TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 347.438 | Formula: C13H9N5OS3
H donors: 0 H acceptors: 3 LogP: 2.48 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: N#CCn1ncn(c1=O)c1sc2c(n1)c1ccsc1SC2C
InChi: 1S/C13H9N5OS3/c1-7-10-9(8-2-5-20-11(8)21-7)16-12(22-10)17-6-15-18(4-3-14)13(17)19/h2,5-7H,4H2,1H3
InChiKey: OAKMOAOMXYPUEM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0024	0.0884	0.0738
Echinococcus multilocularis	allatostatin A receptor	0.0024	0.0884	0.0884
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0884	0.0884
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0157	0.1134
Brugia malayi	G-protein coupled receptor	0.0024	0.0884	0.0738
Echinococcus multilocularis	ATP binding cassette sub family B	0.001	0.0152	0.0152
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0884	0.0738
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0024	0.0884	0.5907
Brugia malayi	neuropeptide F receptor	0.0024	0.0884	0.0738
Onchocerca volvulus		0.0024	0.0884	0.5907
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0024	0.0884	0.0738
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Echinococcus granulosus	tm gpcr rhodopsin	0.0024	0.0884	0.0884
Entamoeba histolytica	P-glycoprotein 5, putative	0.001	0.0157	0.5
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Trichomonas vaginalis	ABC transporter, putative	0.001	0.0157	0.1134
Echinococcus granulosus	tm gpcr rhodopsin	0.0024	0.0884	0.0884
Loa Loa (eye worm)	hypothetical protein	0.001	0.0157	0.0006
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0157	0.1134
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0157	0.1134
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0024	0.0884	0.0884
Brugia malayi	neuropeptide F receptor	0.0024	0.0884	0.0738
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0034	0.1387	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0024	0.0884	0.0884
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0157	0.1134
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0157	0.0157
Brugia malayi	hypothetical protein	0.0024	0.0884	0.0738
Brugia malayi	Carboxylesterase family protein	0.0034	0.1387	0.125
Onchocerca volvulus		0.0024	0.0884	0.5907
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0024	0.0884	0.0884
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0157	0.1134
Brugia malayi	sulfakinin receptor protein	0.0024	0.0884	0.0738
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0024	0.0884	0.0738
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1387	0.1255
Echinococcus multilocularis	dro:myosuppressin receptor	0.0024	0.0884	0.0884
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0884	0.0884
Leishmania major	p-glycoprotein	0.001	0.0157	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0884	0.0884
Echinococcus granulosus	neuropeptide FF receptor 2	0.0024	0.0884	0.0884
Brugia malayi	AKH receptor	0.0024	0.0884	0.0738
Brugia malayi	Dopamine receptor protein 2	0.0024	0.0884	0.0738
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0157	0.0157
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0034	0.1387	0.125
Schistosoma mansoni	hypothetical protein	0.0024	0.0884	0.0738
Echinococcus granulosus	multidrug resistance protein 1	0.001	0.0157	0.0157
Schistosoma mansoni	amine GPCR	0.0024	0.0884	0.0738
Entamoeba histolytica	P-glyco protein 6, putative	0.001	0.0157	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0024	0.0884	0.0884
Brugia malayi	G-protein coupled receptor	0.0024	0.0884	0.0738
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.001	0.0157	0.0006
Mycobacterium ulcerans	carboxylesterase, LipT	0.0034	0.1387	0.5
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0024	0.0884	0.0738
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.001	0.0152	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Schistosoma mansoni	opsin-like receptor	0.0024	0.0884	0.0738
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Schistosoma mansoni	amine GPCR	0.0024	0.0884	0.0738
Echinococcus multilocularis	fmrfamide receptor	0.0024	0.0884	0.0884
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0157	0.0157
Echinococcus granulosus	7TM GPCR rhodopsin	0.0024	0.0884	0.0884
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0024	0.0884	0.0884
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0024	0.0884	0.0884
Echinococcus granulosus	neuropeptides capa receptor	0.0024	0.0884	0.0884
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1387	0.1255
Echinococcus granulosus	para nitrobenzyl esterase	0.0034	0.1387	0.1387
Echinococcus granulosus	fmrfamide receptor	0.0024	0.0884	0.0884
Brugia malayi	putative neuropeptide receptor NPR1	0.0024	0.0884	0.0738
