Detailed information for compound 1578407

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 375.344 | Formula: C15H19BrO2S2
  • H donors: 1 H acceptors: 2 LogP: 7.31 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCc1c(sc2c1scc2Br)C(=O)O
  • InChi: 1S/C15H19BrO2S2/c1-2-3-4-5-6-7-8-10-12-14(11(16)9-19-12)20-13(10)15(17)18/h9H,2-8H2,1H3,(H,17,18)
  • InChiKey: ROIRRXSSPDWUDS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens G protein-coupled receptor 35 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum histone acetyltransferase GCN5 0.0034 0.003 1
Echinococcus multilocularis neuropeptide receptor A26 0.0007 0.0003 0.0091
Onchocerca volvulus 0.0012 0.0009 0.4143
Echinococcus granulosus biogenic amine 5HT receptor 0.0076 0.0072 0.2257
Echinococcus multilocularis cysteine protease 0.0005 0.0002 0.0045
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0021 0.0017 0.054
Echinococcus granulosus tm gpcr rhodopsin 0.0007 0.0003 0.0102
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0029
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.0018 0.1496
Schistosoma mansoni hypothetical protein 0.0011 0.0008 0.0628
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0003 0.0102
Onchocerca volvulus 0.0007 0.0003 0.1545
Brugia malayi steroid hormone receptor 0.0004 0.0001 0.0051
Brugia malayi Dopamine receptor 0.0007 0.0003 0.0269
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0025 0.0021 0.6405
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0017 0.1428
Echinococcus granulosus 7TM GPCR rhodopsin 0.0007 0.0003 0.0102
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.1428
Echinococcus multilocularis potassium voltage gated channel protein 0.0021 0.0017 0.053
Schistosoma mansoni biogenic amine (5HT) receptor 0.0076 0.0072 0.5964
Echinococcus multilocularis neuropeptide Y receptor 0.0007 0.0003 0.0091
Brugia malayi acetyltransferase, GNAT family protein 0.0125 0.0121 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0011 0.0007 0.0566
Brugia malayi nuclear hormone receptor 0.0004 0.0001 0.0051
Brugia malayi hypothetical protein 0.0018 0.0015 0.1198
Onchocerca volvulus 0.0005 0.0002 0.0854
Echinococcus granulosus neuropeptide FF receptor 2 0.0007 0.0003 0.0102
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0021 0.0017 0.054
Loa Loa (eye worm) intermediate filament protein 0.0009 0.0005 0.0424
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0007 0.0003 0.0269
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0021 0.0017 0.1428
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0021 0.0017 0.1428
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0007 0.0003 0.1545
Echinococcus multilocularis neuropeptide s receptor 0.0007 0.0003 0.0091
Brugia malayi RE15519p 0.0007 0.0003 0.0269
Brugia malayi sodium-independent organic anion transporter family protein 0.0018 0.0015 0.1198
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0004 0.0001 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0004 0.0001 0.0051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0003 0.0269
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0021 0.0017 0.054
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0021 0.0017 0.1428
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0021 0.0017 0.1428
Echinococcus granulosus cathepsin l1 0.0005 0.0002 0.0056
Schistosoma mansoni neuropeptide F-like receptor 0.0007 0.0003 0.0269
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.1198
Onchocerca volvulus 0.0005 0.0002 0.0854
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0012 0.0009 0.0722
Echinococcus granulosus synaptic glycoprotein sc2 0.0025 0.0021 0.0659
Brugia malayi putative neuropeptide receptor NPR1 0.0007 0.0003 0.0269
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.1463
Echinococcus granulosus neuropeptide Y receptor 0.0007 0.0003 0.0102
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0004 0.0001 0.0004
Schistosoma mansoni voltage-dependent calcium channel 0.0021 0.0017 0.1428
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0004 0.0001 0.0018
Schistosoma mansoni histamine h1 receptor 0.0007 0.0003 0.0269
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0007 0.0003 0.0269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0005 0.0002 0.0588
Trypanosoma cruzi major cysteine proteinase, putative 0.0016 0.0013 0.5632
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0021 0.0017 0.1428
Trypanosoma cruzi cysteine peptidase, putative 0.0021 0.0017 0.7934
Schistosoma mansoni hypothetical protein 0.0036 0.0033 0.268
Brugia malayi Dopamine receptor protein 2 0.0007 0.0003 0.0269
Toxoplasma gondii transporter, major facilitator family protein 0.0018 0.0015 0.3674
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.1198
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0004 0.0001 0.0019
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0021 0.0017 0.053
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0035 0.0032 0.2614
Loa Loa (eye worm) voltage-gated calcium channel 0.0021 0.0017 0.1428
Echinococcus multilocularis thyroid hormone receptor alpha 0.0004 0.0001 0.0008
Loa Loa (eye worm) G-protein coupled receptor 0.0007 0.0003 0.0269
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0017 0.1428
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0005 0.0002 0.0588
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Echinococcus granulosus sex peptide receptor 0.0007 0.0003 0.0102
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0005 0.0002 0.0588
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0007 0.0003 0.0091
Schistosoma mansoni ryanodine receptor related 0.0021 0.0017 0.1428
Echinococcus granulosus hyperpolarization activated cyclic 0.0021 0.0017 0.054
Onchocerca volvulus Cathepsin F homolog 0.0005 0.0002 0.0854
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0021 0.0017 0.053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0005 0.0002 0.0588
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Schistosoma mansoni cpg binding protein 0.0018 0.0014 0.1152
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.1428
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0027 0.0023 0.1888
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0003 0.0091
Echinococcus multilocularis short transient receptor potential channel 6 0.0021 0.0017 0.053
Echinococcus multilocularis neuropeptide receptor 0.0007 0.0003 0.0091
Echinococcus granulosus zinc finger protein 0.0004 0.0001 0.0011
Schistosoma mansoni amine GPCR 0.0007 0.0003 0.0269
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0004 0 0.0082
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0025 0.0021 0.6405
Echinococcus multilocularis g protein coupled receptor 0.0007 0.0003 0.0091
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0025 0.0021 1
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0021 0.0017 0.4799
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0007 0.0003 0.0269
Brugia malayi Dopamine receptor protein 1 0.0007 0.0003 0.0269
Brugia malayi follicle stimulating hormone receptor 0.0007 0.0003 0.0269
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.1198
Leishmania major cathepsin L-like protease 0.0021 0.0017 0.0481
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0003 0.0091
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Echinococcus multilocularis endothelin converting enzyme 1 0.0043 0.004 0.1224
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0017 0.1428
