TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 534.572 | Formula: C30H29F3N4O2
H donors: 2 H acceptors: 3 LogP: 3.56 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: O=C([C@H]1CNCC[C@]1(O)c1ccc(c(c1)F)F)N(C1CC1)Cc1cn(c2c1c(F)ccc2)Cc1cccnc1
InChi: 1S/C30H29F3N4O2/c31-24-9-6-21(13-26(24)33)30(39)10-12-35-15-23(30)29(38)37(22-7-8-22)18-20-17-36(16-19-3-2-11-34-14-19)27-5-1-4-25(32)28(20)27/h1-6,9,11,13-14,17,22-23,35,39H,7-8,10,12,15-16,18H2/t23-,30+/m1/s1
InChiKey: GTPUUTXWVUCADD-DJUQAAIZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	renin	Starlite/ChEMBL	References
Homo sapiens	potassium voltage-gated channel, subfamily H (eag-related), member 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Theileria parva	pepsinogen, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma japonicum	ko:K01379 cathepsin D [EC3.4.23.5], putative	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma mansoni	cathepsin D (A01 family)	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium knowlesi	plasmepsin IV, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium vivax	plasmepsin IV, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	Get druggable targets OG5_126885	All targets in OG5_126885
Echinococcus granulosus	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	aspartic protease BmAsp-2	Get druggable targets OG5_126885	All targets in OG5_126885
Loa Loa (eye worm)	voltage and ligand gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Candida albicans	vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C)	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Plasmodium falciparum	plasmepsin IV	Get druggable targets OG5_126885	All targets in OG5_126885
Babesia bovis	eukaryotic aspartyl protease family protein	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus multilocularis	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	cathepsin D (A01 family)	Get druggable targets OG5_126885	All targets in OG5_126885
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128858	All targets in OG5_128858
Plasmodium knowlesi	aspartyl protease, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Cryptosporidium parvum	membrane bound aspartyl proteinase with a signal peptide plus transmembrane domain	Get druggable targets OG5_126885	All targets in OG5_126885
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	Get druggable targets OG5_128858	All targets in OG5_128858
Cryptosporidium hominis	aspartyl protease precursor	Get druggable targets OG5_126885	All targets in OG5_126885
Neospora caninum	Renin, related	Get druggable targets OG5_126885	All targets in OG5_126885
Candida albicans	vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C)	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Toxoplasma gondii	aspartyl protease ASP1	Get druggable targets OG5_126885	All targets in OG5_126885
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	Get druggable targets OG5_126885	All targets in OG5_126885
Theileria parva	cathepsin E, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium yoelii	plasmepsin	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium falciparum	plasmepsin VI	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma japonicum	Potassium voltage-gated channel subfamily H member 2, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium berghei	plasmepsin VI	Get druggable targets OG5_126885	All targets in OG5_126885
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium berghei	plasmepsin IV	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium falciparum	plasmepsin II	Get druggable targets OG5_126885	All targets in OG5_126885
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Plasmodium falciparum	plasmepsin I	Get druggable targets OG5_126885	All targets in OG5_126885
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126885	All targets in OG5_126885
Schistosoma japonicum	Cathepsin D precursor, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Plasmodium vivax	aspartyl proteinase, putative	Get druggable targets OG5_126885	All targets in OG5_126885
Neospora caninum	Pepsinogen A1, related	Get druggable targets OG5_126885	All targets in OG5_126885

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	plasmepsin X	renin	406 aa	352 aa	26.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0425	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Leishmania major	DNA polymerase kappa, putative	0.0024	0.0362	0.0193
Plasmodium vivax	JmjC domain containing protein	0.0018	0.0214	0.0364
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0024	0.0362	0.0193
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Trypanosoma brucei	DNA polymerase kappa, putative	0.0047	0.0912	0.0859
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0425	1	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0021	0.028	0.0224
Loa Loa (eye worm)	oxidoreductase	0.0425	1	1
Schistosoma mansoni	rab6-interacting	0.0045	0.0867	0.0867
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0021	0.028	0.028