Echinococcus multilocularis	neuropeptide Y receptor	0.0024	0.0884	0.0884
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0157	0.1134
Onchocerca volvulus		0.0024	0.0884	0.5907
Echinococcus granulosus	multidrug resistance protein 1	0.001	0.0157	0.0157
Echinococcus granulosus	7tm_1 domain containing protein	0.0024	0.0884	0.0884
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0024	0.0884	0.0738
Brugia malayi	Carboxylesterase family protein	0.0034	0.1387	0.125
Loa Loa (eye worm)	hypothetical protein	0.0203	1	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0024	0.0884	0.0738
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0024	0.0884	0.0884
Echinococcus multilocularis	carboxylesterase 5A	0.0203	1	1
Schistosoma mansoni	BC026374 protein (S09 family)	0.0034	0.1387	0.125
Echinococcus granulosus	neuropeptides capa receptor	0.0024	0.0884	0.0884
Echinococcus multilocularis	serotonin receptor	0.0024	0.0884	0.0884
Onchocerca volvulus		0.0024	0.0884	0.5907
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0024	0.0884	0.0744
Echinococcus granulosus	sex peptide receptor	0.0024	0.0884	0.0884
Schistosoma mansoni	hypothetical protein	0.0024	0.0884	0.0738
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0157	0.1134
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0157	0.0157
Loa Loa (eye worm)	carboxylesterase	0.0203	1	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Entamoeba histolytica	P-glycoprotein-1	0.001	0.0157	0.5
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Echinococcus granulosus	G protein coupled receptor 139	0.0024	0.0884	0.0884
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0024	0.0884	0.0738
Echinococcus multilocularis	fmrfamide receptor	0.0024	0.0884	0.0884
Schistosoma mansoni	biogenic amine receptor	0.0024	0.0884	0.0738
Echinococcus granulosus	neuropeptide receptor	0.0024	0.0884	0.0884
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0024	0.0884	0.0884
Brugia malayi	Serotonin receptor	0.0024	0.0884	0.0738
Brugia malayi	hypothetical protein	0.0024	0.0884	0.0738
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Trichomonas vaginalis	abcb9, putative	0.001	0.0157	0.1134
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0157	0.1134
Brugia malayi	G protein-coupled receptor F59B2.13	0.0024	0.0884	0.0738
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Onchocerca volvulus		0.0034	0.1387	1
Onchocerca volvulus		0.0034	0.1387	1
Loa Loa (eye worm)	hypothetical protein	0.0203	1	1
Echinococcus granulosus	somatostatin receptor	0.0024	0.0884	0.0884
Echinococcus granulosus	dro:myosuppressin receptor	0.0024	0.0884	0.0884
Onchocerca volvulus		0.0024	0.0884	0.5907
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0024	0.0884	0.0884
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Echinococcus multilocularis	serotonin receptor	0.0024	0.0884	0.0884
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0024	0.0884	0.0738
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0024	0.0884	0.0744
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0157	0.1134
Onchocerca volvulus		0.0024	0.0884	0.5907
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Schistosoma mansoni	neuropeptide receptor	0.0024	0.0884	0.0738
Echinococcus granulosus	tm gpcr rhodopsin	0.0024	0.0884	0.0884
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0157	0.1134
Loa Loa (eye worm)	melatonin receptor type 1A	0.0024	0.0884	0.0744
Echinococcus multilocularis	sex peptide receptor	0.0024	0.0884	0.0884
Schistosoma mansoni	neuropeptide F-like receptor	0.0024	0.0884	0.0738
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1387	0.1255
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0024	0.0884	0.0738
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0024	0.0884	0.0884
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0884	0.0738
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0024	0.0884	0.0884
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0157	0.0157
Brugia malayi	hypothetical protein	0.0024	0.0884	0.0738
Echinococcus multilocularis	neuroligin	0.0034	0.1387	0.1387
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.001	0.0157	0.5
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.001	0.0157	0.5
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.001	0.0157	0.5
Echinococcus granulosus	g-protein coupled receptor	0.0024	0.0884	0.0884
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0024	0.0884	0.0744
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Echinococcus granulosus	acetylcholinesterase	0.0203	1	1
Brugia malayi	putative neuropeptide receptor	0.0024	0.0884	0.0738
Onchocerca volvulus		0.0024	0.0884	0.5907