Loa Loa (eye worm) melatonin receptor type 1A 0.0007 0.0003 0.0269
Entamoeba histolytica cysteine proteinase, putative 0.0005 0.0002 0.0601
Echinococcus multilocularis two pore calcium channel protein 2 0.0021 0.0017 0.053
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0004 0.0001 0.0004
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0025 0.0021 0.0649
Leishmania major cathepsin L-like protease 0.0021 0.0017 0.0481
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0012 0.0009 0.0722
Onchocerca volvulus 0.0007 0.0003 0.1545
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0005 0.0002 0.0588
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0004 0.0001 0.0008
Onchocerca volvulus 0.0005 0.0002 0.0854
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Brugia malayi SPARC precursor 0.0012 0.0009 0.0722
Echinococcus multilocularis neuropeptides capa receptor 0.0007 0.0003 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0004 0.0001 0.0051
Brugia malayi sodium-independent organic anion transporter family protein 0.0018 0.0015 0.1198
Schistosoma mansoni cathepsin F (C01 family) 0.0005 0.0002 0.0149
Schistosoma mansoni neuropeptide f receptor 76f 0.0007 0.0003 0.0269
Echinococcus multilocularis g-protein coupled receptor 0.0007 0.0003 0.0091
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0012 0.0009 0.0722
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Schistosoma mansoni retinoic acid receptor RXR 0.0004 0.0001 0.0051
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0722
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.1428
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0017 0.4739
Brugia malayi Nuclear hormone receptor-like 1 0.0004 0.0001 0.0051
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0051
Brugia malayi hypothetical protein 0.0007 0.0003 0.0269
Schistosoma mansoni RAR-like nuclear receptor 0.0004 0.0001 0.0051
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0004 0 0.0082
Loa Loa (eye worm) hypothetical protein 0.0033 0.0029 0.2393
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0025 0.0021 0.1743
Onchocerca volvulus Putative organic anion transporter 0.0018 0.0015 0.6872
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0007 0.0003 0.0091
Brugia malayi Serotonin receptor 0.0007 0.0003 0.0269
Echinococcus multilocularis cpg binding protein 0.0018 0.0014 0.0425
Loa Loa (eye worm) hypothetical protein 0.0076 0.0072 0.5964
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0004 0 0.0082
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.1198
Echinococcus granulosus neuropeptide Y receptor 0.0007 0.0003 0.0102
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0025 0.0021 0.6405
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0012 0.0009 0.0722
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0003 0.0091
Echinococcus granulosus serotonin receptor 0.0007 0.0003 0.0102
Onchocerca volvulus 0.0007 0.0003 0.1545
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.1198
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0007 0.0003 0.0091
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0011 0.0008 0.0628
Entamoeba histolytica replication factor A protein 1, putative 0.0006 0.0003 0.0862
Schistosoma mansoni hypothetical protein 0.0011 0.0008 0.0628
Mycobacterium tuberculosis 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) 1.0035 1 1
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0025 0.0021 0.5346
Echinococcus multilocularis two pore calcium channel protein 1 0.0021 0.0017 0.053
Brugia malayi larval opioid receptor 0.0007 0.0003 0.0269
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0025 0.0021 0.1743
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0017 0.4739
Echinococcus multilocularis neuropeptide FF receptor 2 0.0007 0.0003 0.0091
Echinococcus granulosus lamin dm0 0.0009 0.0005 0.016
Echinococcus granulosus voltage dependent calcium channel 0.0021 0.0017 0.054
Brugia malayi G-protein coupled receptor 0.0007 0.0003 0.0269
Brugia malayi Cathepsin L-like precursor 0.0005 0.0002 0.0149
Echinococcus multilocularis shaker cognate 0.0021 0.0017 0.053
Echinococcus granulosus dro:myosuppressin receptor 0.0007 0.0003 0.0102
Loa Loa (eye worm) peptidase family M13 containing protein 0.0032 0.0028 0.2331
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0021 0.0017 0.053
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0022 0.0018 0.1496
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0007 0.0003 0.0091
Echinococcus granulosus transient receptor potential cation channel 0.0021 0.0017 0.054
Echinococcus granulosus 7tm_1 domain containing protein 0.0007 0.0003 0.0102
Schistosoma mansoni steroid hormone receptor ad4bp 0.0004 0.0001 0.0051
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.1428
Echinococcus multilocularis allatostatin A receptor 0.0007 0.0003 0.0091
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0021 0.0017 0.054
Schistosoma mansoni biogenic amine (5HT) receptor 0.0007 0.0003 0.0269
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0004 0.0001 0.0051
Onchocerca volvulus 0.0025 0.0021 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0005 0.0002 0.0045
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0007 0.0003 0.0269
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0021 0.0017 0.438
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0011 0.0007 0.0566
Echinococcus granulosus orexin receptor type 2 0.0007 0.0003 0.0102
Echinococcus multilocularis musashi 0.0009 0.0005 0.0149
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0021 0.0017 0.8193
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0017 0.1428
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0004 0.0001 0.0051
Brugia malayi GnHR receptor homolog 0.0007 0.0003 0.0269
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Onchocerca volvulus 0.0009 0.0005 0.243
Onchocerca volvulus Cathepsin L homolog 0.0005 0.0002 0.0854
Echinococcus multilocularis potassium voltage gated channel protein 0.0021 0.0017 0.053
Toxoplasma gondii transporter, cation channel family protein 0.0021 0.0017 0.438
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0004 0.0001 0.0019
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0025 0.0021 0.0659
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0018 0.0015 0.0453
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0004 0.0001 0.0051
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0003 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0004 0.0001 0.0051
Schistosoma mansoni cpg binding protein 0.0017 0.0013 0.1073
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0005 0.0002 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0005 0.0002 0.0588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0005 0.0002 0.0588
Toxoplasma gondii protease inhibitor PI2 0.0012 0.0009 0.2216
Echinococcus multilocularis fmrfamide receptor 0.0007 0.0003 0.0091
Loa Loa (eye worm) acetyltransferase 0.0125 0.0121 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0722
Echinococcus multilocularis transfer RNA-Gly 0.0021 0.0017 0.053
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0021 0.0017 0.1428
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0003 0.0091
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0025 0.0021 0.685
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0007 0.0003 0.0102
Echinococcus granulosus follistatin 0.0012 0.0009 0.0273
