TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 320.433 | Formula: C14H16N4OS2
H donors: 1 H acceptors: 2 LogP: 2.53 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: S=C(N1CCCCC1)Nc1cccc(c1)c1nnc(o1)S
InChi: 1S/C14H16N4OS2/c20-13(18-7-2-1-3-8-18)15-11-6-4-5-10(9-11)12-16-17-14(21)19-12/h4-6,9H,1-3,7-8H2,(H,15,20)(H,17,21)
InChiKey: SQTZTBIBHAQKLL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0072	0.0794	0.1433
Trichomonas vaginalis	penicillin-binding protein, putative	0.0072	0.0794	0.2768
Toxoplasma gondii	ATPase, AAA family protein	0.001	0.0036	0.0452
Leishmania major	glycosyl hydrolase-like protein	0.0014	0.0081	0.0525
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0165	0.194	0.2545
Brugia malayi	Carboxylesterase family protein	0.0106	0.1216	0.1595
Loa Loa (eye worm)	carboxylesterase	0.0106	0.1216	0.1595
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0122	0.022
Echinococcus multilocularis	para nitrobenzyl esterase	0.0106	0.1216	0.1216
Mycobacterium tuberculosis	Probable lipase LipE	0.0072	0.0794	0.1433
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0015	0.0103	0.0103
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0015	0.0103	0.0186
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.001	0.0036	0.0295
Schistosoma mansoni	topbp1	0.001	0.0036	0.0042
Brugia malayi	Carboxylesterase family protein	0.0106	0.1216	0.1595
Schistosoma mansoni	cpg binding protein	0.0031	0.0291	0.0342
Onchocerca volvulus		0.0072	0.0794	0.2768
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0208	0.1713
Schistosoma mansoni	alpha-glucosidase	0.0142	0.1658	0.1951
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0072	0.0794	0.1041
Echinococcus multilocularis	Niemann Pick C1 protein	0.0143	0.1664	0.1664
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0047
Schistosoma mansoni	microtubule-associated protein tau	0.0699	0.8497	1
Schistosoma mansoni	hypothetical protein	0.0049	0.0513	0.0604
Mycobacterium tuberculosis	Probable esterase LipL	0.0072	0.0794	0.1433
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0439	0.1531
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1216	0.1595
Loa Loa (eye worm)	hypothetical protein	0.005	0.0529	0.0693
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0106	0.1216	0.2196
Echinococcus granulosus	sterol regulatory element binding protein	0.0043	0.0439	0.0517
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0643	0.4167
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0015	0.0103	0.0121
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0043	0.0439	0.0576
Schistosoma mansoni	hypothetical protein	0.0041	0.042	0.0494
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0133	0.1542	1
Echinococcus granulosus	neutral alpha glucosidase AB	0.0037	0.0363	0.0427
Echinococcus granulosus	carboxylesterase 5A	0.0628	0.7622	0.897
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0293	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1216	0.1595
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0037	0.0363	0.1266
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0794	0.1041
Schistosoma mansoni	hypothetical protein	0.0041	0.042	0.0494
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0036	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0628	0.7622	1
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0036	0.0125
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0165	0.194	0.194
Echinococcus granulosus	acetylcholinesterase	0.0628	0.7622	0.897
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0643	0.0643
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0106	0.1216	0.1431
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0037	0.0363	0.0476
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0643	0.0756
Onchocerca volvulus		0.0031	0.0293	0.102
Echinococcus granulosus	survival motor neuron protein 1	0.024	0.2855	0.336
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0643	0.0756
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0794	0.1041
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0134	1
Brugia malayi	Isocitrate dehydrogenase	0.0015	0.0103	0.0135
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0036	0.0125
Loa Loa (eye worm)	hypothetical protein	0.01	0.1138	0.1493
Mycobacterium tuberculosis	Probable hydrolase	0.0072	0.0794	0.1433
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0106	0.1216	0.2196
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0103	0.0103
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.001	0.0036	0.0452
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0208	0.0376
Plasmodium vivax	SET domain protein, putative	0.0031	0.0293	0.3686
Onchocerca volvulus		0.0241	0.2868	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.0363	0.1266
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0014	0.0081	0.0525
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0072	0.0794	0.1433
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0165	0.194	0.2545
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.0794	0.2768
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.0794	0.5146
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0036	0.0233
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0208	0.1713
Echinococcus granulosus	tumor protein p63	0.0342	0.4116	0.4844
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0208	0.1713
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0036	0.0125
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0363	0.2354
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0208	0.1351
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0072	0.0794	0.0794
Echinococcus granulosus	microtubule associated protein 2	0.0699	0.8497	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0014	0.0081	0.0282
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0208	0.1713
Mycobacterium ulcerans	lipase LipD	0.0072	0.0794	0.6527
Loa Loa (eye worm)	beta-lactamase	0.0072	0.0794	0.1041
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0015	0.0103	0.13
