Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear hormone receptor | 0.2127 | 0.837 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2002 | 0.7806 | 0.9325 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.2268 | 0.9003 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.2349 | 0.9367 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.249 | 1 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.2127 | 0.837 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 79 % | Binding affinity to dopamine D4 receptor in Wistar rat brain slices assessed as nonspecific binding at 5 nmol/L measured after 30 mins by In vitro autoradiography presence of nonradioactive ligand | ChEMBL. | 22039961 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.