TDR Targets

Basic information

Technical information

TDR Targets ID: 1575710
Name: 1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)- 4-methyl-2-[[6-(trifluoromethyl)-1H-indol-2-y l]methyl]pentan-2-ol
MW: 477.415 | Formula: C23H22F7NO2
H donors: 2 H acceptors: 1 LogP: 6.8 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1C(CC(C(F)(F)F)(Cc1cc2c([nH]1)cc(cc2)C(F)(F)F)O)(C)C)F
InChi: 1S/C23H22F7NO2/c1-20(2,17-10-15(24)6-7-19(17)33-3)12-21(32,23(28,29)30)11-16-8-13-4-5-14(22(25,26)27)9-18(13)31-16/h4-10,31-32H,11-12H2,1-3H3
InChiKey: NIJXJFCGNYEYSG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1,1,1-trifluoro-4-(5-fluoro-2-methoxy-phenyl)-4-methyl-2-[[6-(trifluoromethyl)-1H-indol-2-yl]methyl]pentan-2-ol

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	Starlite/ChEMBL	References
Homo sapiens	nuclear receptor subfamily 3, group C, member 2	Starlite/ChEMBL	References
Homo sapiens	progesterone receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0031	0.0013	0.015
Schistosoma mansoni	thyroid hormone receptor	0.0031	0.0013	0.0013
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0333	0.0541	0.0735
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0031	0.0013	0.015
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0333	0.0541	0.0735
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0089	0.1061
Trypanosoma cruzi	cruzipain precursor, putative	0.0109	0.015	0.0813
Loa Loa (eye worm)	ctsf protein	0.0333	0.0541	0.6435
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.575	1	1
Toxoplasma gondii	cathepsin CPC1	0.575	1	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0074	0.0089	0.0089
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0333	0.0541	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0031	0.0013	0.015
Schistosoma mansoni	coup transcription factor	0.0031	0.0013	0.0013
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0184	0.028	0.028
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0074	0.0089	0.0089
Entamoeba histolytica	cysteine proteinase 2	0.0184	0.028	0.4227
Toxoplasma gondii	cathepsin CPC2	0.2228	0.385	0.3645
Brugia malayi	cathepsin F-like cysteine proteinase	0.0074	0.0089	0.1061
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0333	0.0541	1
Brugia malayi	Cathepsin L-like precursor	0.0333	0.0541	0.6435
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0505	0.0841	0.0841
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0031	0.0013	0.015
Schistosoma mansoni	cathepsin s	0.0109	0.015	0.015
Onchocerca volvulus		0.0333	0.0541	1
Echinococcus multilocularis	cysteine protease	0.0333	0.0541	0.6435
Loa Loa (eye worm)	hypothetical protein	0.0505	0.0841	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0208	0.0322	0.0322
Leishmania major	cathepsin L-like protease	0.0333	0.0541	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0333	0.0541	0.0735
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0031	0.0013	0.0013
Loa Loa (eye worm)	cathepsin B	0.0208	0.0322	0.3826
Loa Loa (eye worm)	hypothetical protein	0.0224	0.035	0.4163
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0333	0.0541	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0184	0.028	0.2541
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0031	0.0013	0.0013
Onchocerca volvulus	Cathepsin L homolog	0.0333	0.0541	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0333	0.0541	0.6012
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0074	0.0089	0.0089
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0074	0.0089	0.1061
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0074	0.0089	0.0089
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0031	0.0013	0.015
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0333	0.0541	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0013	0.015
Loa Loa (eye worm)	fibroinase	0.0333	0.0541	0.6435
Brugia malayi	nuclear hormone receptor	0.0031	0.0013	0.015
Plasmodium vivax	vivapain-2	0.0333	0.0541	0.0456
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0074	0.0089	0.1061
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0031	0.0013	0.015
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0333	0.0541	0.0735
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.575	1	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0089	0.1061
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0031	0.0013	0.015
Brugia malayi	nuclear receptor NHR-88	0.0031	0.0013	0.015
