TDR Targets

Basic information

Technical information

TDR Targets ID: 1580697
Name: 2-octyl-1,2-benzothiazol-3-one
MW: 263.398 | Formula: C15H21NOS
H donors: 0 H acceptors: 1 LogP: 4.87 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCCCn1sc2c(c1=O)cccc2
InChi: 1S/C15H21NOS/c1-2-3-4-5-6-9-12-16-15(17)13-10-7-8-11-14(13)18-16/h7-8,10-11H,2-6,9,12H2,1H3
InChiKey: WVGPLHUTLSZSGX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Monoglyceride lipase	Starlite/ChEMBL	References
Homo sapiens	monoglyceride lipase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania mexicana	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	Get druggable targets OG5_127037	All targets in OG5_127037
Candida albicans	similar to YJU3	Get druggable targets OG5_127037	All targets in OG5_127037
Mycobacterium ulcerans	lysophospholipase	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	esterase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma brucei gambiense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	valacyclovir hydrolase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium vivax	PST-A protein	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania braziliensis	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma congolense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma congolense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma congolense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	lysophospholipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	lysophospholipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania major	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma brucei gambiense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania donovani	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	Get druggable targets OG5_127037	All targets in OG5_127037
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma cruzi	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	lysophospholipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Candida albicans	similar to YJU3	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania infantum	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma brucei	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma brucei	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Mycobacterium tuberculosis	Possible lysophospholipase	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trichomonas vaginalis	Clan SC, family S9, unassigned serine peptidase	Monoglyceride lipase	303 aa	250 aa	21.2 %
Leishmania braziliensis	hypothetical protein, conserved	Monoglyceride lipase	303 aa	250 aa	24.8 %
Plasmodium knowlesi	lysophospholipase, putative	Monoglyceride lipase	303 aa	280 aa	23.2 %
Plasmodium vivax	PST-A protein	Monoglyceride lipase	303 aa	257 aa	21.0 %
Trypanosoma cruzi	Serine peptidase, Clan SC, Family S09X, putative	Monoglyceride lipase	303 aa	245 aa	23.3 %
Plasmodium falciparum	esterase, putative	Monoglyceride lipase	303 aa	273 aa	19.0 %
Plasmodium vivax	hypothetical protein, conserved	Monoglyceride lipase	303 aa	282 aa	20.6 %
Candida albicans	similar to S. cerevisiae YOR084W	Monoglyceride lipase	303 aa	303 aa	23.4 %
Trypanosoma brucei	Ankyrin repeats (many copies)/Alpha/beta hydrolase family, putative	Monoglyceride lipase	303 aa	276 aa	23.2 %
Plasmodium berghei	alpha/beta hydrolase, putative	Monoglyceride lipase	303 aa	284 aa	20.4 %
Babesia bovis	lysophospholipase, putative	Monoglyceride lipase	303 aa	289 aa	22.8 %
Plasmodium knowlesi	conserved Plasmodium protein, unknown function	Monoglyceride lipase	303 aa	272 aa	20.2 %
Plasmodium knowlesi	alpha/beta hydrolase, putative	Monoglyceride lipase	303 aa	261 aa	21.5 %
Mycobacterium ulcerans	hydrolase	Monoglyceride lipase	303 aa	284 aa	22.5 %
Plasmodium vivax	lysophospholipase, putative	Monoglyceride lipase	303 aa	274 aa	23.4 %
Candida albicans	similar to S. cerevisiae YOR084W	Monoglyceride lipase	303 aa	303 aa	23.4 %
Plasmodium berghei	prodrug activation and resistance esterase, putative	Monoglyceride lipase	303 aa	266 aa	22.9 %
