TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 415.259 | Formula: C19H16BrFN4O
H donors: 3 H acceptors: 3 LogP: 4.85 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccc(cc1)c1[nH]c2c(c1)c(ncn2)NCc1cccc(c1)F.Br
InChi: 1S/C19H15FN4O.BrH/c20-14-3-1-2-12(8-14)10-21-18-16-9-17(24-19(16)23-11-22-18)13-4-6-15(25)7-5-13;/h1-9,11,25H,10H2,(H2,21,22,23,24);1H
InChiKey: WDDJGWWDUPNDSE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	epidermal growth factor receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Tyrosine-protein kinase transforming protein erbB, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Furin-like cysteine rich region family protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-4 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	ko:K05085 receptor tyrosine-protein kinase erbB-4, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	TK/EGFR protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-2 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis		Get druggable targets OG5_128597	All targets in OG5_128597

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tm gpcr rhodopsin	0.0096	0.0387	0.0354
Echinococcus multilocularis	fmrfamide receptor	0.0096	0.0387	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0041	0.0034	0.0034
Schistosoma mansoni	tyrosine kinase	0.0058	0.0143	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Echinococcus granulosus	neuroligin	0.0073	0.0242	0.0208
Echinococcus granulosus	rhodopsin orphan GPCR	0.0096	0.0387	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0242	0.0242
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0096	0.0387	0.0354
Brugia malayi	hypothetical protein	0.0096	0.0387	0.0982
Loa Loa (eye worm)	hypothetical protein	0.1597	1	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0096	0.0387	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Echinococcus granulosus	rhodopsin orphan GPCR	0.0096	0.0387	0.0354
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0096	0.0387	0.0354
Echinococcus granulosus	serotonin receptor	0.0096	0.0387	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0096	0.0387	0.0354
Echinococcus multilocularis	g protein coupled receptor	0.0096	0.0387	0.0354
Schistosoma mansoni	hypothetical protein	0.0096	0.0387	0.0331
Echinococcus granulosus	somatostatin receptor	0.0096	0.0387	0.0354
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0096	0.0387	0.0354
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0096	0.0387	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Brugia malayi	Dopamine receptor	0.0096	0.0387	0.0982
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0096	0.0387	0.0354
Brugia malayi	Carboxylesterase family protein	0.0073	0.0242	0.0577
Echinococcus granulosus	dro:myosuppressin receptor	0.0096	0.0387	0.0354
Schistosoma mansoni	amine GPCR	0.0096	0.0387	0.0331
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0096	0.0387	0.0331
Schistosoma mansoni	opsin-like receptor	0.0096	0.0387	0.0331
Echinococcus multilocularis	insulin receptor	0.0058	0.0143	0.0109
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0096	0.0387	0.0354
Schistosoma mansoni	amine GPCR	0.0096	0.0387	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0096	0.0387	0.0354
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0096	0.0387	0.0331
Brugia malayi	ORL1-like opioid receptor	0.0096	0.0387	0.0982
Echinococcus multilocularis	orexin receptor type 2	0.0096	0.0387	0.0354
Schistosoma mansoni	opsin-like receptor	0.0096	0.0387	0.0331
Echinococcus granulosus	neuropeptide s receptor	0.0096	0.0387	0.0354
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0096	0.0387	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0432	0.2541	0.2541
Echinococcus multilocularis	neuropeptides capa receptor	0.0096	0.0387	0.0354
Schistosoma mansoni	biogenic amine receptor	0.0096	0.0387	0.0331
Brugia malayi	hypothetical protein	0.0096	0.0387	0.0982
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0096	0.0387	0.0331
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0073	0.0242	0.5
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0096	0.0387	0.0354