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0017 0.1428
Onchocerca volvulus 0.0007 0.0003 0.1545
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0324 0.0319 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0021 0.0017 0.053
Onchocerca volvulus 0.0007 0.0003 0.1545
Brugia malayi Cathepsin L-like precursor 0.0005 0.0002 0.0149
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Echinococcus granulosus two pore calcium channel protein 2 0.0021 0.0017 0.054
Loa Loa (eye worm) voltage-gated potassium channel 0.0021 0.0017 0.1428
Brugia malayi secreted modular calcium-binding protein 1 0.0012 0.0009 0.0722
Brugia malayi neuropeptide F receptor 0.0007 0.0003 0.0269
Echinococcus granulosus tm gpcr rhodopsin 0.0007 0.0003 0.0102
Echinococcus multilocularis ecdysone induced protein 78C 0.0004 0.0001 0.0008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0027 0.0023 0.0704
Leishmania major hypothetical protein, conserved 0.0021 0.0017 0.0487
Echinococcus multilocularis synaptic glycoprotein sc2 0.0025 0.0021 0.0649
Loa Loa (eye worm) hypothetical protein 0.0025 0.0021 0.1743
Brugia malayi ecdysteroid receptor 0.0004 0.0001 0.0051
Schistosoma mansoni amine GPCR 0.0007 0.0003 0.0269
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0021 0.0017 0.1428
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0004 0.0001 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0004 0.0001 0.0051
Echinococcus granulosus hypothetical protein 0.0007 0.0003 0.0102
Brugia malayi Cathepsin L-like precursor 0.0005 0.0002 0.0149
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0025 0.0021 0.704
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0005 0.0002 0.0588
Schistosoma mansoni hypothetical protein 0.0007 0.0003 0.0269
Schistosoma mansoni endothelin-converting enzyme-related 0.0011 0.0007 0.0566
Brugia malayi Serotonin receptor 0.0007 0.0003 0.0269
Echinococcus granulosus transient receptor potential cation channel 0.0021 0.0017 0.054
Echinococcus granulosus lamin 0.0009 0.0005 0.016
Onchocerca volvulus Cathepsin L homolog 0.0005 0.0002 0.0854
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0007 0.0003 0.0269
Loa Loa (eye worm) hypothetical protein 0.0043 0.004 0.3261
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0021 0.0017 0.054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0004 0.0001 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0004 0 0.0082
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0125 0.0121 0.3777
Brugia malayi intermediate filament protein 0.0009 0.0005 0.0424
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0021 0.0017 0.1428
Echinococcus multilocularis cysteine protease 0.0005 0.0002 0.0045
Loa Loa (eye worm) hypothetical protein 0.0025 0.0021 0.1743
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0021 0.0017 0.053
Brugia malayi Cathepsin L-like precursor 0.0005 0.0002 0.0149
Loa Loa (eye worm) hypothetical protein 0.0076 0.0072 0.5964
Loa Loa (eye worm) hypothetical protein 0.0032 0.0028 0.2331
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0324 0.0319 1
Trichomonas vaginalis conserved hypothetical protein 0.0004 0 0.0082
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0025 0.0021 0.6413
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0005 0.0001 0.0087
Echinococcus multilocularis transient receptor potential cation channel 0.0021 0.0017 0.053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0005 0.0002 0.0588
Schistosoma mansoni hypothetical protein 0.0021 0.0017 0.1428
Schistosoma mansoni neuropeptide receptor 0.0007 0.0003 0.0269
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0021 0.0017 0.1428
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0005 0.0002 0.0588
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0021 0.0017 0.053
Trypanosoma cruzi cysteine peptidase, putative 0.0021 0.0017 0.7934
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0007 0.0003 0.0269
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.1428
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0017 0.1428
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0012 0.0009 0.2216
Loa Loa (eye worm) neuropeptide F receptor 0.0007 0.0003 0.0269
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.1428
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0021 0.0017 0.1428
Schistosoma mansoni 60S ribosomal protein L21 0.0021 0.0017 0.1428
Onchocerca volvulus 0.0021 0.0017 0.8193
Mycobacterium ulcerans 3-dehydroquinate dehydratase 1.0035 1 1
Brugia malayi Transient-receptor-potential like protein 0.0021 0.0017 0.1428
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0005 0.0002 0.0149
Loa Loa (eye worm) voltage-gated potassium channel 0.0021 0.0017 0.1428
Onchocerca volvulus 0.0007 0.0003 0.1545
Trichomonas vaginalis bromodomain-containing protein, putative 0.0037 0.0033 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0011 0.0007 0.0566
Onchocerca volvulus Neuropeptide F receptor homolog 0.0007 0.0003 0.1545
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0035
Echinococcus granulosus transient receptor potential gamma protein 0.0021 0.0017 0.054
Echinococcus granulosus alpha 1A adrenergic receptor 0.0007 0.0003 0.0102
Brugia malayi Papain family cysteine protease containing protein 0.0005 0.0002 0.0149
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0021 0.0017 0.1428
Echinococcus granulosus g protein coupled receptor 0.0007 0.0003 0.0102
Leishmania major cathepsin L-like protease 0.0021 0.0017 0.0481
Echinococcus granulosus short transient receptor potential channel 6 0.0021 0.0017 0.054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0004 0 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0004 0 0.0082
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0003 0.0102
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0017 0.4739
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0051
Brugia malayi hypothetical protein 0.0007 0.0003 0.0269
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0021 0.0017 0.054
Echinococcus granulosus intermediate filament protein 0.0009 0.0005 0.016
Echinococcus granulosus potassium voltage gated channel protein 0.0021 0.0017 0.054
Schistosoma mansoni opsin-like receptor 0.0007 0.0003 0.0269
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0014 0.0011 0.3314
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0025 0.0021 1
Onchocerca volvulus 0.0018 0.0015 0.6872
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.1428
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0004 0 0.0082
Schistosoma mansoni vesicular amine transporter 0.0021 0.0017 0.1428
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.1428
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.0014 0.0011 0.0339
Brugia malayi Peptidase family M13 containing protein 0.0043 0.004 0.3261
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0021 0.0017 0.053
Plasmodium vivax vivapain-2 0.0005 0.0002 0.061
Echinococcus multilocularis transient receptor potential cation channel 0.0021 0.0017 0.053
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0007 0.0003 0.0102
Brugia malayi hypothetical protein 0.0007 0.0003 0.0269
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0037 0.0033 0.8367
Onchocerca volvulus 0.0007 0.0003 0.1545
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0021 0.0017 0.053
Brugia malayi cation channel family protein 0.0021 0.0017 0.1428
Trichomonas vaginalis helicase, putative 0.0004 0 0.0082
