Detailed information for compound 1578002

Basic information

Technical information
  • TDR Targets ID: 1578002
  • Name: 4-[4-(4-hydroxyphenyl)hexan-3-yl]benzene-1,2- diol
  • MW: 286.365 | Formula: C18H22O3
  • H donors: 3 H acceptors: 3 LogP: 4.81 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(C(c1ccc(cc1)O)CC)c1ccc(c(c1)O)O
  • InChi: 1S/C18H22O3/c1-3-15(12-5-8-14(19)9-6-12)16(4-2)13-7-10-17(20)18(21)11-13/h5-11,15-16,19-21H,3-4H2,1-2H3
  • InChiKey: KWYPVFQNTRXTSH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[1-ethyl-2-(4-hydroxyphenyl)butyl]benzene-1,2-diol
  • 4-[1-ethyl-2-(4-hydroxyphenyl)butyl]pyrocatechol
  • NSC32653

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica protein kinase, putative 0.0147 0.1676 0.4389
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0048 0.006
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0048 0.0268
Echinococcus granulosus RNA directed DNA polymerase 0.0238 0.3038 0.3782
Echinococcus granulosus protein kinase c epsilon type 0.0571 0.8032 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.1424 0.4579
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0327 0.0407
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1633 0.1633
Brugia malayi Ras association domain family 1 isoform A 0.0134 0.1475 0.1837
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.1676 0.2086
Schistosoma mansoni diacylglycerol kinase theta 0.0134 0.1475 0.1837
Loa Loa (eye worm) hypothetical protein 0.0378 0.5147 0.5147
Toxoplasma gondii ABC1 family protein 0.0038 0.0034 0.0201
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0327 0.4438
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0694 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0134 0.1475 0.1837
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0034 0.0187
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.1642 0.5297
Brugia malayi MH2 domain containing protein 0.0144 0.1633 0.2033
Echinococcus granulosus protein kinase c eta type 0.0134 0.1475 0.1837
Trichomonas vaginalis AGC family protein kinase 0.0155 0.1799 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0134 0.1475 0.1837
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0034 0.0187
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0034 0.0042
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0272 0.0339
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0048 0.0268
Loa Loa (eye worm) hypothetical protein 0.0555 0.7795 0.7795
Echinococcus multilocularis expressed protein 0.0451 0.6232 0.7758
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0694 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0327 0.0965
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0147 0.1676 0.2086
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.1642 0.5297
Schistosoma mansoni serine/threonine protein kinase 0.0138 0.1537 0.1913
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0082 0.0694 1
Schistosoma mansoni protein kinase C mu 0.0134 0.1475 0.1837
Schistosoma mansoni serine/threonine protein kinase 0.0531 0.7438 0.926
Brugia malayi Thioredoxin reductase 0.0057 0.0327 0.0407
Loa Loa (eye worm) hypothetical protein 0.0387 0.5271 0.5271
Echinococcus granulosus raf serine:threonine protein kinase 0.0134 0.1475 0.1837
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.0272 0.0786
Brugia malayi glutathione reductase 0.0057 0.0327 0.0407
Leishmania major trypanothione reductase 0.0057 0.0327 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.1475 0.1475
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0327 0.0327
Plasmodium vivax glutathione reductase, putative 0.0057 0.0327 0.4438
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0048 0.0126
Echinococcus multilocularis protein kinase c eta type 0.0134 0.1475 0.1837
Loa Loa (eye worm) AGC/PKN protein kinase 0.0147 0.1676 0.1676
Echinococcus multilocularis protein kinase c epsilon type 0.0571 0.8032 1
Schistosoma mansoni unc-13 (munc13) 0.0146 0.1665 0.2073
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0147 0.1676 0.2086
Echinococcus granulosus protein kinase C gamma type 0.0397 0.5433 0.6763
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.1424 0.4579
Schistosoma mansoni alpha-glucosidase 0.0137 0.1525 0.1899
Echinococcus multilocularis myotubularin protein 13 0.0142 0.1599 0.1991
Brugia malayi protein kinase C II. 0.0571 0.8032 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0327 0.0407
