Detailed information for compound 1580568

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 391.509 | Formula: C23H29N5O
  • H donors: 1 H acceptors: 3 LogP: 2.72 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1)C(c1cccnc1)N1CCC(CC1)NC(=O)N(CC)CC
  • InChi: 1S/C23H29N5O/c1-3-27(4-2)23(29)26-21-11-14-28(15-12-21)22(20-6-5-13-25-17-20)19-9-7-18(16-24)8-10-19/h5-10,13,17,21-22H,3-4,11-12,14-15H2,1-2H3,(H,26,29)
  • InChiKey: XJWCXJGANJAQFX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0065 0.0064
Brugia malayi CHD4 protein 0.0013 0.0016 0.0015
Plasmodium falciparum phd finger protein, putative 0.0029 0.0158 1
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0572 0.0571
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0065 0.0064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.249 1
Echinococcus multilocularis chromobox protein 1 0.0069 0.0517 0.0516
Schistosoma mansoni hypothetical protein 0.0016 0.0041 0.004
Echinococcus multilocularis chromobox protein 1 0.0069 0.0517 0.0516
Loa Loa (eye worm) carboxylesterase 0.0191 0.1606 0.1606
Onchocerca volvulus 0.0191 0.1606 1
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0272 0.109
Onchocerca volvulus 0.0191 0.1606 1
Schistosoma mansoni BC026374 protein (S09 family) 0.0191 0.1606 0.1606
Brugia malayi SET domain containing protein 0.0012 0.0007 0.0006
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.004 0.0039
Loa Loa (eye worm) LGC-31 protein 0.0018 0.0065 0.0064
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0048 0.0047
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0018 0.0065 0.0064
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.0001 0.0057
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0059 0.0234
Schistosoma mansoni nAChR subunit 0.0018 0.0065 0.0064
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0158 0.0157
Schistosoma mansoni cpg binding protein 0.003 0.0172 0.0171
Loa Loa (eye worm) hypothetical protein 0.036 0.3118 0.3117
Mycobacterium tuberculosis Carboxylesterase LipT 0.0191 0.1606 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0157
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0517 0.2075
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0064
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0016 0.0015
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0191 0.1606 0.1606
Loa Loa (eye worm) carboxylesterase 0.0191 0.1606 0.1606
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.0001 0.0057
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0018 0.0065 0.0064
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0065 0.0064
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0016 0.0015
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.004 0.1007
Echinococcus granulosus carboxylesterase 5A 0.1131 1 1
Brugia malayi isocitrate dehydrogenase 0.0016 0.004 0.0039
Echinococcus multilocularis cpg binding protein 0.003 0.0172 0.0171
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0059 0.0234
Onchocerca volvulus 0.0191 0.1606 1
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0018 0.0065 0.0064
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0158 0.0157
Plasmodium falciparum heterochromatin protein 1 0.0011 0.0001 0.0057
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0065 0.0064
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0065 0.0064
Onchocerca volvulus Putative nachr subunit 0.0018 0.0065 0.0397
Echinococcus granulosus chromobox protein 1 0.0069 0.0517 0.0516
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0191 0.1606 0.1606
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0041 0.004
Brugia malayi Isocitrate dehydrogenase 0.0016 0.004 0.0039
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.249 1
Schistosoma mansoni hypothetical protein 0.0029 0.0158 0.0157
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0065 0.0064
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0018 0.0065 0.0064
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0065 0.0064
Onchocerca volvulus 0.0012 0.0007 0.0035
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0126 0.3231
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0018 0.0065 0.0064
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0065 0.0064
Mycobacterium ulcerans carboxylesterase, LipT 0.0191 0.1606 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0059 0.0234
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.249 1
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0016 0.0015
Brugia malayi hypothetical protein 0.0025 0.0126 0.0125
Echinococcus granulosus para nitrobenzyl esterase 0.0191 0.1606 0.1606
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0064
Brugia malayi Cation transporter family protein 0.0018 0.0065 0.0064
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0227 0.0226
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0126 0.028
Brugia malayi Heterochromatin protein 1 0.0069 0.0517 0.0516
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0191 0.1606 0.1606
Echinococcus multilocularis nAChR subunit 0.0018 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0064
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0018 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.249 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0246 0.0984
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0064
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0065 0.0064
Echinococcus granulosus acetylcholinesterase 0.1131 1 1
Brugia malayi jmjC domain containing protein 0.0095 0.0746 0.0745
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.249 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0746 0.0745
Schistosoma mansoni gliotactin 0.0191 0.1606 0.1606
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0018 0.0065 0.0064
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.1165 0.7182
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0018 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0191 0.1606 0.1606
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0018 0.0065 0.0064
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0041 0.004
Loa Loa (eye worm) hypothetical protein 0.0039 0.0246 0.0245
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0064
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0041 0.004
Echinococcus multilocularis para nitrobenzyl esterase 0.0191 0.1606 0.1606