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0025 0.0021 0.6405
Echinococcus granulosus neuropeptides capa receptor 0.0007 0.0003 0.0102
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0007 0.0003 0.0269
Echinococcus granulosus transient receptor potential cation channel 0.0021 0.0017 0.054
Schistosoma mansoni coup transcription factor 0.0004 0.0001 0.0051
Echinococcus multilocularis potassium voltage gated channel protein 0.0021 0.0017 0.053
Schistosoma mansoni neuropeptide receptor 0.0007 0.0003 0.0269
Onchocerca volvulus Bile acid receptor homolog 0.0004 0.0001 0.0294
Schistosoma mansoni replication factor A 1 rfa1 0.0014 0.0011 0.0896
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0025 0.0021 0.6405
Echinococcus multilocularis neuropeptides capa receptor 0.0007 0.0003 0.0091
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0007 0.0003 0.0091
Echinococcus multilocularis hyperpolarization activated cyclic 0.0021 0.0017 0.053
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0021 0.0017 0.1428
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0004 0.0001 0.0051
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Echinococcus granulosus neuropeptides capa receptor 0.0007 0.0003 0.0102
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0004 0.0001 0.0019
Echinococcus granulosus endothelin converting enzyme 1 0.0043 0.004 0.1234
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0007 0.0003 0.0269
Echinococcus granulosus voltage gated potassium channel 0.0021 0.0017 0.054
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0021 0.0017 0.053
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.1428
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0021 0.0017 0.1428
Loa Loa (eye worm) hypothetical protein 0.0033 0.0029 0.2393
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0004 0.0001 0.0008
Schistosoma mansoni organic anion transporter 0.0018 0.0015 0.1198
Brugia malayi hypothetical protein 0.0007 0.0003 0.0269
Schistosoma mansoni amine GPCR 0.0007 0.0003 0.0269
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0007 0.0003 0.0102
Schistosoma mansoni transient receptor potential channel 0.0021 0.0017 0.1428
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0025 0.0021 0.704
Echinococcus multilocularis serotonin receptor 0.0076 0.0072 0.2248
Echinococcus multilocularis transient receptor potential cation channel 0.0021 0.0017 0.053
Schistosoma mansoni bromodomain containing protein 0.0004 0.0001 0.0029
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0012 0.0009 0.2216
Brugia malayi Synaptic glycoprotein SC2 0.0025 0.0021 0.1743
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0424
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0017 0.4739
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0003 0.0102
Loa Loa (eye worm) ctsf protein 0.0005 0.0002 0.0149
Echinococcus granulosus neuropeptide receptor 0.0007 0.0003 0.0102
Toxoplasma gondii hypothetical protein 0.0021 0.0017 0.438
Schistosoma mansoni hypothetical protein 0.0011 0.0008 0.0628
Echinococcus granulosus tumor protein p63 0.014 0.0136 0.4261
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0021 0.0017 0.053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0003 0.0269
Echinococcus granulosus potassium voltage gated channel protein 0.0021 0.0017 0.054
Schistosoma mansoni transient receptor potential channel 0.0021 0.0017 0.1428
Loa Loa (eye worm) hypothetical protein 0.0032 0.0028 0.2331
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0021 0.0017 0.1428
Trichomonas vaginalis conserved hypothetical protein 0.0004 0 0.0082
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0007 0.0003 0.0269
Onchocerca volvulus 0.0007 0.0003 0.1545
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0005 0.0002 0.0588
Echinococcus multilocularis agrin 0.0012 0.0009 0.0262
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.1428
Trypanosoma cruzi cysteine peptidase, putative 0.0021 0.0017 0.7934
Plasmodium falciparum replication protein A1, large subunit 0.0007 0.0004 0.0532
Plasmodium vivax polyprenol reductase, putative 0.0025 0.0021 0.6413
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0025 0.0021 0.6107
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0021 0.0017 0.054
Echinococcus multilocularis ryanodine receptor 44f 0.0021 0.0017 0.053
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0025 0.0021 0.1743
Brugia malayi PHD-finger family protein 0.0004 0.0001 0.0029
Brugia malayi CXXC zinc finger family protein 0.0017 0.0013 0.1073
Echinococcus multilocularis somatostatin receptor 0.0007 0.0003 0.0091
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0021 0.0017 0.1428
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0004 0.0001 0.0007
Loa Loa (eye worm) neuropeptide F receptor 0.0007 0.0003 0.0269
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0021 0.0017 0.1428
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0027 0.0023 0.1888
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0007 0.0004 0.104
Schistosoma mansoni hypothetical protein 0.0007 0.0003 0.0269
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0017 0.1428
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0018 0.0015 0.0443
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0017 0.1428
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0021 0.0017 0.1428
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0722
Schistosoma mansoni lamin 0.0009 0.0005 0.0424
Brugia malayi hypothetical protein 0.0007 0.0003 0.0269
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.1428
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0007 0.0003 0.0091
Schistosoma mansoni bromodomain containing protein 0.0004 0.0001 0.0029
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Brugia malayi Steroid receptor seven-up type 2 0.0004 0.0001 0.0051
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.1428
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0025 0.0021 0.0607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0005 0.0002 0.0588
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0004 0.0001 0.0051
Onchocerca volvulus 0.0018 0.0015 0.6872
Loa Loa (eye worm) hypothetical protein 0.0033 0.0029 0.2393
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0021 0.6405
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0001 0.004
Entamoeba histolytica hypothetical protein 0.0025 0.0021 0.704
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0021 0.0017 0.053
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0012 0.0009 0.2216
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0011 0.0007 0.0566
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0021 0.0017 0.054
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0007 0.0003 0.0269
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0025 0.0021 0.5346
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0021 0.0017 0.8024
Echinococcus multilocularis transient receptor potential cation channel 0.0021 0.0017 0.053
Entamoeba histolytica cysteine proteinase, putative 0.0005 0.0002 0.0601
Schistosoma mansoni neuropeptide receptor 0.0007 0.0003 0.0269
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0007 0.0003 0.0091
Onchocerca volvulus 0.0007 0.0003 0.1545
Echinococcus granulosus g-protein coupled receptor 0.0007 0.0003 0.0102
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0021 0.0017 0.1428
Onchocerca volvulus 0.0007 0.0003 0.1545