Schistosoma mansoni	jumonji domain containing protein	0.0018	0.0214	0.0214
Trypanosoma cruzi	cytochrome P450, putative	0.0026	0.0413	0.0352
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0021	0.028	0.0218
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0018	0.0214	0.0158
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0425	1	1
Loa Loa (eye worm)	oxidoreductase	0.0425	1	1
Schistosoma mansoni	rab6-interacting	0.0045	0.0867	0.0867
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0017	0.0181	0.0181
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Schistosoma mansoni	cathepsin D (A01 family)	0.0174	0.3965	0.3965
Brugia malayi	Doublecortin family protein	0.0045	0.0867	0.0867
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0021	0.03	0.013
Schistosoma mansoni	ap endonuclease	0.0021	0.03	0.03
Mycobacterium ulcerans	DNA polymerase IV	0.0047	0.0912	0.0752
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0027	0.0027
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0064	0.0064
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0014	0.0119	0.0119
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0123	0.2743	0.2743
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0425	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0012	0.0064	0.0064
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0064	0.0064
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0017	0.0181	0.0181
Echinococcus multilocularis	voltage gated potassium channel	0.0013	0.0094	0.0094
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0021	0.03	0.013
Schistosoma mansoni	protein phosphatase 2C	0.0018	0.0214	0.0214
Mycobacterium tuberculosis	Conserved protein	0.0123	0.2743	0.2615
Brugia malayi	jmjC domain containing protein	0.0018	0.0214	0.0214
Trypanosoma brucei	DNA polymerase kappa, putative	0.0047	0.0912	0.0859
Echinococcus multilocularis	jumonji domain containing 1A	0.0018	0.0214	0.0214
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0214	0.0214
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0425	1	1
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0016	0.0172	0.0085
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0425	1	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0425	1	1
Schistosoma mansoni	cytochrome P450	0.0016	0.0172	0.0172
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0021	0.028	0.028
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0021	0.028	0.011
Onchocerca volvulus		0.0425	1	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0867	0.0867
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0075	0.1597	0.1543
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0198	0.454	0.454
Toxoplasma gondii	aspartyl protease ASP1	0.0059	0.1202	0.1123
Schistosoma mansoni	cathepsin D (A01 family)	0.0174	0.3965	0.3965
Trypanosoma cruzi	aldo/keto reductase, putative	0.0123	0.2743	0.2696
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.03	0.03
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0058	0.1183	0.1105
Brugia malayi	hypothetical protein	0.0045	0.0867	0.0867
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0058	0.1183	0.1127
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.03	0.03
Schistosoma mansoni	loxhd1	0.0045	0.0867	0.0867
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0425	1	1
Brugia malayi	cytochrome P450	0.0016	0.0172	0.0172
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0021	0.028	0.0194
Echinococcus granulosus	Polycystic kidney disease protein	0.0045	0.0867	0.0867
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0123	0.2743	0.2743
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0016	0.0172	0.0109
Brugia malayi	ImpB/MucB/SamB family protein	0.0017	0.0181	0.0181
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0425	1	1
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0021	0.028	0.028
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Brugia malayi	jmjC domain containing protein	0.0018	0.0214	0.0214
Trichomonas vaginalis	aldo-keto reductase, putative	0.0425	1	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0425	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0425	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0047	0.0912	0.0859
Brugia malayi	Cytochrome P450 family protein	0.0016	0.0172	0.0172
Trypanosoma brucei	DNA polymerase kappa, putative	0.0047	0.0912	0.0859
Giardia lamblia	DINP protein human, muc B family	0.0024	0.0362	0.0084
Giardia lamblia	Aldose reductase	0.0425	1	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0021	0.028	0.0218
Entamoeba histolytica	hypothetical protein	0.0028	0.0466	0.0405
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0239	0.0182
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0021	0.028	0.028
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0058	0.1183	0.1183
Entamoeba histolytica	aldose reductase, putative	0.0425	1	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0014	0.0119	0.0119
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0123	0.2743	1