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0096	0.0387	0.0387
Schistosoma mansoni	neuropeptide receptor	0.0096	0.0387	0.0331
Loa Loa (eye worm)	TK/EGFR protein kinase	0.018	0.0928	0.0928
Brugia malayi	Carboxylesterase family protein	0.0432	0.2541	0.6972
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0096	0.0387	0.0982
Echinococcus granulosus	rhodopsin orphan GPCR	0.0096	0.0387	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Loa Loa (eye worm)	acetylcholinesterase 1	0.0432	0.2541	0.2541
Schistosoma mansoni	neuropeptide receptor	0.0096	0.0387	0.0331
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0096	0.0387	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Echinococcus multilocularis	neuropeptide Y receptor	0.0096	0.0387	0.0354
Brugia malayi	hypothetical protein	0.0096	0.0387	0.0982
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0096	0.0387	0.0982
Echinococcus granulosus	neuropeptide Y receptor	0.0096	0.0387	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Onchocerca volvulus		0.0096	0.0387	1
Schistosoma mansoni	neuropeptide receptor	0.0096	0.0387	0.0331
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0096	0.0387	0.0331
Schistosoma mansoni	tyrosine kinase	0.0097	0.0394	0.0338
Echinococcus multilocularis	neuropeptide receptor	0.0096	0.0387	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0242	0.0242
Echinococcus granulosus	hypothetical protein	0.0096	0.0387	0.0354
Echinococcus granulosus	rhodopsin orphan GPCR	0.0096	0.0387	0.0354
Onchocerca volvulus		0.0096	0.0387	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0096	0.0387	0.0331
Echinococcus multilocularis	para nitrobenzyl esterase	0.0073	0.0242	0.0208
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0096	0.0387	1
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Schistosoma mansoni	tyrosine kinase	0.0096	0.0387	0.0331
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0096	0.0387	0.0982
Schistosoma mansoni	hypothetical protein	0.0096	0.0387	0.0331
Brugia malayi	Carboxylesterase family protein	0.0073	0.0242	0.0577
Echinococcus multilocularis	epidermal growth factor receptor	0.0097	0.0394	0.0361
Echinococcus granulosus	orexin receptor type 2	0.0096	0.0387	0.0354
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0096	0.0387	0.0331
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0096	0.0387	0.0331
Echinococcus granulosus	g protein coupled receptor	0.0096	0.0387	0.0354
Echinococcus granulosus	neuropeptide FF receptor 2	0.0096	0.0387	0.0354
Onchocerca volvulus		0.0096	0.0387	1
Echinococcus multilocularis	serotonin receptor	0.1597	1	1
Brugia malayi	putative neuropeptide receptor	0.0096	0.0387	0.0982
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0096	0.0387	0.0354
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0058	0.0143	0.0109
Echinococcus granulosus	acetylcholinesterase	0.0432	0.2541	0.2515
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0073	0.0242	0.5
Onchocerca volvulus		0.0096	0.0387	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0073	0.0242	0.0185
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0096	0.0387	0.0331
Loa Loa (eye worm)	carboxylesterase	0.0073	0.0242	0.0242
Echinococcus granulosus	neuropeptides capa receptor	0.0096	0.0387	0.0354
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0096	0.0387	0.0354
Echinococcus granulosus	7TM GPCR rhodopsin	0.0096	0.0387	0.0354
Brugia malayi	sulfakinin receptor protein	0.0096	0.0387	0.0982
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0073	0.0242	0.5
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Loa Loa (eye worm)	neuropeptide F receptor	0.0096	0.0387	0.0387
Onchocerca volvulus		0.0096	0.0387	1
Onchocerca volvulus		0.0096	0.0387	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0096	0.0387	0.0331
Brugia malayi	Furin-like cysteine rich region family protein	0.018	0.0928	0.2485
Schistosoma mansoni	acetylcholinesterase	0.0073	0.0242	0.0185
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0096	0.0387	0.0354
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0096	0.0387	0.0331
