Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium tuberculosis | DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | 0.0228 | 0.4266 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0205 | 0.3772 | 0.8836 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0435 | 0.0972 |
Mycobacterium ulcerans | DNA-directed RNA polymerase subunit beta | 0.0496 | 1 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0023 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0023 | 0.0036 |
Treponema pallidum | DNA-directed RNA polymerase subunit beta | 0.0496 | 1 | 0.5 |
Plasmodium falciparum | DNA-directed RNA polymerase subunit beta, putative | 0.0496 | 1 | 0.5 |
Mycobacterium leprae | DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) | 0.0496 | 1 | 0.5 |
Echinococcus granulosus | tumor protein p63 | 0.0332 | 0.6501 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA-directed RNA polymerase subunit beta/beta' | 0.0496 | 1 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.0233 | 0.4377 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0205 | 0.3772 | 0.8836 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0023 | 0.5 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.0435 | 1 |
Onchocerca volvulus | 0.0049 | 0.0435 | 0.0947 | |
Onchocerca volvulus | 0.0233 | 0.4377 | 1 | |
Mycobacterium tuberculosis | DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) | 0.0496 | 1 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0228 | 0.4266 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0332 | 0.6501 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.021 uM | Inhibition of wild type Mycobacterium tuberculosis RNA polymerase after 10 mins using ribo green staining by rolling circle transcription assay | ChEMBL. | 21903392 |
logIC50 (binding) | = -1.6795 | Inhibition of wild type Mycobacterium tuberculosis RNA polymerase after 10 mins using ribo green staining by rolling circle transcription assay | ChEMBL. | 21903392 |
MIC90 (functional) | = 0.2 uM | Antimicrobial activity against replicating Mycobacterium tuberculosis after 8 days by micro plate alamar blue assay | ChEMBL. | 21903392 |
MIC90 (functional) | = 3 uM | Antimicrobial activity against non-replicating Mycobacterium tuberculosis after 11 days by luminescence based low oxygen recovery assay | ChEMBL. | 21903392 |
MIC90 (functional) | = 3.125 uM | Antimicrobial activity against Escherichia coli EC2880 mutant after 16 to 20 hrs | ChEMBL. | 21903392 |
MIC90 (functional) | > 100 uM | Antimicrobial activity against wild type Escherichia coli TG2 after 16 to 20 hrs | ChEMBL. | 21903392 |
MIC90 (functional) | > 100 uM | Antimicrobial activity against wild type Escherichia coli DH5[alpha] after 16 to 20 hrs | ChEMBL. | 21903392 |
Ratio IC50 (binding) | = 2 | Ratio of compound IC50 to Rifamycin S IC50 for wild type Mycobacterium tuberculosis RNA polymerase | ChEMBL. | 21903392 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.