Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.059 | 0.1884 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0093 | 0.3129 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.059 | 0.1884 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0061 | 0.14 | 0.4474 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0068 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.059 | 0.1884 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0093 | 0.3129 | 1 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.0093 | 0.3129 | 1 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0102 | 0.3573 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.059 | 0.1884 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0068 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.059 | 0.1884 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0036 | 0.0068 | 0.0216 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0068 | 0.0216 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0068 | 0.0216 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.059 | 0.1884 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0093 | 0.3129 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.059 | 0.1884 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0102 | 0.3573 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0068 | 0.5 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0061 | 0.14 | 0.3918 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0102 | 0.3573 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0068 | 0.0216 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0102 | 0.3573 | 0.5 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.0102 | 0.3573 | 1 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0093 | 0.3129 | 1 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0093 | 0.3129 | 0.5 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0102 | 0.3573 | 1 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0093 | 0.3129 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0068 | 0.5 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0093 | 0.3129 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.059 | 0.1884 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.0093 | 0.3129 | 1 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0093 | 0.3129 | 1 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.0102 | 0.3573 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.059 | 0.1884 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0093 | 0.3129 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0068 | 0.0216 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Amount of TNF-alpha (functional) | = 75 % | Tumor necrosis factor-alpha production in human leukemia cell line (HL-60) stimulated with 50 nM okadaic acid (OA) ,at 30 microMolar. | ChEMBL. | 9288167 |
Amount of TNF-alpha (functional) | = 75 % | Tumor necrosis factor-alpha production in human leukemia cell line (HL-60) stimulated with 50 nM okadaic acid (OA) ,at 30 microMolar. | ChEMBL. | 9288167 |
Amount of TNF-alpha (functional) | = 138 % | Tumor necrosis factor-alpha production in human leukemia cell line (HL-60) stimulated with 10 nM 12-O-tetradecanoylphorbol 13-acetate (TPA) at 30 microMolar. | ChEMBL. | 9288167 |
Amount of TNF-alpha (functional) | = 138 % | Tumor necrosis factor-alpha production in human leukemia cell line (HL-60) stimulated with 10 nM 12-O-tetradecanoylphorbol 13-acetate (TPA) at 30 microMolar. | ChEMBL. | 9288167 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.