Plasmodium knowlesi	esterase, putative	Monoglyceride lipase	303 aa	259 aa	25.5 %
Toxoplasma gondii	phospholipase	Monoglyceride lipase	303 aa	378 aa	20.9 %
Plasmodium vivax	PST-A protein	Monoglyceride lipase	303 aa	261 aa	24.1 %
Mycobacterium tuberculosis	Possible hydrolase	Monoglyceride lipase	303 aa	263 aa	23.2 %
Neospora caninum	Lysophospholipase, related	Monoglyceride lipase	303 aa	380 aa	21.1 %
Plasmodium falciparum	epoxide hydrolase 2	Monoglyceride lipase	303 aa	254 aa	22.4 %
Plasmodium falciparum	esterase, putative	monoglyceride lipase	303 aa	254 aa	19.7 %
Plasmodium falciparum	esterase, putative	Monoglyceride lipase	303 aa	265 aa	21.5 %
Plasmodium knowlesi	lysophospholipase, putative	Monoglyceride lipase	303 aa	250 aa	22.4 %
Plasmodium vivax	unspecified product	Monoglyceride lipase	303 aa	274 aa	23.4 %
Plasmodium vivax	lysophospholipase, putative	Monoglyceride lipase	303 aa	361 aa	21.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0061	0.0398	0.0393
Mycobacterium tuberculosis	Hypothetical protein	0.005	0.0292	0.0479
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0036	0.0169	0.0272
Echinococcus multilocularis	transcription factor Dp 1	0.0038	0.0191	0.0276
Trypanosoma brucei	carnitine O-palmitoyltransferase II, putative	0.0024	0.006	0.0044
Schistosoma mansoni	ran	0.0021	0.0032	0.0051
Brugia malayi	hypothetical protein	0.012	0.0924	0.0909
Brugia malayi	Dihydrofolate reductase	0.0376	0.3221	0.321
Brugia malayi	AF-10 protein	0.0019	0.0018	0.0002
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.012	0.0924	0.3381
Loa Loa (eye worm)	carboxylesterase	0.012	0.0924	0.0919
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0066	0.0441	0.1552
Schistosoma mansoni	hypothetical protein	0.0421	0.3626	0.5831
Toxoplasma gondii	ABC1 family protein	0.0038	0.0186	0.0741
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0032	0.0016
Echinococcus multilocularis	calmodulin	0.0026	0.0083	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0024	0.006	0.0054
Onchocerca volvulus		0.0026	0.0083	0.0121
Trichomonas vaginalis	calmodulin, putative	0.0026	0.0083	0.0196
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0106	0.017
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0061	0.0398	0.064
Loa Loa (eye worm)	hypothetical protein	0.1131	1	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.0924	0.0919
Echinococcus granulosus	transcription factor Dp 1	0.0038	0.0191	0.0307
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0179	0.0164
Brugia malayi	hypothetical protein	0.005	0.0292	0.0276
Trichomonas vaginalis	inositol monophosphatase, putative	0.0037	0.0179	0.056
Echinococcus granulosus	histone lysine methyltransferase setb	0.0048	0.0275	0.0441
Loa Loa (eye worm)	hypothetical protein	0.0578	0.5036	0.5034
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0051	0.0035
Onchocerca volvulus		0.012	0.0924	0.4486
Plasmodium vivax	hypothetical protein, conserved	0.0038	0.0186	0.0741
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.0441	0.0426
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0179	0.0288
Brugia malayi	Carboxylesterase family protein	0.012	0.0924	0.0909
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0275	0.0269
Brugia malayi	Choline/Carnitine o-acyltransferase family protein	0.0024	0.006	0.0044
Leishmania major	hypothetical protein, conserved	0.0038	0.0186	0.017
Echinococcus granulosus	phd:f box containing protein	0.0019	0.0016	0.0026
Mycobacterium tuberculosis	Carboxylesterase LipT	0.012	0.0924	0.2533
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.012	0.0924	0.1485
Loa Loa (eye worm)	jmjC domain-containing protein	0.0074	0.0514	0.0508
Schistosoma mansoni	hypothetical protein	0.0334	0.2843	0.4571
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0032	0.0051
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0038	0.0186	0.017
Brugia malayi	TAR-binding protein	0.0061	0.0398	0.0383
Loa Loa (eye worm)	inositol-1	0.0037	0.0179	0.0174
Loa Loa (eye worm)	jmjC domain-containing protein	0.0019	0.0016	0.0011
Echinococcus multilocularis	dihydrofolate reductase	0.0376	0.3221	0.4664