Echinococcus multilocularis g protein coupled receptor 0.0007 0.0003 0.0091
Toxoplasma gondii transporter, cation channel family protein 0.0021 0.0017 0.438
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0027 0.0023 0.0714
Echinococcus granulosus cpg binding protein 0.0018 0.0014 0.0436
Schistosoma mansoni adenoreceptor 0.0007 0.0003 0.0269
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0007 0.0003 0.0269
Echinococcus granulosus tm gpcr rhodopsin 0.0007 0.0003 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0005 0.0002 0.0588
Schistosoma mansoni voltage-gated ion channel 0.0021 0.0017 0.1428
Brugia malayi G-protein coupled receptor 0.0007 0.0003 0.0269
Echinococcus granulosus sodium channel protein 0.0324 0.0319 1
Giardia lamblia Histone acetyltransferase GCN5 0.0034 0.003 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0003 0.0102
Echinococcus multilocularis transient receptor potential gamma protein 0.0021 0.0017 0.053
Echinococcus granulosus hyperpolarization activated cyclic 0.0021 0.0017 0.054
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0004 0.0001 0.0008
Brugia malayi replication factor A 73 kDa subunit 0.0014 0.0011 0.0896
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0021 0.0017 0.053
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0021 0.0017 0.8024
Onchocerca volvulus 0.0007 0.0003 0.1545
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0004 0.0001 0.0008
Schistosoma mansoni opsin-like receptor 0.0007 0.0003 0.0269
Brugia malayi cation channel family protein 0.0021 0.0017 0.1428
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0027 0.0023 0.0704
Trichomonas vaginalis conserved hypothetical protein 0.0004 0 0.0082
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0051
Echinococcus granulosus transient receptor potential cation channel 0.0021 0.0017 0.054
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Brugia malayi G protein-coupled receptor 0.0007 0.0003 0.0269
Onchocerca volvulus 0.002 0.0017 0.7981
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0021 0.0017 0.1428
Loa Loa (eye worm) TYRA-2 protein 0.0007 0.0003 0.0269
Echinococcus granulosus calcium activated potassium channel 0.0021 0.0017 0.054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0005 0.0002 0.0588
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0029
Echinococcus multilocularis short transient receptor potential channel 6 0.0021 0.0017 0.053
Echinococcus multilocularis calcium activated potassium channel 0.0021 0.0017 0.053
Plasmodium vivax replication protein A1, large subunit, putative 0.0007 0.0004 0.1061
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0049
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0037 0.0033 0.8367
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0007 0.0003 0.0269
Onchocerca volvulus 0.0004 0.0001 0.0294
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0043 0.004 0.3261
Echinococcus multilocularis voltage dependent calcium channel 0.0021 0.0017 0.053
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0011 0.0007 0.0566
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0004 0.0001 0.0019
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.1198
Brugia malayi putative neuropeptide receptor 0.0007 0.0003 0.0269
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.0018 0.1496
Schistosoma mansoni neuropeptide F-like receptor 0.0007 0.0003 0.0269
Echinococcus granulosus potassium large conductance calcium activated 0.0021 0.0017 0.054
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0021 0.0017 0.8193
Trichomonas vaginalis conserved hypothetical protein 0.0004 0 0.0082
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0007 0.0003 0.0091
Onchocerca volvulus 0.0007 0.0003 0.1545
Loa Loa (eye worm) hypothetical protein 0.0032 0.0028 0.2331
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0007 0.0003 0.0269
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0018 0.0015 0.0443
Brugia malayi Melatonin receptor type 1A 0.0007 0.0003 0.0269
Loa Loa (eye worm) hypothetical protein 0.0033 0.0029 0.2393
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0017 0.5255
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0021 0.0017 0.054
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0012 0.0009 0.0722
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0004 0.0001 0.0051
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0021 0.0017 0.054
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0005 0.0002 0.0047
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0005 0.0002 0.0588
Echinococcus granulosus voltage gated hydrogen channel 1 0.0021 0.0017 0.054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0004 0.0001 0.0051
Brugia malayi hypothetical protein 0.0007 0.0003 0.0269
Echinococcus granulosus potassium voltage gated channel protein 0.0021 0.0017 0.054
Schistosoma mansoni biogenic amine receptor 0.0007 0.0003 0.0269
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0003 0.0269
Brugia malayi voltage-dependent calcium channel 0.0021 0.0017 0.1428
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0005 0.0002 0.0036
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0007 0.0003 0.0091
Onchocerca volvulus 0.0007 0.0003 0.1545
Trichomonas vaginalis conserved hypothetical protein 0.0004 0 0.0082
Echinococcus multilocularis orexin receptor type 2 0.0007 0.0003 0.0091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0017 0.4739
Brugia malayi hypothetical protein 0.0018 0.0015 0.1198
Trypanosoma cruzi MFS transporter, putative 0.0018 0.0015 0.658
Echinococcus granulosus hypothetical protein 0.0021 0.0017 0.054
Loa Loa (eye worm) steroid hormone receptor 0.0004 0.0001 0.0051
Toxoplasma gondii cathepsin CPL 0.0005 0.0002 0.0458
Brugia malayi olfactory channel protein osm-9 0.0021 0.0017 0.1428
Onchocerca volvulus 0.0007 0.0003 0.1545
Echinococcus granulosus allatostatin A receptor 0.0007 0.0003 0.0102
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0004 0 0.0082
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0007 0.0003 0.0269
Echinococcus granulosus ryanodine receptor 44f 0.0021 0.0017 0.054
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0021 0.0017 0.054
Schistosoma mansoni lamin 0.0009 0.0005 0.0424
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0021 0.0017 0.1428
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0021 0.0017 0.1428
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0007 0.0003 0.0269
Toxoplasma gondii replication factor-a protein 1 (rpa1) subfamily protein 0.0007 0.0004 0.0837
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0025 0.0021 1
Echinococcus granulosus TRP transient receptor potential channel 0.0021 0.0017 0.054
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0051
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0021 0.0017 0.1428
Trichomonas vaginalis conserved hypothetical protein 0.0004 0 0.0082
Echinococcus granulosus mixed lineage leukemia protein mll 0.0004 0.0001 0.0015
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0022 0.0018 0.1496
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Echinococcus multilocularis lamin dm0 0.0009 0.0005 0.0149
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0007 0.0003 0.0269
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0007 0.0003 0.0102
Trypanosoma cruzi cruzipain precursor, putative 0.0021 0.0017 0.7934
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0003 0.0269