Echinococcus granulosus	lysine specific demethylase 5A	0.0069	0.1444	0.1444
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0075	0.1597	0.1543
Echinococcus multilocularis	serine protein kinase ATM	0.0028	0.0466	0.0466
Trichomonas vaginalis	aldo-keto reductase, putative	0.0425	1	1
Plasmodium vivax	aldehyde reductase, putative	0.0123	0.2743	1
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.03	0.03
Echinococcus multilocularis	aldo keto reductase	0.0425	1	1
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0094	0.0094
Echinococcus multilocularis	lysine specific demethylase 5A	0.0067	0.1399	0.1399
Echinococcus multilocularis	JmjC domain containing protein 4	0.0018	0.0214	0.0214
Trypanosoma brucei	cytochrome P450, putative	0.0026	0.0413	0.0357
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0425	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0425	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0047	0.0912	0.0859
Mycobacterium ulcerans	hypothetical protein	0.0123	0.2743	0.2615
Schistosoma mansoni	aldo-keto reductase	0.0425	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0123	0.2743	0.2743
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0.03	0.5
Echinococcus granulosus	cpg binding protein	0.0035	0.0617	0.0617
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0784	0.0784
Onchocerca volvulus		0.0045	0.0867	0.0757
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1202	0.1202
Schistosoma mansoni	ap endonuclease	0.0021	0.03	0.03
Mycobacterium leprae	Possible oxidoreductase	0.0123	0.2743	0.2615
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.002	0.0259	0.0259
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0012	0.0064	0.0064
Echinococcus multilocularis	aldo keto reductase	0.0425	1	1
Onchocerca volvulus		0.0425	1	1
Brugia malayi	MAP kinase sur-1	0.0058	0.1183	0.1183
Echinococcus granulosus	RUN	0.0045	0.0867	0.0867
Toxoplasma gondii	aspartyl protease ASP3	0.0014	0.0119	0.0031
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0047	0.0912	0.0853
Schistosoma mansoni	cpg binding protein	0.0035	0.0617	0.0617
Trichomonas vaginalis	aldo-keto reductase, putative	0.0425	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0425	1	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0062	0.1278	0.1201
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0064	0.0064
Leishmania major	aldo-keto reductase-like protein	0.0425	1	1
Brugia malayi	polk-prov protein	0.0036	0.0637	0.0637
Schistosoma mansoni	potassium channel beta	0.0123	0.2743	0.2743
Schistosoma mansoni	serine/threonine protein kinase	0.0058	0.1183	0.1183
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0017	0.0181	0.0009
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0012	0.0064	0.0064
Echinococcus granulosus	transcription factor Dp 1	0.0044	0.0833	0.0833
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0027	0.0027
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0058	0.1183	0.1127
Trypanosoma brucei	unspecified product	0.0039	0.073	0.0677
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0058	0.1183	0.1132
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0064	0.0064
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0013	0.0096	0.0096
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0425	1	1
Trypanosoma cruzi	aldo-keto reductase	0.0425	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0123	0.2743	0.2743
Echinococcus multilocularis	lysine specific demethylase 6a	0.0018	0.0214	0.0214
Brugia malayi	jmjC domain containing protein	0.0018	0.0214	0.0214
Loa Loa (eye worm)	jmjC domain-containing protein	0.0018	0.0214	0.0214
Brugia malayi	jmjC domain containing protein	0.0069	0.1444	0.1444
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0017	0.0181	0.0118
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0021	0.028	0.0224
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0075	0.1597	0.1597
Loa Loa (eye worm)	hypothetical protein	0.0057	0.1142	0.1142
Trypanosoma brucei	DNA polymerase kappa, putative	0.0047	0.0912	0.0859
Trypanosoma brucei	aldo-keto reductase, putative	0.0425	1	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0784	0.0784
Echinococcus granulosus	lipoxygenase domain containing protein	0.0045	0.0867	0.0867
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0021	0.028	0.0218
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0953	0.0953
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0425	1	1
Schistosoma mansoni	phd/f-box containing protein	0.0018	0.0214	0.0214
Schistosoma mansoni	phosphatidylserine receptor	0.0018	0.0214	0.0214
Trichomonas vaginalis	CMGC family protein kinase	0.0058	0.1183	0.1183
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0058	0.1183	0.1183
Toxoplasma gondii	aldo-keto reductase	0.0123	0.2743	0.2678
Echinococcus granulosus	voltage gated potassium channel	0.0013	0.0094	0.0094
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0047	0.0912	0.0912
Schistosoma mansoni	memapsin-2 (A01 family)	0.0014	0.0119	0.0119