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0096	0.0387	0.0354
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0143	0.0302
Echinococcus multilocularis	g-protein coupled receptor	0.0096	0.0387	0.0354
Onchocerca volvulus		0.0096	0.0387	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0096	0.0387	0.0354
Trichomonas vaginalis	spcc417.12 protein, putative	0.0073	0.0242	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0096	0.0387	0.0331
Mycobacterium ulcerans	carboxylesterase, LipT	0.0073	0.0242	0.5
Echinococcus multilocularis	carboxylesterase 5A	0.0432	0.2541	0.2515
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Brugia malayi	RE15519p	0.0096	0.0387	0.0982
Brugia malayi	Serotonin receptor	0.0602	0.3629	1
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Brugia malayi	hypothetical protein	0.0096	0.0387	0.0982
Schistosoma mansoni	myosin xvIII	0.0096	0.0387	0.0331
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0096	0.0387	0.0354
Schistosoma mansoni	tyrosine kinase	0.018	0.0928	0.0875
Echinococcus granulosus	tm gpcr rhodopsin	0.0096	0.0387	0.0354
Brugia malayi	neuropeptide F receptor	0.0096	0.0387	0.0982
Echinococcus granulosus	epidermal growth factor receptor	0.0097	0.0394	0.0361
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0432	0.2541	0.2497
Schistosoma mansoni	amine GPCR	0.0096	0.0387	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Brugia malayi	Serotonin receptor	0.0096	0.0387	0.0982
Echinococcus multilocularis	sex peptide receptor	0.0096	0.0387	0.0354
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0096	0.0387	0.0331
Echinococcus multilocularis	serotonin receptor	0.1597	1	1
Echinococcus multilocularis	fmrfamide receptor	0.0096	0.0387	0.0354
Schistosoma mansoni	hypothetical protein	0.0096	0.0387	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Schistosoma mansoni	growth hormone secretagogue receptor	0.0096	0.0387	0.0331
Schistosoma mansoni	biogenic amine receptor	0.0096	0.0387	0.0331
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0096	0.0387	0.0331
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0096	0.0387	0.0331
Echinococcus granulosus	para nitrobenzyl esterase	0.0073	0.0242	0.0208
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0096	0.0387	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Schistosoma mansoni	opsin-like receptor	0.0096	0.0387	0.0331
Echinococcus granulosus	neuropeptide receptor A26	0.0096	0.0387	0.0354
Loa Loa (eye worm)	melatonin receptor type 1A	0.0096	0.0387	0.0387
Echinococcus multilocularis	allatostatin A receptor	0.0096	0.0387	0.0354
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0096	0.0387	0.0331
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0096	0.0387	0.0354
Echinococcus multilocularis	g protein coupled receptor	0.0096	0.0387	0.0354
Schistosoma mansoni	BC026374 protein (S09 family)	0.0073	0.0242	0.0185
Schistosoma mansoni	tyrosine kinase	0.0097	0.0394	0.0338
Onchocerca volvulus		0.0096	0.0387	1
Brugia malayi	Dopamine receptor protein 1	0.0096	0.0387	0.0982
Echinococcus granulosus	rhodopsin orphan GPCR	0.0096	0.0387	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0096	0.0387	0.0354
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0096	0.0387	0.0387
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0096	0.0387	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Echinococcus granulosus	BC026374 protein S09 family	0.0073	0.0242	0.0208
Echinococcus multilocularis	neuroligin	0.0073	0.0242	0.0208
Schistosoma mansoni	neuropeptide receptor	0.0096	0.0387	0.0331
Echinococcus multilocularis	neuropeptide s receptor	0.0096	0.0387	0.0354
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0096	0.0387	0.0331
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0073	0.0242	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0096	0.0387	0.0354
Echinococcus multilocularis	dro:myosuppressin receptor	0.0096	0.0387	0.0354
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0096	0.0387	0.0354
Echinococcus multilocularis	acetylcholinesterase	0.0432	0.2541	0.2515
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0073	0.0242	0.0185