Leishmania major	hypothetical protein, conserved	0.0072	0.0794	0.5146
Echinococcus granulosus	nibrin	0.001	0.0036	0.0042
Schistosoma mansoni	hypothetical protein	0.0041	0.042	0.0494
Echinococcus granulosus	Niemann Pick C1 protein	0.0143	0.1664	0.1958
Schistosoma mansoni	survival motor neuron protein	0.0049	0.0513	0.0604
Mycobacterium tuberculosis	Probable lipase LipD	0.0072	0.0794	0.1433
Schistosoma mansoni	patched 1	0.0043	0.0439	0.0517
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0212	0.251	0.3293
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0134	0.0175
Echinococcus multilocularis	protein patched	0.0043	0.0439	0.0439
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0293	0.0293
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0134	0.0242
Treponema pallidum	DNA ligase (lig)	0.001	0.0036	0.5
Schistosoma mansoni	acetylcholinesterase	0.0106	0.1216	0.1431
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0081	0.0106
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0106	0.1216	0.424
Trypanosoma brucei	hypothetical protein, conserved	0.0072	0.0794	0.5146
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.0529	0.0622
Trichomonas vaginalis	alpha-glucosidase, putative	0.0014	0.0081	0.0282
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0208	0.1351
Echinococcus granulosus	beta LACTamase domain containing family member	0.0072	0.0794	0.0934
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.0363	0.1266
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0047
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.0134	0.11
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0133	0.1542	0.1542
Mycobacterium tuberculosis	Conserved protein	0.0072	0.0794	0.1433
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0036	0.0047
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0293	0.0344
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0133	0.1542	1
Brugia malayi	Pre-SET motif family protein	0.0212	0.251	0.3293
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0015	0.0103	0.7712
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.001	0.0036	0.5
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0643	0.5285
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0047
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0106	0.1216	0.1431
Echinococcus multilocularis	carboxylesterase 5A	0.0628	0.7622	0.7622
Brugia malayi	CHE-14 protein	0.0043	0.0439	0.0576
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0293	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1216	0.1595
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.0685	0.0806
Echinococcus multilocularis	nibrin	0.001	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0208	0.0273
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0106	0.1216	0.2196
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0643	0.1161
Toxoplasma gondii	isocitrate dehydrogenase	0.0015	0.0103	0.13
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0133	0.1542	1
Mycobacterium ulcerans	beta-lactamase	0.0072	0.0794	0.6527
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0363	0.1266
Brugia malayi	hypothetical protein	0.001	0.0036	0.0047
Trichomonas vaginalis	set domain proteins, putative	0.0241	0.2868	1
Brugia malayi	Carboxylesterase family protein	0.0628	0.7622	1
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0133	0.1542	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0122	0.022
Onchocerca volvulus		0.0106	0.1216	0.424
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0103	0.0669
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0037	0.0363	0.1266
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.0604	0.7609
Plasmodium vivax	hypothetical protein, conserved	0.0072	0.0794	1
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.01	0.1138	0.7379
Echinococcus multilocularis	sterol regulatory element binding protein	0.0043	0.0439	0.0439
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0628	0.7622	0.897
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0208	0.1713
Toxoplasma gondii	ABC1 family protein	0.0072	0.0794	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.0513	0.0674
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0036	0.0125
Trichomonas vaginalis	spcc417.12 protein, putative	0.0106	0.1216	0.424
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0208	0.1713
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0103	0.0669
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0643	0.5285
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1216	0.1595
Brugia malayi	beta-lactamase	0.0072	0.0794	0.1041
Onchocerca volvulus		0.0049	0.0513	0.179
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0037	0.0363	0.2354
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0208	0.0273
Brugia malayi	DKFZp564C0469 protein	0.001	0.0036	0.0047
Onchocerca volvulus		0.0096	0.1086	0.3785
Brugia malayi	hypothetical protein	0.0106	0.1216	0.1595
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0072	0.0794	0.0934
Schistosoma mansoni	alpha-glucosidase	0.0142	0.1658	0.1951
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0293	0.0344
Onchocerca volvulus		0.0106	0.1216	0.424
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0014	0.0081	0.0525
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0208	0.2625
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0136	0.1581	0.1861
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0072	0.0794	0.0934
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0208	0.1351
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0106	0.1216	0.1216
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0038	0.0044
Echinococcus multilocularis	cpg binding protein	0.0031	0.0291	0.0291
Echinococcus multilocularis	acetylcholinesterase	0.0628	0.7622	0.7622
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0136	0.1581	0.1861
Onchocerca volvulus		0.0106	0.1216	0.424
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0101	0.1157	0.1362