Brugia malayi Cation transporter family protein 0.0018 0.0065 0.0064
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0001 0.0057
Treponema pallidum fructose-bisphosphate aldolase 0.029 0.249 0.5
Brugia malayi Cation transporter family protein 0.0018 0.0065 0.0064
Schistosoma mansoni hypothetical protein 0.0016 0.0041 0.004
Schistosoma mansoni chromobox protein 0.0069 0.0517 0.0516
Loa Loa (eye worm) hypothetical protein 0.0191 0.1606 0.1606
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0347 0.0346
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0041 0.004
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0158 0.4066
Schistosoma mansoni nAChR subunit 0.0018 0.0065 0.0064
Brugia malayi Carboxylesterase family protein 0.0191 0.1606 0.1606
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0065 0.0064
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.004
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0246 0.1526
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.004 0.0039
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0065 0.0064
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.004 0.252
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0126 0.7959
Schistosoma mansoni hypothetical protein 0.0034 0.0205 0.0205
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.004 0.252
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0191 0.1606 0.1606
Trypanosoma brucei C-8 sterol isomerase, putative 0.036 0.3118 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0126 0.0125
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0063 0.0062
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0065 0.0064
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.004 0.0039
Loa Loa (eye worm) carboxylesterase 0.1131 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0064
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0059 0.0234
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0018 0.0065 0.0064
Schistosoma mansoni hypothetical protein 0.0016 0.0041 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0032 0.0126
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0191 0.1606 0.6451
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0028 0.0109
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0347 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0145 0.0579
Echinococcus granulosus nAChR subunit 0.0018 0.0065 0.0064
Echinococcus multilocularis peregrin 0.0029 0.0158 0.0157
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0191 0.1606 0.1606
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0191 0.1606 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0041 0.004
Onchocerca volvulus 0.0018 0.0065 0.0397
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0001 0.0057
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0059 0.0234
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.004 0.0039
Schistosoma mansoni chromobox protein 0.0069 0.0517 0.0516
Onchocerca volvulus 0.0018 0.0065 0.0397
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0065 0.0064
Trichomonas vaginalis spcc417.12 protein, putative 0.0191 0.1606 0.6451
Brugia malayi ERG2 and Sigma1 receptor like protein 0.036 0.3118 0.3117
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0059 0.0234
Loa Loa (eye worm) hypothetical protein 0.1131 1 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0388 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0018 0.0065 0.0064
Brugia malayi Carboxylesterase family protein 0.0191 0.1606 0.1606
Loa Loa (eye worm) hypothetical protein 0.0191 0.1606 0.1606
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0227 0.0226
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0065 0.0064
Onchocerca volvulus 0.0018 0.0065 0.0397
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.004 0.1007
Brugia malayi hypothetical protein 0.0191 0.1606 0.1606
Onchocerca volvulus 0.0018 0.0065 0.0397
Echinococcus granulosus cpg binding protein 0.003 0.0172 0.0171
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0227 0.0226
Onchocerca volvulus 0.0029 0.0157 0.0975
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0064
Onchocerca volvulus 0.0018 0.0065 0.0397
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0205 0.0205
Leishmania major C-8 sterol isomerase-like protein 0.036 0.3118 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0065 0.0064
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0184 0.1545 0.1544
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0018 0.0065 0.0064
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0065 0.0064
Schistosoma mansoni nAChR subunit 0.0018 0.0065 0.0064
Brugia malayi Carboxylesterase family protein 0.1131 1 1
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0065 0.0064
Onchocerca volvulus 0.003 0.0171 0.106
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0064
Echinococcus granulosus acetylcholinesterase 0.1131 1 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0018 0.0065 0.0064
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.004 0.0039
Onchocerca volvulus 0.0191 0.1606 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0065 0.0064
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0517 0.0516
Schistosoma mansoni nAChR subunit 0.0018 0.0065 0.0064
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0059 0.0234
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0041 0.004
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0064
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0018 0.0065 0.0064
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0032 0.0126
Schistosoma mansoni neuroligin 3 (S09 family) 0.0191 0.1606 0.1606
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0272 0.169
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0018 0.0065 0.0064
Onchocerca volvulus 0.0018 0.0065 0.0397
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0272 0.109
Echinococcus multilocularis carboxylesterase 5A 0.1131 1 1
Schistosoma mansoni cpg binding protein 0.003 0.0172 0.0171
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0018 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.005 0.0343 0.0342
Echinococcus granulosus peregrin 0.0029 0.0158 0.0157
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0158 1
Loa Loa (eye worm) hypothetical protein 0.0191 0.1606 0.1606