Trypanosoma cruzi	calmodulin, putative	0.0026	0.0083	0.0067
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0066	0.0441	0.0639
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0186	0.0135
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0032	0.0026
Leishmania major	GTP-binding protein, putative	0.0021	0.0032	0.0016
Echinococcus multilocularis	lysine specific demethylase 5A	0.0071	0.0481	0.0697
Brugia malayi	Choline/Carnitine o-acyltransferase family protein	0.0024	0.006	0.0044
Brugia malayi	Carboxylesterase family protein	0.012	0.0924	0.0909
Schistosoma mansoni	phd/f-box containing protein	0.0019	0.0016	0.0026
Mycobacterium ulcerans	lysophospholipase	0.0168	0.1359	0.3879
Brugia malayi	calmodulin	0.0026	0.0083	0.0067
Brugia malayi	CXXC zinc finger family protein	0.003	0.0112	0.0096
Trichomonas vaginalis	set domain proteins, putative	0.0238	0.1985	0.7406
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0038	0.0186	0.0269
Echinococcus granulosus	carnitine O palmitoyltransferase 2	0.0024	0.006	0.0096
Mycobacterium tuberculosis	Probable esterase LipL	0.0038	0.0186	0.0135
Echinococcus granulosus	BC026374 protein S09 family	0.012	0.0924	0.1485
Brugia malayi	Bromodomain containing protein	0.0038	0.0191	0.0175
Echinococcus multilocularis	jumonji domain containing protein	0.0081	0.0576	0.0835
Echinococcus granulosus	choline O acetyltransferase	0.0024	0.006	0.0096
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.0064	0.0104
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0168	0.1359	0.5032
Brugia malayi	MH2 domain containing protein	0.0239	0.1989	0.1976
Leishmania major	monoglyceride lipase, putative	0.0168	0.1359	0.1345
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0038	0.0186	0.0135
Echinococcus granulosus	neuroligin	0.012	0.0924	0.1485
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0186	0.0181
Schistosoma mansoni	neuroligin 3 (S09 family)	0.012	0.0924	0.1485
Loa Loa (eye worm)	hypothetical protein	0.012	0.0924	0.0919
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0186	0.0181
Echinococcus granulosus	dihydrofolate reductase	0.0376	0.3221	0.5178
Schistosoma mansoni	cpg binding protein	0.0033	0.0145	0.0232
Trypanosoma brucei	calmodulin	0.0026	0.0083	0.0067
Giardia lamblia	PHD finger protein 15	0.0058	0.0371	0.1286
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0394	0.0633
Echinococcus granulosus	para nitrobenzyl esterase	0.012	0.0924	0.1485
Schistosoma mansoni	hypothetical protein	0.0334	0.2843	0.4571
Loa Loa (eye worm)	hypothetical protein	0.012	0.0924	0.0919
Echinococcus granulosus	geminin	0.0334	0.2843	0.4571
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0137	0.0132
Echinococcus granulosus	beta LACTamase domain containing family member	0.0038	0.0186	0.0299
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0037	0.0182	0.0571
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0168	0.1359	0.5032
Plasmodium falciparum	esterase, putative	0.0168	0.1359	0.5861
Loa Loa (eye worm)	choline O-acetyltransferase	0.0024	0.006	0.0054
Trypanosoma cruzi	calmodulin	0.0026	0.0083	0.0067
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0051	0.0035
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.012	0.0924	0.2533
Trypanosoma brucei	C-8 sterol isomerase, putative	0.1131	1	1
Brugia malayi	RNA, U transporter 1	0.008	0.0561	0.0546
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0037	0.0182	0.0123
Echinococcus granulosus	JmjC domain containing protein 4	0.0019	0.0016	0.0026
Schistosoma mansoni	cpg binding protein	0.003	0.0112	0.0181
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0093	0.0682	0.0677
Echinococcus multilocularis	JmjC domain containing protein 4	0.0019	0.0016	0.0023
Brugia malayi	jmjC domain containing protein	0.0191	0.1564	0.155
Echinococcus granulosus	lysine specific demethylase 5A	0.0074	0.0514	0.0826
Loa Loa (eye worm)	PHD-finger family protein	0.0021	0.0032	0.0027
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.0441	0.0426
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0074	0.0514	0.0826
