Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | isoleucyl-tRNA synthetase family protein | 0.0097 | 0.1422 | 1 |
Schistosoma mansoni | threonyl-tRNA synthetase | 0.0044 | 0.054 | 0.3795 |
Onchocerca volvulus | 0.0024 | 0.0198 | 0.1591 | |
Trichomonas vaginalis | valyl-tRNA synthetase, putative | 0.0014 | 0.0033 | 0.0231 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0014 | 0.0036 | 0.0036 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0021 | 0.0148 | 0.1041 |
Onchocerca volvulus | 0.0077 | 0.1078 | 1 | |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0021 | 0.0148 | 0.1041 |
Toxoplasma gondii | isoleucyl-tRNA synthetase family protein | 0.0097 | 0.1422 | 0.1422 |
Trichomonas vaginalis | leucyl-tRNA synthetase, putative | 0.0034 | 0.0377 | 0.2653 |
Leishmania major | isoleucyl-tRNA synthetase, putative | 0.0097 | 0.1422 | 1 |
Trypanosoma cruzi | leucyl-tRNA synthetase, putative | 0.0014 | 0.0033 | 0.0231 |
Echinococcus multilocularis | isoleucyl tRNA synthetase, cytoplasmic | 0.0097 | 0.1422 | 1 |
Mycobacterium tuberculosis | Probable valyl-tRNA synthase protein ValS (valyl-tRNA synthetase) (valine--tRNA ligase) (valine translase) | 0.0034 | 0.0377 | 0.0347 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0014 | 0.0031 | 0.0218 |
Mycobacterium leprae | PROBABLE VALYL-tRNA SYNTHASE PROTEIN VALS (VALYL-tRNA SYNTHETASE) (VALINE--tRNA LIGASE) (VALINE TRANSLASE) ELONGS TO CLASS-I AMI | 0.0034 | 0.0377 | 0.0377 |
Mycobacterium ulcerans | peptide synthetase Nrp (peptide synthase) | 0.0024 | 0.0198 | 0.0198 |
Onchocerca volvulus | 0.0034 | 0.0377 | 0.3309 | |
Toxoplasma gondii | leucyl-tRNA synthetase (LeuRS2) | 0.0034 | 0.0377 | 0.0377 |
Trichomonas vaginalis | valyl-tRNA synthetase, putative | 0.0021 | 0.0148 | 0.1041 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0058 | 0.041 |
Plasmodium vivax | isoleucine--tRNA ligase, putative | 0.0097 | 0.1422 | 1 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtE | 0.0024 | 0.0198 | 0.0198 |
Plasmodium falciparum | isoleucine--tRNA ligase, putative | 0.013 | 0.1964 | 1 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0543 | 0.8846 | 0.8842 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0538 | 0.8756 | 0.8753 |
Mycobacterium ulcerans | phenyloxazoline synthase MbtB | 0.0188 | 0.2942 | 0.2942 |
Echinococcus granulosus | leucyl tRNA synthetase | 0.0034 | 0.0377 | 0.2653 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0034 | 0.0377 | 0.2653 |
Plasmodium falciparum | leucine--tRNA ligase, putative | 0.0034 | 0.0377 | 0.1921 |
Leishmania major | valyl-tRNA synthetase, putative | 0.0034 | 0.0377 | 0.2653 |
Toxoplasma gondii | valyl-tRNA synthetase | 0.0034 | 0.0377 | 0.0377 |
Plasmodium falciparum | threonine--tRNA ligase | 0.0049 | 0.0618 | 0.3147 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0033 | 0.0231 |
Giardia lamblia | Isoleucyl-tRNA synthetase | 0.0097 | 0.1422 | 1 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0034 | 0.0377 | 0.2653 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0198 | 0.1389 |
Schistosoma mansoni | isoleucine--tRNA ligase | 0.0097 | 0.1422 | 1 |
Giardia lamblia | Threonyl-tRNA synthetase | 0.0049 | 0.0618 | 0.4347 |
Brugia malayi | isoleucyl-tRNA synthetase | 0.0097 | 0.1422 | 1 |
Mycobacterium ulcerans | valyl-tRNA synthetase | 0.0034 | 0.0377 | 0.0377 |