Echinococcus granulosus histone acetyltransferase KAT2B 0.0121 0.0117 0.3675
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0017 0.1428
Loa Loa (eye worm) agrin synaptic family protein 0.0012 0.0009 0.0722
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Brugia malayi Cyclic-nucleotide gated cation channel 0.0021 0.0017 0.1428
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Toxoplasma gondii histone lysine methyltransferase SET1 0.0035 0.0031 0.7837
Brugia malayi hypothetical protein 0.0007 0.0003 0.0269
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0005 0.0002 0.0588
Brugia malayi ion channel NompC 0.0021 0.0017 0.1428
Schistosoma mansoni zinc finger protein 0.0004 0.0001 0.0029
Schistosoma mansoni voltage-gated cation channel 0.0021 0.0017 0.1428
Onchocerca volvulus 0.0017 0.0013 0.6158
Mycobacterium ulcerans zinc metalloprotease 0.0043 0.004 0.0018
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Echinococcus granulosus transient receptor potential cation channel 0.0021 0.0017 0.054
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.1428
Brugia malayi hypothetical protein 0.0021 0.0017 0.1428
Schistosoma mansoni transient receptor potential channel 4 0.0021 0.0017 0.1428
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0021 0.0017 0.1428
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0004 0.0001 0.0008
Echinococcus multilocularis potassium voltage gated channel protein 0.0021 0.0017 0.053
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0004 0.0001 0.0051
Echinococcus multilocularis voltage gated potassium channel 0.0021 0.0017 0.053
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Echinococcus multilocularis transient receptor potential cation channel 0.0021 0.0017 0.053
Brugia malayi neuropeptide F receptor 0.0007 0.0003 0.0269
Echinococcus granulosus short transient receptor potential channel 6 0.0021 0.0017 0.054
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0012 0.0009 0.2216
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0004 0.0001 0.0051
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0004 0.0001 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0004 0.0001 0.0051
Loa Loa (eye worm) histone methyltransferase 0.0005 0.0002 0.0124
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0005 0.0002 0.0588
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0021 0.0017 0.054
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0017 0.1428
Schistosoma mansoni cpg binding protein 0.0018 0.0014 0.1152
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0004 0.0001 0.0051
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.1428
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0027 0.0023 0.1888
Schistosoma mansoni thyroid hormone receptor 0.0004 0.0001 0.0051
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0007 0.0003 0.0091
Echinococcus granulosus ecdysone induced protein 78C 0.0004 0.0001 0.0019
Loa Loa (eye worm) zinc metallopeptidase 4 0.0011 0.0007 0.0566
Schistosoma mansoni thyroid hormone receptor 0.0004 0.0001 0.0051
Schistosoma mansoni neuropeptide receptor 0.0007 0.0003 0.0269
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0004 0.0001 0.0051
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0003 0.0091
Echinococcus multilocularis sex peptide receptor 0.0007 0.0003 0.0091
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0027 0.0023 0.1888
Brugia malayi peptidase family M13 containing protein 0.0011 0.0007 0.0566
Onchocerca volvulus 0.0007 0.0003 0.1545
Schistosoma mansoni organic anion transporter 0.0018 0.0015 0.1198
Echinococcus granulosus cathepsin l cysteine peptidase 0.0005 0.0002 0.0056
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0021 0.0017 0.1428
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0025 0.0021 0.6405
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0021 0.0017 0.1428
Echinococcus granulosus neuropeptide receptor A26 0.0007 0.0003 0.0102
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0004 0 0.0082
Loa Loa (eye worm) ion channel NompC 0.0021 0.0017 0.1428
Schistosoma mansoni hypothetical protein 0.0011 0.0008 0.0628
Echinococcus granulosus tachykinin peptides receptor 99D 0.0007 0.0003 0.0102
Echinococcus granulosus Solute carrier organic anion transporter family 0.0018 0.0015 0.0453
Brugia malayi Bromodomain containing protein 0.0004 0.0001 0.0029
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0004 0.0001 0.0019
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0021 0.0017 0.054
Echinococcus granulosus potassium voltage gated channel protein 0.0021 0.0017 0.054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0017 0.4739
Echinococcus granulosus biogenic amine 5HT receptor 0.0007 0.0003 0.0102
Plasmodium falciparum polyprenol reductase, putative 0.0025 0.0021 0.685
Echinococcus multilocularis tumor protein p63 0.014 0.0136 0.4255
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0019 0.0015 0.7
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0003 0.0102
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0021 0.0017 0.1428
Echinococcus granulosus cathepsin L cysteine proteinase 0.0005 0.0002 0.0056
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Echinococcus multilocularis g protein coupled receptor 0.0007 0.0003 0.0091
Brugia malayi cytoplasmic intermediate filament protein 0.0005 0.0001 0.0087
Echinococcus multilocularis voltage gated potassium channel 0.0021 0.0017 0.053
Leishmania major hypothetical protein, unknown function 0.0021 0.0017 0.0487
Schistosoma mansoni agrin 0.0012 0.0009 0.0722
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0021 0.0017 0.054
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0149
Loa Loa (eye worm) hypothetical protein 0.0033 0.0029 0.2393
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.1428
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0004 0.0001 0.0051
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0018 0.0015 0.1198
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0025 0.0021 0.704
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0025 0.0021 0.6405
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0017 0.5255
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0004 0.0001 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0004 0 0.0082
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.1428
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0017 0.4739
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0017 0.4739
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0004 0.0001 0.0051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0003 0.0269
Loa Loa (eye worm) hypothetical protein 0.0033 0.0029 0.2393
Echinococcus multilocularis voltage dependent calcium channel 0.0021 0.0017 0.053
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0021 0.0017 0.053
Echinococcus granulosus sodium leak channel non selective protein 0.0021 0.0017 0.054
Echinococcus multilocularis lamin 0.0009 0.0005 0.0149
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Schistosoma mansoni alpha-1 adrenergic receptor 0.0007 0.0003 0.0269
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0017 0.1428
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0005 0.0002 0.0045
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0021 0.0017 0.053
Loa Loa (eye worm) hypothetical protein 0.0025 0.0021 0.1743
Onchocerca volvulus 0.0018 0.0015 0.6872
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0017 0.1428
