Detailed information for compound 1578224

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 370.467 | Formula: C14H14N2O4S3
  • H donors: 1 H acceptors: 4 LogP: 3.18 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)S1=NS(=O)(=O)c2c1cc(cc2)S(=O)(=O)N
  • InChi: 1S/C14H14N2O4S3/c1-2-10-3-5-11(6-4-10)21-13-9-12(22(15,17)18)7-8-14(13)23(19,20)16-21/h3-9H,2H2,1H3,(H2,15,17,18)
  • InChiKey: AEIGNYASJQDSDA-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0196 0.8679 0.5
Loa Loa (eye worm) hypothetical protein 0.0196 0.8679 0.8679
Schistosoma mansoni short chain dehydrogenase 0.0196 0.8679 1
Brugia malayi Retinol dehydrogenase 12 0.0196 0.8679 0.8679
Mycobacterium ulcerans short-chain dehydrogenase 0.0196 0.8679 0.5
Loa Loa (eye worm) hypothetical protein 0.0196 0.8679 0.8679
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0196 0.8679 0.8679
Loa Loa (eye worm) oxidoreductase 0.0196 0.8679 0.8679
Leishmania major 3-keto-dihydrosphingosine reductase 0.0196 0.8679 0.5
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0421 0.0485
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0196 0.8679 0.8679
Echinococcus granulosus carbonyl reductase 1 0.0196 0.8679 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0421 0.0421
Onchocerca volvulus 0.0196 0.8679 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0017 0.0421 0.0421
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0196 0.8679 1
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0421 0.0485
Leishmania major hypothetical protein, conserved 0.0196 0.8679 0.5
Echinococcus granulosus WW domain containing oxidoreductase 0.0196 0.8679 1
Loa Loa (eye worm) hypothetical protein 0.0196 0.8679 0.8679
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0196 0.8679 1
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0196 0.8679 1
Entamoeba histolytica hypothetical protein, conserved 0.0196 0.8679 1
Mycobacterium ulcerans short chain dehydrogenase 0.0196 0.8679 0.5
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0017 0.0421 0.0485
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0196 0.8679 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0196 0.8679 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.0045 0.0045
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0196 0.8679 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0421 0.0421
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0196 0.8679 0.5
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0196 0.8679 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0196 0.8679 0.8679
Trichomonas vaginalis steroid dehydrogenase, putative 0.0196 0.8679 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.6155 0.7092
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0196 0.8679 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0017 0.0421 0.0421
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0017 0.0421 0.0485
Schistosoma mansoni short chain dehydrogenase 0.0196 0.8679 1
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0196 0.8679 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0196 0.8679 0.5
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0196 0.8679 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.5972 0.6881
Mycobacterium ulcerans short chain dehydrogenase 0.0196 0.8679 0.5
Loa Loa (eye worm) hypothetical protein 0.0196 0.8679 0.8679
Onchocerca volvulus 0.0064 0.2579 0.2971
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0196 0.8679 1
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0196 0.8679 0.8679
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0196 0.8679 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0017 0.0421 0.0421
Mycobacterium ulcerans short-chain type oxidoreductase 0.0196 0.8679 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0196 0.8679 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0196 0.8679 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0017 0.0421 0.0421
Schistosoma mansoni steroid hormone receptor ad4bp 0.0017 0.0421 0.0485
Schistosoma mansoni jun-related protein 0.0066 0.2682 0.309
Mycobacterium ulcerans short chain dehydrogenase 0.0196 0.8679 0.5
Schistosoma mansoni carbonyl reductase 0.0196 0.8679 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0196 0.8679 0.8679
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0196 0.8679 0.8679
Mycobacterium ulcerans short chain dehydrogenase 0.0196 0.8679 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0196 0.8679 0.8679
Leishmania major hypothetical protein, conserved 0.0196 0.8679 0.5
Loa Loa (eye worm) dehydrogenase 0.0196 0.8679 0.8679
Onchocerca volvulus 0.0196 0.8679 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0196 0.8679 0.8679