Toxoplasma gondii AGC kinase 0.0147 0.1676 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0147 0.1676 0.1676
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.1424 0.8644
Trichomonas vaginalis AGC family protein kinase 0.0155 0.1799 1
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0146 0.1665 0.2073
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.1676 0.2086
Schistosoma mansoni atypical protein kinase C 0.0459 0.635 0.7905
Loa Loa (eye worm) hypothetical protein 0.0555 0.7795 0.7795
Loa Loa (eye worm) hypothetical protein 0.0038 0.0034 0.0034
Echinococcus multilocularis N chimaerin 0.0134 0.1475 0.1837
Trichomonas vaginalis AGC family protein kinase 0.0155 0.1799 1
Onchocerca volvulus 0.0387 0.5271 0.6748
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.1858 0.2313
Entamoeba histolytica protein kinase, putative 0.0147 0.1676 0.4389
Schistosoma mansoni hypothetical protein 0.0205 0.254 0.3162
Loa Loa (eye worm) hypothetical protein 0.0245 0.3142 0.3142
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0138 0.1537 0.1913
Schistosoma mansoni protein kinase C 0.0146 0.1665 0.2073
Schistosoma mansoni serine/threonine protein kinase 0.0138 0.1537 0.1913
Loa Loa (eye worm) hypothetical protein 0.0038 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0038 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0134 0.1475 0.1475
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0373 0.0373
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0255 0.3288 0.3288
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0138 0.1537 0.1913
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0147 0.1676 0.1676
Schistosoma mansoni diacylglycerol kinase theta 0.0134 0.1475 0.1837
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0571 0.8032 0.8032
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0694 0.4142
Loa Loa (eye worm) inositol-1 0.0039 0.0048 0.0048
Toxoplasma gondii diacylglycerol kinase, putative 0.0134 0.1475 0.8805
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.0694 1
Echinococcus multilocularis geminin 0.0205 0.254 0.3162
Loa Loa (eye worm) hypothetical protein 0.006 0.0373 0.0373
Entamoeba histolytica diacylglycerol kinase, putative 0.0134 0.1475 0.3865
Trypanosoma brucei rac serine-threonine kinase, putative 0.0155 0.1799 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0282 0.3694 0.4599
Schistosoma mansoni rac gtpase activating protein 0.0134 0.1475 0.1837
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0531 0.7438 0.926
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.0694 0.5
Loa Loa (eye worm) raf kinase 0.0134 0.1475 0.1475
Trichomonas vaginalis AGC family protein kinase 0.0155 0.1799 1
Brugia malayi RhoGAP domain containing protein 0.0134 0.1475 0.1837
Loa Loa (eye worm) hypothetical protein 0.0082 0.0694 0.0694
Entamoeba histolytica hypothetical protein 0.0134 0.1475 0.3865
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.1475 0.1837
Brugia malayi beta-lactamase family protein 0.0038 0.0034 0.0042
Schistosoma mansoni vav2 0.0142 0.1599 0.1991
Echinococcus granulosus protein kinase c iota type 0.0446 0.6167 0.7678
Schistosoma mansoni unc-13 (munc13) 0.0146 0.1665 0.2073
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0147 0.1676 0.2086
Echinococcus multilocularis Rac GTPase activating protein 1 0.0134 0.1475 0.1837
Brugia malayi beta-lactamase family protein 0.0038 0.0034 0.0042
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0034 0.0034
Schistosoma mansoni protein kinase C mu 0.0383 0.5208 0.6484
Brugia malayi Protein kinase domain containing protein 0.0138 0.1537 0.1913
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0147 0.1676 0.2086
Brugia malayi diacylglycerol kinase 0.0134 0.1475 0.1837
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0383 0.5208 0.6484
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.1858 0.1858
Loa Loa (eye worm) hypothetical protein 0.0134 0.1475 0.1475
Onchocerca volvulus 0.0245 0.3142 0.4005
Trichomonas vaginalis AGC family protein kinase 0.0147 0.1676 0.9312
Schistosoma mansoni hypothetical protein 0.0041 0.0088 0.0109
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0048 0.0268
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0134 0.1475 0.1837
Leishmania major hypothetical protein, conserved 0.0038 0.0034 0.1032
Echinococcus multilocularis RNA directed DNA polymerase 0.0238 0.3038 0.3782
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0082 0.0694 0.0864
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.0272 0.0786