Echinococcus granulosus voltage gated potassium channel 0.0021 0.0017 0.054
Trypanosoma brucei RNA helicase, putative 0.0036 0.0033 1
Echinococcus granulosus voltage dependent calcium channel 0.0021 0.0017 0.054
Echinococcus granulosus histone acetyltransferase KAT2B 0.0037 0.0033 0.1032
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0017 0.1428
Brugia malayi prostaglandin transporter 0.0018 0.0015 0.1198
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0025 0.0021 0.6107
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0021 0.0017 0.1428
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0021 0.0017 0.438
Schistosoma mansoni two-pore calcium channel 0.0021 0.0017 0.1428
Echinococcus multilocularis fmrfamide receptor 0.0007 0.0003 0.0091
Schistosoma mansoni transient receptor potential channel 0.0021 0.0017 0.1428
Echinococcus granulosus somatostatin receptor 0.0007 0.0003 0.0102
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.1391
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0005 0.0002 0.0588
Toxoplasma gondii peptidase family M13 protein 0.0043 0.004 1
Schistosoma mansoni calcium-activated potassium channel 0.0021 0.0017 0.1428
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0005 0.0002 0.0588
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0021 0.0017 0.1428
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0021 0.0017 0.054
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0025 0.0021 0.5346
Schistosoma mansoni hypothetical protein 0.0011 0.0008 0.0628
Toxoplasma gondii hypothetical protein 0.0021 0.0017 0.438
Schistosoma mansoni amine GPCR 0.0007 0.0003 0.0269
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Plasmodium vivax vivapain-2 0.0005 0.0002 0.061
Echinococcus granulosus transient receptor potential cation channel 0.0021 0.0017 0.054
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.1428
Echinococcus granulosus FTZ F1 alpha 0.0004 0.0001 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0004 0 0.0045
Loa Loa (eye worm) cysteine protease 0.0005 0.0002 0.0149
Echinococcus multilocularis follistatin 0.0012 0.0009 0.0262
Brugia malayi Cathepsin L-like precursor 0.0005 0.0002 0.0149
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.1428
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0005 0.0002 0.0588
Schistosoma mansoni neprilysin 0.0011 0.0008 0.0628
Loa Loa (eye worm) hypothetical protein 0.0043 0.004 0.3261
Echinococcus granulosus neuropeptide receptor 0.0007 0.0003 0.0102
Brugia malayi AKH receptor 0.0007 0.0003 0.0269
Echinococcus multilocularis conserved hypothetical protein 0.0021 0.0017 0.053
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0004 0.0001 0.0019
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0021 0.0017 0.1428
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0013 0.001 0.4418
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0021 0.0017 0.1428
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0003 0.0269
Onchocerca volvulus 0.0005 0.0002 0.0854
Onchocerca volvulus 0.0021 0.0018 0.8397
Loa Loa (eye worm) calcium channel 0.0021 0.0017 0.1428
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0051
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0021 0.0017 0.1428
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0021 0.0017 0.1428
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0007 0.0003 0.0269
Echinococcus granulosus potassium voltage gated channel protein 0.0021 0.0017 0.054
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0004 0.0001 0.0294
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0009 0.0005 0.0424
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0007 0.0003 0.0269
Brugia malayi nuclear receptor NHR-88 0.0004 0.0001 0.0051
Onchocerca volvulus 0.0018 0.0015 0.6872
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.1428
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0005 0.0002 0.0588
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0005 0.0002 0.0588
Echinococcus granulosus peptide allatostatin:somatostatin 0.0007 0.0003 0.0102
Schistosoma mansoni biogenic amine receptor 0.0007 0.0003 0.0269
Echinococcus multilocularis serotonin receptor 0.0076 0.0072 0.2248
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Echinococcus granulosus shaker cognate 0.0021 0.0017 0.054
Echinococcus multilocularis G-protein coupled receptor, putative 0.0007 0.0003 0.0091
Schistosoma mansoni cathepsin F (C01 family) 0.0005 0.0002 0.0149
Schistosoma mansoni myosin xvIII 0.0007 0.0003 0.0269
Brugia malayi sulfakinin receptor protein 0.0007 0.0003 0.0269
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0007 0.0003 0.0102
Schistosoma mansoni biogenic amine receptor 0.0007 0.0003 0.0269
Echinococcus multilocularis sodium leak channel non selective protein 0.0021 0.0017 0.053
Loa Loa (eye worm) hypothetical protein 0.0043 0.004 0.3261
Echinococcus granulosus fmrfamide receptor 0.0007 0.0003 0.0102
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0014 0.001 0.3098
Echinococcus granulosus agrin 0.0012 0.0009 0.0273
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.041
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0021 0.0017 0.053
Brugia malayi Cathepsin L-like precursor 0.0005 0.0002 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0004 0.0001 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0017 0.4739
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0005 0.0002 0.0588
Loa Loa (eye worm) ryanodine receptor 0.0021 0.0017 0.1428
Onchocerca volvulus Protein ultraspiracle homolog 0.0004 0.0001 0.0294
Brugia malayi Intermediate filament tail domain containing protein 0.0009 0.0005 0.0424
Onchocerca volvulus 0.0005 0.0002 0.0854
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0021 0.0017 0.053
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0007 0.0003 0.0091
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0021 0.0017 0.1428
Schistosoma mansoni intermediate filament proteins 0.0009 0.0005 0.0424
Entamoeba histolytica cysteine protease, putative 0.0005 0.0002 0.0601
Leishmania major replication factor A, 51kDa subunit, putative 0.0007 0.0004 0.0047
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0035
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0007 0.0003 0.0269
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0003 0.0091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0005 0.0002 0.0588
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0007 0.0003 0.0269
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0017 0.1428
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0021 0.6405
Onchocerca volvulus 0.0007 0.0003 0.1545
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0017 0.4739
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0021 0.0017 0.053
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0005 0.0002 0.0588
Onchocerca volvulus 0.0005 0.0002 0.0854
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0021 0.0017 0.1428
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0003 0.0269
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0722
Echinococcus multilocularis expressed protein 0.0012 0.0009 0.0262
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0027 0.0023 0.1888
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0125 0.0121 1
Schistosoma mansoni hypothetical protein 0.0007 0.0003 0.0269
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0004 0.0001 0.0019
Echinococcus multilocularis neuropeptide receptor 0.0007 0.0003 0.0091
