Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | metabotropic glutamate receptor | 0.0533 | 0.1131 | 0.1004 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1205 | 0.3813 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.2532 | 0.9118 | 1 |
Brugia malayi | thymidylate synthase | 0.2532 | 0.9118 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0577 | 0.1305 | 0.12 |
Onchocerca volvulus | 0.2532 | 0.9118 | 0.5 | |
Chlamydia trachomatis | dihydrofolate reductase | 0.0577 | 0.1305 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2753 | 1 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2532 | 0.9118 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2753 | 1 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0784 | 0.2132 | 0.1253 |
Echinococcus multilocularis | thymidylate synthase | 0.2532 | 0.9118 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.2532 | 0.9118 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.2532 | 0.9118 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2753 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.2532 | 0.9118 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2753 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0577 | 0.1305 | 0.12 |
Schistosoma mansoni | dihydrofolate reductase | 0.0577 | 0.1305 | 0.12 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.2532 | 0.9118 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0577 | 0.1304 | 0.12 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0637 | 0.1544 | 0.1469 |
Echinococcus granulosus | dihydrofolate reductase | 0.0577 | 0.1305 | 0.0218 |
Loa Loa (eye worm) | hypothetical protein | 0.0784 | 0.2132 | 0.2338 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0784 | 0.2132 | 0.1253 |
Loa Loa (eye worm) | glutamate receptor | 0.0637 | 0.1544 | 0.1693 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0577 | 0.1305 | 0.0218 |
Brugia malayi | hypothetical protein | 0.1205 | 0.3813 | 0.4025 |
Mycobacterium tuberculosis | Hypothetical protein | 0.1205 | 0.3813 | 0.321 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2753 | 1 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0724 | 0.1893 | 0.1862 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0577 | 0.1305 | 0.1431 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 30 uM | Antagonist activity at 20% inactivated human sodium channel Nav1.7 expressed in human HEK293 cells by patch-clamp electrophysiological assay | ChEMBL. | 22209205 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.