Trichomonas vaginalis | leucyl-tRNA synthetase, putative | 0.0034 | 0.0377 | 0.2653 |
Trypanosoma cruzi | leucyl-tRNA synthetase, putative | 0.0034 | 0.0377 | 0.2653 |
Trypanosoma cruzi | threonyl-tRNA synthetase, putative | 0.0056 | 0.0728 | 0.5117 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0377 | 0.2653 |
Brugia malayi | protein ZK524.3 | 0.0014 | 0.0033 | 0.0231 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1078 | 0.7578 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1422 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0014 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0033 | 0.0231 |
Mycobacterium tuberculosis | Isoleucyl-tRNA synthetase IleS | 0.0063 | 0.0848 | 0.082 |
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0034 | 0.0377 | 0.2653 |
Plasmodium falciparum | valine--tRNA ligase, putative | 0.0034 | 0.0377 | 0.1921 |
Trypanosoma cruzi | valyl-tRNA synthetase, putative | 0.0021 | 0.0148 | 0.1041 |
Wolbachia endosymbiont of Brugia malayi | isoleucyl-tRNA synthetase | 0.0097 | 0.1422 | 1 |
Plasmodium falciparum | leucine--tRNA ligase, putative | 0.0014 | 0.0033 | 0.0167 |
Brugia malayi | threonyl-tRNA synthetase, cytoplasmic | 0.0056 | 0.0728 | 0.5117 |
Mycobacterium ulcerans | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase | 0.0543 | 0.8846 | 0.8846 |
Echinococcus multilocularis | isoleucyl tRNA synthetase, mitochondrial | 0.0077 | 0.1078 | 0.7578 |
Onchocerca volvulus | 0.0021 | 0.0148 | 0.1119 | |
Mycobacterium ulcerans | threonyl-tRNA synthetase | 0.0049 | 0.0618 | 0.0618 |
Mycobacterium tuberculosis | Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) | 0.0049 | 0.0618 | 0.0589 |
Echinococcus granulosus | isoleucyl trna synthetase mitochondrial | 0.0077 | 0.1078 | 0.7578 |
Plasmodium vivax | threonine--tRNA ligase, putative | 0.0049 | 0.0618 | 0.4347 |
Trichomonas vaginalis | valyl-tRNA synthetase, putative | 0.0014 | 0.0033 | 0.0231 |
Mycobacterium leprae | isoleucyl-tRNA synthetase IleS | 0.0097 | 0.1422 | 0.1422 |
Chlamydia trachomatis | valine--tRNA ligase | 0.0034 | 0.0377 | 0.2653 |
Trichomonas vaginalis | leucyl-tRNA synthetase, putative | 0.0021 | 0.0148 | 0.1041 |
Chlamydia trachomatis | isoleucine--tRNA ligase | 0.0097 | 0.1422 | 1 |
Onchocerca volvulus | 0.0024 | 0.0198 | 0.1591 | |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0148 | 0.1041 |
Entamoeba histolytica | isoleucyl-tRNA synthetase, putative | 0.0097 | 0.1422 | 1 |
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0014 | 0.0033 | 0.0231 |
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.0612 | 1 | 1 |
Leishmania major | leucyl-tRNA synthetase, putative | 0.0034 | 0.0377 | 0.2653 |
Loa Loa (eye worm) | isoleucyl-tRNA synthetase | 0.0097 | 0.1422 | 1 |
Trichomonas vaginalis | isoleucyl tRNA synthetase, putative | 0.0097 | 0.1422 | 1 |
Wolbachia endosymbiont of Brugia malayi | formamidopyrimidine-DNA glycosylase | 0.0095 | 0.139 | 0.9776 |
Entamoeba histolytica | threonyl-tRNA synthetase, putative | 0.0049 | 0.0618 | 0.4347 |
Trypanosoma brucei | valyl-tRNA synthetase, putative | 0.0034 | 0.0377 | 0.2653 |
Schistosoma mansoni | isoleucine--tRNA ligase | 0.0097 | 0.1422 | 1 |
Trypanosoma cruzi | valyl-tRNA synthetase, putative | 0.0034 | 0.0377 | 0.2653 |
Echinococcus granulosus | isoleucyl tRNA synthetase, cytoplasmic | 0.0097 | 0.1422 | 1 |
