Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.009 | 0.0612 | 0.6918 |
Plasmodium falciparum | polyprenol reductase, putative | 0.009 | 0.0612 | 0.5 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0114 | 0.0878 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0637 | 0.6597 | 1 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.009 | 0.0612 | 0.0599 |
Plasmodium vivax | polyprenol reductase, putative | 0.009 | 0.0612 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.6597 | 1 |
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.06 | 0.6194 | 0.9389 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0637 | 0.6597 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0637 | 0.6597 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0637 | 0.6597 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0637 | 0.6597 | 1 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.009 | 0.0612 | 0.6968 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0637 | 0.6597 | 0.5 |
Onchocerca volvulus | 0.009 | 0.0612 | 0.2259 | |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.06 | 0.6194 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.0277 | 0.2661 | 0.3424 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.009 | 0.0612 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0243 | 0.2293 | 0.3463 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.009 | 0.0612 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0637 | 0.6597 | 1 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0637 | 0.6597 | 1 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.009 | 0.0612 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0612 | 0.0908 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.009 | 0.0612 | 0.0908 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.009 | 0.0612 | 0.0908 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0612 | 0.0908 |
Schistosoma mansoni | lipoxygenase | 0.0114 | 0.0878 | 1 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.009 | 0.0612 | 0.0599 |
Schistosoma mansoni | lipoxygenase | 0.008 | 0.0503 | 0.5662 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0114 | 0.0878 | 0.0865 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0035 | 0.0014 | 0.016 |
Mycobacterium leprae | Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.06 | 0.6194 | 0.5 |
Onchocerca volvulus | 0.0277 | 0.2661 | 1 | |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.009 | 0.0612 | 0.6968 |
Brugia malayi | Synaptic glycoprotein SC2 | 0.009 | 0.0612 | 0.0908 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0637 | 0.6597 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0243 | 0.2293 | 0.3463 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.009 | 0.0612 | 0.6918 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0637 | 0.6597 | 1 |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.0637 | 0.6597 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 174.92 % | Protection against H2O2-induced toxicity in human ECV304 cells assessed as proliferation rate at 100 uM pretreated for 24 hrs before H2O2 challenge measured after 12 hrs by MTT assay | ChEMBL. | 21993151 |
Activity (functional) | = 306.5 % | Protection against H2O2-induced toxicity in human ECV304 cells assessed as proliferation rate at 12.5 uM pretreated for 24 hrs before H2O2 challenge measured after 12 hrs by MTT assay | ChEMBL. | 21993151 |
Activity (functional) | = 378.38 % | Protection against H2O2-induced toxicity in human ECV304 cells assessed as proliferation rate at 25 uM pretreated for 24 hrs before H2O2 challenge measured after 12 hrs by MTT assay | ChEMBL. | 21993151 |
Activity (functional) | = 472.99 % | Protection against H2O2-induced toxicity in human ECV304 cells assessed as proliferation rate at 50 uM pretreated for 24 hrs before H2O2 challenge measured after 12 hrs by MTT assay | ChEMBL. | 21993151 |
EC50 (functional) | = 0.02 mM | Protection against H2O2-induced toxicity in human ECV304 cells assessed as proliferation rate pretreated for 24 hrs before H2O2 challenge measured after 12 hrs by MTT assay | ChEMBL. | 21993151 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.