Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lamin | 0.0021 | 0.0285 | 0.0256 |
Echinococcus granulosus | dihydrofolate reductase | 0.0356 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0356 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0356 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0356 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.003 | 0.003 |
Schistosoma mansoni | dihydrofolate reductase | 0.0356 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0447 | 0.0447 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0012 | 0.003 | 0.003 |
Loa Loa (eye worm) | thymidylate synthase | 0.0099 | 0.2534 | 0.2534 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0012 | 0.003 | 0.003 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0017 | 0.0154 | 0.0125 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0015 | 0.0099 | 0.0096 |
Echinococcus granulosus | lamin | 0.0021 | 0.0285 | 0.0256 |
Brugia malayi | intermediate filament protein | 0.0021 | 0.0285 | 0.0285 |
Plasmodium falciparum | importin beta, putative | 0.0023 | 0.0328 | 0.0414 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.026 | 0.7205 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0015 | 0.0099 | 0.0099 |
Schistosoma mansoni | ap endonuclease | 0.0015 | 0.0099 | 0.0069 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0017 | 0.0154 | 0.0172 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0017 | 0.0154 | 0.0154 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0015 | 0.0099 | 0.0099 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0017 | 0.0154 | 0.0172 |
Brugia malayi | hypothetical protein | 0.0047 | 0.1033 | 0.1033 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0015 | 0.0099 | 0.0096 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0015 | 0.0099 | 0.0069 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0012 | 0.0031 | 0.0031 |
Brugia malayi | Isocitrate dehydrogenase | 0.0012 | 0.0031 | 0.0031 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0039 | 0.0807 | 0.0807 |
Echinococcus granulosus | importin subunit beta 1 | 0.0023 | 0.0328 | 0.0299 |
Brugia malayi | thymidylate synthase | 0.0099 | 0.2534 | 0.2534 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.0447 | 0.0418 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0356 | 1 | 0.5 |
Trichomonas vaginalis | ran, putative | 0.0017 | 0.0154 | 0.059 |
Leishmania major | GTP-binding protein, putative | 0.0017 | 0.0154 | 0.0172 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0021 | 0.0285 | 0.0285 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0012 | 0.0031 | 0.0001 |
Echinococcus multilocularis | snurportin 1 | 0.0242 | 0.6687 | 0.6677 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0018 | 0.0204 | 0.0241 |
Schistosoma mansoni | hypothetical protein | 0.0242 | 0.6687 | 0.6677 |
Echinococcus granulosus | thymidylate synthase | 0.0099 | 0.2534 | 0.2512 |
Trichomonas vaginalis | importin beta-1, putative | 0.0018 | 0.0204 | 0.1117 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0015 | 0.0099 | 0.0096 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0012 | 0.0031 | 0.0001 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0015 | 0.0099 | 0.0096 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0015 | 0.0099 | 0.0069 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0012 | 0.0031 | 0.0001 |
Brugia malayi | isocitrate dehydrogenase | 0.0012 | 0.0031 | 0.0031 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0012 | 0.0031 | 0.0001 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0017 | 0.0154 | 0.0125 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0015 | 0.0099 | 0.5 |
Onchocerca volvulus | 0.0099 | 0.2534 | 1 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0047 | 0.1033 | 0.1397 |
Entamoeba histolytica | hypothetical protein | 0.0018 | 0.0204 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0012 | 0.003 | 0.003 |
Schistosoma mansoni | lamin | 0.0021 | 0.0285 | 0.0256 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0328 | 0.0328 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0285 | 0.0285 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0012 | 0.0031 | 0.0001 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0015 | 0.0099 | 0.0096 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0356 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0274 | 0.0274 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0027 | 0.0447 | 0.0447 |
Plasmodium vivax | importin-beta 2, putative | 0.0023 | 0.0328 | 0.0414 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0012 | 0.0031 | 0.0001 |
Loa Loa (eye worm) | intermediate filament protein | 0.0021 | 0.0285 | 0.0285 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0018 | 0.0204 | 0.1117 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0356 | 1 | 1 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0017 | 0.0154 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0015 | 0.0099 | 0.0069 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0039 | 0.0807 | 0.0807 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0023 | 0.0328 | 0.0414 |
Schistosoma mansoni | lamin | 0.0021 | 0.0285 | 0.0256 |
Brugia malayi | Importin beta-1 subunit | 0.0023 | 0.0328 | 0.0328 |
Entamoeba histolytica | Ran family GTPase | 0.0017 | 0.0154 | 0.5279 |
Brugia malayi | Dihydrofolate reductase | 0.0356 | 1 | 1 |
Schistosoma mansoni | ran | 0.0017 | 0.0154 | 0.0125 |
Brugia malayi | RNA, U transporter 1 | 0.0064 | 0.154 | 0.154 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0015 | 0.0099 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.026 | 0.7205 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.026 | 0.7205 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0099 | 0.2534 | 0.2459 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0017 | 0.0154 | 0.0172 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.026 | 0.7205 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0242 | 0.6687 | 0.6687 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0017 | 0.0154 | 0.0154 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0018 | 0.0204 | 0.1117 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0099 | 0.2534 | 0.2511 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0023 | 0.0328 | 0.0414 |
Echinococcus multilocularis | lamin dm0 | 0.0021 | 0.0285 | 0.0256 |
Toxoplasma gondii | exonuclease III APE | 0.0015 | 0.0099 | 0.0096 |
Schistosoma mansoni | intermediate filament proteins | 0.0021 | 0.0285 | 0.0256 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.026 | 0.7205 | 1 |
Schistosoma mansoni | ran | 0.0017 | 0.0154 | 0.0125 |
Leishmania major | importin beta-1 subunit, putative | 0.0018 | 0.0204 | 0.0241 |
Echinococcus multilocularis | thymidylate synthase | 0.0099 | 0.2534 | 0.2512 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0015 | 0.0099 | 0.0096 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0017 | 0.0154 | 0.0172 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0023 | 0.0328 | 0.0299 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0017 | 0.0154 | 0.0172 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0012 | 0.0031 | 0.0001 |
Echinococcus granulosus | snurportin 1 | 0.0242 | 0.6687 | 0.6677 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0039 | 0.0807 | 0.0807 |
Echinococcus granulosus | lamin dm0 | 0.0021 | 0.0285 | 0.0256 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0021 | 0.0285 | 0.0285 |
Echinococcus multilocularis | musashi | 0.0021 | 0.0285 | 0.0256 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0047 | 0.1033 | 0.1005 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0099 | 0.2534 | 0.2512 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0023 | 0.0328 | 0.0414 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0807 | 0.0807 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.026 | 0.7205 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.1033 | 1 |
Schistosoma mansoni | importin beta-1 | 0.0023 | 0.0328 | 0.0299 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0015 | 0.0099 | 0.0069 |
Echinococcus granulosus | intermediate filament protein | 0.0021 | 0.0285 | 0.0256 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0017 | 0.0154 | 0.0172 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 9733490 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.