Entamoeba histolytica | leucyl-tRNA synthetase, putative | 0.0034 | 0.0377 | 0.2653 |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.0612 | 1 | 1 |
Echinococcus granulosus | leucyl tRNA synthetase | 0.0034 | 0.0377 | 0.2653 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0021 | 0.0148 | 0.1041 |
Plasmodium falciparum | valine--tRNA ligase, putative | 0.0034 | 0.0377 | 0.1921 |
Mycobacterium leprae | Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA GLYCOSYLASE) | 0.0095 | 0.139 | 0.139 |
Trichomonas vaginalis | leucyl-tRNA synthetase, putative | 0.0014 | 0.0033 | 0.0231 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0148 | 0.1041 |
Chlamydia trachomatis | threonine--tRNA ligase | 0.0056 | 0.0728 | 0.5117 |
Echinococcus granulosus | valyl tRNA synthetase | 0.0034 | 0.0377 | 0.2653 |
Trypanosoma cruzi | valyl-tRNA synthetase, putative | 0.0014 | 0.0033 | 0.0231 |
Giardia lamblia | Leucyl-tRNA synthetase | 0.0014 | 0.0033 | 0.0231 |
Wolbachia endosymbiont of Brugia malayi | valyl-tRNA synthetase | 0.0034 | 0.0377 | 0.2653 |
Brugia malayi | valyl-tRNA synthetase family protein | 0.0034 | 0.0377 | 0.2653 |
Toxoplasma gondii | leucyl-tRNA synthetase | 0.0034 | 0.0377 | 0.0377 |
Entamoeba histolytica | valyl-tRNA synthetase, putative | 0.0034 | 0.0377 | 0.2653 |
Brugia malayi | leucyl-tRNA synthetase | 0.0034 | 0.0377 | 0.2653 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0024 | 0.0198 | 0.1389 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0024 | 0.0198 | 0.0167 |
Plasmodium vivax | valine--tRNA ligase, putative | 0.0014 | 0.0033 | 0.0231 |
Mycobacterium tuberculosis | Possible DNA glycosylase | 0.0095 | 0.139 | 0.1364 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0021 | 0.0148 | 0.1041 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0024 | 0.0198 | 0.0167 |
Mycobacterium ulcerans | thioesterase | 0.0165 | 0.2548 | 0.2548 |
Mycobacterium leprae | Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) | 0.0049 | 0.0618 | 0.0618 |
Mycobacterium tuberculosis | Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA glycosylase) | 0.0095 | 0.139 | 0.1364 |
Toxoplasma gondii | isoleucyl-tRNA synthetase, putative | 0.0034 | 0.0377 | 0.0377 |
Trichomonas vaginalis | isoleucyl, leucyl, tyrosyl, valyl and methionyl-tRNA synthetases, putative | 0.0014 | 0.0033 | 0.0231 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtF | 0.0024 | 0.0198 | 0.0198 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0014 | 0.0031 | 0.0218 |
Schistosoma mansoni | valine-tRNA ligase | 0.0034 | 0.0377 | 0.2653 |
Plasmodium vivax | hypothetical protein, conserved | 0.0034 | 0.0377 | 0.2653 |
Entamoeba histolytica | valyl tRNA synthetase, putative | 0.0034 | 0.0377 | 0.2653 |
Trichomonas vaginalis | threonyl-tRNA synthetase, putative | 0.0049 | 0.0618 | 0.4347 |
Mycobacterium leprae | Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) | 0.0014 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | threonyl-tRNA synthetase | 0.0056 | 0.0728 | 0.5117 |
Trypanosoma cruzi | threonyl-tRNA synthetase, putative | 0.0056 | 0.0728 | 0.5117 |
Mycobacterium ulcerans | formamidopyrimidine-DNA glycosylase | 0.0095 | 0.139 | 0.139 |
Wolbachia endosymbiont of Brugia malayi | threonyl-tRNA synthetase | 0.0049 | 0.0618 | 0.4347 |