Brugia malayi	NADH-dependent xylose reductase	0.0123	0.2743	0.2743
Echinococcus multilocularis	aldehyde reductase	0.0302	0.7041	0.7041
Schistosoma mansoni	aldo-keto reductase	0.0425	1	1
Echinococcus multilocularis	aldo keto reductase	0.0425	1	1
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0059	0.1202	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0713	0.0713
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0018	0.0214	0.0152
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0045	0.0867	0.0867
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0466	0.0466
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0067	0.1399	0.1399
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0214	0.0214
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.03	0.0691
Mycobacterium ulcerans	DNA polymerase IV	0.0047	0.0912	0.0752
Brugia malayi	CXXC zinc finger family protein	0.0033	0.0572	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0024	0.037	0.037
Plasmodium falciparum	aldehyde reductase, putative	0.0123	0.2743	1
Leishmania major	aldo/keto reductase, putative,aldo/keto reductase family-like protein	0.0123	0.2743	0.2615
Trichomonas vaginalis	aldo-keto reductase, putative	0.0425	1	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0028	0.0466	0.0466
Loa Loa (eye worm)	jmjC domain-containing protein	0.0069	0.1444	0.1444
Trichomonas vaginalis	aldo-keto reductase, putative	0.0425	1	1
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.002	0.0259	0.0259
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0017	0.0181	0.0181
Echinococcus multilocularis	RUN	0.0045	0.0867	0.0867
Echinococcus granulosus	jumonji domain containing 1A	0.0018	0.0214	0.0214
Loa Loa (eye worm)	oxidoreductase	0.0425	1	1
Leishmania major	prostaglandin f synthase, putative	0.0425	1	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0867	0.0867
Trichomonas vaginalis	CMGC family protein kinase	0.0058	0.1183	0.1183
Onchocerca volvulus		0.0425	1	1
Echinococcus granulosus	dna polymerase eta	0.0017	0.0181	0.0181
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.007	0.1457	0.1457
Trypanosoma brucei	DNA polymerase kappa, putative	0.0047	0.0912	0.0859
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0075	0.1597	0.1597
Echinococcus granulosus	lysine specific demethylase 6a	0.0018	0.0214	0.0214
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0047	0.0912	0.0853
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0069	0.1444	0.1444
Toxoplasma gondii	aldose reductase, putative	0.0425	1	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0.03	0.5
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.03	0.03
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0425	1	1
Mycobacterium ulcerans	oxidoreductase	0.0425	1	1
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0198	0.454	0.454
Plasmodium vivax	multidomain scavenger receptor, putative	0.0045	0.0867	0.2851
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0021	0.028	0.0224
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0014	0.0119	0.0119
Brugia malayi	Cytochrome P450 family protein	0.0026	0.0413	0.0413
Loa Loa (eye worm)	cytochrome P450 family protein	0.0026	0.0413	0.0413
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0024	0.037	0.0309
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0021	0.028	0.0224
Trypanosoma brucei	DNA polymerase IV, putative	0.0039	0.073	0.0677
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0047	0.0912	0.0853
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Trichomonas vaginalis	aldo-keto reductase, putative	0.0123	0.2743	0.2743
Echinococcus multilocularis	dna polymerase kappa	0.0047	0.0912	0.0912
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0094	0.0094
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0075	0.1597	0.1543
Loa Loa (eye worm)	doublecortin family protein	0.0045	0.0867	0.0867
Trypanosoma cruzi	target of rapamycin kinase 3	0.0021	0.028	0.0218
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0067	0.1399	0.1399
Trypanosoma cruzi	aldo/keto reductase, putative	0.0425	1	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.03	0.0238
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0021	0.028	0.0218
Echinococcus granulosus	cytochrome P450 2K1	0.0016	0.0172	0.0172
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.0854	0.0854
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0637	0.0583
Trichomonas vaginalis	DNA polymerase eta, putative	0.0047	0.0912	0.0912
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0064	0.0064
Schistosoma mansoni	pol-related	0.0425	1	1
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0021	0.028	0.0218
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0425	1	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0014	0.0119	0.0119
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0021	0.03	0.0244
Trichomonas vaginalis	CMGC family protein kinase	0.0058	0.1183	0.1183
Leishmania major	cytochrome p450-like protein	0.0026	0.0413	0.0245