Echinococcus granulosus	CalModulin family member cmd 1	0.0026	0.0083	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0186	0.0181
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.0682	0.1097
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0074	0.0514	0.0826
Brugia malayi	exodeoxyribonuclease III family protein	0.0037	0.0182	0.0167
Trypanosoma cruzi	calmodulin, putative	0.0026	0.0083	0.0067
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0066	0.0441	0.0426
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0037	0.0179	0.0713
Echinococcus multilocularis	acetylcholinesterase	0.071	0.6219	0.9007
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0394	0.0633
Schistosoma mansoni	hypothetical protein	0.0299	0.2528	0.4065
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0066	0.0441	0.0426
Echinococcus multilocularis	para nitrobenzyl esterase	0.012	0.0924	0.1338
Brugia malayi	RNA recognition motif domain containing protein	0.0061	0.0398	0.0383
Echinococcus multilocularis	carboxylesterase 5A	0.071	0.6219	0.9007
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.0168	0.1359	0.3948
Echinococcus granulosus	calmodulin	0.0026	0.0083	0.0134
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0032	0.0016
Trypanosoma cruzi	hypothetical protein, conserved	0.0024	0.006	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0764	0.0759
Brugia malayi	PHD-finger family protein	0.0058	0.0371	0.0356
Chlamydia trachomatis	dihydrofolate reductase	0.0376	0.3221	0.5
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.0019	0.0018	0.0009
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.071	0.6219	1
Trypanosoma cruzi	choline/carnitine O-acyltransferase, putative	0.0024	0.006	0.0044
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0376	0.3221	1
Plasmodium vivax	PST-A protein	0.0168	0.1359	0.5861
Schistosoma mansoni	bromodomain containing protein	0.0065	0.043	0.0692
Loa Loa (eye worm)	hypothetical protein	0.01	0.0746	0.074
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0038	0.0186	0.0135
Mycobacterium ulcerans	thymidylate synthase	0.0104	0.0782	0.1982
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.0682	0.1097
Schistosoma mansoni	choline o-acyltransferase	0.0024	0.006	0.0096
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0179	0.0288
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0168	0.1359	0.5032
Schistosoma mansoni	acetylcholinesterase	0.012	0.0924	0.1485
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0154	0.1226	0.3515
Echinococcus multilocularis	choline O acetyltransferase	0.0024	0.006	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0186	0.0181
Loa Loa (eye worm)	choline/Carnitine O-acyltransferase	0.0024	0.006	0.0054
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.0064	0.0093
Onchocerca volvulus		0.0038	0.0186	0.0655
Echinococcus multilocularis	zinc finger protein	0.0021	0.0038	0.0055
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0093	0.0682	0.0667
Plasmodium falciparum	importin beta, putative	0.0028	0.0098	0.0358
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0186	0.017
Echinococcus granulosus	jumonji domain containing protein	0.0081	0.0576	0.0927
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0019	0.0016	0.0026
Echinococcus granulosus	zinc finger protein	0.0021	0.0038	0.0061
Brugia malayi	Choline O-acetyltransferase	0.0024	0.006	0.0044
Onchocerca volvulus		0.0238	0.1985	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0037	0.0182	0.0293
Brugia malayi	jmjC domain containing protein	0.0074	0.0514	0.0498
Echinococcus multilocularis	jumonji domain containing 1A	0.0019	0.0016	0.0023
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0168	0.1359	0.5032
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0098	0.0082
Onchocerca volvulus		0.012	0.0924	0.4486
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0168	0.1359	0.5032
Echinococcus multilocularis	carnitine O palmitoyltransferase 1, liver	0.0129	0.1008	0.146
Schistosoma mansoni	protein phosphatase 2C	0.0019	0.0016	0.0026