Onchocerca volvulus		0.0333	0.0541	1
Entamoeba histolytica	cysteine protease, putative	0.0184	0.028	0.4227
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0333	0.0541	1
Leishmania major	cathepsin L-like protease	0.0333	0.0541	1
Brugia malayi	Cathepsin L-like precursor	0.0333	0.0541	0.6435
Entamoeba histolytica	cysteine proteinase, putative	0.0224	0.035	0.5773
Schistosoma mansoni	cathepsin C	0.0074	0.0089	0.0089
Onchocerca volvulus	Cathepsin F homolog	0.0333	0.0541	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0333	0.0541	0.0735
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.2228	0.385	0.3794
Entamoeba histolytica	cysteine protease, putative	0.0333	0.0541	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0089	0.1061
Leishmania major	cathepsin L-like protease	0.0333	0.0541	1
Onchocerca volvulus		0.0333	0.0541	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0333	0.0541	0.0735
Loa Loa (eye worm)	hypothetical protein	0.0109	0.015	0.1789
Schistosoma mansoni	voltage-gated potassium channel	0.0088	0.0113	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0224	0.035	0.4163
Brugia malayi	Cathepsin L-like precursor	0.0224	0.035	0.4163
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0333	0.0541	0.0735
Echinococcus granulosus	cathepsin L	0.0074	0.0089	0.1061
Plasmodium vivax	vivapain-3	0.0184	0.028	0.0193
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.575	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0074	0.0089	0.1061
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0333	0.0541	0.0735
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0333	0.0541	0.0456
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0031	0.0013	0.015
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0505	0.0841	0.0841
Loa Loa (eye worm)	hypothetical protein	0.0224	0.035	0.4163
Brugia malayi	photoreceptor-specific nuclear receptor	0.0031	0.0013	0.015
Trypanosoma cruzi	cysteine peptidase, putative	0.0333	0.0541	0.6012
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0031	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0089	0.1061
Echinococcus multilocularis	ecdysone induced protein 78C	0.0031	0.0013	0.015
Entamoeba histolytica	cysteine proteinase, putative	0.0184	0.028	0.4227
Giardia lamblia	Cathepsin B precursor	0.0208	0.0322	0.0235
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0031	0.0013	0.015
Schistosoma mansoni	cathepsin B (C01 family)	0.0074	0.0089	0.0089
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0074	0.0089	0.1061
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0224	0.035	0.0424
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.008	0.01	0.1184
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0333	0.0541	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0031	0.0013	0.015
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0031	0.0013	0.015
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0031	0.0013	0.0013
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.008	0.01	0.1184
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0031	0.0013	0.015
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0031	0.0013	0.015
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.3596	0.6239	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0333	0.0541	0.6435
Brugia malayi	cathepsin L-like cysteine proteinase	0.0074	0.0089	0.1061
Trypanosoma cruzi	cysteine peptidase, putative	0.0333	0.0541	0.6012
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0031	0.0013	0.015
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0333	0.0541	0.0735
Giardia lamblia	Cathepsin B precursor	0.0208	0.0322	0.0235
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0184	0.028	0.0311
Entamoeba histolytica	cysteine protease, putative	0.0184	0.028	0.4227
Schistosoma mansoni	retinoic acid receptor RXR	0.0031	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.007	0.0081	0.0964
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0333	0.0541	1
Entamoeba histolytica	cysteine protease, putative	0.0184	0.028	0.4227
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0031	0.0013	0.0013
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0333	0.0541	0.0735
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0333	0.0541	0.0735
Schistosoma mansoni	cathepsin F (C01 family)	0.0333	0.0541	0.0541
Entamoeba histolytica	cysteine protease, putative	0.0184	0.028	0.4227