Echinococcus granulosus	voltage gated potassium channel subunit	0.0123	0.2743	0.2743
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0017	0.0181	0.0181
Toxoplasma gondii	FATC domain-containing protein	0.0028	0.0466	0.0381
Leishmania major	hypothetical protein, conserved	0.0018	0.0214	0.0043
Schistosoma mansoni	hypothetical protein	0.0016	0.0172	0.0172
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.0014	0.0119	0.0031
Trichomonas vaginalis	aldo-keto reductase, putative	0.0425	1	1
Trypanosoma brucei	DNA polymerase eta, putative	0.0017	0.0181	0.0124
Brugia malayi	hypothetical protein	0.0045	0.0867	0.0867
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0012	0.0064	0.0064
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0058	0.1183	0.1127
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0058	0.1183	0.1029
Giardia lamblia	Kinase, CMGC MAPK	0.0058	0.1183	0.0929
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0058	0.1183	0.1029
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Plasmodium falciparum	plasmepsin II	0.0059	0.1202	0.4127
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0214	0.0214
Toxoplasma gondii	aspartyl protease	0.0014	0.0119	0.0031
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0239	0.0182
Trichomonas vaginalis	aldo-keto reductase, putative	0.0425	1	1
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0017	0.0181	0.0181
Onchocerca volvulus		0.0123	0.2743	0.2656
Trypanosoma brucei	DNA polymerase kappa, putative	0.0047	0.0912	0.0859
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0181	0.0181
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0075	0.1597	0.1597
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0016	0.0172	0.0115
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0059	0.1202	0.1202
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0021	0.028	0.0224
Loa Loa (eye worm)	cytochrome P450	0.0016	0.0172	0.0172
Brugia malayi	Cytochrome P450 family protein	0.006	0.1221	0.1221
Trypanosoma brucei	prostaglandin f synthase	0.0425	1	1
Toxoplasma gondii	aldo/keto reductase family oxidoreductase	0.0123	0.2743	0.2678
Entamoeba histolytica	aldose reductase, putative	0.0425	1	1
Trichomonas vaginalis	CMGC family protein kinase	0.0058	0.1183	0.1183
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0119	0.0119
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0018	0.0214	0.0127
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0018	0.0214	0.0127
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.03	0.0691
Echinococcus granulosus	phd:f box containing protein	0.0018	0.0214	0.0214
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0021	0.028	0.028
Plasmodium vivax	aspartyl proteinase, putative	0.0059	0.1202	0.4127
Mycobacterium leprae	Conserved hypothetical protein	0.0302	0.7041	0.6989
Echinococcus multilocularis	cpg binding protein	0.0035	0.0617	0.0617
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0058	0.1183	0.1127
Brugia malayi	Pepsin A precursor	0.0014	0.0119	0.0119
Schistosoma mansoni	cpg binding protein	0.0033	0.0572	0.0572
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0021	0.028	0.011
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0123	0.2743	0.2696
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0064	0.0064
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0425	1	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.03	0.03
Schistosoma mansoni	lipoxygenase	0.0117	0.259	0.259
Schistosoma mansoni	DNA polymerase eta	0.0017	0.0181	0.0181
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0021	0.028	0.011
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0018	0.0214	0.0214
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0239	0.0182
Trypanosoma brucei	DNA polymerase IV, putative	0.0047	0.0912	0.0859
Echinococcus multilocularis	tumor protein p63	0.0386	0.9066	0.9066
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0425	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0021	0.028	0.028
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0024	0.0024
Echinococcus granulosus	aldehyde reductase	0.0302	0.7041	0.7041
Echinococcus multilocularis	transcription factor Dp 1	0.0044	0.0833	0.0833
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Trichomonas vaginalis	aldo-keto reductase, putative	0.0425	1	1
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0075	0.1597	0.1548
Echinococcus granulosus	tumor protein p63	0.0386	0.9066	0.9066
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0425	1	1
Plasmodium falciparum	aldo-keto reductase, putative	0.0123	0.2743	1
Loa Loa (eye worm)	hypothetical protein	0.0425	1	1
Schistosoma mansoni	hypothetical protein	0.0045	0.0867	0.0867
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0123	0.2743	0.2743
Loa Loa (eye worm)	phosphatidylinositol 3	0.0021	0.028	0.028
Entamoeba histolytica	aldose reductase, putative	0.0425	1	1
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0021	0.0281	0.0111
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0425	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0024	0.0362	0.0306