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0037	0.0182	0.0571
Trypanosoma brucei	calmodulin	0.0026	0.0083	0.0067
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0104	0.0782	0.1258
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0032	0.0016
Mycobacterium leprae	Probable lipase LipE	0.0038	0.0186	0.0135
Trypanosoma cruzi	carnitine/choline acetyltransferase, putative	0.0024	0.006	0.0044
Loa Loa (eye worm)	TAR-binding protein	0.0061	0.0398	0.0393
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0112	0.0107
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0314	0.2669	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0245	0.024
Echinococcus multilocularis	neuroligin	0.012	0.0924	0.1338
Trypanosoma brucei	calmodulin	0.0026	0.0083	0.0067
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0394	0.1647
Echinococcus multilocularis	geminin	0.0334	0.2843	0.4117
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0016	0.0011
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0154	0.1226	0.3515
Echinococcus granulosus	jumonji domain containing 1A	0.0019	0.0016	0.0026
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0186	0.0585
Leishmania major	calmodulin, putative	0.0026	0.0083	0.0067
Trypanosoma cruzi	carnitine O-acetyltransferase, putative	0.0024	0.006	0.0044
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0179	0.056
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0098	0.0358
Plasmodium falciparum	lysophospholipase, putative	0.0168	0.1359	0.5861
Plasmodium falciparum	phd finger protein, putative	0.0058	0.0371	0.1549
Leishmania major	C-8 sterol isomerase-like protein	0.1131	1	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0394	0.0704
Trypanosoma brucei	monoglyceride lipase, putative	0.0168	0.1359	0.1345
Schistosoma mansoni	phosphatidylserine receptor	0.0019	0.0016	0.0026
Onchocerca volvulus		0.0038	0.0186	0.0655
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0209	0.1726	0.1722
Giardia lamblia	Fructose-bisphosphate aldolase	0.0314	0.2669	1
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0098	0.0142
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0186	0.0585
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0154	0.1226	0.344
Onchocerca volvulus		0.0038	0.0186	0.0655
Echinococcus multilocularis	carnitine O palmitoyltransferase 2	0.0024	0.006	0.0087
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0376	0.3221	1
Entamoeba histolytica	calmodulin, putative	0.0026	0.0083	0.0196
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.012	0.0924	0.1485
Plasmodium vivax	SET domain protein, putative	0.0031	0.0121	0.046
Schistosoma mansoni	ap endonuclease	0.0037	0.0182	0.0293
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0179	0.0164
Echinococcus multilocularis	snurportin 1	0.0299	0.2528	0.3661
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0051	0.0071
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0186	0.017
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0083	0.0078
Echinococcus granulosus	GPCR family 2	0.0032	0.0137	0.022
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0394	0.0704
Echinococcus granulosus	snurportin 1	0.0299	0.2528	0.4065
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0051	0.0071
Echinococcus multilocularis	peregrin	0.0061	0.0392	0.0568
Schistosoma mansoni	BC026374 protein (S09 family)	0.012	0.0924	0.1485
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0314	0.2669	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0038	0.0186	0.0135
Schistosoma mansoni	cpg binding protein	0.0033	0.0145	0.0232
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.0682	0.1097
Echinococcus granulosus	cpg binding protein	0.0033	0.0145	0.0232
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0137	0.0132
Loa Loa (eye worm)	dihydrofolate reductase	0.0376	0.3221	0.3217
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0186	0.0135
Echinococcus multilocularis	calmodulin	0.0026	0.0083	0.0121
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0398	0.064
Loa Loa (eye worm)	MH2 domain-containing protein	0.0239	0.1989	0.1985
