Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peroxisome proliferator-activated receptor alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma japonicum | IPR008946,Nuclear receptor, ligand-binding,domain-containing | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma japonicum | ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | peroxisome proliferator-activated receptor alpha | 468 aa | 397 aa | 25.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carboxylesterase 5A | 0.0362 | 0.8319 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0362 | 0.8319 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0362 | 0.8319 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0061 | 0 | 0.5 |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0362 | 0.8319 | 0.8319 |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0362 | 0.8319 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.8319 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0362 | 0.8319 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.8319 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0362 | 0.8319 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0061 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0362 | 0.8319 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0362 | 0.8319 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0061 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0362 | 0.8319 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0362 | 0.8319 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0061 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0061 | 0 | 0.5 |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0061 | 0 | 0.5 |
Onchocerca volvulus | 0.0061 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 14.3 uM | Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assay | ChEMBL. | 19791744 |
FC (functional) | = 1.6 | Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at 150 uM by luciferase reporter gene assay relative to control | ChEMBL. | 19791744 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.