TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 442.295 | Formula: C22H17Cl2N3O3
H donors: 1 H acceptors: 4 LogP: 3.93 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C1CC(C(=O)N1c1ccc(cc1Cl)NC(=O)c1ccccn1)c1ccccc1.Cl
InChi: 1S/C22H16ClN3O3.ClH/c23-17-12-15(25-21(28)18-8-4-5-11-24-18)9-10-19(17)26-20(27)13-16(22(26)29)14-6-2-1-3-7-14;/h1-12,16H,13H2,(H,25,28);1H
InChiKey: JZVYSVFXHFWDBQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.0011	0.0367	0.0367
Echinococcus granulosus	nmda type glutamate receptor	0.0011	0.0367	0.0367
Echinococcus granulosus	dro:myosuppressin receptor	0.007	0.3308	0.3308
Schistosoma mansoni	hypothetical protein	0.007	0.3308	0.3308
Schistosoma mansoni	adenoreceptor	0.007	0.3308	0.3308
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0011	0.0367	0.0367
Brugia malayi	putative neuropeptide receptor	0.007	0.3308	0.3308
Brugia malayi	acetyltransferase, GNAT family protein	0.0115	0.5553	0.5553
Mycobacterium ulcerans	carboxylesterase, LipT	0.0034	0.1516	1
Brugia malayi	Guanylyl cyclase protein 23	0.0011	0.0367	0.0367
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.3308	0.3308
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.007	0.3308	0.3308
Schistosoma mansoni	amine GPCR	0.007	0.3308	0.3308
Echinococcus multilocularis	fmrfamide receptor	0.007	0.3308	0.3308
Brugia malayi	Dopamine receptor protein 1	0.007	0.3308	0.3308
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0031	0.1361	0.1361
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Brugia malayi	Serotonin receptor	0.007	0.3308	0.3308
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0367	0.0367
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0034	0.1516	1
Loa Loa (eye worm)	neuropeptide F receptor	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Brugia malayi	neuropeptide F receptor	0.007	0.3308	0.3308
Brugia malayi	sulfakinin receptor protein	0.007	0.3308	0.3308
Loa Loa (eye worm)	histone methyltransferase	0.0007	0.0159	0.0159
Brugia malayi	hypothetical protein	0.0034	0.1516	0.1516
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.007	0.3308	0.3308
Schistosoma mansoni	BC026374 protein (S09 family)	0.0034	0.1516	0.1516
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0013	0.0434	0.1995
Entamoeba histolytica	hypothetical protein	0.0041	0.1861	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.007	0.3308	0.3308
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.007	0.3308	0.3308
Brugia malayi	Cytochrome P450 family protein	0.0059	0.2743	0.2743
Echinococcus granulosus	GPCR family 3 C terminal	0.002	0.0785	0.0785
Brugia malayi	Tachykinin-like peptides receptor 99D	0.007	0.3308	0.3308
Brugia malayi	putative neuropeptide receptor NPR1	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Schistosoma mansoni	biogenic amine receptor	0.007	0.3308	0.3308
Onchocerca volvulus		0.007	0.3308	1
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0034	0.1516	0.1516
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.3308	0.3308
Echinococcus granulosus	receptor type guanylyl cyclase	0.0011	0.0367	0.0367
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Echinococcus granulosus	7tm_1 domain containing protein	0.007	0.3308	0.3308
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0041	0.1861	0.1861
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0115	0.5553	0.5553
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0367	0.0367
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0034	0.1516	1
Schistosoma mansoni	tyrosine kinase	0.0011	0.0367	0.0367
Brugia malayi	Receptor family ligand binding region containing protein	0.0031	0.1361	0.1361
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0034	0.1486	1
Echinococcus multilocularis	glutamate receptor 2	0.0011	0.0367	0.0367
Echinococcus granulosus	sex peptide receptor	0.007	0.3308	0.3308
Onchocerca volvulus	Neuropeptide F receptor homolog	0.007	0.3308	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0011	0.0367	0.0367
Brugia malayi	hypothetical protein	0.007	0.3308	0.3308
Brugia malayi	hypothetical protein	0.007	0.3308	0.3308
Echinococcus granulosus	carboxylesterase 5A	0.0204	1	1
Brugia malayi	hypothetical protein	0.007	0.3308	0.3308
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0011	0.0367	0.0367
Onchocerca volvulus		0.007	0.3308	1
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0034	0.1516	0.1516
Schistosoma mansoni	hypothetical protein	0.0041	0.1861	0.1861
Echinococcus granulosus	atrial natriuretic peptide receptor	0.0011	0.0367	0.0367
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Echinococcus granulosus	BC026374 protein S09 family	0.0034	0.1516	0.1516