Echinococcus multilocularis retinol dehydrogenase 11 0.0196 0.8679 1
Echinococcus granulosus retinol dehydrogenase 11 0.0196 0.8679 1
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0196 0.8679 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0196 0.8679 1
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.4997 0.4997
Echinococcus multilocularis carbonyl reductase 1 0.0196 0.8679 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0421 0.0421
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0196 0.8679 0.5
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0196 0.8679 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0196 0.8679 1
Brugia malayi Dehydrogenases, short chain protein 2 0.0196 0.8679 0.8679
Entamoeba histolytica hypothetical protein 0.0196 0.8679 1
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0196 0.8679 0.5
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0196 0.8679 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0421 0.0485
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0196 0.8679 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0196 0.8679 0.5
Leishmania major hypothetical protein, conserved 0.0196 0.8679 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0017 0.0421 0.0421
Giardia lamblia Short-chain dehydrogenase, putative 0.0196 0.8679 1
Schistosoma mansoni coup transcription factor 0.0017 0.0421 0.0485
Loa Loa (eye worm) hypothetical protein 0.0196 0.8679 0.8679
Echinococcus multilocularis carbonyl reductase 1 0.0196 0.8679 1
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0196 0.8679 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0017 0.0421 0.0485
Mycobacterium tuberculosis Probable oxidoreductase 0.0196 0.8679 0.5
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0196 0.8679 1
Trypanosoma cruzi short chain dehydrogenase, putative 0.0196 0.8679 0.5
Echinococcus granulosus FTZ F1 alpha 0.0017 0.0421 0.0485
Leishmania major pteridine reductase 1 0.0196 0.8679 0.5
Echinococcus multilocularis thyroid hormone receptor alpha 0.0017 0.0421 0.0485
Trypanosoma cruzi hypothetical protein, conserved 0.0196 0.8679 0.5
Brugia malayi dehydrogenases, short chain protein 2 0.0196 0.8679 0.8679
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0009 0.0045 0.0052
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0017 0.0421 0.0421
Loa Loa (eye worm) hypothetical protein 0.0017 0.0421 0.0421
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0421 0.0421
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0082 0.3386 0.3902
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0017 0.0421 0.0485
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0196 0.8679 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0017 0.0421 0.0485
Echinococcus multilocularis jun protein 0.0082 0.3386 0.3902
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0196 0.8679 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0196 0.8679 0.5
Onchocerca volvulus 0.0196 0.8679 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0196 0.8679 0.5
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0009 0.0045 0.0045
Leishmania major hypothetical protein, conserved 0.0196 0.8679 0.5
Mycobacterium leprae Probable oxidoreductase 0.0196 0.8679 0.5
Echinococcus multilocularis retinol dehydrogenase 13 0.0196 0.8679 1
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.6155 0.6155
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0196 0.8679 0.5
Echinococcus granulosus oxidoreductase 0.0196 0.8679 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0045 0.0045
Mycobacterium ulcerans short-chain dehydrogenase 0.0196 0.8679 0.5
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0196 0.8679 0.8679
Echinococcus multilocularis carbonyl reductase 1 0.0196 0.8679 1
Brugia malayi hypothetical protein 0.0064 0.2579 0.2579
Trypanosoma cruzi hypothetical protein, conserved 0.0196 0.8679 0.5
Schistosoma mansoni steroid dehydrogenase 0.0196 0.8679 1
Loa Loa (eye worm) oxidoreductase 0.0196 0.8679 0.8679
Leishmania major short chain dehydrogenase-like protein 0.0196 0.8679 0.5
Echinococcus multilocularis retinol dehydrogenase 11 0.0196 0.8679 1
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0196 0.8679 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0196 0.8679 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0196 0.8679 0.5
Onchocerca volvulus 0.0017 0.0421 0.0485
Schistosoma mansoni steroid dehydrogenase 0.0196 0.8679 1
Mycobacterium ulcerans short chain dehydrogenase 0.0196 0.8679 0.5
Schistosoma mansoni short chain dehydrogenase 0.0196 0.8679 1
Echinococcus granulosus ecdysone induced protein 78C 0.0017 0.0421 0.0485
Loa Loa (eye worm) hypothetical protein 0.0196 0.8679 0.8679
