Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | aldose reductase, putative | 0.0038 | 0.0228 | 0.0718 |
Toxoplasma gondii | aldose reductase, putative | 0.0038 | 0.0228 | 0.0121 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0145 | 0.1261 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.1048 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0133 | 0.1148 | 0.1052 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0129 | 0.1102 | 0.1005 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0066 | 0.0501 | 0.2348 |
Echinococcus multilocularis | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0129 | 0.1102 | 0.1005 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0038 | 0.0228 | 0.0228 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.0228 | 0.0121 |
Echinococcus multilocularis | serine:threonine protein kinase:endoribonuclease | 0.0067 | 0.0503 | 0.04 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1048 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1048 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1048 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.1048 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.1048 | 1 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0061 | 0.0444 | 0.0339 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0038 | 0.0228 | 0.0228 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0038 | 0.0228 | 0.0121 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0038 | 0.0228 | 0.0121 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0133 | 0.1148 | 0.1052 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase, putative | 0.0061 | 0.0444 | 0.0339 |
Entamoeba histolytica | protein kinase, putative | 0.0067 | 0.0503 | 0.2366 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0038 | 0.0228 | 0.0228 |
Brugia malayi | GMP reductase | 0.0064 | 0.0478 | 0.0373 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0096 | 0.0785 | 0.0785 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0038 | 0.0228 | 0.0121 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.0228 | 0.0121 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.0228 | 0.0121 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.0945 | 0.9002 | 0.8991 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0198 | 0.1779 | 0.169 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0133 | 0.1148 | 0.1052 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.0228 | 0.0121 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0038 | 0.0228 | 0.0228 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0158 | 0.1387 | 0.7652 |
Brugia malayi | Stress-activated protein kinase jnk-1 | 0.0945 | 0.9002 | 0.8991 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.0228 | 0.0121 |
Trichomonas vaginalis | serine threonine-protein kinase, putative | 0.0055 | 0.0386 | 0.0386 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0136 | 0.1178 | 0.1178 |
Giardia lamblia | Aldose reductase | 0.0038 | 0.0228 | 0.0228 |
Echinococcus multilocularis | aldo keto reductase | 0.0038 | 0.0228 | 0.0121 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0945 | 0.9002 | 0.8991 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0145 | 0.1261 | 0.921 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0198 | 0.1779 | 0.169 |
Mycobacterium leprae | PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) | 0.0073 | 0.0566 | 0.3625 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0073 | 0.0566 | 0.3015 |
Echinococcus granulosus | phosphatidylinositol 45 bisphosphate 3 kinase | 0.0373 | 0.3472 | 0.3401 |
Giardia lamblia | Aldose reductase | 0.0038 | 0.0228 | 0.0228 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.1048 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.1048 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0038 | 0.0228 | 0.0121 |
Loa Loa (eye worm) | oxidoreductase | 0.0038 | 0.0228 | 0.0121 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.1048 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.1048 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.1048 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.0228 | 0.0121 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0133 | 0.1148 | 0.1052 |
Loa Loa (eye worm) | oxidoreductase | 0.0038 | 0.0228 | 0.0121 |
Echinococcus granulosus | aldo keto reductase | 0.0038 | 0.0228 | 0.0121 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0154 | 0.1349 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0154 | 0.1349 | 0.1255 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0175 | 0.155 | 0.1458 |
Trypanosoma cruzi | GMP reductase | 0.0154 | 0.1349 | 0.1255 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0154 | 0.1349 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0228 | 0.0121 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1048 | 1 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0154 | 0.1349 | 0.1255 |
Entamoeba histolytica | aldose reductase, putative | 0.0038 | 0.0228 | 0.0718 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0026 | 0.0108 | 0.0108 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.1048 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.0228 | 0.0121 |
Loa Loa (eye worm) | IRE protein kinase | 0.0067 | 0.0503 | 0.04 |
Echinococcus granulosus | aldo keto reductase | 0.0038 | 0.0228 | 0.0121 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0154 | 0.1349 | 0.1255 |
Echinococcus granulosus | hypothetical protein | 0.0038 | 0.0228 | 0.0121 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.0228 | 0.0121 |
Trypanosoma brucei | prostaglandin f synthase | 0.0038 | 0.0228 | 0.0121 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0133 | 0.1148 | 0.1052 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0373 | 0.3472 | 0.3401 |
Entamoeba histolytica | hypothetical protein | 0.0158 | 0.1387 | 0.7652 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0038 | 0.0228 | 0.0228 |
Schistosoma mansoni | pol-related | 0.0038 | 0.0228 | 0.0121 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0136 | 0.1178 | 0.1178 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0133 | 0.1148 | 0.1052 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0038 | 0.0228 | 0.0228 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0081 | 0.0641 | 0.4233 |
Trypanosoma cruzi | GMP reductase | 0.0154 | 0.1349 | 0.1255 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0133 | 0.1148 | 0.1052 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1048 | 1 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0154 | 0.1349 | 0.1255 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.0228 | 0.0121 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0038 | 0.0228 | 0.0228 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.1102 | 0.1005 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0333 | 0.3079 | 0.3004 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.0228 | 0.0121 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0154 | 0.1349 | 0.1255 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0154 | 0.1349 | 0.1255 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0066 | 0.0501 | 0.0397 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0535 | 0.0431 |