Echinococcus granulosus	calmodulin	0.0026	0.0083	0.0134
Loa Loa (eye worm)	hypothetical protein	0.071	0.6219	0.6217
Mycobacterium tuberculosis	Possible lysophospholipase	0.0168	0.1359	0.3948
Brugia malayi	latrophilin 2 splice variant baaae	0.007	0.0474	0.0458
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0048	0.0275	0.0441
Brugia malayi	Inositol-1	0.0037	0.0179	0.0164
Trichomonas vaginalis	conserved hypothetical protein	0.0168	0.1359	0.5032
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0019	0.0018	0.0002
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0104	0.0782	0.2073
Trypanosoma brucei	calmodulin	0.0026	0.0083	0.0067
Echinococcus granulosus	tar DNA binding protein	0.0061	0.0398	0.064
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0037	0.0182	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0186	0.0299
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.0682	0.0988
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0104	0.0782	0.2073
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0299	0.2528	0.2524
Schistosoma mansoni	ran	0.0021	0.0032	0.0051
Loa Loa (eye worm)	jmjC domain-containing protein	0.0019	0.0016	0.0011
Schistosoma mansoni	hypothetical protein	0.0021	0.0032	0.0052
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0274	0.2308	0.2295
Mycobacterium leprae	conserved hypothetical protein	0.0038	0.0186	0.0135
Echinococcus multilocularis	calmodulin	0.0026	0.0083	0.0121
Leishmania major	carnitine/choline acetyltransferase, putative	0.0024	0.006	0.0044
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0032	0.0068
Loa Loa (eye worm)	acetylcholinesterase 1	0.071	0.6219	0.6217
Echinococcus multilocularis	dnaJ subfamily B	0.0421	0.3626	0.5252
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.0682	0.1097
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0398	0.064
Trypanosoma cruzi	calmodulin, putative	0.0026	0.0083	0.0067
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.0064	0.0104
Trichomonas vaginalis	esterase, putative	0.0038	0.0186	0.0585
Trypanosoma cruzi	calmodulin	0.0026	0.0083	0.0067
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0168	0.1359	0.5032
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0292	0.0986
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0098	0.0358
Brugia malayi	Carboxylesterase family protein	0.012	0.0924	0.0909
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0098	0.0158
Schistosoma mansoni	zinc finger protein	0.0021	0.0038	0.0061
Mycobacterium ulcerans	carboxylesterase, LipT	0.012	0.0924	0.2447
Trypanosoma cruzi	choline/carnitine O-acyltransferase, putative	0.0129	0.1008	0.0994
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0051	0.0045
Loa Loa (eye worm)	hypothetical protein	0.007	0.0474	0.0469
Echinococcus granulosus	carboxylesterase 5A	0.071	0.6219	1
Toxoplasma gondii	exonuclease III APE	0.0037	0.0182	0.0726
Brugia malayi	beta-lactamase family protein	0.0038	0.0186	0.017
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0032	0.0068
Toxoplasma gondii	PHD-finger domain-containing protein	0.0019	0.0018	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0482	0.0477
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0314	0.2669	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0102	0.0764	0.0759
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0037	0.0182	0.0726
Onchocerca volvulus	Alhambra homolog	0.0058	0.0371	0.1616
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0037	0.0182	0.0177
Loa Loa (eye worm)	carboxylesterase	0.012	0.0924	0.0919
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0314	0.2669	1
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0137	0.0121
Echinococcus multilocularis	lysine specific demethylase 6a	0.0019	0.0016	0.0023
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0121	0.0195
Echinococcus granulosus	PHD finger protein rhinoceros	0.0058	0.0371	0.0597
Loa Loa (eye worm)	hypothetical protein	0.012	0.0924	0.0919
Toxoplasma gondii	PHD-finger domain-containing protein	0.0058	0.0371	0.1549