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0027	0.0027
Echinococcus granulosus	JmjC domain containing protein 4	0.0018	0.0214	0.0214
Trypanosoma cruzi	cytochrome P450, putative	0.0026	0.0413	0.0352
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0075	0.1597	0.1597
Echinococcus granulosus	hypothetical protein	0.0425	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0425	1	1
Loa Loa (eye worm)	oxidoreductase	0.0425	1	1
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0021	0.028	0.011
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0014	0.0119	0.0119
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0026	0.0413	0.0245
Echinococcus granulosus	mitogen activated protein kinase	0.0058	0.1183	0.1183
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0637	0.0637
Trypanosoma brucei	DNA polymerase kappa, putative	0.0047	0.0912	0.0859
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Toxoplasma gondii	oxidoreductase, aldo/keto reductase family protein	0.0123	0.2743	0.2678
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0096	0.0096
Echinococcus granulosus	dna polymerase kappa	0.0047	0.0912	0.0912
Trypanosoma brucei	protein kinase, putative	0.0058	0.1183	0.1132
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0425	1	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0014	0.0119	0.0119
Schistosoma mansoni	cpg binding protein	0.0035	0.0617	0.0617
Brugia malayi	aspartic protease BmAsp-2, identical	0.0014	0.0119	0.0119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Brugia malayi	ImpB/MucB/SamB family protein	0.0017	0.0181	0.0181
Loa Loa (eye worm)	hypothetical protein	0.001	0.0024	0.0024
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0028	0.0466	0.0466
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0021	0.03	0.002
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0123	0.2743	0.2743
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0016	0.0172	0.0109
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0075	0.1597	0.1597
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0045	0.0867	0.0867
Schistosoma mansoni	polycystin 1-related	0.0045	0.0867	0.0867
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0018	0.0214	0.0364
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0059	0.1202	0.1123
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0953	0.0953
Onchocerca volvulus		0.0057	0.1142	0.1036
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0021	0.028	0.028
Onchocerca volvulus		0.0425	1	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0013	0.0094	0.0094
Schistosoma mansoni	jumonji domain containing protein	0.0067	0.1399	0.1399
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0059	0.1202	0.1202
Trypanosoma cruzi	DNA polymerase eta, putative	0.0017	0.0181	0.0118
Brugia malayi	hypothetical protein	0.0014	0.0119	0.0119
Giardia lamblia	Aldose reductase	0.0425	1	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0425	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0637	0.0583
Loa Loa (eye worm)	CYP4Cod1	0.0026	0.0413	0.0413
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0021	0.028	0.028
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0425	1	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.03	0.0238
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.0854	0.0854
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0033	0.0572	0.0572
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0425	1	1
Plasmodium falciparum	plasmepsin VI	0.0059	0.1202	0.4127
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0425	1	1
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0013	0.0096	0.0038
Echinococcus multilocularis		0.0016	0.0172	0.0172
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0059	0.1202	0.1202
Schistosoma mansoni	lipoxygenase	0.0198	0.454	0.454
Echinococcus multilocularis	phd:f box containing protein	0.0018	0.0214	0.0214
Echinococcus multilocularis	mitogen activated protein kinase	0.0058	0.1183	0.1183
Echinococcus granulosus	lipoxygenase domain containing protein	0.0045	0.0867	0.0867
Loa Loa (eye worm)	aspartyl protease 6	0.0014	0.0119	0.0119
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0021	0.028	0.028
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0021	0.028	0.011
Echinococcus granulosus	aldo keto reductase	0.0425	1	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0047	0.0912	0.0859
Onchocerca volvulus		0.0045	0.0867	0.0757
Brugia malayi	Cytochrome P450 family protein	0.0026	0.0413	0.0413
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0059	0.1202	0.1202
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0028	0.0466	0.0405
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.0854	0.0854
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0013	0.0096	0.0008
Leishmania major	DNA polymerase eta, putative	0.0017	0.0181	0.0009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0064	0.0064
Brugia malayi	aspartic protease BmAsp-1, identical	0.0014	0.0119	0.0119