Onchocerca volvulus	Cathepsin L homolog	0.0333	0.0541	1
Brugia malayi	cathepsin B-like cysteine proteinase	0.0505	0.0841	1
Entamoeba histolytica	cysteine protease, putative	0.0184	0.028	0.4227
Brugia malayi	Nuclear hormone receptor-like 1	0.0031	0.0013	0.015
Brugia malayi	cathepsin F-like cysteine proteinase	0.0109	0.015	0.1789
Onchocerca volvulus	Cathepsin L homolog	0.0074	0.0089	0.145
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0013	0.015
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0074	0.0089	0.0089
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0031	0.0013	0.015
Leishmania major	cathepsin L-like protease	0.0333	0.0541	1
Entamoeba histolytica	cysteine proteinase, putative	0.0184	0.028	0.4227
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0333	0.0541	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.2228	0.385	0.3794
Echinococcus granulosus	cathepsin b	0.0505	0.0841	1
Leishmania major	cathepsin L-like protease	0.0333	0.0541	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0089	0.1061
Trypanosoma cruzi	cysteine proteinase, putative	0.0184	0.028	0.2541
Brugia malayi	Cathepsin L-like precursor	0.0333	0.0541	0.6435
Trypanosoma cruzi	cysteine proteinase, putative	0.0184	0.028	0.2541
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0333	0.0541	0.0735
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0333	0.0541	0.6435
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0074	0.0089	0.0089
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0031	0.0013	0.015
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0031	0.0013	0.015
Loa Loa (eye worm)	hypothetical protein	0.0109	0.015	0.1789
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0031	0.0013	0.0013
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0109	0.015	0.1789
Echinococcus granulosus	cathepsin l1	0.0224	0.035	0.4163
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0109	0.015	0.1789
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0333	0.0541	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0505	0.0841	1
Echinococcus granulosus	cathepsin l1	0.0333	0.0541	0.6435
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0208	0.0322	0.3093
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0031	0.0013	0.015
Echinococcus multilocularis	cysteine protease	0.0333	0.0541	0.6435
Brugia malayi	Cathepsin L-like precursor	0.0333	0.0541	0.6435
Giardia lamblia	Encystation-specific protease	0.2228	0.385	0.3794
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0013	0.015
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0224	0.035	0.347
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0333	0.0541	0.0735
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0333	0.0541	0.0735
Schistosoma mansoni	cathepsin F (C01 family)	0.0333	0.0541	0.0541
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0333	0.0541	0.0735
Leishmania major	cathepsin L-like protease	0.0333	0.0541	1
Brugia malayi	fibroinase precursor	0.0074	0.0089	0.1061
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0333	0.0541	0.0456
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0333	0.0541	0.0735
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0224	0.035	0.0424
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0505	0.0841	0.0841
Loa Loa (eye worm)	cysteine protease	0.0333	0.0541	0.6435
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0031	0.0013	0.015
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0333	0.0541	0.6435
Entamoeba histolytica	cysteine proteinase, putative	0.0333	0.0541	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0031	0.0013	0.015
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0031	0.0013	0.015
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0031	0.0013	0.015
Onchocerca volvulus		0.0224	0.035	0.6385
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.008	0.01	0.1184
Brugia malayi	Cathepsin L-like precursor	0.0224	0.035	0.4163
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0031	0.0013	0.015
Brugia malayi	ecdysteroid receptor	0.0031	0.0013	0.015
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0333	0.0541	0.6435
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0031	0.0013	0.015
Onchocerca volvulus		0.0333	0.0541	1
Entamoeba histolytica	cysteine protease, putative	0.0184	0.028	0.4227
Echinococcus granulosus	cathepsin L cysteine protease	0.0184	0.028	0.3333