Mycobacterium tuberculosis Possible oxidoreductase 0.0196 0.8679 0.5
Echinococcus granulosus carbonyl reductase 1 0.0196 0.8679 1
Leishmania major short chain dehydrogenase, putative 0.0196 0.8679 0.5
Brugia malayi ecdysteroid receptor 0.0017 0.0421 0.0421
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0196 0.8679 0.5
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0196 0.8679 1
Trypanosoma cruzi hypothetical protein, conserved 0.0196 0.8679 0.5
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0196 0.8679 1
Entamoeba histolytica hypothetical protein, conserved 0.0196 0.8679 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0045 0.0045
Onchocerca volvulus 0.0196 0.8679 1
Onchocerca volvulus 0.0196 0.8679 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0196 0.8679 0.5
Loa Loa (eye worm) oxidoreductase 0.0196 0.8679 0.8679
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0196 0.8679 0.8679
Toxoplasma gondii carbonyl reductase 1, putative 0.0196 0.8679 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0196 0.8679 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0196 0.8679 1
Mycobacterium ulcerans short chain dehydrogenase 0.0196 0.8679 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0196 0.8679 1
Brugia malayi nuclear receptor RXR 0.0009 0.0045 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0421 0.0421
Echinococcus multilocularis transient receptor potential cation channel 0.0196 0.8679 1
Schistosoma mansoni hypothetical protein 0.0142 0.6182 0.7123
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0196 0.8679 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0196 0.8679 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0421 0.0485
Echinococcus granulosus hypothetical protein 0.0196 0.8679 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0017 0.0421 0.0485
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0196 0.8679 0.5
Schistosoma mansoni steroid dehydrogenase 0.0196 0.8679 1
Echinococcus multilocularis oxidoreductase 0.0196 0.8679 1
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0196 0.8679 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0196 0.8679 0.8679
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0196 0.8679 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0421 0.0421
Leishmania major quinonoid dihydropteridine reductase 0.0196 0.8679 0.5
Loa Loa (eye worm) oxidoreductase 0.0196 0.8679 0.8679
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0196 0.8679 0.5
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0196 0.8679 1
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0017 0.0421 0.0421
Mycobacterium ulcerans oxidoreductase 0.0196 0.8679 0.5
Schistosoma mansoni carbonyl reductase 0.0196 0.8679 1
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0196 0.8679 0.5
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0196 0.8679 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0421 0.0421
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0017 0.0421 0.0421
Trypanosoma cruzi short chain dehydrogenase, putative 0.0196 0.8679 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0196 0.8679 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0196 0.8679 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0196 0.8679 0.5
Brugia malayi bZIP transcription factor family protein 0.0082 0.3386 0.3386
Echinococcus granulosus carbonyl reductase 1 0.0196 0.8679 1
Plasmodium vivax steroid dehydrogenase, putative 0.0196 0.8679 1
Schistosoma mansoni steroid dehydrogenase 0.0196 0.8679 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0196 0.8679 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0196 0.8679 0.5
Leishmania major short chain dehydrogenase/reductase, putative 0.0196 0.8679 0.5
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0421 0.0485
Mycobacterium ulcerans short chain dehydrogenase 0.0196 0.8679 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0196 0.8679 0.5
Leishmania major short chain dehydrogenase/reductase, putative 0.0196 0.8679 0.5
Mycobacterium tuberculosis Probable dehydrogenase 0.0196 0.8679 0.5
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0017 0.0421 0.0485
Brugia malayi oxidoreductase 0.0196 0.8679 0.8679
Brugia malayi hypothetical protein 0.0009 0.0045 0.0045
Schistosoma mansoni short chain dehydrogenase 0.0196 0.8679 1
Loa Loa (eye worm) steroid hormone receptor 0.0017 0.0421 0.0421
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.1545 0.178
Leishmania major quinonoid dihydropteridine reductase 0.0196 0.8679 0.5
Loa Loa (eye worm) oxidoreductase 0.0196 0.8679 0.8679
Mycobacterium ulcerans short chain dehydrogenase 0.0196 0.8679 0.5
