TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 316.395 | Formula: C18H24N2O3
H donors: 1 H acceptors: 2 LogP: 1.8 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)[C@@H]1C2CC[C@@H](N2C)C[C@@H]1c1ccc(cc1)NC(=O)C
InChi: 1S/C18H24N2O3/c1-11(21)19-13-6-4-12(5-7-13)15-10-14-8-9-16(20(14)2)17(15)18(22)23-3/h4-7,14-17H,8-10H2,1-3H3,(H,19,21)/t14-,15-,16?,17+/m1/s1
InChiKey: VZDGLCMFFRBUGI-YKNYVSNTSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Dopamine transporter	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	IPR000175,Sodium:neurotransmitter symporter,domain-containing	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Brugia malayi	Sodium:neurotransmitter symporter family protein	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	serotonin transporter b	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	solute carrier family 6 member 4	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent noradrenaline transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	sodium/chloride dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	norepinephrine/norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Onchocerca volvulus		Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Treponema pallidum	sodium- and chloride- dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus granulosus	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	sodium/chloride dependent transporter	Dopamine transporter	619 aa	588 aa	40.3 %
Schistosoma mansoni	sodium/chloride dependent transporter	Dopamine transporter	619 aa	558 aa	41.8 %
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	Dopamine transporter	619 aa	604 aa	37.9 %
Schistosoma japonicum	ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative	Dopamine transporter	619 aa	509 aa	40.1 %
Onchocerca volvulus	High affinity copper uptake protein 1 homolog	Dopamine transporter	619 aa	599 aa	44.2 %
Brugia malayi	Sodium:neurotransmitter symporter family protein	Dopamine transporter	619 aa	578 aa	33.4 %
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	Dopamine transporter	619 aa	636 aa	31.8 %
Drosophila melanogaster	CG13796 gene product from transcript CG13796-RD	Dopamine transporter	619 aa	557 aa	23.9 %
Echinococcus granulosus	sodium and chloride dependent glycine	Dopamine transporter	619 aa	594 aa	41.4 %
Drosophila melanogaster	CG1698 gene product from transcript CG1698-RA	Dopamine transporter	619 aa	522 aa	36.0 %
Onchocerca volvulus		Dopamine transporter	619 aa	612 aa	23.5 %
Echinococcus multilocularis	sodium and chloride dependent glycine	Dopamine transporter	619 aa	599 aa	41.9 %
Onchocerca volvulus	Transmembrane protein 120 homolog	Dopamine transporter	619 aa	578 aa	32.9 %
Schistosoma japonicum	ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative	Dopamine transporter	619 aa	551 aa	39.9 %
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	Dopamine transporter	619 aa	578 aa	32.9 %
Neospora caninum	sodium-dependent transporter, putative	Dopamine transporter	619 aa	498 aa	32.3 %
Plasmodium vivax	hypothetical protein, conserved	Dopamine transporter	619 aa	657 aa	20.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0023	0.0094	0.0094
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0388	0.6469	0.6469
Loa Loa (eye worm)	transcription factor SMAD2	0.0252	0.4099	0.6336
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0094	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0094	0.0146
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0038	0.5
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0019	0.0025	0.0038
Onchocerca volvulus		0.0023	0.0094	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0596	0.0922
Loa Loa (eye worm)	hypothetical protein	0.0109	0.1611	0.249
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0183	0.2893	0.4472
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0109	0.1611	0.1611
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0388	0.6469	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0094	0.0146
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0023	0.0094	0.0094
Echinococcus granulosus	tar DNA binding protein	0.0064	0.081	0.081
Loa Loa (eye worm)	hypothetical protein	0.0205	0.3276	0.5064
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0162	0.2532	0.3914
Schistosoma mansoni	coup transcription factor	0.0388	0.6469	0.6469
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0025	0.0038
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0023	0.0094	0.0146
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0081	0.1113	0.1113
Echinococcus granulosus	nAChR subunit	0.0023	0.0094	0.0094
Brugia malayi	ecdysone receptor	0.0183	0.2893	0.4472
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0019	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0183	0.2893	0.4472
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0019	0.0025	0.0025
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0183	0.2893	0.4451
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0094	0.0146
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0019	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0094	0.0146
Brugia malayi	nuclear receptor NHR-88	0.0183	0.2893	0.4472
Schistosoma mansoni	nAChR subunit	0.0023	0.0094	0.0094
Schistosoma mansoni	hypothetical protein	0.0111	0.1636	0.1636
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0388	0.6469	0.6469
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0388	0.6469	1
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0038	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0388	0.6469	1