Brugia malayi	neuropeptide F receptor	0.0096	0.0387	0.0982
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0096	0.0387	0.0331
Schistosoma mansoni	amine GPCR	0.0096	0.0387	0.0331
Brugia malayi	Carboxylesterase family protein	0.0432	0.2541	0.6972
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0096	0.0387	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Brugia malayi	Dopamine receptor protein 2	0.0096	0.0387	0.0982
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0096	0.0387	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Brugia malayi	hypothetical protein	0.0096	0.0387	0.0982
Echinococcus granulosus	g-protein coupled receptor	0.0096	0.0387	0.0354
Echinococcus granulosus	rhodopsin orphan GPCR	0.0096	0.0387	0.0354
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0096	0.0387	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0242	0.0242
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0096	0.0387	0.0354
Echinococcus granulosus	neuropeptide receptor	0.0096	0.0387	0.0354
Onchocerca volvulus		0.0096	0.0387	1
Onchocerca volvulus		0.0096	0.0387	1
Schistosoma mansoni	adenoreceptor	0.0096	0.0387	0.0331
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0096	0.0387	0.0982
Echinococcus multilocularis	neuropeptide receptor A26	0.0096	0.0387	0.0354
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0096	0.0387	0.0354
Schistosoma mansoni	tyrosine kinase	0.0058	0.0143	0.0085
Brugia malayi	G protein-coupled receptor	0.0096	0.0387	0.0982
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0096	0.0387	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0096	0.0387	0.0387
Echinococcus granulosus	acetylcholinesterase	0.0432	0.2541	0.2515
Echinococcus granulosus	neuropeptide receptor	0.0096	0.0387	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0073	0.0242	0.0208
Schistosoma mansoni	tyrosine kinase	0.0096	0.0387	0.0331
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0096	0.0387	0.0354
Brugia malayi	hypothetical protein	0.0096	0.0387	0.0982
Loa Loa (eye worm)	neuropeptide F receptor	0.0096	0.0387	0.0387
Echinococcus granulosus	g protein coupled receptor	0.0096	0.0387	0.0354
Echinococcus granulosus	G protein coupled receptor 139	0.0096	0.0387	0.0354
Loa Loa (eye worm)	hypothetical protein	0.1597	1	1
Brugia malayi	GnHR receptor homolog	0.0096	0.0387	0.0982
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0096	0.0387	0.0982
Echinococcus multilocularis	neuropeptide Y receptor	0.0096	0.0387	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0058	0.0143	0.0109
Loa Loa (eye worm)	TYRA-2 protein	0.0096	0.0387	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0242	0.0242
Brugia malayi	hypothetical protein	0.0073	0.0242	0.0577
Onchocerca volvulus		0.0096	0.0387	1
Echinococcus granulosus	epidermal growth factor receptor	0.018	0.0928	0.0896
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0242	0.0242
Onchocerca volvulus		0.0096	0.0387	1
Loa Loa (eye worm)	hypothetical protein	0.0432	0.2541	0.2541
Brugia malayi	hypothetical protein	0.0096	0.0387	0.0982
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Schistosoma mansoni	hypothetical protein	0.0096	0.0387	0.0331
Echinococcus granulosus	biogenic amine 5HT receptor	0.0096	0.0387	0.0354
Echinococcus multilocularis	neuropeptide receptor	0.0096	0.0387	0.0354
Brugia malayi	hypothetical protein	0.0096	0.0387	0.0982
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0073	0.0242	0.0208
Brugia malayi	G-protein coupled receptor	0.0096	0.0387	0.0982
Echinococcus multilocularis	epidermal growth factor receptor	0.018	0.0928	0.0896
Echinococcus granulosus	neuropeptides capa receptor	0.0096	0.0387	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0096	0.0387	0.0387
Echinococcus granulosus	7tm_1 domain containing protein	0.0096	0.0387	0.0354
Echinococcus granulosus	neuropeptide Y receptor	0.0096	0.0387	0.0354
Brugia malayi	G-protein coupled receptor	0.0096	0.0387	0.0982
Echinococcus granulosus	fmrfamide receptor	0.0096	0.0387	0.0354
Echinococcus granulosus	insulin receptor	0.0058	0.0143	0.0109
Onchocerca volvulus		0.0096	0.0387	1