Loa Loa (eye worm) hypothetical protein 0.0041 0.0088 0.0088
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0147 0.1676 0.1676
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.1642 0.5297
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.1642 1
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0134 0.1475 0.1837
Schistosoma mansoni serine/threonine protein kinase 0.0531 0.7438 0.926
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.1858 0.2313
Echinococcus granulosus myotubularin protein 13 0.0142 0.1599 0.1991
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0048 0.1478
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0143 0.1614 0.8972
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0034 0.0187
Loa Loa (eye worm) beta-lactamase 0.0038 0.0034 0.0034
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0048 0.0221
Brugia malayi Probable ClpP-like protease 0.0082 0.0694 0.0864
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0048 0.0268
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0134 0.1475 0.1475
Brugia malayi RhoGEF domain containing protein 0.0134 0.1475 0.1837
Brugia malayi Protein kinase domain containing protein 0.0147 0.1676 0.2086
Entamoeba histolytica PH domain containing protein kinase, putative 0.029 0.3817 1
Entamoeba histolytica protein kinase, putative 0.0155 0.1799 0.4714
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.1676 0.2086
Brugia malayi Protein kinase domain containing protein 0.0147 0.1676 0.2086
Loa Loa (eye worm) RasGEF domain-containing protein 0.0134 0.1475 0.1475
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.1676 0.2086
Schistosoma mansoni peptidase Clp (S14 family) 0.0082 0.0694 0.0864
Echinococcus multilocularis protein kinase c iota type 0.0446 0.6167 0.7678
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0373 0.0465
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0034 0.0042
Schistosoma mansoni serine/threonine kinase 0.0147 0.1676 0.2086
Trichomonas vaginalis AGC family protein kinase 0.0147 0.1676 0.9312
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0316 0.4205 0.4205
Brugia malayi Protein kinase domain containing protein 0.0155 0.1799 0.224
Echinococcus granulosus geminin 0.0205 0.254 0.3162
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.307 1
Echinococcus granulosus Rac GTPase activating protein 1 0.0134 0.1475 0.1837
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0694 1
Trypanosoma brucei trypanothione reductase 0.0057 0.0327 0.1816
Loa Loa (eye worm) hypothetical protein 0.0146 0.1665 0.1665
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0383 0.5208 0.5208
Schistosoma mansoni inositol monophosphatase 0.0039 0.0048 0.006
Brugia malayi diacylglycerol kinase 0.0134 0.1475 0.1837
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0272 0.0339
Trichomonas vaginalis AGC family protein kinase 0.0155 0.1799 1
Echinococcus multilocularis serine threonine protein kinase 0.0397 0.5433 0.6763
Onchocerca volvulus 0.0146 0.1665 0.2102
Onchocerca volvulus 0.0092 0.0851 0.1053
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0034 0.0187
Echinococcus granulosus Diacylglycerol kinase theta 0.0134 0.1475 0.1837
Entamoeba histolytica protein kinase, putative 0.0155 0.1799 0.4714
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0694 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0034 0.0042
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0147 0.1676 0.2086
Loa Loa (eye worm) hypothetical protein 0.0134 0.1475 0.1475
Schistosoma mansoni inositol monophosphatase 0.0039 0.0048 0.006
Echinococcus multilocularis raf serine:threonine protein kinase 0.0134 0.1475 0.1837
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.1858 0.2313
Loa Loa (eye worm) hypothetical protein 0.0038 0.0034 0.0034
Brugia malayi Pleckstrin Homology Domain 0.0142 0.1599 0.1991
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0048 0.006
Loa Loa (eye worm) hypothetical protein 0.0689 0.98 0.98
Schistosoma mansoni alpha-glucosidase 0.0137 0.1525 0.1899
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0373 0.0465
Toxoplasma gondii thioredoxin reductase 0.0057 0.0327 0.195
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0034 0.0187
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0134 0.1475 0.1475
Echinococcus multilocularis serine:threonine protein kinase N2 0.0425 0.5838 0.7268
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0249 0.3203 0.3203