Echinococcus multilocularis	GPCR, family 2	0.0051	0.0596	0.0596
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1052	0.1627
Echinococcus multilocularis	glycine receptor subunit beta	0.0023	0.0094	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0094	0.0146
Schistosoma mansoni	hypothetical protein	0.0051	0.0596	0.0596
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0038	1
Loa Loa (eye worm)	hypothetical protein	0.0388	0.6469	1
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0019	0.0025	0.0025
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0162	0.2532	0.3914
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.081	0.1252
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0183	0.2893	0.2893
Loa Loa (eye worm)	hypothetical protein	0.0183	0.2893	0.4472
Schistosoma mansoni	nuclear hormone receptor	0.0388	0.6469	0.6469
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0051	0.0596	0.0596
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0388	0.6469	1
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0019	0.0025	0.0025
Schistosoma mansoni	hypothetical protein	0.0051	0.0596	0.0596
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0051	0.0596	0.0922
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0051	0.0596	0.0596
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0183	0.2893	0.4472
Brugia malayi	Nuclear hormone receptor-like 1	0.0205	0.3276	0.5064
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0183	0.2893	0.2893
Echinococcus granulosus	GPCR family 2	0.0051	0.0596	0.0596
Schistosoma mansoni	nuclear receptor	0.0183	0.2893	0.2893
Onchocerca volvulus		0.0023	0.0094	0.0108
Brugia malayi	Latrophilin receptor protein 2	0.0051	0.0596	0.0922
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0109	0.1611	0.249
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0388	0.6469	1
Echinococcus granulosus	glycine receptor subunit beta	0.0023	0.0094	0.0094
Schistosoma mansoni	zinc finger protein	0.0183	0.2893	0.2893
Loa Loa (eye worm)	hypothetical protein	0.0205	0.3276	0.5064
Echinococcus multilocularis	Zinc finger protein jing protein	0.059	1	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0025	0.0038
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0388	0.6469	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.0183	0.2893	0.2893
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.081	0.081
Brugia malayi	Nuclear hormone receptor-like 1	0.0205	0.3276	0.5064
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0183	0.2893	0.2893
Loa Loa (eye worm)	serotonin transporter b	0.0109	0.1611	0.249
Loa Loa (eye worm)	hypothetical protein	0.0205	0.3276	0.5064
Schistosoma mansoni	ap endonuclease	0.0019	0.0038	0.0038
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0183	0.2893	0.4451
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0094	0.0146
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0388	0.6469	0.6469
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0183	0.2893	0.2893
Onchocerca volvulus		0.0388	0.6469	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0038	0.5
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0205	0.3276	0.3276
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0025	0.0038
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0023	0.0094	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0388	0.6469	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0388	0.6469	1
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0019	0.0025	0.0025
Brugia malayi	photoreceptor-specific nuclear receptor	0.0388	0.6469	1
Loa Loa (eye worm)	hypothetical protein	0.0388	0.6469	1
Onchocerca volvulus		0.0183	0.2893	0.4451
Loa Loa (eye worm)	hypothetical protein	0.0183	0.2893	0.4472
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0038	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0183	0.2893	0.2893
Brugia malayi	MH2 domain containing protein	0.0252	0.4099	0.6336
Onchocerca volvulus	Bile acid receptor homolog	0.0388	0.6469	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0388	0.6469	0.6469
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0023	0.0094	0.0094
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0023	0.0094	0.0094
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0038	0.5
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0094	0.0146
Schistosoma mansoni	nuclear receptor	0.0183	0.2893	0.2893
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.081	0.081
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0019	0.0025	0.0038
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0023	0.0094	0.0094
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0023	0.0094	0.0094
Echinococcus granulosus	nuclear receptor nhr 48	0.0183	0.2893	0.2893
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0023	0.0094	0.0146
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0388	0.6469	0.6469
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0023	0.0094	0.0146
Brugia malayi	TAR-binding protein	0.0064	0.081	0.1252
Brugia malayi	hypothetical protein	0.0183	0.2893	0.4472
Onchocerca volvulus		0.0023	0.0094	0.0108
Echinococcus granulosus	sodium channel protein	0.0081	0.1113	0.1113
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0162	0.2532	0.3914
Schistosoma mansoni	hypothetical protein	0.0328	0.542	0.542
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0388	0.6469	1
Loa Loa (eye worm)	LGC-31 protein	0.0023	0.0094	0.0146
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0388	0.6469	1
