Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0423 | 1 | 1 |
Echinococcus granulosus | snurportin 1 | 0.032 | 0.695 | 0.6762 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0423 | 1 | 1 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0158 | 0.2153 | 0.1669 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0423 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0423 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.2692 | 0.2241 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0158 | 0.2153 | 0.1669 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0158 | 0.2153 | 0.1669 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0158 | 0.2153 | 0.1669 |
Brugia malayi | proteasome subunit beta type 1 | 0.0158 | 0.2153 | 0.2153 |
Brugia malayi | hypothetical protein | 0.0157 | 0.2127 | 0.2127 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0158 | 0.2153 | 0.1669 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0423 | 1 | 1 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0423 | 1 | 1 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0158 | 0.2153 | 0.1669 |
Onchocerca volvulus | 0.0157 | 0.2127 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.2127 | 0.1642 |
Mycobacterium ulcerans | proteasome PrcB | 0.0423 | 1 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0423 | 1 | 0.5 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0158 | 0.2153 | 0.1669 |
Schistosoma mansoni | hypothetical protein | 0.032 | 0.695 | 0.6762 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0423 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain | 0.0423 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0423 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0423 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.2692 | 0.2241 |
Echinococcus granulosus | geminin | 0.0176 | 0.2692 | 0.2241 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0158 | 0.2153 | 0.1669 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0158 | 0.2153 | 0.1669 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0423 | 1 | 1 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0158 | 0.2153 | 0.1669 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0423 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0158 | 0.2153 | 0.1669 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0158 | 0.2153 | 0.1669 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0423 | 1 | 1 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0158 | 0.2153 | 0.1669 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0423 | 1 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.032 | 0.695 | 0.6762 |
Echinococcus multilocularis | geminin | 0.0176 | 0.2692 | 0.2241 |
Brugia malayi | proteasome subunit beta type 2 | 0.0105 | 0.0581 | 0.0581 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0423 | 1 | 1 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0158 | 0.2153 | 0.1669 |
Echinococcus multilocularis | snurportin 1 | 0.032 | 0.695 | 0.6762 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 220 nM | Compound was evaluated for inhibition of ex vivo ADP mediated platelet aggregation of human gel filtered platelets | ChEMBL. | No reference |
IC50 (functional) | = 220 nM | Compound was evaluated for inhibition of ex vivo ADP mediated platelet aggregation of human gel filtered platelets | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.