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0034	0.1516	1
Brugia malayi	hypothetical protein	0.0041	0.1861	0.1861
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0018	0.07	0.07
Onchocerca volvulus		0.007	0.3308	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.007	0.3308	0.3308
Echinococcus granulosus	neuropeptide FF receptor 2	0.007	0.3308	0.3308
Entamoeba histolytica	hypothetical protein	0.0041	0.1861	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Echinococcus granulosus	biogenic amine 5HT receptor	0.007	0.3308	0.3308
Brugia malayi	cytochrome P450	0.0013	0.0434	0.0434
Echinococcus multilocularis	fmrfamide receptor	0.007	0.3308	0.3308
Entamoeba histolytica	hypothetical protein	0.0041	0.1861	1
Echinococcus multilocularis	GPCR, family 3, C terminal	0.002	0.0785	0.0785
Loa Loa (eye worm)	metabotropic glutamate receptor 8	0.0011	0.0367	0.0367
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.07	0.07
Schistosoma mansoni	neuropeptide f receptor 76f	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1516	0.1516
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1516	0.1516
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0011	0.0367	0.0367
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.007	0.3308	0.3308
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0034	0.1516	0.1516
Brugia malayi	isocitrate dehydrogenase	0.0018	0.07	0.07
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.3308	0.3308
Brugia malayi	G protein-coupled receptor	0.007	0.3308	0.3308
Echinococcus granulosus	metabotropic glutamate receptor 5	0.015	0.7332	0.7332
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1516	0.1516
Echinococcus multilocularis	cpg binding protein	0.0025	0.1047	0.1047
Echinococcus multilocularis	neuropeptide Y receptor	0.007	0.3308	0.3308
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.3308	0.3308
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0018	0.07	0.07
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.007	0.3308	0.3308
Brugia malayi	CXXC zinc finger family protein	0.0024	0.0979	0.0979
Echinococcus granulosus	hypothetical protein	0.007	0.3308	0.3308
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Schistosoma mansoni	cpg binding protein	0.0024	0.0979	0.0979
Echinococcus granulosus	tm gpcr rhodopsin	0.007	0.3308	0.3308
Echinococcus granulosus	tyrosine kinase	0.0011	0.0367	0.0367
Echinococcus multilocularis	serotonin receptor	0.007	0.3308	0.3308
Brugia malayi	ORL1-like opioid receptor	0.007	0.3308	0.3308
Echinococcus granulosus	neuropeptide receptor	0.007	0.3308	0.3308
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0034	0.1516	0.1516
Schistosoma mansoni	transcription factor LCR-F1	0.0041	0.1861	0.1861
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0018	0.07	1
Trichomonas vaginalis	spcc417.12 protein, putative	0.0034	0.1516	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0006	0.0086	0.0086
Echinococcus multilocularis	neuropeptide receptor A26	0.007	0.3308	0.3308
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.3308	0.3308
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.007	0.3308	0.3308
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0122	0.5917	0.5917
Brugia malayi	Dopamine receptor	0.007	0.3308	0.3308
Loa Loa (eye worm)	glutamate receptor	0.0048	0.2201	0.2201
Entamoeba histolytica	acetyltransferase, GNAT family	0.0031	0.1344	0.6542
Brugia malayi	hypothetical protein	0.007	0.3308	0.3308
Echinococcus granulosus	somatostatin receptor	0.007	0.3308	0.3308
Echinococcus granulosus	G protein coupled receptor 139	0.007	0.3308	0.3308
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0006	0.0086	0.0086
Schistosoma mansoni	protein kinase	0.0011	0.0367	0.0367
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.007	0.3308	0.3308
Trypanosoma cruzi	cytochrome P450, putative	0.0013	0.0434	0.1995
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Onchocerca volvulus		0.0034	0.1516	0.3907
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.007	0.3308	0.3308
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0011	0.0367	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0204	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.3308	0.3308
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0006	0.0086	0.0086
Echinococcus granulosus	allatostatin A receptor	0.007	0.3308	0.3308
Echinococcus multilocularis	sex peptide receptor	0.007	0.3308	0.3308
Schistosoma mansoni	hypothetical protein	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Schistosoma mansoni	cpg binding protein	0.0025	0.1047	0.1047
