Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 6.8 % | Induction of apoptosis in human AGS cells assessed as early apoptosis level at 15 ug/mL after 24 hrs by Annexin V-FITC apoptosis assay | ChEMBL. | 21899268 |
Activity (functional) | = 25.2 % | Induction of apoptosis in human AGS cells assessed as early apoptosis level at 15 ug/mL after 48 hrs by Annexin V-FITC apoptosis assay | ChEMBL. | 21899268 |
IC50 (functional) | = 23.9 uM | Cytotoxicity against human AGS cells after 48 hrs by MTT assay | ChEMBL. | 21899268 |
IC50 (functional) | = 46.8 uM | Cytotoxicity against mouse NIH/3T3 cells after 48 hrs by MTT assay | ChEMBL. | 21899268 |
IC50 (functional) | = 64.4 uM | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay | ChEMBL. | 21899268 |
IC50 (functional) | = 68.8 uM | Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay | ChEMBL. | 21899268 |
IC50 (functional) | > 100 uM | Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay | ChEMBL. | 21899268 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.