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0196 0.8679 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0196 0.8679 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0017 0.0421 0.0421
Schistosoma mansoni steroid dehydrogenase 0.0196 0.8679 1
Giardia lamblia Reductase, putative 0.0196 0.8679 1
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0196 0.8679 1
Leishmania major oxidoreductase-like protein 0.0196 0.8679 0.5
Onchocerca volvulus 0.0196 0.8679 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0196 0.8679 0.5
Onchocerca volvulus Bile acid receptor homolog 0.0017 0.0421 0.0485
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0045 0.0052
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0196 0.8679 0.8679
Schistosoma mansoni steroid dehydrogenase 0.0196 0.8679 1
Schistosoma mansoni retinoic acid receptor RXR 0.0017 0.0421 0.0485
Entamoeba histolytica short chain dehydrogenase family protein 0.0196 0.8679 1
Brugia malayi hypothetical protein 0.0196 0.8679 0.8679
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0196 0.8679 0.5
Schistosoma mansoni hypothetical protein 0.0066 0.2682 0.309
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0017 0.0421 0.0485
Mycobacterium ulcerans short chain dehydrogenase 0.0196 0.8679 0.5
Brugia malayi nuclear receptor NHR-88 0.0017 0.0421 0.0421
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0196 0.8679 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0196 0.8679 0.5
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0196 0.8679 1
Loa Loa (eye worm) oxidoreductase 0.0196 0.8679 0.8679
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0196 0.8679 0.8679
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0196 0.8679 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0421 0.0485
Schistosoma mansoni short chain dehydrogenase 0.0196 0.8679 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0196 0.8679 1
Echinococcus multilocularis steroid dehydrogenase 0.0196 0.8679 1
Brugia malayi Dehydrogenases, short chain protein 30 0.0196 0.8679 0.8679
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0196 0.8679 1
Schistosoma mansoni short chain dehydrogenase 0.0196 0.8679 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0017 0.0421 0.0485
Onchocerca volvulus Sepiapterin reductase homolog 0.0196 0.8679 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0017 0.0421 0.0421
Trypanosoma brucei short-chain dehydrogenase, putative 0.0196 0.8679 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0196 0.8679 1
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0196 0.8679 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0196 0.8679 0.8679
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0196 0.8679 0.5
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0017 0.0421 0.0421
Loa Loa (eye worm) hypothetical protein 0.0196 0.8679 0.8679
Echinococcus multilocularis ecdysone induced protein 78C 0.0017 0.0421 0.0485
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.4997 0.4997
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0196 0.8679 0.5
Mycobacterium ulcerans oxidoreductase 0.0196 0.8679 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0196 0.8679 1
Mycobacterium ulcerans short chain dehydrogenase 0.0196 0.8679 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0196 0.8679 0.5
Brugia malayi Steroid receptor seven-up type 2 0.0017 0.0421 0.0421
Mycobacterium ulcerans short chain dehydrogenase 0.0196 0.8679 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0196 0.8679 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0421 0.0421
Onchocerca volvulus 0.0196 0.8679 1
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0196 0.8679 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0196 0.8679 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0196 0.8679 1
Toxoplasma gondii oxidoreductase, putative 0.0196 0.8679 1
Schistosoma mansoni short chain dehydrogenase 0.0196 0.8679 1
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0196 0.8679 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0082 0.3386 0.3902
Onchocerca volvulus 0.0196 0.8679 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0196 0.8679 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0196 0.8679 0.5
Brugia malayi hypothetical protein 0.0196 0.8679 0.8679
Mycobacterium ulcerans ketoacyl reductase 0.0196 0.8679 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0196 0.8679 0.5
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0196 0.8679 0.5
Schistosoma mansoni retinal dehydrogenase 0.0196 0.8679 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0017 0.0421 0.0421
Onchocerca volvulus 0.0196 0.8679 1
Plasmodium vivax hypothetical protein, conserved 0.0196 0.8679 1