Loa Loa (eye worm)	hypothetical protein	0.0109	0.015	0.1789
Plasmodium vivax	vivapain-1	0.0184	0.028	0.0193
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0031	0.0013	0.015
Trypanosoma cruzi	cysteine peptidase, putative	0.0109	0.015	0.0813
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0031	0.0013	0.015
Schistosoma mansoni	cathepsin S (C01 family)	0.0074	0.0089	0.0089
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0074	0.0089	0.1061
Brugia malayi	Steroid receptor seven-up type 2	0.0031	0.0013	0.015
Trypanosoma cruzi	cysteine peptidase, putative	0.0333	0.0541	0.6012
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0224	0.035	0.4163
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0031	0.0013	0.015
Echinococcus granulosus	cathepsin L	0.0184	0.028	0.3333
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0333	0.0541	0.0735
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0333	0.0541	1
Echinococcus granulosus	cysteine protease	0.0184	0.028	0.3333
Schistosoma mansoni	thyroid hormone receptor	0.0031	0.0013	0.0013
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0075	0.009	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0013	0.015
Brugia malayi	Cathepsin L-like precursor	0.0109	0.015	0.1789
Brugia malayi	cathepsin L precursor	0.0074	0.0089	0.1061
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0184	0.028	0.028
Trypanosoma cruzi	cysteine protease, putative	0.0184	0.028	0.2541
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0333	0.0541	0.0735
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0333	0.0541	0.0735
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.575	1	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0031	0.0013	0.015
Brugia malayi	Cathepsin L-like precursor	0.0333	0.0541	0.6435
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0031	0.0013	0.015
Entamoeba histolytica	cysteine protease, putative	0.0184	0.028	0.4227
Schistosoma mansoni	voltage-gated potassium channel	0.0088	0.0113	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0013	0.015
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0074	0.0089	0.1061
Brugia malayi	Papain family cysteine protease containing protein	0.0184	0.028	0.3333
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.2228	0.385	0.3794
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0184	0.028	0.2541
Leishmania major	cathepsin L-like protease	0.0333	0.0541	1
Onchocerca volvulus		0.0333	0.0541	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0184	0.028	0.0311
Echinococcus multilocularis	cathepsin L cysteine protease	0.0333	0.0541	0.6435
Schistosoma mansoni	cathepsin F (C01 family)	0.0224	0.035	0.035
Brugia malayi	Papain family cysteine protease containing protein	0.0184	0.028	0.3333
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.008	0.01	0.1184
Leishmania major	cysteine peptidase A (CPA)	0.0333	0.0541	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0333	0.0541	0.0735
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0031	0.0013	0.015
Entamoeba histolytica	cysteine protease, putative	0.0184	0.028	0.4227
Entamoeba histolytica	cysteine proteinase, putative	0.0184	0.028	0.4227
Entamoeba histolytica	cysteine proteinase, putative	0.0184	0.028	0.4227
Brugia malayi	cathepsin L-like precursor	0.0224	0.035	0.4163
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.2228	0.385	0.3794
Giardia lamblia	Cathepsin B precursor	0.0208	0.0322	0.0235
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.575	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0074	0.0089	0.0089
Brugia malayi	Papain family cysteine protease containing protein	0.0074	0.0089	0.1061
Toxoplasma gondii	preprocathepsin c precursor, putative	0.575	1	1
Echinococcus granulosus	FTZ F1 alpha	0.0031	0.0013	0.015
Plasmodium vivax	vivapain-2	0.0333	0.0541	0.0456
Schistosoma mansoni	RAR-like nuclear receptor	0.0031	0.0013	0.0013
Entamoeba histolytica	cysteine protease, putative	0.0184	0.028	0.4227
Onchocerca volvulus		0.0333	0.0541	1
Brugia malayi	Papain family cysteine protease containing protein	0.0333	0.0541	0.6435
Leishmania major	cathepsin L-like protease	0.0333	0.0541	1
Loa Loa (eye worm)	steroid hormone receptor	0.0031	0.0013	0.015
Echinococcus multilocularis	cathepsin b	0.0505	0.0841	1
Schistosoma mansoni	nuclear hormone receptor	0.0031	0.0013	0.0013
Onchocerca volvulus		0.0333	0.0541	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0089	0.1061
