Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | plasminogen activator, urokinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | Mastin | plasminogen activator, urokinase | 414 aa | 340 aa | 24.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0016 | 0.2231 | 0.1927 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.5483 | 0.5306 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.2148 | 0.1841 |
Giardia lamblia | Kinase, NEK-frag | 0.0003 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.2148 | 0.1841 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.5506 | 1 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0011 | 0.1411 | 0.1075 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0035 | 0.5506 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.517 | 0.4981 |
Giardia lamblia | Kinase, NEK | 0.0003 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.1411 | 0.1075 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.5506 | 0.533 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.517 | 0.4981 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Onchocerca volvulus | 0.0035 | 0.5506 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.5483 | 0.5306 |
Brugia malayi | hypothetical protein | 0.0025 | 0.3705 | 0.3459 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.2148 | 0.1841 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0035 | 0.5506 | 1 |
Trichomonas vaginalis | serine threonine-protein kinase, putative | 0.0051 | 0.8047 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.2148 | 0.1841 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0051 | 0.8047 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0035 | 0.5506 | 0.533 |
Brugia malayi | Kringle domain containing protein | 0.0035 | 0.5506 | 0.533 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.2148 | 0.1841 |
Entamoeba histolytica | protein kinase, putative | 0.0051 | 0.8099 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.3705 | 0.3459 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0011 | 0.1411 | 0.1075 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.5483 | 0.5306 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0051 | 0.8099 | 0.8025 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.5483 | 0.5306 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase:endoribonuclease | 0.0051 | 0.8099 | 0.8025 |
Brugia malayi | TAR-binding protein | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2148 | 0.1841 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.7773 | 0.7686 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.7773 | 0.7686 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.2148 | 0.1841 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.2148 | 0.1841 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.3705 | 0.5 |
Giardia lamblia | Kinase, NEK | 0.0003 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase:endoribonuclease | 0.0051 | 0.8099 | 0.8025 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.2148 | 0.1841 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 1 | 1 |
Brugia malayi | Ribonuclease 2-5A family protein | 0.0051 | 0.8099 | 0.8025 |
Loa Loa (eye worm) | IRE protein kinase | 0.0051 | 0.8099 | 0.8025 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.5506 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.7773 | 0.7686 |
Giardia lamblia | Kinase, NEK | 0.0003 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0005 | 0.0377 | 0.5 |
Giardia lamblia | Kinase, NEK | 0.0003 | 0 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.2148 | 0.1841 |
Brugia malayi | hypothetical protein | 0.0035 | 0.5483 | 0.5306 |
Echinococcus granulosus | GPCR family 2 | 0.0015 | 0.2148 | 0.1841 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.7773 | 0.7686 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0035 | 0.5506 | 0.533 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0051 | 0.8099 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.0035 | 0.5506 | 1 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0035 | 0.5506 | 0.533 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0035 | 0.5506 | 0.533 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.517 | 0.4981 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.5506 | 0.533 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.2148 | 0.1841 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.2148 | 0.1841 |
Echinococcus multilocularis | GPCR, family 2 | 0.0015 | 0.2148 | 0.1841 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10 uM | Inhibition of urokinase-type plasminogen activator | ChEMBL. | 21978672 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.