Echinococcus multilocularis	allatostatin A receptor	0.007	0.3308	0.3308
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.007	0.3308	0.3308
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.007	0.3308	0.3308
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0034	0.1516	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.007	0.3308	0.3308
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0018	0.07	0.2463
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.3308	0.3308
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0034	0.1486	0.9791
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0006	0.0086	0.0086
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0139	0.6756	0.6756
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0048	0.2183	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0434	0.0434
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.007	0.3308	0.3308
Onchocerca volvulus		0.007	0.3308	1
Loa Loa (eye worm)	G-protein coupled receptor	0.007	0.3308	0.3308
Brugia malayi	Carboxylesterase family protein	0.0034	0.1516	0.1516
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.3308	0.3308
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.3308	0.3308
Loa Loa (eye worm)	acetylcholinesterase 1	0.0204	1	1
Echinococcus granulosus	g protein coupled receptor	0.007	0.3308	0.3308
Brugia malayi	hypothetical protein	0.007	0.3308	0.3308
Onchocerca volvulus		0.007	0.3308	1
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0034	0.1516	0.1516
Echinococcus granulosus	g-protein coupled receptor	0.007	0.3308	0.3308
Brugia malayi	G-protein coupled receptor	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0367	0.0367
Brugia malayi	G-protein coupled receptor	0.007	0.3308	0.3308
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.007	0.3308	0.3308
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.005	0.2311	0.2311
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Plasmodium falciparum	histone acetyltransferase GCN5	0.0031	0.1344	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Echinococcus multilocularis	neuropeptide s receptor	0.007	0.3308	0.3308
Brugia malayi	Receptor family ligand binding region containing protein	0.0011	0.0367	0.0367
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0018	0.07	1
Brugia malayi	hypothetical protein	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Schistosoma mansoni	neuropeptide receptor	0.007	0.3308	0.3308
Schistosoma mansoni	amine GPCR	0.007	0.3308	0.3308
Onchocerca volvulus		0.0034	0.1516	0.3907
Schistosoma mansoni	glutamate receptor NMDA	0.0011	0.0367	0.0367
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0024	0.0979	0.0979
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.015	0.7332	0.7332
Echinococcus multilocularis	neuropeptide FF receptor 2	0.007	0.3308	0.3308
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.3308	0.3308
Schistosoma mansoni	hypothetical protein	0.002	0.0785	0.0785
Onchocerca volvulus	Poor gastrulation protein homolog	0.002	0.0785	0.1422
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Schistosoma mansoni	amine GPCR	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.3308	0.3308
Echinococcus granulosus	neuropeptides capa receptor	0.007	0.3308	0.3308
Schistosoma mansoni	metabotropic glutamate receptor	0.006	0.2777	0.2777
Brugia malayi	follicle stimulating hormone receptor	0.007	0.3308	0.3308
Schistosoma mansoni	opsin-like receptor	0.007	0.3308	0.3308
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.007	0.3308	0.3308
Echinococcus granulosus	neuropeptides capa receptor	0.007	0.3308	0.3308
Schistosoma mansoni	hypothetical protein	0.0013	0.0434	0.0434
Echinococcus granulosus	biogenic amine 5HT receptor	0.007	0.3308	0.3308
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0434	0.0434
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Brugia malayi	metabotropic glutamate receptor type 2	0.006	0.2777	0.2777
Onchocerca volvulus		0.007	0.3308	1
Echinococcus multilocularis		0.0013	0.0434	0.0434
Echinococcus multilocularis	neuropeptides capa receptor	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0367	0.0367
Schistosoma mansoni	opsin-like receptor	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0006	0.0086	0.0086
Echinococcus granulosus	7TM GPCR rhodopsin	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Loa Loa (eye worm)	cytochrome P450	0.0013	0.0434	0.0434
Schistosoma mansoni	hypothetical protein	0.007	0.3308	0.3308
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0034	0.1486	0.6013
Echinococcus multilocularis	isocitrate dehydrogenase	0.0018	0.07	0.07
Echinococcus granulosus	serotonin receptor	0.007	0.3308	0.3308