Echinococcus multilocularis	serotonin transporter	0.0109	0.1611	0.1611
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.081	0.081
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0388	0.6469	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0388	0.6469	0.6469
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0038	1
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0019	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0025	0.0038
Schistosoma mansoni	nuclear hormone receptor	0.0183	0.2893	0.2893
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0388	0.6469	1
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.081	0.081
Brugia malayi	hypothetical protein	0.0183	0.2893	0.4472
Schistosoma mansoni	RAR-like nuclear receptor	0.0388	0.6469	0.6469
Loa Loa (eye worm)	hypothetical protein	0.0183	0.2893	0.4472
Brugia malayi	orphan nuclear receptor NR2E1	0.0183	0.2893	0.4472
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0038	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0094	0.0146
Treponema pallidum	sodium- and chloride- dependent transporter	0.0109	0.1611	1
Loa Loa (eye worm)	hypothetical protein	0.0183	0.2893	0.4472
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.081	0.1252
Echinococcus granulosus	histone lysine N methyltransferase Ez	0.0283	0.4645	0.4645
Schistosoma mansoni	nuclear hormone receptor	0.0183	0.2893	0.2893
Onchocerca volvulus		0.0183	0.2893	0.4451
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0388	0.6469	1
Echinococcus multilocularis	nAChR subunit	0.0023	0.0094	0.0094
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0388	0.6469	1
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0023	0.0094	0.0094
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0183	0.2893	0.2893
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0388	0.6469	0.6469
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0388	0.6469	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0388	0.6469	0.6469
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0388	0.6469	1
Loa Loa (eye worm)	hypothetical protein	0.0109	0.1611	0.249
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0183	0.2893	0.4472
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0205	0.3276	0.3276
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0094	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0025	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0094	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0094	0.0146
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0094	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0205	0.3276	0.5064
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0388	0.6469	0.6469
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0023	0.0094	0.0094
Schistosoma mansoni	sodium/chloride dependent transporter	0.0109	0.1611	0.1611
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0081	0.1113	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0183	0.2893	0.2893
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0025	0.0038
Loa Loa (eye worm)	DR-78	0.0183	0.2893	0.4472
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0183	0.2893	0.2893
Echinococcus granulosus	sodium and chloride dependent glycine	0.0019	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0183	0.2893	0.4472
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0183	0.2893	0.2893
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0023	0.0094	0.0094
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0388	0.6469	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0388	0.6469	1
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0019	0.0025	0.5
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0094	0.0146
Onchocerca volvulus	Putative nachr subunit	0.0023	0.0094	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0094	0.0146
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0023	0.0094	0.0146
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0038	0.5
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0023	0.0094	0.0146
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0038	0.0038
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0023	0.0094	0.0094
Schistosoma mansoni	embryonic ectoderm development protein	0.0096	0.1369	0.1369
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0019	0.0025	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0109	0.1611	0.249
Loa Loa (eye worm)	SET domain-containing protein	0.0283	0.4645	0.718
Brugia malayi	tailless protein	0.0183	0.2893	0.4472
Onchocerca volvulus	Protein ultraspiracle homolog	0.0388	0.6469	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0388	0.6469	0.6469
Schistosoma mansoni	nAChR subunit	0.0023	0.0094	0.0094
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0023	0.0094	0.0146
Echinococcus multilocularis	histone lysine N methyltransferase E(z)	0.0283	0.4645	0.4645
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0038	0.5
Schistosoma mansoni	enhancer of zeste ezh	0.0283	0.4645	0.4645
Schistosoma mansoni	nAChR subunit	0.0023	0.0094	0.0094
Loa Loa (eye worm)	RNA binding protein	0.0064	0.081	0.1252
Echinococcus granulosus	glycine receptor subunit beta	0.0023	0.0094	0.0094
Loa Loa (eye worm)	nuclear hormone receptor	0.0183	0.2893	0.4472
Echinococcus granulosus	sodium and chloride dependent glycine	0.0019	0.0025	0.0025
Echinococcus granulosus	polycomb protein EED	0.0096	0.1369	0.1369
Loa Loa (eye worm)	hypothetical protein	0.0388	0.6469	1
Echinococcus granulosus	polycomb protein suz12 A	0.0328	0.542	0.542
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0094	0.0146