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0196 0.8679 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0196 0.8679 0.5
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0196 0.8679 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0017 0.0421 0.0485
Echinococcus multilocularis carbonyl reductase 1 0.0196 0.8679 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0017 0.0421 0.0485
Brugia malayi steroid hormone receptor 0.0017 0.0421 0.0421
Schistosoma mansoni short chain dehydrogenase 0.0196 0.8679 1
Schistosoma mansoni steroid dehydrogenase 0.0196 0.8679 1
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0421 0.0421
Schistosoma mansoni carbonyl reductase 0.0196 0.8679 1
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0196 0.8679 1
Mycobacterium ulcerans carveol-like dehydrogenase 0.0196 0.8679 0.5
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0196 0.8679 0.5
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0017 0.0421 0.0421
Schistosoma mansoni steroid dehydrogenase 0.0196 0.8679 1
Brugia malayi hypothetical protein 0.0009 0.0045 0.0045
Loa Loa (eye worm) oxidoreductase 0.0196 0.8679 0.8679
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0017 0.0421 0.0421
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0196 0.8679 0.8679
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0196 0.8679 0.8679
Mycobacterium ulcerans short chain dehydrogenase 0.0196 0.8679 0.5
Loa Loa (eye worm) acetyltransferase 0.0142 0.6155 0.6155
Giardia lamblia Hypothetical protein 0.0196 0.8679 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0045 0.0045
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0421 0.0485
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0017 0.0421 0.0421
Mycobacterium ulcerans short chain dehydrogenase 0.0196 0.8679 0.5
Schistosoma mansoni steroid dehydrogenase 0.0196 0.8679 1
Schistosoma mansoni short chain dehydrogenase 0.0196 0.8679 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0196 0.8679 0.8679
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0196 0.8679 0.5
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0196 0.8679 1
Mycobacterium ulcerans dehydrogenase 0.0196 0.8679 0.5
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0196 0.8679 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0196 0.8679 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0196 0.8679 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0196 0.8679 0.8679
Leishmania major short chain dehydrogenase, putative 0.0196 0.8679 0.5
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0196 0.8679 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0196 0.8679 0.8679
Mycobacterium ulcerans short chain dehydrogenase 0.0196 0.8679 0.5
Echinococcus multilocularis steroid dehydrogenase 0.0196 0.8679 1
Schistosoma mansoni RAR-like nuclear receptor 0.0017 0.0421 0.0485
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0009 0.0045 0.0052
Loa Loa (eye worm) hypothetical protein 0.0079 0.3283 0.3283
Toxoplasma gondii oxidoreductase, putative 0.0196 0.8679 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0196 0.8679 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0421 0.0421
Echinococcus multilocularis FTZ F1 alpha 0.0017 0.0421 0.0485
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0196 0.8679 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0196 0.8679 1
Schistosoma mansoni short chain dehydrogenase 0.0196 0.8679 1
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0196 0.8679 1
Loa Loa (eye worm) hypothetical protein 0.0196 0.8679 0.8679
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0196 0.8679 0.5
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0017 0.0421 0.0485
Mycobacterium ulcerans ketoacyl reductase 0.0196 0.8679 0.5
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0017 0.0421 0.0485
Trypanosoma cruzi hypothetical protein, conserved 0.0196 0.8679 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0196 0.8679 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0196 0.8679 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0196 0.8679 0.5
Schistosoma mansoni steroid dehydrogenase 0.0196 0.8679 1
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0196 0.8679 0.5
Brugia malayi photoreceptor-specific nuclear receptor 0.0017 0.0421 0.0421
Echinococcus granulosus retinol dehydrogenase 11 0.0196 0.8679 1
Mycobacterium ulcerans dehydrogenase/reductase 0.0196 0.8679 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0196 0.8679 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0196 0.8679 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0421 0.0485
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0196 0.8679 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0196 0.8679 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0421 0.0421