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0314	0.2669	1
Trichomonas vaginalis	spcc417.12 protein, putative	0.012	0.0924	0.3381
Giardia lamblia	Calmodulin	0.0026	0.0083	0.0196
Onchocerca volvulus	Calmodulin homolog	0.0026	0.0083	0.0122
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0037	0.0182	0.0167
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0022	0.0048	0.007
Schistosoma mansoni	hypothetical protein	0.0032	0.0137	0.022
Echinococcus granulosus	inositol monophosphatase 1	0.0037	0.0179	0.0288
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0038	0.0186	0.0022
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0168	0.1359	0.5032
Trypanosoma brucei	pteridine reductase 1	0.0188	0.1539	0.1525
Echinococcus multilocularis	inositol monophosphatase 1	0.0037	0.0179	0.026
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0037	0.0182	0.0726
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0038	0.0186	0.0181
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0058	0.0371	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1008	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0016	0.0011
Entamoeba histolytica	hypothetical protein	0.0023	0.0051	0.0071
Trypanosoma cruzi	carnitine/choline acetyltransferase, putative	0.0024	0.006	0.0044
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.012	0.0924	0.2533
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.005	0.0292	0.0276
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0028	0.0094	0.0151
Onchocerca volvulus		0.012	0.0924	0.4486
Loa Loa (eye worm)	transcription factor SMAD2	0.0239	0.1989	0.1985
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0398	0.064
Brugia malayi	Importin beta-1 subunit	0.0028	0.0098	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0371	0.0366
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0137	0.022
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0037	0.0182	0.0167
Echinococcus granulosus	thymidylate synthase	0.0104	0.0782	0.1258
Loa Loa (eye worm)	hypothetical protein	0.012	0.0924	0.0919
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0064	0.042	0.0675
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0241	0.2013	0.6075
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0186	0.0585
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.012	0.0924	0.1338
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.012	0.0924	0.1485
Schistosoma mansoni	choline o-acyltransferase	0.0024	0.006	0.0096
Echinococcus granulosus	lysine specific demethylase 6a	0.0019	0.0016	0.0026
Echinococcus multilocularis	tar DNA binding protein	0.0061	0.0398	0.0577
Schistosoma mansoni	jumonji domain containing protein	0.0019	0.0016	0.0026
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0102	0.0764	0.0749
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0314	0.2669	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0394	0.0809
Echinococcus granulosus	acetylcholinesterase	0.071	0.6219	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0786	0.6905	1
Brugia malayi	Carboxylesterase family protein	0.071	0.6219	0.6213
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0394	0.0633
Trypanosoma brucei	carnitine O-palmitoyltransferase, putative	0.0024	0.006	0.0044
Echinococcus multilocularis	CalModulin family member (cmd 1)	0.0026	0.0083	0.0121
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0137	0.0198
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0179	0.056
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0274	0.2308	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0031	0.0126	0.011
Leishmania major	carnitine palmitoyltransferase-like protein	0.0024	0.006	0.0044
Leishmania major	choline/Carnitine o-acyltransferase-like protein	0.0129	0.1008	0.0994
Echinococcus multilocularis	phd:f box containing protein	0.0019	0.0016	0.0023
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0191	0.1564	0.2264
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0048	0.0275	0.0441
Mycobacterium ulcerans	lipase LipD	0.0038	0.0186	0.0022
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0102	0.0764	0.0749
