Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0027 | 0 | 0.5 | |
Giardia lamblia | Kinase, CMGC MAPK | 0.0051 | 1 | 0.5 |
Onchocerca volvulus | 0.0027 | 0 | 0.5 | |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0051 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0051 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0051 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0051 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0051 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0051 | 1 | 1 |
Onchocerca volvulus | 0.0027 | 0 | 0.5 | |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0051 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0051 | 1 | 1 |
Onchocerca volvulus | 0.0027 | 0 | 0.5 | |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0051 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 1 | 0.5 |
Onchocerca volvulus | Putative organic anion transporter | 0.0027 | 0 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0051 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 1 | 0.5 |
Onchocerca volvulus | 0.0027 | 0 | 0.5 | |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0051 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0051 | 1 | 0.5 |
Onchocerca volvulus | Putative organic anion transporter | 0.0027 | 0 | 0.5 |
Onchocerca volvulus | Putative organic anion transporter | 0.0027 | 0 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0051 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0051 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0051 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 50 uM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by FACS analysis | ChEMBL. | 21958736 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.