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0011	0.0367	0.0367
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Brugia malayi	hypothetical protein	0.007	0.3308	0.3308
Loa Loa (eye worm)	carboxylesterase	0.0034	0.1516	0.1516
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0018	0.07	0.07
Loa Loa (eye worm)	carboxylesterase	0.0204	1	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.1361	0.1361
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.007	0.3308	0.3308
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.007	0.3308	0.3308
Echinococcus multilocularis	para nitrobenzyl esterase	0.0034	0.1516	0.1516
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0112	0.5392	0.5392
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1516	0.1516
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0011	0.0367	0.0367
Echinococcus granulosus	tachykinin peptides receptor 99D	0.007	0.3308	0.3308
Echinococcus multilocularis	dro:myosuppressin receptor	0.007	0.3308	0.3308
Loa Loa (eye worm)	melatonin receptor type 1A	0.007	0.3308	0.3308
Echinococcus multilocularis	acetylcholinesterase	0.0204	1	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0159	0.0159
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.007	0.3308	0.3308
Echinococcus granulosus	tm gpcr rhodopsin	0.007	0.3308	0.3308
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0011	0.0367	0.0367
Schistosoma mansoni	cpg binding protein	0.0025	0.1047	0.1047
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0115	0.5553	0.5553
Schistosoma mansoni	neuropeptide receptor	0.007	0.3308	0.3308
Echinococcus multilocularis	somatostatin receptor	0.007	0.3308	0.3308
Echinococcus multilocularis	neuropeptide receptor	0.007	0.3308	0.3308
Schistosoma mansoni	biogenic amine (5HT) receptor	0.007	0.3308	0.3308
Schistosoma mansoni	growth hormone secretagogue receptor	0.007	0.3308	0.3308
Schistosoma mansoni	neuropeptide F-like receptor	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.007	0.3308	0.3308
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.07	0.07
Brugia malayi	GnHR receptor homolog	0.007	0.3308	0.3308
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.3308	0.3308
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.007	0.3308	0.3308
Brugia malayi	Dopamine receptor protein 2	0.007	0.3308	0.3308
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.002	0.0785	0.0785
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0204	1	1
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0011	0.0367	0.0367
Schistosoma mansoni	metabotropic glutamate receptor	0.0102	0.4923	0.4923
Echinococcus granulosus	alpha 1A adrenergic receptor	0.007	0.3308	0.3308
Echinococcus multilocularis	nmda type glutamate receptor	0.0011	0.0367	0.0367
Loa Loa (eye worm)	hypothetical protein	0.015	0.7332	0.7332
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0204	1	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0034	0.1516	0.1516
Schistosoma mansoni	histamine h1 receptor	0.007	0.3308	0.3308
Echinococcus multilocularis	tyrosine kinase	0.0011	0.0367	0.0367
Onchocerca volvulus		0.007	0.3308	1
Echinococcus granulosus	neuropeptide Y receptor	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1516	0.1516
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0367	0.0367
Onchocerca volvulus		0.0034	0.1516	0.3907
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.007	0.3308	0.3308
Echinococcus multilocularis	orexin receptor type 2	0.007	0.3308	0.3308
Echinococcus granulosus	para nitrobenzyl esterase	0.0034	0.1516	0.1516
Echinococcus granulosus	neuropeptide Y receptor	0.007	0.3308	0.3308
Brugia malayi	Isocitrate dehydrogenase	0.0018	0.07	0.07
Echinococcus multilocularis	neuropeptide Y receptor	0.007	0.3308	0.3308
Onchocerca volvulus		0.007	0.3308	1
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0013	0.0434	0.1995
Echinococcus granulosus	acetylcholinesterase	0.0204	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.007	0.3308	0.3308
Brugia malayi	G protein-coupled receptor F59B2.13	0.007	0.3308	0.3308
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.3308	0.3308
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.007	0.3308	0.3308
Brugia malayi	hypothetical protein	0.0011	0.0367	0.0367
Schistosoma mansoni	opsin-like receptor	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Brugia malayi	Carboxylesterase family protein	0.0034	0.1516	0.1516
Schistosoma mansoni	neuropeptide F-like receptor	0.007	0.3308	0.3308
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0031	0.1361	0.1361