Giardia lamblia | Phosphoinositide-3-kinase, class 3 | 0.0046 | 0.0307 | 0.0307 |
Entamoeba histolytica | protein kinase, putative | 0.0067 | 0.0503 | 0.2366 |
Echinococcus multilocularis | aldo keto reductase | 0.0038 | 0.0228 | 0.0121 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0198 | 0.1779 | 0.1779 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0038 | 0.0228 | 0.0228 |
Loa Loa (eye worm) | GMP reductase | 0.0064 | 0.0478 | 0.0373 |
Trypanosoma cruzi | aldo-keto reductase | 0.0038 | 0.0228 | 0.0121 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0154 | 0.1349 | 0.1255 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0038 | 0.0228 | 0.0228 |
Entamoeba histolytica | aldose reductase, putative | 0.0038 | 0.0228 | 0.0718 |
Loa Loa (eye worm) | oxidoreductase | 0.0038 | 0.0228 | 0.0121 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1048 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.0228 | 0.0121 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0038 | 0.0228 | 0.0228 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.0228 | 0.0121 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0038 | 0.0228 | 0.0228 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0193 | 0.1722 | 0.966 |
Echinococcus multilocularis | aldehyde reductase | 0.0027 | 0.0121 | 0.0013 |
Echinococcus granulosus | serine:threonine protein kinase:endoribonuclease | 0.0067 | 0.0503 | 0.04 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0055 | 0.0386 | 0.0386 |
Brugia malayi | Ribonuclease 2-5A family protein | 0.0067 | 0.0503 | 0.04 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0066 | 0.0501 | 0.0501 |
Leishmania major | prostaglandin f synthase, putative | 0.0038 | 0.0228 | 0.0121 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0066 | 0.0501 | 0.0397 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0038 | 0.0228 | 0.0228 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0066 | 0.0501 | 0.0501 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.0228 | 0.0121 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0064 | 0.0478 | 0.0373 |
Schistosoma mansoni | aldo-keto reductase | 0.0038 | 0.0228 | 0.0121 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.0228 | 0.0121 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0198 | 0.1779 | 0.169 |
Toxoplasma gondii | IMP dehydrogenas | 0.0154 | 0.1349 | 0.1255 |
Leishmania major | aldo-keto reductase-like protein | 0.0038 | 0.0228 | 0.0121 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1048 | 1 | 1 |
Echinococcus granulosus | aldehyde reductase | 0.0027 | 0.0121 | 0.0013 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0133 | 0.1148 | 0.1052 |
Loa Loa (eye worm) | oxidoreductase | 0.0038 | 0.0228 | 0.0121 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0088 | 0.071 | 0.3601 |
Giardia lamblia | Kinase, CMGC MAPK | 0.1048 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0038 | 0.0228 | 0.0228 |
Echinococcus granulosus | aldo keto reductase | 0.0038 | 0.0228 | 0.0121 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0133 | 0.1148 | 0.1052 |
Echinococcus granulosus | mitogen activated protein kinase | 0.1048 | 1 | 1 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0133 | 0.1148 | 0.1052 |
Leishmania major | guanosine monophosphate reductase | 0.0154 | 0.1349 | 0.1255 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0066 | 0.0501 | 0.2348 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0154 | 0.1349 | 1 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0066 | 0.0501 | 0.0397 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0038 | 0.0228 | 0.0121 |
Brugia malayi | P38 map kinase family protein 2 | 0.0133 | 0.1148 | 0.1052 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.0373 | 0.3472 | 0.3401 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.0228 | 0.0121 |
Echinococcus granulosus | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0129 | 0.1102 | 0.1005 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.0228 | 0.0121 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0064 | 0.0478 | 0.0373 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0145 | 0.1261 | 1 |
Trypanosoma brucei | GMP reductase | 0.0154 | 0.1349 | 0.1255 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0038 | 0.0228 | 0.0873 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.1048 | 1 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0066 | 0.0501 | 0.0501 |
Schistosoma mansoni | aldo-keto reductase | 0.0038 | 0.0228 | 0.0121 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0038 | 0.0228 | 0.0228 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0038 | 0.0228 | 0.0228 |
Onchocerca volvulus | Putative GMP reductase | 0.0064 | 0.0478 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0038 | 0.0228 | 0.0228 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0133 | 0.1148 | 0.1052 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0081 | 0.0641 | 0.3681 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | 0.0945 | 0.9002 | 0.8991 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0038 | 0.0228 | 0.0121 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.0228 | 0.0121 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0038 | 0.0228 | 0.0121 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0038 | 0.0228 | 0.0121 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0198 | 0.1779 | 0.1779 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0026 | 0.0108 | 0.0108 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0198 | 0.1779 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0038 | 0.0228 | 0.0121 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0154 | 0.1349 | 0.1255 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0038 | 0.0228 | 0.0228 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0154 | 0.1349 | 0.1255 |
Echinococcus multilocularis | aldo keto reductase | 0.0038 | 0.0228 | 0.0121 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0067 | 0.0503 | 0.04 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0038 | 0.0228 | 0.0121 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.0228 | 0.0121 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0038 | 0.0228 | 0.0121 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0038 | 0.0228 | 0.0228 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.1048 | 1 | 1 |
Trichomonas vaginalis | phosphatidylinositol 4-kinase, putative | 0.0026 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | oxidoreductase | 0.0038 | 0.0228 | 0.0121 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0066 | 0.0501 | 0.0397 |
Echinococcus granulosus | c-Jun N-terminal kinases | 0.0945 | 0.9002 | 0.8991 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0198 | 0.1779 | 0.1779 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0154 | 0.1349 | 0.1255 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0154 | 0.1349 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 460 uM | Inhibitory concentration of the compound against aldose reductase obtained from rat lens | ChEMBL. | 2491890 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.