Echinococcus multilocularis	g protein coupled receptor	0.0096	0.0387	0.0354
Brugia malayi	putative neuropeptide receptor NPR1	0.0096	0.0387	0.0982
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Loa Loa (eye worm)	carboxylesterase	0.0073	0.0242	0.0242
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0096	0.0387	0.0354
Brugia malayi	Carboxylesterase family protein	0.0073	0.0242	0.0577
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0096	0.0387	0.0354
Echinococcus granulosus	g protein coupled receptor	0.0096	0.0387	0.0354
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0073	0.0242	0.0185
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0096	0.0387	0.0354
Loa Loa (eye worm)	G-protein coupled receptor	0.0096	0.0387	0.0387
Brugia malayi	hypothetical protein	0.0096	0.0387	0.0982
Onchocerca volvulus		0.0096	0.0387	1
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0096	0.0387	0.0982
Onchocerca volvulus		0.0096	0.0387	1
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0073	0.0242	0.0185
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0096	0.0387	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0096	0.0387	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Brugia malayi	larval opioid receptor	0.0096	0.0387	0.0982
Loa Loa (eye worm)	TK/INSR protein kinase	0.0058	0.0143	0.0143
Schistosoma mansoni	biogenic amine receptor	0.0096	0.0387	0.0331
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0096	0.0387	0.0331
Loa Loa (eye worm)	G-protein coupled receptor	0.0096	0.0387	0.0387
Echinococcus granulosus	allatostatin A receptor	0.0096	0.0387	0.0354
Echinococcus granulosus	rhodopsin orphan GPCR	0.0096	0.0387	0.0354
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0096	0.0387	0.0331
Schistosoma mansoni	tyrosine kinase	0.0096	0.0387	0.0331
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0073	0.0242	0.0208
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0096	0.0387	0.0354
Brugia malayi	Melatonin receptor type 1A	0.0096	0.0387	0.0982
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Echinococcus granulosus	tm gpcr rhodopsin	0.0096	0.0387	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0097	0.0394	0.0361
Brugia malayi	G protein-coupled receptor F59B2.13	0.0096	0.0387	0.0982
Onchocerca volvulus		0.0096	0.0387	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0096	0.0387	0.0354
Echinococcus multilocularis		0.0056	0.0131	0.0097
Onchocerca volvulus		0.0096	0.0387	1
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0096	0.0387	0.0387
Echinococcus multilocularis	somatostatin receptor	0.0096	0.0387	0.0354
Brugia malayi	Carboxylesterase family protein	0.0073	0.0242	0.0577
Echinococcus granulosus	sex peptide receptor	0.0096	0.0387	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Loa Loa (eye worm)	carboxylesterase	0.0432	0.2541	0.2541
Schistosoma mansoni	histamine h1 receptor	0.0096	0.0387	0.0331
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0096	0.0387	0.0331
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0096	0.0387	0.0331
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0096	0.0387	0.0354
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0096	0.0387	0.0331
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0096	0.0387	0.0354
Echinococcus multilocularis	G protein coupled receptor 139	0.0096	0.0387	0.0354
Brugia malayi	hypothetical protein	0.0096	0.0387	0.0982
Echinococcus granulosus	carboxylesterase 5A	0.0432	0.2541	0.2515
Schistosoma mansoni	biogenic amine (5HT) receptor	0.1597	1	1
Brugia malayi	follicle stimulating hormone receptor	0.0096	0.0387	0.0982
Echinococcus multilocularis	acetylcholinesterase	0.0432	0.2541	0.2515
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0387	0.0387
Schistosoma mansoni	amine GPCR	0.0096	0.0387	0.0331
Brugia malayi	AKH receptor	0.0096	0.0387	0.0982
Schistosoma mansoni	gliotactin	0.0073	0.0242	0.0185

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 52 nM	Inhibition of EGFR by Z-LYTE assay	ChEMBL.	22018877

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1914664

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1579949