000024618
Echinococcus granulosus cytidine deaminase 0.0052 0.1453 0.1453
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0104 0.0104
Entamoeba histolytica adenosine deaminase, putative 0.0166 0.5004 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.1522 0.2496
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0041 0.1103 0.2465
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0274 0.0449
Onchocerca volvulus Adenosine deaminase homolog 0.0166 0.5004 0.7149
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0143 0.0286
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0143 0.0143
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0131 0.3919 1
Leishmania major adenine aminohydrolase 0.0166 0.5004 1
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0086 0.251 0.6306
Leishmania major adenosine monophosphate deaminase, putative,AMP deaminase, putative 0.0054 0.1522 0.2908
Loa Loa (eye worm) hypothetical protein 0.001 0.0143 0.0235
Loa Loa (eye worm) hypothetical protein 0.0112 0.3322 0.5448
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0131 0.3919 1
Brugia malayi nuclear receptor NHR-88 0.001 0.0143 0.0235
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0143 0.0071
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0405 0.0788
Brugia malayi hypothetical protein 0.0008 0.0094 0.0155
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0104 0.0171
Schistosoma mansoni ap endonuclease 0.0018 0.0405 0.0809
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0143 0.0235
Brugia malayi Pre-SET motif family protein 0.0029 0.0737 0.1209
Trichomonas vaginalis adenosine deaminase, putative 0.0166 0.5004 0.7112
Loa Loa (eye worm) AMP deaminase 0.0054 0.1522 0.2496
Echinococcus multilocularis lamin 0.0026 0.065 0.065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0737 0.1473
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0231 0.0231
Brugia malayi Hypothetical 22.2 kDa protein C28F5.2 in chromosome II, putative 0.0008 0.0094 0.0155
Giardia lamblia Cytidine deaminase 0.0052 0.1453 0.3536
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0143 0.0143
Schistosoma mansoni thyroid hormone receptor 0.001 0.0143 0.0286
Trypanosoma cruzi AMP deaminase, putative 0.0054 0.1522 0.3585
Toxoplasma gondii cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein 0.0052 0.1453 0.2753
Entamoeba histolytica AMP deaminase, putative 0.0054 0.1522 0.2778
Loa Loa (eye worm) hypothetical protein 0.0012 0.0216 0.0354
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0041 0.1103 0.2465
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0143 0.0235
Onchocerca volvulus 0.0054 0.1522 0.2079
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0131 0.3919 0.7706
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0481 0.0789
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0131 0.3919 0.5512
Brugia malayi cytidine deaminase, identical 0.0052 0.1453 0.2383
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0143 0.0235
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0086 0.251 0.6229
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0737 0.1291
Loa Loa (eye worm) hypothetical protein 0.0008 0.0094 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0143 0.0235
Leishmania major AMP deaminase, putative 0.0054 0.1522 0.2908
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0131 0.3919 0.5512
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0209 0.0072
Brugia malayi Adenosine/AMP deaminase family protein 0.0166 0.5004 0.8207
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0405 0.0614
Trypanosoma brucei adenosine monophosphate deaminase, putative 0.0054 0.1522 0.3585
Brugia malayi ecdysteroid receptor 0.001 0.0143 0.0235
Schistosoma mansoni ap endonuclease 0.0018 0.0405 0.0809
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0405 0.0405
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0131 0.3919 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0143 0.0286
Loa Loa (eye worm) hypothetical protein 0.0026 0.065 0.1067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0143 0.0235
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0143 0.0286
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0131 0.3919 0.7832
Loa Loa (eye worm) hypothetical protein 0.001 0.0143 0.0235
Onchocerca volvulus 0.0052 0.1453 0.1979
Onchocerca volvulus 0.0029 0.0737 0.0936
Schistosoma mansoni adenosine deaminase-related 0.0166 0.5004 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0351 0.0576
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0131 0.3919 0.3919
Echinococcus granulosus lamin 0.0026 0.065 0.065
Echinococcus granulosus adenosine deaminase 0.0166 0.5004 0.5004
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.6098 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0008 0.0094 0.0155
Brugia malayi Cytochrome P450 family protein 0.0012 0.0209 0.0343
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0131 0.3919 0.7832
Trypanosoma brucei AMP deaminase, putative 0.0054 0.1522 0.3585
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0143 0.0235
Loa Loa (eye worm) hypothetical protein 0.0009 0.0104 0.0171
Loa Loa (eye worm) intermediate filament protein 0.0026 0.065 0.1067
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0091 0.2655 0.4355
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0131 0.3919 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0143 0.0235
Echinococcus multilocularis musashi 0.0026 0.065 0.065
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0143 0.0286
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) 0.0166 0.5004 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0104 0.0104
Trypanosoma cruzi AMP deaminase, putative 0.0054 0.1522 0.3585
Loa Loa (eye worm) hypothetical protein 0.0008 0.0103 0.0169
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0086 0.251 0.492
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0143 0.0143
Echinococcus granulosus AMP deaminase 2 0.0054 0.1522 0.1522
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0143 0.0235
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0143 0.0143
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0045 0.1246 0.1569
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0041 0.1103 0.2465
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0012 0.0209 0.0234
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0131 0.3919 0.5512
Brugia malayi Globin family protein 0.0008 0.0094 0.0155
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0143 0.0143
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0405 0.0633
Plasmodium vivax SET domain protein, putative 0.0029 0.0737 0.098
Onchocerca volvulus 0.0052 0.1453 0.1979
Brugia malayi hypothetical protein 0.0008 0.0094 0.0155
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0143 0.0143
Loa Loa (eye worm) globin family protein 0.0008 0.0094 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0143 0.0235
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0131 0.3919 0.7832
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0405 0.0405
Schistosoma mansoni intermediate filament proteins 0.0026 0.065 0.13
Mycobacterium leprae PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE) 0.0052 0.1453 0.0545
Loa Loa (eye worm) hypothetical protein 0.0008 0.0094 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0143 0.0235
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0131 0.3919 0.7786
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0143 0.0235
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0131 0.3919 1
Trypanosoma brucei cytidine deaminase 0.0052 0.1453 0.3401
Entamoeba histolytica cytidine deaminase, putative 0.0052 0.1453 0.2636

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 69 % Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 at 6.25 ug/mL by microplate alamar blue assay ChEMBL. 21937153
MIC (functional) Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 by microplate alamar blue assay ChEMBL. 21937153

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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