Schistosoma mansoni	opsin-like receptor	0.0024	0.0884	0.0738
Brugia malayi	Carboxylesterase family protein	0.0034	0.1387	0.125
Onchocerca volvulus		0.0024	0.0884	0.5907
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0884	0.0884
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0034	0.1387	0.125
Echinococcus multilocularis	neuropeptide receptor A26	0.0024	0.0884	0.0884
Echinococcus granulosus	neuropeptide s receptor	0.0024	0.0884	0.0884
Echinococcus granulosus	g protein coupled receptor	0.0024	0.0884	0.0884
Trichomonas vaginalis	spcc417.12 protein, putative	0.0034	0.1387	1
Trichomonas vaginalis	taga, putative	0.001	0.0157	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Brugia malayi	hypothetical protein	0.0024	0.0884	0.0738
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.001	0.0157	0.0157
Schistosoma mansoni	acetylcholinesterase	0.0034	0.1387	0.125
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0157	0.1134
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0884	0.0738
Echinococcus granulosus	serotonin receptor	0.0024	0.0884	0.0884
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0024	0.0884	0.0738
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0157	0.1134
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0024	0.0884	0.0744
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0024	0.0884	0.0738
Echinococcus granulosus	biogenic amine 5HT receptor	0.0024	0.0884	0.0884
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0884	0.0884
Echinococcus multilocularis	g protein coupled receptor	0.0024	0.0884	0.0884
Echinococcus multilocularis	orexin receptor type 2	0.0024	0.0884	0.0884
Brugia malayi	Melatonin receptor type 1A	0.0024	0.0884	0.0738
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0024	0.0884	0.0884
Loa Loa (eye worm)	neuropeptide F receptor	0.0024	0.0884	0.0744
Onchocerca volvulus		0.0024	0.0884	0.5907
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0024	0.0884	0.0738
Brugia malayi	Dopamine receptor	0.0024	0.0884	0.0738
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1387	0.1255
Schistosoma mansoni	biogenic amine receptor	0.0024	0.0884	0.0738
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.001	0.0157	0.5
Brugia malayi	larval opioid receptor	0.0024	0.0884	0.0738
Brugia malayi	hypothetical protein	0.0024	0.0884	0.0738
Schistosoma mansoni	neuropeptide receptor	0.0024	0.0884	0.0738
Echinococcus granulosus	BC026374 protein S09 family	0.0034	0.1387	0.1387
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0884	0.0884
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0024	0.0884	0.0884
Schistosoma mansoni	amine GPCR	0.0024	0.0884	0.0738
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0024	0.0884	0.0884
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0884	0.0738
Trichomonas vaginalis	ABC transporter, putative	0.001	0.0157	0.1134
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0024	0.0884	0.0884
Onchocerca volvulus		0.0024	0.0884	0.5907
Echinococcus granulosus	g protein coupled receptor	0.0024	0.0884	0.0884
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1387	0.1255
Trichomonas vaginalis	abcb9, putative	0.001	0.0157	0.1134
Brugia malayi	Serotonin receptor	0.0024	0.0884	0.0738
Brugia malayi	Carboxylesterase family protein	0.0203	1	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0024	0.0884	0.0738
Schistosoma mansoni	histamine h1 receptor	0.0024	0.0884	0.0738
Echinococcus multilocularis	g-protein coupled receptor	0.0024	0.0884	0.0884
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0157	0.1134
Brugia malayi	hypothetical protein	0.0024	0.0884	0.0738
Entamoeba histolytica	P-glycoprotein-2	0.001	0.0157	0.5
Echinococcus granulosus	g protein coupled receptor	0.0024	0.0884	0.0884
Schistosoma mansoni	neuropeptide f receptor 76f	0.0024	0.0884	0.0738
Echinococcus granulosus	neuroligin	0.0034	0.1387	0.1387
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0884	0.0884
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0884	0.0884
Schistosoma mansoni	gliotactin	0.0034	0.1387	0.125
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0024	0.0884	0.5907
Trichomonas vaginalis	abcb9, putative	0.001	0.0157	0.1134
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0024	0.0884	0.0884
Schistosoma mansoni	opsin-like receptor	0.0024	0.0884	0.0738
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0024	0.0884	0.0738
Echinococcus granulosus	neuropeptide Y receptor	0.0024	0.0884	0.0884
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0024	0.0884	0.0744
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0024	0.0884	0.0884
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0157	0.1134