Echinococcus multilocularis neuropeptide Y receptor 0.0007 0.0003 0.0091
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0021 0.0017 0.054
Brugia malayi Tachykinin-like peptides receptor 99D 0.0007 0.0003 0.0269
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0017 0.4739
Brugia malayi sodium-independent organic anion transporter family protein 0.0018 0.0015 0.1198
Echinococcus granulosus g protein coupled receptor 0.0007 0.0003 0.0102
Echinococcus multilocularis cathepsin L cysteine protease 0.0005 0.0002 0.0045
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.1198
Loa Loa (eye worm) hypothetical protein 0.0032 0.0028 0.2331
Schistosoma mansoni amine GPCR 0.0007 0.0003 0.0269
Brugia malayi hypothetical protein 0.0007 0.0003 0.0269
Schistosoma mansoni cellular tumor antigen P53 0.002 0.0017 0.1391
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0004 0.0001 0.0051
Echinococcus multilocularis FTZ F1 alpha 0.0004 0.0001 0.0008
Onchocerca volvulus 0.0018 0.0015 0.6872
Loa Loa (eye worm) hypothetical protein 0.0004 0.0001 0.0051
Loa Loa (eye worm) voltage-dependent calcium channel 0.0021 0.0017 0.1428
Schistosoma mansoni nuclear hormone receptor 0.0004 0.0001 0.0051
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0004 0.0001 0.0011
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0021 0.0017 0.1428
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0007 0.0003 0.0269
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0004 0.0001 0.0051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0003 0.0269
Echinococcus granulosus g protein coupled receptor 0.0007 0.0003 0.0102
Echinococcus multilocularis transient receptor potential cation channel 0.0021 0.0017 0.053
Brugia malayi F/Y-rich N-terminus family protein 0.0005 0.0002 0.0119
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0003 0.0102
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.0014 0.0011 0.0896
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0017 0.1428
Brugia malayi hypothetical protein 0.0007 0.0003 0.0269
Trypanosoma cruzi Replication factor A protein 1 0.0007 0.0004 0.0776
Brugia malayi ORL1-like opioid receptor 0.0007 0.0003 0.0269
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Onchocerca volvulus 0.0007 0.0003 0.1545
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0027 0.0023 0.0714
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Echinococcus multilocularis G protein coupled receptor 139 0.0007 0.0003 0.0091
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0007 0.0003 0.0091
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.0014 0.0011 0.0328
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0043 0.004 0.3261
Brugia malayi photoreceptor-specific nuclear receptor 0.0004 0.0001 0.0051
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0007 0.0003 0.0091
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0017 0.1428
Onchocerca volvulus Putative organic anion transporter 0.0018 0.0015 0.6872
Toxoplasma gondii transporter, cation channel family protein 0.0021 0.0017 0.438
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.1428
Entamoeba histolytica acetyltransferase, GNAT family 0.0034 0.003 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0037 0.0033 1
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0021 0.0017 0.4799
Schistosoma mansoni neprilysin-2 (M13 family) 0.0022 0.0018 0.1496
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Schistosoma mansoni hypothetical protein 0.0007 0.0003 0.0269
Schistosoma mansoni follistatin 0.0012 0.0009 0.0722
Loa Loa (eye worm) G-protein coupled receptor 0.0007 0.0003 0.0269
Schistosoma mansoni hypothetical protein 0.0011 0.0008 0.0628
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0004 0 0.0082
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.1428
Loa Loa (eye worm) fibroinase 0.0005 0.0002 0.0149
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0021 0.0017 0.053
Echinococcus multilocularis cathepsin L cysteine protease 0.0005 0.0002 0.0045
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0004 0.0001 0.0008
Schistosoma mansoni growth hormone secretagogue receptor 0.0007 0.0003 0.0269
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0017 0.1428
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.1428
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0004 0.0001 0.0051
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0007 0.0003 0.0269
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0003 0.0269
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Echinococcus granulosus two pore calcium channel protein 1 0.0021 0.0017 0.054
Loa Loa (eye worm) CXXC zinc finger family protein 0.0017 0.0013 0.1073
Brugia malayi hypothetical protein 0.0007 0.0003 0.0269
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Onchocerca volvulus 0.0009 0.0005 0.243
Echinococcus multilocularis potassium large conductance calcium activated 0.0021 0.0017 0.053
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0014 0.0011 0.3314
Onchocerca volvulus 0.0005 0.0002 0.0854
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0037 0.0033 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0007 0.0003 0.0269
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0007 0.0003 0.0269
Loa Loa (eye worm) peptidase family M13 containing protein 0.0032 0.0028 0.2331
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0017 0.1428
Schistosoma mansoni opsin-like receptor 0.0007 0.0003 0.0269
Echinococcus granulosus G protein coupled receptor 139 0.0007 0.0003 0.0102
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0269
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0004 0 0.0082
Echinococcus multilocularis dro:myosuppressin receptor 0.0007 0.0003 0.0091
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0007 0.0003 0.0102
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0003 0.0091
Echinococcus granulosus neuropeptide s receptor 0.0007 0.0003 0.0102
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0003 0.0102
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0007 0.0003 0.0091
Onchocerca volvulus Putative organic anion transporter 0.0018 0.0015 0.6872
Echinococcus multilocularis sodium channel protein 0.0324 0.0319 1

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 8 % Agonist activity at GPR35 in human U20S cells expressing beta-lactamase and GPR35-GA14-VP16 transcription factor fusion protein assessed as transcriptional activation after 5 hrs by tango beta-arrestin translocation reporter assay relative to zaprinast ChEMBL. 21950657
Activity (functional) = 103 % Agonist activity at GPR35 in human HT-29 cells after 1 hr by dynamic mass redistribution assay relative to zaprinast ChEMBL. 21950657
EC50 (functional) = 1.46 uM Agonist activity at GPR35 in human HT-29 cells after 1 hr by dynamic mass redistribution assay ChEMBL. 21950657
EC50 (functional) > 50 uM Agonist activity at GPR35 in human U20S cells expressing beta-lactamase and GPR35-GA14-VP16 transcription factor fusion protein assessed as transcriptional activation after 5 hrs by tango beta-arrestin translocation reporter assay ChEMBL. 21950657
IC50 (functional) = 1.05 uM Agonist activity at GPR35 in human HT-29 cells assessed as desensitization of 1 uM zaprinast-induced DMR after 1 hr by dynamic mass redistribution assay ChEMBL. 21950657

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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