Echinococcus granulosus	cytochrome P450 2K1	0.0013	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Echinococcus granulosus	neuropeptide receptor A26	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Loa Loa (eye worm)	CYP4Cod1	0.0013	0.0434	0.0434
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.3308	0.3308
Schistosoma mansoni	tyrosine kinase	0.0011	0.0367	0.0367
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.007	0.3308	0.3308
Loa Loa (eye worm)	cytochrome P450 family protein	0.0059	0.2743	0.2743
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0018	0.07	1
Echinococcus multilocularis	acetylcholinesterase	0.0204	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.007	0.3308	0.3308
Schistosoma mansoni	amine GPCR	0.007	0.3308	0.3308
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.007	0.3308	0.3308
Echinococcus multilocularis	g protein coupled receptor	0.007	0.3308	0.3308
Onchocerca volvulus		0.0034	0.1516	0.3907
Schistosoma mansoni	myosin xvIII	0.007	0.3308	0.3308
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.007	0.3308	0.3308
Schistosoma mansoni	acetylcholinesterase	0.0034	0.1516	0.1516
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.3308	0.3308
Echinococcus granulosus	neuroligin	0.0034	0.1516	0.1516
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0159	0.0159
Brugia malayi	neuropeptide F receptor	0.007	0.3308	0.3308
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0011	0.0367	0.0367
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.007	0.3308	0.3308
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.3308	0.3308
Schistosoma mansoni	neuropeptide receptor	0.007	0.3308	0.3308
Onchocerca volvulus		0.007	0.3308	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.007	0.3308	0.3308
Brugia malayi	Serotonin receptor	0.007	0.3308	0.3308
Schistosoma mansoni	amine GPCR	0.007	0.3308	0.3308
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0011	0.0367	0.0367
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0011	0.0367	0.0367
Echinococcus granulosus	acetylcholinesterase	0.0204	1	1
Brugia malayi	Carboxylesterase family protein	0.0034	0.1516	0.1516
Onchocerca volvulus	Metabotropic glutamate receptor homolog	0.002	0.0785	0.1422
Loa Loa (eye worm)	carboxylesterase	0.0034	0.1516	0.1516
Loa Loa (eye worm)	glutamate receptor	0.0122	0.5917	0.5917
Schistosoma mansoni	biogenic amine receptor	0.007	0.3308	0.3308
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.007	0.3308	0.3308
Echinococcus granulosus	g protein coupled receptor	0.007	0.3308	0.3308
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0013	0.0434	0.1995
Loa Loa (eye worm)	G-protein coupled receptor	0.007	0.3308	0.3308
Brugia malayi	Carboxylesterase family protein	0.0034	0.1516	0.1516
Brugia malayi	hypothetical protein	0.007	0.3308	0.3308
Echinococcus granulosus	orexin receptor type 2	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Brugia malayi	Melatonin receptor type 1A	0.007	0.3308	0.3308
Leishmania major	cytochrome p450-like protein	0.0013	0.0434	0.1995
Toxoplasma gondii	isocitrate dehydrogenase	0.0018	0.07	0.1524
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0034	0.1486	0.9791
Schistosoma mansoni	cytochrome P450	0.0013	0.0434	0.0434
Echinococcus multilocularis	neuropeptides capa receptor	0.007	0.3308	0.3308
Echinococcus granulosus	glutamate receptor 2	0.0011	0.0367	0.0367
Echinococcus multilocularis	G-protein coupled receptor, putative	0.007	0.3308	0.3308
Mycobacterium leprae	Conserved hypothetical protein	0.0013	0.0434	0.5
Echinococcus granulosus	cpg binding protein	0.0025	0.1047	0.1047
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.007	0.3308	1
Echinococcus granulosus	fmrfamide receptor	0.007	0.3308	0.3308
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.007	0.3308	0.3308
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0102	0.4923	0.4923
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Onchocerca volvulus		0.007	0.3308	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Schistosoma mansoni	biogenic amine (5HT) receptor	0.007	0.3308	0.3308
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.007	0.3308	0.3308
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0102	0.4923	0.4923
Echinococcus multilocularis	g-protein coupled receptor	0.007	0.3308	0.3308
Loa Loa (eye worm)	acetyltransferase	0.0115	0.5553	0.5553
Echinococcus granulosus	neuropeptide receptor	0.007	0.3308	0.3308
Onchocerca volvulus		0.007	0.3308	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.007	0.3308	0.3308
Trypanosoma cruzi	cytochrome P450, putative	0.0013	0.0434	0.1995
Echinococcus multilocularis	neuropeptide receptor	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.002	0.0785	0.0785