Brugia malayi	hypothetical protein	0.0024	0.0884	0.0738
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0024	0.0884	0.0884
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0884	0.0884
Schistosoma mansoni	myosin xvIII	0.0024	0.0884	0.0738
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0024	0.0884	0.0884
Echinococcus granulosus	carboxylesterase 5A	0.0203	1	1
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0034	0.1387	0.1387
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0024	0.0884	0.0738
Echinococcus multilocularis	g protein coupled receptor	0.0024	0.0884	0.0884
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0034	0.1387	0.125
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0024	0.0884	0.0884
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0024	0.0884	0.0738
Echinococcus granulosus	acetylcholinesterase	0.0203	1	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Brugia malayi	follicle stimulating hormone receptor	0.0024	0.0884	0.0738
Schistosoma mansoni	amine GPCR	0.0024	0.0884	0.0738
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0034	0.1387	1
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0034	0.1387	0.1387
Echinococcus multilocularis	multidrug resistance protein 1	0.001	0.0157	0.0157
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0157	0.1134
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0024	0.0884	0.0738
Echinococcus multilocularis	G protein coupled receptor 139	0.0024	0.0884	0.0884
Echinococcus granulosus	hypothetical protein	0.0024	0.0884	0.0884
Schistosoma mansoni	hypothetical protein	0.0024	0.0884	0.0738
Schistosoma mansoni	biogenic amine receptor	0.0024	0.0884	0.0738
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0024	0.0884	0.0738
Plasmodium vivax	multidrug resistance protein 1, putative	0.001	0.0157	0.5
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0024	0.0884	0.0884
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Schistosoma mansoni	neuropeptide F-like receptor	0.0024	0.0884	0.0738
Echinococcus multilocularis	acetylcholinesterase	0.0203	1	1
Echinococcus multilocularis	neuropeptide receptor	0.0024	0.0884	0.0884
Onchocerca volvulus		0.0024	0.0884	0.5907
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0.0157	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Entamoeba histolytica	P-glycoprotein-5	0.001	0.0157	0.5
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0157	0.0157
Echinococcus granulosus	orexin receptor type 2	0.0024	0.0884	0.0884
Onchocerca volvulus		0.0024	0.0884	0.5907
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1387	0.1255
Onchocerca volvulus		0.0034	0.1387	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0024	0.0884	0.0738
Echinococcus multilocularis	neuropeptide Y receptor	0.0024	0.0884	0.0884
Schistosoma mansoni	hypothetical protein	0.0024	0.0884	0.0738
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0884	0.0884
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1387	0.1255
Echinococcus granulosus	multidrug resistance protein 1	0.001	0.0157	0.0157
Onchocerca volvulus		0.0024	0.0884	0.5907
Onchocerca volvulus		0.0024	0.0884	0.5907
Onchocerca volvulus		0.0024	0.0884	0.5907
Echinococcus granulosus	neuropeptide receptor	0.0024	0.0884	0.0884
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Echinococcus granulosus	allatostatin A receptor	0.0024	0.0884	0.0884
Loa Loa (eye worm)	G-protein coupled receptor	0.0024	0.0884	0.0744
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0884	0.0884
Entamoeba histolytica	P-glycoprotein-2, putative	0.001	0.0157	0.5
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0034	0.1387	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0157	0.1134
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.001	0.0157	0.1134
Loa Loa (eye worm)	carboxylesterase	0.0034	0.1387	0.1255
Onchocerca volvulus		0.0024	0.0884	0.5907
Brugia malayi	GnHR receptor homolog	0.0024	0.0884	0.0738
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0884	0.0738
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Loa Loa (eye worm)	TYRA-2 protein	0.0024	0.0884	0.0744
Onchocerca volvulus		0.0034	0.1387	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Brugia malayi	Dopamine receptor protein 1	0.0024	0.0884	0.0738
Loa Loa (eye worm)	acetylcholinesterase 1	0.0203	1	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0024	0.0884	0.0738
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.001	0.0157	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Brugia malayi	ORL1-like opioid receptor	0.0024	0.0884	0.0738
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Schistosoma mansoni	neuropeptide receptor	0.0024	0.0884	0.0738