Plasmodium vivax	unspecified product	0.0184	0.028	0.0193
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0208	0.0322	0.1589
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0505	0.0841	0.0841
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0333	0.0541	0.6435
Brugia malayi	Cathepsin L-like precursor	0.0333	0.0541	0.6435
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0333	0.0541	0.0456
Echinococcus granulosus	ecdysone induced protein 78C	0.0031	0.0013	0.015
Echinococcus multilocularis	cathepsin b	0.0505	0.0841	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0074	0.0089	0.1061
Entamoeba histolytica	cysteine protease, putative	0.0184	0.028	0.4227
Plasmodium vivax	unspecified product	0.0109	0.015	0.0062
Echinococcus multilocularis	FTZ F1 alpha	0.0031	0.0013	0.015
Trypanosoma cruzi	cruzipain precursor, putative	0.0333	0.0541	0.6012
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0333	0.0541	0.0735
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0184	0.028	0.0193
Echinococcus granulosus	cathepsin b	0.0505	0.0841	1
Brugia malayi	steroid hormone receptor	0.0031	0.0013	0.015
Echinococcus multilocularis	cathepsin L	0.0074	0.0089	0.1061
Toxoplasma gondii	cathepsin CPL	0.0333	0.0541	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0013	0.015
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0013	0.015
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0333	0.0541	0.0735
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0031	0.0013	0.015
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0031	0.0013	0.015
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0333	0.0541	0.0735
Entamoeba histolytica	cysteine protease, putative	0.0184	0.028	0.4227
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0208	0.0322	0.0378
Loa Loa (eye worm)	hypothetical protein	0.0333	0.0541	0.6435
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0013	0.015
Entamoeba histolytica	cysteine protease, putative	0.0184	0.028	0.4227
Echinococcus multilocularis	cathepsin L cysteine protease	0.0333	0.0541	0.6435
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0333	0.0541	0.6435
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0031	0.0013	0.0013
Entamoeba histolytica	cysteine proteinase, putative	0.0333	0.0541	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0184	0.028	0.4227
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0333	0.0541	0.0735
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0184	0.028	0.028
Brugia malayi	Papain family cysteine protease containing protein	0.0074	0.0089	0.1061
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0031	0.0013	0.015
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0075	0.009	0.0002
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0074	0.0089	0.0089
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0333	0.0541	0.0735
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0031	0.0013	0.015
Onchocerca volvulus		0.0074	0.0089	0.145
Echinococcus multilocularis	cathepsin L	0.0184	0.028	0.3333
Entamoeba histolytica	cysteine protease, putative	0.0184	0.028	0.4227
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0333	0.0541	1

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	> 2000 nM	Transactivation activity of glucocorticoid receptor in HFF assessed as induction of aromatase activity by measuring beta-estradiol activity after 18 to 24 hrs by ELISA	ChEMBL.	21963986
IC50 (binding)	= 77 nM	Displacement of tetramethylrhodamine-labeled Dexamethasone from human recombinant glucocorticoid receptor expressed in baculovirus infected insect cells by fluorescence polarization assay	ChEMBL.	21963986
IC50 (binding)	= 910 nM	Displacement of tetramethylrhodamine-labeled Dexamethasone from human recombinant mineralocorticoid receptor expressed in baculovirus infected insect cells by fluorescence polarization assay	ChEMBL.	21963986
IC50 (binding)	= 1600 nM	Displacement of tetramethylrhodamine-labeled RU-486 from human recombinant progesterone receptor expressed in baculovirus infected insect cells by fluorescence polarization assay	ChEMBL.	21963986
IC50 (functional)	> 2000 nM	Agonist activity at glucocorticoid receptor in HFF assessed as inhibition of IL1-induced IL-6 production after 18 to 24 hrs	ChEMBL.	21963986

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1911653

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1575710