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.0694 0.5
Brugia malayi Inositol-1 0.0039 0.0048 0.006
Brugia malayi RhoGAP domain containing protein 0.0134 0.1475 0.1837
Echinococcus granulosus NDR protein kinase 0.0147 0.1676 0.2086
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0082 0.0694 0.4106
Echinococcus granulosus unc 13 munc13 0.0146 0.1665 0.2073
Trichomonas vaginalis esterase, putative 0.0038 0.0034 0.0187
Trichomonas vaginalis AGC family protein kinase 0.0155 0.1799 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.1424 0.4579
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0147 0.1676 0.1676
Echinococcus multilocularis Diacylglycerol kinase theta 0.0134 0.1475 0.1837
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0048 0.1478
Brugia malayi C1-like domain containing protein 0.0383 0.5208 0.6484
Loa Loa (eye worm) AGC/AKT protein kinase 0.0155 0.1799 0.1799
Echinococcus multilocularis serine:threonine protein kinase N2 0.0147 0.1676 0.2086
Brugia malayi Variant SH3 domain containing protein 0.0134 0.1475 0.1837
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0147 0.1676 0.2086
Echinococcus granulosus Protein kinase C brain isozyme 0.0531 0.7438 0.926
Loa Loa (eye worm) hypothetical protein 0.0134 0.1475 0.1475
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1633 0.1633
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0034 0.1032
Schistosoma mansoni hypothetical protein 0.0205 0.254 0.3162
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0088 0.0109
Brugia malayi Hr1 repeat family protein 0.0147 0.1676 0.2086
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0082 0.0694 0.0864
Brugia malayi Protein kinase c protein 2 0.0388 0.5294 0.659
Echinococcus granulosus serine:threonine protein kinase N2 0.0147 0.1676 0.2086
Loa Loa (eye worm) hypothetical protein 0.0372 0.5043 0.5043
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.1424 0.4579
Brugia malayi p70 ribosomal S6 kinase beta 0.0147 0.1676 0.2086
Echinococcus granulosus N chimaerin 0.0134 0.1475 0.1837
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0694 0.4142
Loa Loa (eye worm) hypothetical protein 0.0555 0.7795 0.7795
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0238 0.3038 0.3782
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0034 0.0187
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0146 0.1665 0.2073
Entamoeba histolytica diacylglycerol kinase, putative 0.0134 0.1475 0.3865
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0048 0.1478
Trichomonas vaginalis AGC family protein kinase 0.0155 0.1799 1
Brugia malayi protein kinase C3,putative 0.0304 0.4023 0.5008
Echinococcus granulosus expressed protein 0.0451 0.6232 0.7758
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0048 0.0288
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.1424 0.4579
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.1858 0.2313
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0034 0.0042
Trichomonas vaginalis AGC family protein kinase 0.0147 0.1676 0.9312
Mycobacterium tuberculosis Probable reductase 0.013 0.1424 0.4579
Trichomonas vaginalis AGC family protein kinase 0.0155 0.1799 1
Echinococcus multilocularis unc 13 (munc13) 0.0146 0.1665 0.2073
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.0272 0.1484
Onchocerca volvulus 0.0378 0.5147 0.6589
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0034 0.0042
Onchocerca volvulus 0.0555 0.7795 1
Echinococcus multilocularis serine:threonine protein kinase 38 0.0147 0.1676 0.2086
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0034 0.1032
Loa Loa (eye worm) hypothetical protein 0.0038 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0134 0.1475 0.1837
Schistosoma mansoni serine/threonine protein kinase 0.0571 0.8032 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0034 0.0034
Loa Loa (eye worm) glutathione reductase 0.0057 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.0134 0.1475 0.1475
Brugia malayi beta-lactamase 0.0038 0.0034 0.0042
Loa Loa (eye worm) hypothetical protein 0.0245 0.3142 0.3142
Loa Loa (eye worm) hypothetical protein 0.0142 0.1599 0.1599
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0327 1
Loa Loa (eye worm) hypothetical protein 0.0238 0.3038 0.3038
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0134 0.1475 0.1475
Loa Loa (eye worm) AGC/NDR protein kinase 0.0147 0.1676 0.1676

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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