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0134	0.1685
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0134	0.0175
Onchocerca volvulus		0.0106	0.1216	0.424
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0134	1
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0133	0.1542	0.2023
Onchocerca volvulus		0.001	0.0036	0.0125
Echinococcus multilocularis	isocitrate dehydrogenase	0.0015	0.0103	0.0103
Onchocerca volvulus		0.0072	0.0794	0.2768
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0165	0.194	0.194
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0016	0.0019
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0036	0.0233
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0072	0.0794	0.1433
Brugia malayi	beta-lactamase family protein	0.0072	0.0794	0.1041
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0134	0.0175
Echinococcus granulosus	para nitrobenzyl esterase	0.0106	0.1216	0.1431
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0293	0.0344
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0014	0.0081	0.0282
Brugia malayi	Pax transcription activation domain interacting protein	0.001	0.0036	0.0047
Trypanosoma brucei	glucosidase, putative	0.0037	0.0363	0.2354
Echinococcus multilocularis	tumor protein p63	0.0342	0.4116	0.4116
Echinococcus multilocularis	acetylcholinesterase	0.0628	0.7622	0.7622
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0136	0.1581	0.1861
Loa Loa (eye worm)	carboxylesterase	0.0628	0.7622	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0643	0.8097
Leishmania major	alpha glucosidase II subunit, putative	0.0037	0.0363	0.2354
Schistosoma mansoni	gliotactin	0.0106	0.1216	0.1431
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0643	0.0756
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0014	0.0081	0.0106
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0208	0.2625
Echinococcus multilocularis	expressed conserved protein	0.0094	0.1064	0.1064
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0016	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1216	0.1595
Brugia malayi	Carboxylesterase family protein	0.0628	0.7622	1
Onchocerca volvulus		0.005	0.0529	0.1843
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0015	0.0103	0.0669
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0103	0.0103
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0136	0.1581	0.2074
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0293	0.0344
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0133	0.1542	0.1815
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0038	0.0038
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0106	0.1216	0.1216
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0208	0.0273
Trichomonas vaginalis	alpha-glucosidase, putative	0.0014	0.0081	0.0282
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0036	0.0233
Mycobacterium leprae	conserved hypothetical protein	0.0072	0.0794	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0208	0.0273
Echinococcus multilocularis	transcription factor Dp 1	0.0077	0.0856	0.0856
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0036	0.0125
Echinococcus multilocularis	survival motor neuron protein 1	0.024	0.2855	0.2855
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0363	0.1266
Echinococcus granulosus	lysosomal alpha glucosidase	0.0165	0.194	0.2283
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0037	0.0363	0.0363
Echinococcus granulosus	replication factor c subunit 1	0.001	0.0036	0.0042
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0363	0.1266
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0134	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0134	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0557	0.0731
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0047
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0208	0.1351
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0036	0.0125
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0122	0.022
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0643	0.5285
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0439	0.0576
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0136	0.1581	0.1581
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0271	0.0319
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0036	0.0125
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0136	0.1581	0.1861
Onchocerca volvulus		0.0029	0.0271	0.0944
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0016	0.0019
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0038	0.0049
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0014	0.0081	0.0525
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.0794	0.2768
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.0794	0.5146
Echinococcus multilocularis	replication factor c subunit 1	0.001	0.0036	0.0036
Mycobacterium tuberculosis	Conserved protein	0.0072	0.0794	0.1433
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0133	0.1542	0.1815
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0271	0.0355
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.001	0.0036	0.0047
Brugia malayi	hypothetical protein	0.001	0.0036	0.0047
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0014	0.0081	0.0282
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0015	0.0103	0.0121
Echinococcus multilocularis	Niemann Pick C1 protein	0.01	0.1138	0.1138
Onchocerca volvulus		0.0024	0.0208	0.0726
Schistosoma mansoni	BC026374 protein (S09 family)	0.0106	0.1216	0.1431
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.001	0.0036	0.0233
Onchocerca volvulus		0.0106	0.1216	0.424
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1216	0.1595
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0037	0.0363	0.4575
Trichomonas vaginalis	penicillin-binding protein, putative	0.0072	0.0794	0.2768
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0208	0.1713
Mycobacterium tuberculosis	Conserved protein	0.0072	0.0794	0.1433