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.007	0.3308	0.3308
Echinococcus multilocularis	g protein coupled receptor	0.007	0.3308	0.3308
Echinococcus multilocularis	serotonin receptor	0.007	0.3308	0.3308
Schistosoma mansoni	gliotactin	0.0034	0.1516	0.1516
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.07	0.07
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.3308	0.3308
Onchocerca volvulus		0.007	0.3308	1
Echinococcus granulosus	neuropeptide s receptor	0.007	0.3308	0.3308
Echinococcus multilocularis	g protein coupled receptor	0.007	0.3308	0.3308
Loa Loa (eye worm)	neuropeptide F receptor	0.007	0.3308	0.3308
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0011	0.0367	0.0367
Echinococcus multilocularis	G protein coupled receptor 139	0.007	0.3308	0.3308
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.3308	0.3308
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.007	0.3308	0.3308
Echinococcus granulosus	g protein coupled receptor	0.007	0.3308	0.3308
Leishmania major	cytochrome p450-like protein	0.0013	0.0434	0.1995
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1516	0.1516
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.007	0.3308	0.3308
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.007	0.3308	0.3308
Entamoeba histolytica	hypothetical protein	0.0041	0.1861	1
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0018	0.07	1
Onchocerca volvulus		0.0024	0.0979	0.2081
Brugia malayi	larval opioid receptor	0.007	0.3308	0.3308
Onchocerca volvulus		0.007	0.3308	1
Leishmania major	cytochrome p450-like protein	0.0013	0.0434	0.1995
Brugia malayi	F/Y-rich N-terminus family protein	0.0007	0.0154	0.0154
Brugia malayi	hypothetical protein	0.007	0.3308	0.3308
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0018	0.07	0.07
Mycobacterium leprae	putative cytochrome p450	0.0013	0.0434	0.5
Schistosoma mansoni	hypothetical protein	0.007	0.3308	0.3308
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0434	0.0434
Schistosoma mansoni	alpha-1 adrenergic receptor	0.007	0.3308	0.3308
Brugia malayi	AKH receptor	0.007	0.3308	0.3308
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0034	0.1486	0.1486
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0034	0.1516	0.1516
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Onchocerca volvulus		0.007	0.3308	1
Onchocerca volvulus		0.007	0.3308	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.3308	0.3308
Echinococcus multilocularis	glutamate receptor 2	0.0011	0.0367	0.0367
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0111	0.5341	0.5341
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Onchocerca volvulus		0.0034	0.1516	0.3907
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Echinococcus multilocularis	carboxylesterase 5A	0.0204	1	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.007	0.3308	0.3308
Onchocerca volvulus		0.007	0.3308	1
Echinococcus multilocularis	neuroligin	0.0034	0.1516	0.1516
Giardia lamblia	Histone acetyltransferase GCN5	0.0031	0.1344	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1516	0.1516
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0434	0.0434
Toxoplasma gondii	isocitrate dehydrogenase	0.0018	0.07	0.1524
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Brugia malayi	hypothetical protein	0.007	0.3308	0.3308
Brugia malayi	RE15519p	0.007	0.3308	0.3308
Echinococcus granulosus	peptide allatostatin:somatostatin	0.007	0.3308	0.3308
Echinococcus multilocularis	rhodopsin orphan GPCR	0.007	0.3308	0.3308
Echinococcus granulosus	tm gpcr rhodopsin	0.007	0.3308	0.3308
Loa Loa (eye worm)	TYRA-2 protein	0.007	0.3308	0.3308
Brugia malayi	Carboxylesterase family protein	0.0204	1	1
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0018	0.07	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0367	0.0367
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Schistosoma mansoni	biogenic amine receptor	0.007	0.3308	0.3308
Schistosoma mansoni	neuropeptide receptor	0.007	0.3308	0.3308
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.007	0.3308	0.3308
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0367	0.0367
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0013	0.0434	0.1995
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0034	0.1486	0.6013
Loa Loa (eye worm)	hypothetical protein	0.007	0.3308	0.3308
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0041	0.1861	0.1861
Onchocerca volvulus		0.007	0.3308	1
Echinococcus granulosus	glutamate receptor 2	0.0011	0.0367	0.0367

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1921965

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1576668