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0023	0.0094	0.0094
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0023	0.0094	0.0094
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0019	0.0025	0.0025
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0388	0.6469	0.6469
Brugia malayi	ecdysteroid receptor	0.0388	0.6469	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0388	0.6469	1
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0019	0.0025	0.0025
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0205	0.3276	0.5064
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0019	0.0025	0.0025
Schistosoma mansoni	thyroid hormone receptor	0.0388	0.6469	0.6469
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0388	0.6469	0.6469
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0019	0.0025	0.0025
Schistosoma mansoni	nAChR subunit	0.0023	0.0094	0.0094
Onchocerca volvulus		0.0077	0.1052	0.1595
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0388	0.6469	0.6469
Schistosoma mansoni	nuclear receptor nhr-48	0.0183	0.2893	0.2893
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0094	0.0146
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0183	0.2893	0.2893
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0051	0.0596	0.0922
Schistosoma mansoni	sodium/chloride dependent transporter	0.0019	0.0025	0.0025
Schistosoma mansoni	sodium/chloride dependent transporter	0.0019	0.0025	0.0025
Onchocerca volvulus		0.0023	0.0094	0.0108
Loa Loa (eye worm)	norepinephrine transporter	0.0109	0.1611	0.249
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0023	0.0094	0.0146
Brugia malayi	nuclear receptor NHR-88	0.0388	0.6469	1
Brugia malayi	WD domain containing protein	0.0096	0.1369	0.2117
Onchocerca volvulus		0.0023	0.0094	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0111	0.1636	0.2529
Loa Loa (eye worm)	hypothetical protein	0.0388	0.6469	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0183	0.2893	0.2893
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0019	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0094	0.0146
Brugia malayi	Nuclear hormone receptor E75	0.0183	0.2893	0.4472
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0205	0.3276	0.3276
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.081	0.081
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0388	0.6469	1
Brugia malayi	Cation transporter family protein	0.0023	0.0094	0.0146
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0019	0.0025	0.0038
Echinococcus multilocularis	ecdysone induced protein 78C	0.0388	0.6469	0.6469
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0094	0.0146
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0023	0.0094	0.0094
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0023	0.0094	0.0146
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0038	0.5
Brugia malayi	nuclear hormone receptor family member odr-7	0.0183	0.2893	0.4472
Schistosoma mansoni	ae-1 binding protein aebp2	0.059	1	1
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0023	0.0094	0.0094
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0023	0.0094	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0094	0.0146
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0023	0.0094	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0183	0.2893	0.4472
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0038	0.0059
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0019	0.0025	0.0038
Brugia malayi	steroid hormone receptor	0.0388	0.6469	1
Schistosoma mansoni	hypothetical protein	0.0051	0.0596	0.0596
Brugia malayi	RNA binding protein	0.0064	0.081	0.1252
Brugia malayi	hypothetical protein	0.0019	0.0025	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0183	0.2893	0.4472
Loa Loa (eye worm)	ACC-1 protein	0.0023	0.0094	0.0146
Brugia malayi	nuclear receptor RXR	0.0183	0.2893	0.4472
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0023	0.0094	0.0146
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0023	0.0094	0.0146
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.081	0.1252
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0019	0.0025	0.0025
Brugia malayi	hypothetical protein	0.0205	0.3276	0.5064
Brugia malayi	latrophilin 2 splice variant baaae	0.0111	0.1636	0.2529
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0388	0.6469	0.6469
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0023	0.0094	0.0094
Schistosoma mansoni	nAChR subunit	0.0023	0.0094	0.0094
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0388	0.6469	0.6469
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0205	0.3276	0.3276
Echinococcus multilocularis	polycomb protein EED	0.0096	0.1369	0.1369
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0094	0.0146
Echinococcus multilocularis	sodium channel protein	0.0081	0.1113	0.1113
Loa Loa (eye worm)	hypothetical protein	0.0183	0.2893	0.4472
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0094	0.0146
Brugia malayi	nuclear receptor NHR-67	0.0183	0.2893	0.4472
Brugia malayi	SET domain containing protein	0.0283	0.4645	0.718
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0023	0.0094	0.0094
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0388	0.6469	1
Schistosoma mansoni	thyroid hormone receptor	0.0388	0.6469	0.6469
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0023	0.0094	0.0094
Brugia malayi	hypothetical protein	0.0205	0.3276	0.5064
Loa Loa (eye worm)	hypothetical protein	0.0183	0.2893	0.4472
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0019	0.0025	0.0025