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0794	0.1041
Mycobacterium ulcerans	hypothetical protein	0.0072	0.0794	0.6527
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0363	0.1266
Brugia malayi	topoisomerase	0.001	0.0036	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0208	0.0273
Plasmodium falciparum	replication factor C subunit 1, putative	0.001	0.0036	0.2682
Trichomonas vaginalis	alpha-glucosidase, putative	0.0014	0.0081	0.0282
Echinococcus granulosus	cpg binding protein	0.0031	0.0291	0.0342
Brugia malayi	beta-lactamase family protein	0.0072	0.0794	0.1041
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0015	0.0103	0.0669
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0208	0.1351
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0271	0.0355
Schistosoma mansoni	topbp1	0.001	0.0036	0.0042
Brugia malayi	hypothetical protein	0.024	0.2855	0.3745
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0036	0.0233
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0208	0.0376
Plasmodium vivax	replication factor C subunit 1, putative	0.001	0.0036	0.0452
Trypanosoma brucei	glycosyl hydrolase-like protein	0.0014	0.0081	0.0525
Trichomonas vaginalis	alpha-glucosidase, putative	0.0014	0.0081	0.0282
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0106	0.1216	0.1431
Trichomonas vaginalis	replication factor C large subunit, putative	0.001	0.0036	0.0125
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0136	0.1581	0.1861
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0037	0.0363	0.2354
Echinococcus granulosus	acetylcholinesterase	0.0628	0.7622	0.897
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0794	0.1041
Echinococcus granulosus	transcription factor Dp 1	0.0077	0.0856	0.1008
Loa Loa (eye worm)	hypothetical protein	0.024	0.2855	0.3745
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0014	0.0081	0.0282
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.0794	0.2768
Schistosoma mansoni	alpha glucosidase	0.0037	0.0363	0.0427
Brugia malayi	Carboxylesterase family protein	0.0106	0.1216	0.1595
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0293	0.3686
Echinococcus multilocularis	microtubule associated protein 2	0.0699	0.8497	0.8497
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1216	0.1595
Schistosoma mansoni	chromosome transmission fidelity factor	0.001	0.0036	0.0042
Mycobacterium ulcerans	carboxylesterase, LipT	0.0106	0.1216	1
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.0014	0.0081	0.0282
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0458	0.5537	1
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0208	0.0273
Schistosoma mansoni	hypothetical protein	0.0041	0.042	0.0494
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0363	0.2354
Mycobacterium ulcerans	esterase/lipase LipP	0.0072	0.0794	0.6527
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0133	0.1542	0.2023
Echinococcus granulosus	BC026374 protein S09 family	0.0106	0.1216	0.1431
Brugia malayi	Carboxylesterase family protein	0.0106	0.1216	0.1595
Schistosoma mansoni	DNA ligase IV	0.001	0.0036	0.0042
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0103	0.0103
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0208	0.1351
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0794	0.1041
Giardia lamblia	Replication factor C, subunit 1	0.001	0.0036	0.5
Echinococcus granulosus	Niemann Pick C1 protein	0.01	0.1138	0.1339
Brugia malayi	Pre-SET motif family protein	0.0031	0.0293	0.0384
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0072	0.0794	0.6527
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0293	0.0293
Echinococcus granulosus	expressed conserved protein	0.0094	0.1064	0.1252
Onchocerca volvulus		0.0072	0.0794	0.2768
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0106	0.1216	0.1431
Echinococcus multilocularis	protein dispatched 1	0.0049	0.0513	0.0513
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0133	0.1542	1
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0106	0.1216	0.1431
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0015	0.0103	0.0135
Trichomonas vaginalis	esterase, putative	0.0072	0.0794	0.2768
Loa Loa (eye worm)	hypothetical protein	0.0628	0.7622	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0136	0.1581	0.1581
Brugia malayi	isocitrate dehydrogenase	0.0015	0.0103	0.0135
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0122	0.022
Schistosoma mansoni	cpg binding protein	0.0029	0.0271	0.0319
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0208	0.1713
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0136	0.1581	0.2074
Schistosoma mansoni	cpg binding protein	0.0031	0.0291	0.0342
Echinococcus granulosus	neuroligin	0.0106	0.1216	0.1431
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0016	0.0016
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0016	0.0016
Brugia malayi	Niemann-Pick C1 protein precursor	0.01	0.1138	0.1493
Loa Loa (eye worm)	carboxylesterase	0.0106	0.1216	0.1595
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0072	0.0794	0.1041
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0103	0.0669
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0363	0.1266
Toxoplasma gondii	isocitrate dehydrogenase	0.0015	0.0103	0.13
Trypanosoma cruzi	FHA domain containing protein, putative	0.001	0.0036	0.0233
Echinococcus granulosus	Protein patched homolog 1	0.0043	0.0439	0.0517
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0036	0.0125
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0037	0.0363	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0794	0.1041
Mycobacterium leprae	Probable lipase LipE	0.0072	0.0794	1
Entamoeba histolytica	hypothetical protein	0.001	0.0036	0.0233
Echinococcus multilocularis	neuroligin	0.0106	0.1216	0.1216
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.001	0.0036	0.0452
Loa Loa (eye worm)	acetylcholinesterase 1	0.0628	0.7622	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1917152

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1576773