Trypanosoma brucei oxidoreductase-like protein 0.0196 0.8679 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0196 0.8679 0.5
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0009 0.0045 0.0052
Echinococcus granulosus steroid dehydrogenase 0.0196 0.8679 1
Onchocerca volvulus 0.0196 0.8679 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0017 0.0421 0.0485
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0196 0.8679 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0017 0.0421 0.0485
Echinococcus granulosus hypothetical protein 0.0196 0.8679 1
Loa Loa (eye worm) oxidoreductase 0.0196 0.8679 0.8679
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0196 0.8679 0.5
Onchocerca volvulus 0.0196 0.8679 1
Trypanosoma cruzi hypothetical protein, conserved 0.0196 0.8679 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0196 0.8679 0.8679
Leishmania major hypothetical protein, conserved 0.0196 0.8679 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0196 0.8679 0.5
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0017 0.0421 0.0485
Loa Loa (eye worm) hypothetical protein 0.0017 0.0421 0.0421
Echinococcus multilocularis conserved hypothetical protein 0.0196 0.8679 1
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0196 0.8679 0.5
Brugia malayi dehydrogenases, short chain protein 9 0.0196 0.8679 0.8679
Schistosoma mansoni short chain dehydrogenase 0.0196 0.8679 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0196 0.8679 0.8679
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0196 0.8679 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.0045 0.0045
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.6155 0.7092
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0196 0.8679 0.5
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0196 0.8679 1
Loa Loa (eye worm) hypothetical protein 0.0196 0.8679 0.8679
Brugia malayi nuclear hormone receptor 0.0017 0.0421 0.0421
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0196 0.8679 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0196 0.8679 1
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0196 0.8679 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0196 0.8679 1
Echinococcus granulosus jun protein 0.0082 0.3386 0.3902
Schistosoma mansoni short chain dehydrogenase 0.0196 0.8679 1
Mycobacterium ulcerans short chain dehydrogenase 0.0196 0.8679 0.5
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0196 0.8679 1
Echinococcus granulosus carbonyl reductase 1 0.0196 0.8679 1
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0196 0.8679 0.5
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0196 0.8679 1
Mycobacterium ulcerans short chain dehydrogenase 0.0196 0.8679 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0045 0.0045
Schistosoma mansoni short chain dehydrogenase 0.0196 0.8679 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0196 0.8679 0.5
Leishmania major dehydrogenase-like protein 0.0196 0.8679 0.5
Onchocerca volvulus 0.0196 0.8679 1
Entamoeba histolytica short chain dehydrogenase family protein 0.0196 0.8679 1
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0196 0.8679 1
Loa Loa (eye worm) oxidoreductase 0.0196 0.8679 0.8679
Plasmodium falciparum steroid dehydrogenase, putative 0.0196 0.8679 1
Loa Loa (eye worm) hypothetical protein 0.0196 0.8679 0.8679
Loa Loa (eye worm) dehydrogenase 0.0196 0.8679 0.8679
Schistosoma mansoni short chain dehydrogenase 0.0196 0.8679 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0196 0.8679 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0196 0.8679 0.5
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0196 0.8679 1
Loa Loa (eye worm) hypothetical protein 0.0196 0.8679 0.8679
Schistosoma mansoni short chain dehydrogenase 0.0196 0.8679 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0196 0.8679 0.8679
Onchocerca volvulus 0.0196 0.8679 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0421 0.0421
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0196 0.8679 0.5
Brugia malayi MH2 domain containing protein 0.0117 0.4997 0.4997

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) Inhibition of human recombinant COX2 expressed in Sf21 cells assessed as conversion of arachidonic acid to PGE2 at 10 uM preincubated for 15 mins measured after 5 mins by enzyme immunoassay ChEMBL. 21958737
Inhibition (binding) = 7 % Inhibition of recombinant human 5-LOX in human PBML assessed as inhibition of A23187-induced LTB4 production at 10 uM preincubated for 15 mins measured after 15 mins by enzyme immunoassay ChEMBL. 21958737

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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