Brugia malayi	RE15519p	0.0024	0.0884	0.0738
Brugia malayi	hypothetical protein	0.0034	0.1387	0.125
Onchocerca volvulus		0.0034	0.1387	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0024	0.0884	0.0884
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0884	0.0738
Echinococcus multilocularis	multidrug resistance protein 1	0.001	0.0157	0.0157
Brugia malayi	hypothetical protein	0.0024	0.0884	0.0738
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0884	0.0738
Loa Loa (eye worm)	neuropeptide F receptor	0.0024	0.0884	0.0744
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Entamoeba histolytica	P-glycoprotein-2	0.001	0.0157	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0024	0.0884	0.0884
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0024	0.0884	0.0738
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Trichomonas vaginalis	ABC transporter, putative	0.001	0.0157	0.1134
Echinococcus multilocularis	neuropeptides capa receptor	0.0024	0.0884	0.0884
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0884	0.0884
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0884	0.0884
Brugia malayi	hypothetical protein	0.0024	0.0884	0.0738
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0034	0.1387	0.125
Loa Loa (eye worm)	G-protein coupled receptor	0.0024	0.0884	0.0744
Schistosoma mansoni	neuropeptide receptor	0.0024	0.0884	0.0738
Onchocerca volvulus		0.0024	0.0884	0.5907
Loa Loa (eye worm)	multidrug resistance protein 3	0.001	0.0157	0.0006
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0024	0.0884	0.0884
Loa Loa (eye worm)	hypothetical protein	0.001	0.0157	0.0006
Brugia malayi	hypothetical protein	0.0024	0.0884	0.0738
Echinococcus granulosus	biogenic amine 5HT receptor	0.0024	0.0884	0.0884
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Echinococcus multilocularis	g protein coupled receptor	0.0024	0.0884	0.0884
Schistosoma mansoni	amine GPCR	0.0024	0.0884	0.0738
Echinococcus multilocularis	acetylcholinesterase	0.0203	1	1
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0034	0.1387	0.1387
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0884	0.0884
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0024	0.0884	0.0884
Brugia malayi	Carboxylesterase family protein	0.0034	0.1387	0.125
Echinococcus granulosus	neuropeptide receptor A26	0.0024	0.0884	0.0884
Echinococcus multilocularis	neuropeptide s receptor	0.0024	0.0884	0.0884
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0157	0.1134
Schistosoma mansoni	adenoreceptor	0.0024	0.0884	0.0738
Echinococcus multilocularis	somatostatin receptor	0.0024	0.0884	0.0884
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0884	0.0738
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0.0157	0.1134
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0024	0.0884	0.0738
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0203	1	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0884	0.0744
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0884	0.0738
Plasmodium falciparum	multidrug resistance protein 1	0.001	0.0157	0.5
Echinococcus multilocularis	para nitrobenzyl esterase	0.0034	0.1387	0.1387
Echinococcus granulosus	neuropeptide Y receptor	0.0024	0.0884	0.0884
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0.0157	0.1134
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0884	0.0884
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0024	0.0884	0.0884
Loa Loa (eye worm)	carboxylesterase	0.0034	0.1387	0.1255
Brugia malayi	G protein-coupled receptor	0.0024	0.0884	0.0738
Trichomonas vaginalis	ABC transporter, putative	0.001	0.0157	0.1134
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0024	0.0884	0.0738
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0024	0.0884	0.0884
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0034	0.1387	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.001	0.0157	0.0157

Activities

Activity type	Activity value	Assay description	Source	Reference
IZ (functional)	= 11 mm	Antibacterial activity against Escherichia coli at 100 ug/ml after 24 hrs by disc diffusion method	ChEMBL.	21920741
IZ (functional)	= 13 mm	Antibacterial activity against Escherichia coli at 200 ug/ml after 24 hrs by disc diffusion method	ChEMBL.	21920741
IZ (functional)	= 14 mm	Antifungal activity against Candida albicans at 100 ug/ml after 48 hrs by disc diffusion method	ChEMBL.	21920741
IZ (functional)	= 18 mm	Antifungal activity against Candida albicans at 200 ug/ml after 48 hrs by disc diffusion method	ChEMBL.	21920741

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1914519

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1578691