Toxoplasma gondii	exonuclease III APE	0.0021	0.03	0.0214
Loa Loa (eye worm)	oxidoreductase	0.0425	1	1
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0013	0.0094	0.0094
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0028	0.0466	0.0411
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0425	1	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.006	0.1221	0.1221
Echinococcus granulosus	aldo keto reductase	0.0425	1	1
Plasmodium falciparum	plasmepsin IV	0.0059	0.1202	0.4127
Loa Loa (eye worm)	cytochrome P450 family protein	0.0026	0.0413	0.0413
Mycobacterium tuberculosis	Probable oxidoreductase	0.0425	1	1
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0018	0.0214	0.0152
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0425	1	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0096	0.0096
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.03	0.03
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0123	0.2743	0.2696
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0014	0.0119	0.0119
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0024	0.0362	0.0193
Plasmodium falciparum	plasmepsin I	0.0059	0.1202	0.4127
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0014	0.0119	0.0119
Onchocerca volvulus		0.0425	1	1
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0016	0.0172	0.0109
Loa Loa (eye worm)	jmjC domain-containing protein	0.0018	0.0214	0.0214
Trichomonas vaginalis	aldo-keto reductase, putative	0.0425	1	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0021	0.03	0.013
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0045	0.0854	0.0854
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0014	0.0119	0.0119
Brugia malayi	hypothetical protein	0.0014	0.0119	0.0119
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0425	1	1
Echinococcus multilocularis	Polycystic kidney disease protein	0.0045	0.0867	0.0867
Echinococcus multilocularis	dna polymerase eta	0.0017	0.0181	0.0181
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0075	0.1597	0.145
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0014	0.0119	0.0119
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0021	0.03	0.0238
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0069	0.1444	0.1444
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Trichomonas vaginalis	aldo-keto reductase, putative	0.0425	1	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0119	0.0119
Echinococcus multilocularis	aldo keto reductase	0.0425	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Schistosoma mansoni	cellular tumor antigen P53	0.0057	0.1142	0.1142
Plasmodium vivax	plasmepsin IV, putative	0.0059	0.1202	0.4127
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0021	0.028	0.0218
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Echinococcus granulosus	serine protein kinase ATM	0.0028	0.0466	0.0466
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Brugia malayi	jmjC domain containing protein	0.0018	0.0214	0.0214
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0425	1	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0013	0.0094	0.0094
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0047	0.0912	0.0853
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0123	0.2743	0.2743
Trichomonas vaginalis	aldo/keto reductase, putative	0.0425	1	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0021	0.0281	0.0219
Trypanosoma brucei	aldo/keto reductase, putative	0.0123	0.2743	0.2701
Plasmodium falciparum	LCCL domain-containing protein	0.0045	0.0867	0.2851
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0094	0.0094
Trichomonas vaginalis	aldo-keto reductase, putative	0.0425	1	1
Echinococcus granulosus	mitogen activated protein kinase 3	0.0058	0.1183	0.1183
Brugia malayi	jmjC domain containing protein	0.0067	0.1399	0.1399
Loa Loa (eye worm)	jmjC domain-containing protein	0.0018	0.0214	0.0214
Onchocerca volvulus		0.0033	0.0572	0.0459
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Echinococcus granulosus	aldo keto reductase	0.0425	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.028	0.028
Trichomonas vaginalis	conserved hypothetical protein	0.0123	0.2743	0.2743
Trichomonas vaginalis	aldo-keto reductase, putative	0.0425	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (ADMET)	= 3 %	Reversible inhibition of CYP3A4 assessed as conversion of testosterone to 6-beta-hydroxytestosterone at 10 uM relative to control	ChEMBL.	21641209
IC50 (binding)	= 0.1 nM	Inhibition of human recombinant renin using DNP-Lys-His-Pro-Phe-His-Leu-Val-Ile-His-D,L-Amp as Q-FRET substrate after 3 hrs by fluorescence assay	ChEMBL.	21641209
IC50 (binding)	= 3.4 nM	Inhibition of human recombinant renin in human plasma using QXL520-Lys-His-Pro-Phe-His-Leu-Val-Ile-His-Lys-(5-FAM) as Q-FRET substrate after 1 hr by fluorescence assay	ChEMBL.	21641209
Ki (binding)	= 0.34 uM	Binding affinity to human ERG	ChEMBL.	21641209

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1910321

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1578529