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0433 0.0432
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1131 1 1
Trypanosoma cruzi C-8 sterol isomerase, putative 0.036 0.3118 1
Schistosoma mansoni hypothetical protein 0.0016 0.0041 0.004
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0227 0.0226
Plasmodium vivax heterochromatin protein 1, putative 0.0011 0.0001 0.0057
Loa Loa (eye worm) hypothetical protein 0.0191 0.1606 0.1606
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0018 0.0065 0.0064
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0065 0.0064
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0065 0.0064
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0126 0.7959
Giardia lamblia Fructose-bisphosphate aldolase 0.029 0.249 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.1131 1 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.0041 0.004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.249 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0018 0.0065 0.0064
Loa Loa (eye worm) acetylcholinesterase 1 0.1131 1 1
Brugia malayi jmjC domain containing protein 0.0037 0.0227 0.0226
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0347 0.0346
Echinococcus granulosus jumonji domain containing protein 0.004 0.0259 0.0259
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0065 0.0064
Onchocerca volvulus Alhambra homolog 0.0029 0.0158 0.098
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0065 0.0064
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0126 0.7959
Schistosoma mansoni nAChR subunit 0.0018 0.0065 0.0064
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0018 0.0065 0.0064
Schistosoma mansoni nAChR subunit 0.0018 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0064
Brugia malayi excitatory GABA receptor EXP-1A 0.0018 0.0065 0.0064
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0746 0.0745
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.0065 0.0064
Echinococcus multilocularis acetylcholinesterase 0.1131 1 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0007 0.0006
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0158 0.4066
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0191 0.1606 0.1606
Brugia malayi Carboxylesterase family protein 0.0191 0.1606 0.1606
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0126 0.028
Schistosoma mansoni acetylcholinesterase 0.0191 0.1606 0.1606
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0126 0.028
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0018 0.0065 0.0064
Echinococcus multilocularis acetylcholinesterase 0.1131 1 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0158 0.0157
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0191 0.1606 0.1606
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0064
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0041 0.004
Echinococcus multilocularis BC026374 protein (S09 family) 0.0191 0.1606 0.1606
Brugia malayi PHD-finger family protein 0.0029 0.0158 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0246 0.0984
Echinococcus granulosus chromobox protein 1 0.0069 0.0517 0.0516
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0158 0.0157
Onchocerca volvulus 0.0191 0.1606 1
Echinococcus granulosus BC026374 protein S09 family 0.0191 0.1606 0.1606
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0191 0.1606 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.249 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0145 0.0579
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0064
Echinococcus granulosus GPCR family 2 0.0016 0.0041 0.004
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0016 0.0015
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0018 0.0065 0.0064
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.004 0.0039
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.004 0.0039
Schistosoma mansoni nAChR subunit 0.0018 0.0065 0.0064
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0018 0.0065 0.0064
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0446 0.0445
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0213 0.0212
Brugia malayi Bromodomain containing protein 0.0029 0.0158 0.0157
Loa Loa (eye worm) hypothetical protein 0.0034 0.0205 0.0205
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0065 0.0064
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.005 0.0347 0.0346
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0065 0.0064
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0018 0.0065 0.0064
Brugia malayi Carboxylesterase family protein 0.0191 0.1606 0.1606
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0065 0.0064
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0517 0.2075
Schistosoma mansoni cpg binding protein 0.0029 0.0157 0.0157
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.249 1
Brugia malayi chromobox protein homolog 3 0.0039 0.0246 0.0245
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0018 0.0065 0.0064
Brugia malayi hypothetical protein 0.0016 0.0046 0.0045
Leishmania major hypothetical protein, conserved 0.0025 0.0126 0.028
Loa Loa (eye worm) hypothetical protein 0.003 0.0171 0.017
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0065 0.0064
Echinococcus multilocularis neuroligin 0.0191 0.1606 0.1606
Brugia malayi CXXC zinc finger family protein 0.0029 0.0157 0.0157
Echinococcus granulosus neuroligin 0.0191 0.1606 0.1606
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0064
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0157 0.0157
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0142 0.1165 0.5
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.029 0.249 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0059 0.0234
Loa Loa (eye worm) hypothetical protein 0.0018 0.0065 0.0064
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.029 0.249 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.028 uM DNDI: Inhibition of Chagas Disease parasite Trypanosoma cruzi (Tulahuen LacZ, Clone C4), in vitro. ChEMBL. No reference
IC90 (functional) = 0.085 uM DNDI: Inhibition of Chagas Disease parasite Trypanosoma cruzi (Tulahuen LacZ, Clone C4), in vitro. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma cruzi ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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