Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | peptidyl-prolyl cis-trans isomerase, putative | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | 163 aa | 133 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.004 | 0.0087 | 0.0087 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0039 | 0.008 | 0.008 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.1505 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0085 | 0.0386 | 0.0308 |
Echinococcus multilocularis | adenosine deaminase | 0.0085 | 0.0386 | 0.0386 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0085 | 0.0386 | 0.0386 |
Plasmodium falciparum | adenosylhomocysteinase | 0.1505 | 1 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0039 | 0.008 | 0.008 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0199 | 0.0199 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.1505 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.0085 | 0.0386 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0039 | 0.008 | 0.008 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0085 | 0.0386 | 0.0308 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0039 | 0.008 | 0.008 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0931 | 0.6117 | 0.6117 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0199 | 0.0199 |
Echinococcus granulosus | expressed protein | 0.004 | 0.0087 | 0.0087 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.1505 | 1 | 1 |
Echinococcus granulosus | adenosylhomocysteinase | 0.1505 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0085 | 0.0386 | 0.0386 |
Echinococcus granulosus | adenosine deaminase | 0.0085 | 0.0386 | 0.0386 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0931 | 0.6117 | 0.6117 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0386 | 0.0386 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.1505 | 1 | 1 |
Trichomonas vaginalis | rotamase, putative | 0.004 | 0.0087 | 0.0006 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0085 | 0.0386 | 0.0386 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0931 | 0.6117 | 0.6117 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0.0087 | 0.0006 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0085 | 0.0386 | 0.0386 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0085 | 0.0386 | 1 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.1505 | 1 | 1 |
Brugia malayi | Adenosine/AMP deaminase family protein | 0.0085 | 0.0386 | 0.0386 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0039 | 0.008 | 0.008 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0472 | 0.3011 | 0.2955 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.1505 | 1 | 1 |
Leishmania major | adenine aminohydrolase | 0.0085 | 0.0386 | 0.0386 |
Schistosoma mansoni | adenosylhomocysteinase | 0.1505 | 1 | 1 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.1505 | 1 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.1505 | 1 | 1 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.1505 | 1 | 1 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.1505 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0931 | 0.6117 | 0.6117 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.1505 | 1 | 1 |
Schistosoma mansoni | rotamase | 0.004 | 0.0087 | 0.0087 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.1505 | 1 | 1 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.004 | 0.0087 | 0.0087 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0199 | 0.0199 |
Schistosoma mansoni | adenosine deaminase | 0.0085 | 0.0386 | 0.0386 |
Echinococcus multilocularis | expressed protein | 0.004 | 0.0087 | 0.0087 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0039 | 0.008 | 0.008 |
Plasmodium falciparum | adenosine deaminase | 0.0085 | 0.0386 | 0.0386 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.1505 | 1 | 1 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.1505 | 1 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.1505 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0199 | 0.0199 |
Schistosoma mansoni | adenosine deaminase-related | 0.0085 | 0.0386 | 0.0386 |
Plasmodium vivax | adenosine deaminase, putative | 0.0085 | 0.0386 | 0.0386 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.9811 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.