Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0039 | 0.0654 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.023 | 0.2595 |
Schistosoma mansoni | ferritin light chain | 0.0017 | 0.0013 | 0.0013 |
Loa Loa (eye worm) | RNA binding protein | 0.0124 | 0.3209 | 0.7898 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.002 | 0.0081 | 0.1062 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0654 | 0.161 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0081 | 0.0199 |
Echinococcus granulosus | expressed protein | 0.0017 | 0.0013 | 0.0013 |
Echinococcus multilocularis | expressed protein | 0.0017 | 0.0013 | 0.0013 |
Schistosoma mansoni | DNA polymerase eta | 0.002 | 0.0081 | 0.0081 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0039 | 0.0654 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0039 | 0.0654 | 1 |
Brugia malayi | TAR-binding protein | 0.0124 | 0.3209 | 0.7898 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0654 | 0.161 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0039 | 0.0654 | 0.0654 |
Trichomonas vaginalis | esterase, putative | 0.0039 | 0.0654 | 1 |
Schistosoma mansoni | ferritin | 0.0017 | 0.0013 | 0.0013 |
Schistosoma mansoni | hypothetical protein | 0.0349 | 1 | 1 |
Schistosoma mansoni | ferritin | 0.0017 | 0.0013 | 0.0013 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.023 | 0.2595 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.002 | 0.0081 | 0.5 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.002 | 0.0081 | 0.0199 |
Echinococcus granulosus | ferritin | 0.0017 | 0.0013 | 0.0013 |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.0654 | 0.0927 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.002 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0654 | 0.161 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0654 | 0.0654 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.0654 | 1 |
Schistosoma mansoni | apoferritin-2 | 0.0017 | 0.0013 | 0.0013 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0247 | 0.693 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0039 | 0.0654 | 0.161 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.4063 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.023 | 0.2595 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0039 | 0.0654 | 0.0927 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0017 | 0.0013 | 0.5 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0081 | 0.0081 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.1102 | 0.2713 |
Plasmodium vivax | hypothetical protein, conserved | 0.0039 | 0.0654 | 1 |
Onchocerca volvulus | 0.0039 | 0.0654 | 0.5 | |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.0654 | 0.0927 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.023 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0081 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.023 | 0.0566 |
Onchocerca volvulus | 0.0039 | 0.0654 | 0.5 | |
Brugia malayi | beta-lactamase | 0.0039 | 0.0654 | 0.161 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0654 | 0.0654 |
Toxoplasma gondii | ABC1 family protein | 0.0039 | 0.0654 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0654 | 0.161 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0039 | 0.0654 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0654 | 0.161 |
Schistosoma mansoni | apoferritin-2 | 0.0017 | 0.0013 | 0.0013 |
Brugia malayi | Muscleblind-like protein | 0.0152 | 0.4063 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.002 | 0.0081 | 0.1062 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.002 | 0.0081 | 0.0098 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.1102 | 0.2713 |
Echinococcus multilocularis | ferritin | 0.0017 | 0.0013 | 0.0013 |
Schistosoma mansoni | ferritin | 0.0017 | 0.0013 | 0.0013 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.1102 | 0.2713 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0654 | 0.161 |
Schistosoma mansoni | ferritin light chain | 0.0017 | 0.0013 | 0.0013 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0039 | 0.0654 | 0.0654 |
Mycobacterium ulcerans | beta-lactamase | 0.0039 | 0.0654 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.023 | 0.0566 |
Mycobacterium leprae | Probable lipase LipE | 0.0039 | 0.0654 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0592 | 0.0592 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0592 | 0.1457 |
Echinococcus multilocularis | tar DNA binding protein | 0.0124 | 0.3209 | 0.3209 |
Brugia malayi | RNA binding protein | 0.0124 | 0.3209 | 0.7898 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0125 | 0.3237 | 0.7968 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.0654 | 1 |
Onchocerca volvulus | 0.0039 | 0.0654 | 0.5 | |
Brugia malayi | RNA recognition motif domain containing protein | 0.0124 | 0.3209 | 0.7898 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0039 | 0.0654 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0152 | 0.4063 | 0.4063 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0081 | 0.0199 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.0654 | 1 |
Echinococcus multilocularis | geminin | 0.0349 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.4063 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0039 | 0.0654 | 0.0927 |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.0654 | 0.0927 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0039 | 0.0654 | 0.161 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.0654 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0654 | 0.161 |
Mycobacterium leprae | conserved hypothetical protein | 0.0039 | 0.0654 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.0081 | 0.1062 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0.0081 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0125 | 0.3237 | 0.7968 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.3209 | 0.3209 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.023 | 0.2595 |
Schistosoma mansoni | ferritin | 0.0017 | 0.0013 | 0.0013 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.3209 | 0.3209 |
Echinococcus granulosus | dna polymerase eta | 0.002 | 0.0081 | 0.0081 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0039 | 0.0654 | 0.0927 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.023 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0152 | 0.4063 | 0.4063 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0039 | 0.0654 | 0.0927 |
Echinococcus multilocularis | dna polymerase eta | 0.002 | 0.0081 | 0.0081 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0039 | 0.0654 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0039 | 0.0654 | 0.161 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0654 | 0.161 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.0654 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0349 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0124 | 0.3209 | 0.7898 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0039 | 0.0654 | 0.0927 |
Echinococcus granulosus | muscleblind protein | 0.0152 | 0.4063 | 0.4063 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0124 | 0.3209 | 0.7898 |
Echinococcus granulosus | dna polymerase kappa | 0.002 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0125 | 0.3237 | 0.7968 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1102 | 0.2713 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.3209 | 0.3209 |
Mycobacterium ulcerans | hypothetical protein | 0.0039 | 0.0654 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.3209 | 0.3209 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.0081 | 0.1062 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0039 | 0.0654 | 0.0927 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0592 | 0.1457 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.3209 | 0.3209 |
Echinococcus granulosus | tar DNA binding protein | 0.0124 | 0.3209 | 0.3209 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.002 | 0.0081 | 0.0081 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0039 | 0.0654 | 0.0927 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.002 | 0.0081 | 0.0098 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0017 | 0.0013 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.002 | 0.0081 | 0.0081 |
Mycobacterium ulcerans | lipase LipD | 0.0039 | 0.0654 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.