Plasmodium vivax | valine--tRNA ligase, putative | 0.0034 | 0.0377 | 0.2653 |
Mycobacterium ulcerans | leucyl-tRNA synthetase | 0.0021 | 0.0148 | 0.0148 |
Trypanosoma brucei | isoleucyl-tRNA synthetase, putative | 0.0097 | 0.1422 | 1 |
Treponema pallidum | isoleucyl-tRNA synthetase | 0.0097 | 0.1422 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0033 | 0.0231 |
Treponema pallidum | threonyl-tRNA synthetase | 0.0049 | 0.0618 | 0.4347 |
Loa Loa (eye worm) | VRS-2 protein | 0.0014 | 0.0033 | 0.0231 |
Trichomonas vaginalis | valyl-tRNA synthetase, putative | 0.0014 | 0.0033 | 0.0231 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0024 | 0.0198 | 0.0167 |
Brugia malayi | Valyl-tRNA synthetase | 0.0034 | 0.0377 | 0.2653 |
Chlamydia trachomatis | leucine--tRNA ligase | 0.0021 | 0.0148 | 0.1041 |
Trypanosoma brucei | threonyl-tRNA synthetase, putative | 0.0056 | 0.0728 | 0.5117 |
Mycobacterium ulcerans | formamidopyrimidine-DNA glycosylase | 0.0095 | 0.139 | 0.139 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0014 | 0.0036 | 0.0036 |
Mycobacterium ulcerans | isoleucyl-tRNA synthetase | 0.0097 | 0.1422 | 0.1422 |
Toxoplasma gondii | Isoleucine-tRNA ligase | 0.0014 | 0.0033 | 0.0033 |
Treponema pallidum | leucyl-tRNA synthetase | 0.0021 | 0.0148 | 0.1041 |
Trypanosoma cruzi | isoleucyl-tRNA synthetase, putative | 0.0097 | 0.1422 | 1 |
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0014 | 0.0033 | 0.0231 |
Trypanosoma brucei | leucyl-tRNA synthetase, putative | 0.0034 | 0.0377 | 0.2653 |
Giardia lamblia | Valine-tRNA ligase | 0.0034 | 0.0377 | 0.2653 |
Wolbachia endosymbiont of Brugia malayi | leucyl-tRNA synthetase | 0.0034 | 0.0377 | 0.2653 |
Leishmania major | threonyl-tRNA synthetase, putative | 0.0056 | 0.0728 | 0.5117 |
Toxoplasma gondii | threonyl-tRNA synthetase family protein | 0.0049 | 0.0618 | 0.0618 |
Trichomonas vaginalis | isoleucyl, leucyl, tyrosyl, valyl and methionyl-tRNA synthetases, putative | 0.0021 | 0.0148 | 0.1041 |
Schistosoma mansoni | valine-tRNA ligase | 0.0034 | 0.0377 | 0.2653 |
Echinococcus granulosus | valyl tRNA synthetase | 0.0034 | 0.0377 | 0.2653 |
Mycobacterium ulcerans | pantoate--beta-alanine ligase | 0.0612 | 1 | 1 |
Echinococcus multilocularis | valyl tRNA synthetase | 0.0034 | 0.0377 | 0.2653 |
Plasmodium falciparum | isoleucine--tRNA ligase, putative | 0.0097 | 0.1422 | 0.7241 |
Brugia malayi | AMP-binding enzyme family protein | 0.0015 | 0.0058 | 0.041 |
Echinococcus multilocularis | valyl tRNA synthetase | 0.0034 | 0.0377 | 0.2653 |
Toxoplasma gondii | tRNA synthetase, putative | 0.0034 | 0.0377 | 0.0377 |
Treponema pallidum | valyl-tRNA synthetase | 0.0034 | 0.0377 | 0.2653 |
Echinococcus granulosus | Threonyl tRNA synthetase C | 0.0056 | 0.0728 | 0.5117 |
Echinococcus multilocularis | Threonyl tRNA synthetase, C | 0.0056 | 0.0728 | 0.5117 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 0 % | Cytotoxicity against human HuH7 cells assessed as rRNA level at 10 uM | ChEMBL. | 21983447 |
CC50 (ADMET) | > 100 uM | Cytotoxicity against human PBMC after 5 days | ChEMBL. | 21983447 |
CC50 (ADMET) | > 100 uM | Cytotoxicity against human CEM after 5 days | ChEMBL. | 21983447 |
CC50 (ADMET) | > 100 uM | Cytotoxicity against human PBMC after 6 days by trypan blue exclusion assay | ChEMBL. | 26819659 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.