Brugia malayi	Cation transporter family protein	0.0023	0.0094	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0025	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0388	0.6469	1
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0019	0.0025	0.0038
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0023	0.0094	0.0146
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0023	0.0094	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0094	0.0146
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0183	0.2893	0.4472
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0388	0.6469	0.6469
Loa Loa (eye worm)	hypothetical protein	0.0183	0.2893	0.4472
Brugia malayi	Cation transporter family protein	0.0023	0.0094	0.0146
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0038	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0388	0.6469	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0388	0.6469	0.6469
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0109	0.1611	0.249
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0388	0.6469	0.6469
Brugia malayi	hypothetical protein	0.0077	0.1052	0.1627
Loa Loa (eye worm)	hypothetical protein	0.0388	0.6469	1
Schistosoma mansoni	ap endonuclease	0.0019	0.0038	0.0038
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0038	0.0038
Brugia malayi	Nuclear hormone receptor E75	0.0183	0.2893	0.4472
Loa Loa (eye worm)	hypothetical protein	0.0388	0.6469	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0038	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.081	0.081
Echinococcus multilocularis	polycomb protein suz12 A	0.0328	0.542	0.542
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0023	0.0094	0.0094
Echinococcus granulosus	ecdysone induced protein 78C	0.0388	0.6469	0.6469
Schistosoma mansoni	nAChR subunit	0.0023	0.0094	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0094	0.0146
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0388	0.6469	0.6469
Onchocerca volvulus		0.0023	0.0094	0.0108
Schistosoma mansoni	nAChR subunit	0.0023	0.0094	0.0094
Echinococcus granulosus	serotonin transporter	0.0109	0.1611	0.1611
Echinococcus granulosus	thyroid hormone receptor alpha	0.0183	0.2893	0.2893
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0388	0.6469	0.6469
Brugia malayi	Steroid receptor seven-up type 2	0.0388	0.6469	1
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0023	0.0094	0.0094
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0023	0.0094	0.0146
Brugia malayi	nuclear hormone receptor	0.0388	0.6469	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0023	0.0094	0.0094
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0019	0.0025	0.0025
Loa Loa (eye worm)	WD domain-containing protein	0.0096	0.1369	0.2117
Loa Loa (eye worm)	MH2 domain-containing protein	0.0252	0.4099	0.6336
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0019	0.0025	0.0025
Onchocerca volvulus		0.0109	0.1611	0.2461
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0023	0.0094	0.0094
Brugia malayi	excitatory GABA receptor EXP-1A	0.0023	0.0094	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0183	0.2893	0.4472
Echinococcus multilocularis	FTZ F1 alpha	0.0388	0.6469	0.6469
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0023	0.0094	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0205	0.3276	0.5064
Loa Loa (eye worm)	steroid hormone receptor	0.0388	0.6469	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0051	0.0596	0.0596
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0019	0.0025	0.0025
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0388	0.6469	0.6469
Toxoplasma gondii	exonuclease III APE	0.0019	0.0038	1
Loa Loa (eye worm)	hypothetical protein	0.0162	0.2532	0.3914
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0023	0.0094	0.0094
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0023	0.0094	0.0094
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0023	0.0094	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0094	0.0146
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0023	0.0094	0.0146
Echinococcus multilocularis	glycine receptor subunit beta	0.0023	0.0094	0.0094
Schistosoma mansoni	hypothetical protein	0.0051	0.0596	0.0596
Brugia malayi	conserved hypotetical protein	0.0183	0.2893	0.4472
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0019	0.0025	0.0025
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0388	0.6469	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0051	0.0596	0.0596
Echinococcus granulosus	FTZ F1 alpha	0.0388	0.6469	0.6469
Loa Loa (eye worm)	hypothetical protein	0.0183	0.2893	0.4472
Loa Loa (eye worm)	ACC-1 protein	0.0023	0.0094	0.0146
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0388	0.6469	0.6469
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0023	0.0094	0.0094
Brugia malayi	nuclear hormone receptor	0.0183	0.2893	0.4472
Brugia malayi	nuclear receptor RXR	0.0205	0.3276	0.5064

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 64.2 nM	Affinity against cocaine binding site of dopamine transporter in rat striatum using [3H]-2b as radioligand.	ChEMBL.	1895292
IC50 (binding)	= 64.2 nM	Concentration required to inhibit 50% of radioligand binding ([3H]-WIN 35428) to the dopamine (DA) transporter in rat	ChEMBL.	8071935
IC50 (binding)	= 0.064 uM	Potency of the compound for the inhibition of [3H]-WIN-35,428 binding to the dopamine transporter	ChEMBL.	1552510

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2310855

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1578923