Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.1382 | 0.1382 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0857 | 0.0857 |
Brugia malayi | Carboxylesterase family protein | 0.0218 | 0.1382 | 0.1379 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0218 | 0.1382 | 0.1379 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0047 | 0.0004 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1291 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0218 | 0.1382 | 0.1379 |
Plasmodium falciparum | protein kinase 5 | 0.0047 | 0.0004 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1291 | 1 | 1 |
Onchocerca volvulus | 0.0218 | 0.1382 | 0.5 | |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.046 | 0.3326 | 0.3323 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0047 | 0.0004 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.1291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.1848 | 0.1848 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0047 | 0.0004 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0692 | 0.0692 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0218 | 0.1382 | 0.1379 |
Echinococcus multilocularis | serotonin receptor | 0.0153 | 0.0857 | 0.0853 |
Brugia malayi | Carboxylesterase family protein | 0.0218 | 0.1382 | 0.1379 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1291 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0218 | 0.1382 | 0.1379 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0218 | 0.1382 | 0.1379 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.1382 | 0.1382 |
Brugia malayi | Carboxylesterase family protein | 0.0218 | 0.1382 | 0.1379 |
Loa Loa (eye worm) | carboxylesterase | 0.1291 | 1 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0047 | 0.0004 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0692 | 0.0692 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0218 | 0.1382 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0218 | 0.1382 | 0.1379 |
Loa Loa (eye worm) | carboxylesterase | 0.0218 | 0.1382 | 0.1382 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.046 | 0.3326 | 0.3323 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.1382 | 0.1382 |
Loa Loa (eye worm) | carboxylesterase | 0.0218 | 0.1382 | 0.1382 |
Schistosoma mansoni | acetylcholinesterase | 0.0218 | 0.1382 | 0.1379 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0047 | 0.0004 | 0.5 |
Onchocerca volvulus | 0.0218 | 0.1382 | 0.5 | |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0218 | 0.1382 | 0.1379 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0218 | 0.1382 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0047 | 0.0004 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0153 | 0.0857 | 0.0853 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.046 | 0.3326 | 0.3323 |
Giardia lamblia | Kinase, CMGC CDK | 0.0047 | 0.0004 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0218 | 0.1382 | 0.1379 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0062 | 0.0058 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0062 | 0.0058 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0218 | 0.1382 | 0.1379 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0047 | 0.0004 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 5 activator 1 | 0.0276 | 0.1848 | 0.1845 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.1382 | 0.1382 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0218 | 0.1382 | 0.1379 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0218 | 0.1382 | 0.1379 |
Onchocerca volvulus | 0.0218 | 0.1382 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0218 | 0.1382 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0218 | 0.1382 | 0.1379 |
Echinococcus multilocularis | serotonin receptor | 0.0153 | 0.0857 | 0.0853 |
Echinococcus granulosus | acetylcholinesterase | 0.1291 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0218 | 0.1382 | 0.1379 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0047 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0062 | 0.0062 |
Plasmodium vivax | protein kinase Crk2 | 0.0047 | 0.0004 | 0.5 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0047 | 0.0004 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.1382 | 0.1382 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0047 | 0.0004 | 0.0004 |
Echinococcus granulosus | neuroligin | 0.0218 | 0.1382 | 0.1379 |
Echinococcus granulosus | acetylcholinesterase | 0.1291 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1291 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1291 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1291 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1291 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0218 | 0.1382 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0218 | 0.1382 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0047 | 0.0004 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0047 | 0.0004 | 0.0004 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0047 | 0.0004 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.1382 | 0.1382 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0218 | 0.1382 | 0.1379 |
Brugia malayi | hypothetical protein | 0.0132 | 0.0692 | 0.0688 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.1382 | 0.1382 |
Onchocerca volvulus | 0.0218 | 0.1382 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0218 | 0.1382 | 1 |
Schistosoma mansoni | gliotactin | 0.0218 | 0.1382 | 0.1379 |
Echinococcus multilocularis | acetylcholinesterase | 0.1291 | 1 | 1 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0047 | 0.0004 | 0.5 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0047 | 0.0004 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0857 | 0.0857 |
Echinococcus granulosus | cyclin dependent kinase 5 activator 1 | 0.0276 | 0.1848 | 0.1845 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0062 | 0.0062 |
Schistosoma mansoni | cyclin-dependent kinase 5 activator | 0.0276 | 0.1848 | 0.1845 |
Onchocerca volvulus | 0.0218 | 0.1382 | 0.5 | |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0153 | 0.0857 | 0.0853 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | Displacement of [3H]-ketanserin from 5-HT2A receptor in rat cortex by liquid scintillation counting | ChEMBL. | 22001327 | |
Ki (binding) | Displacement of [3H]-LSD from human 5-HT6 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting | ChEMBL. | 22001327 | |
Ki (binding) | = 21 nM | Displacement of [3H]-8-OH-DPAT from 5-HT1A receptor in rat hippocampus by liquid scintillation counting | ChEMBL. | 22001327 |
Ki (binding) | = 41 nM | Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting | ChEMBL. | 22001327 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.