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0314	0.2669	1
Echinococcus multilocularis	calmodulin	0.0026	0.0083	0.0121
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.0682	0.0988
Mycobacterium ulcerans	hypothetical protein	0.0038	0.0186	0.0022
Brugia malayi	Carboxylesterase family protein	0.071	0.6219	0.6213
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0186	0.0299
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0037	0.0182	0.001
Loa Loa (eye worm)	thymidylate synthase	0.0104	0.0782	0.0777
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0137	0.0198
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0274	0.2308	0.2295
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0398	0.064
Echinococcus granulosus	calmodulin	0.0026	0.0083	0.0134
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.0168	0.1359	0.5032
Schistosoma mansoni	hypothetical protein	0.0032	0.0137	0.022
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0213	0.0207
Trypanosoma brucei	hypothetical protein, conserved	0.0024	0.006	0.0044
Schistosoma mansoni	dihydrofolate reductase	0.0376	0.3221	0.5178
Loa Loa (eye worm)	RNA binding protein	0.0061	0.0398	0.0393
Schistosoma mansoni	hypothetical protein	0.0032	0.0137	0.022
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0037	0.0182	0.0167
Loa Loa (eye worm)	PHD-finger family protein	0.0058	0.0371	0.0366
Brugia malayi	Choline/Carnitine o-acyltransferase family protein	0.0129	0.1008	0.0994
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0066	0.0441	0.0709
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0137	0.022
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0066	0.0441	0.0436
Brugia malayi	dihydrofolate reductase family protein	0.0376	0.3221	0.321
Echinococcus multilocularis	cpg binding protein	0.0033	0.0145	0.0209
Mycobacterium ulcerans	esterase/lipase LipP	0.0038	0.0186	0.0022
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0038	0.0186	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0191	0.0186
Brugia malayi	PHD-finger family protein	0.0023	0.0051	0.0034
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.0682	0.1097
Trypanosoma cruzi	hypothetical protein, conserved	0.0024	0.006	0.0044
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0186	0.0585
Schistosoma mansoni	gliotactin	0.012	0.0924	0.1485
Onchocerca volvulus		0.0031	0.0121	0.032
Trypanosoma brucei	monoglyceride lipase, putative	0.0168	0.1359	0.1345
Trypanosoma cruzi	hypothetical protein, conserved	0.0024	0.006	0.0044
Loa Loa (eye worm)	beta-lactamase	0.0038	0.0186	0.0181
Schistosoma mansoni	importin beta-1	0.0028	0.0098	0.0158
Trypanosoma cruzi	choline/carnitine O-acyltransferase, putative	0.0129	0.1008	0.0994
Brugia malayi	Bromodomain containing protein	0.0061	0.0392	0.0377
Loa Loa (eye worm)	hypothetical protein	0.012	0.0924	0.0919
Echinococcus granulosus	carnitine O palmitoyltransferase 1 liver	0.0129	0.1008	0.1621
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0398	0.064
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0179	0.0164
Brugia malayi	Carboxylesterase family protein	0.012	0.0924	0.0909
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0032	0.0068
Brugia malayi	Bromodomain containing protein	0.0077	0.0535	0.052
Trypanosoma cruzi	hypothetical protein, conserved	0.0024	0.006	0.0044
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0274	0.2308	0.2295
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0274	0.2308	1
Loa Loa (eye worm)	carnitine O-palmitoyltransferase I isoform	0.0024	0.006	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0186	0.0181
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0019	0.0018	0.0002
Plasmodium falciparum	lysophospholipase, putative	0.0168	0.1359	0.5861
Loa Loa (eye worm)	hypothetical protein	0.012	0.0924	0.0919
Trypanosoma brucei	carnitine O-palmitoyltransferase II, putative	0.0024	0.006	0.0044
Mycobacterium tuberculosis	Probable hydrolase	0.0038	0.0186	0.0135
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0186	0.0135
Plasmodium falciparum	calmodulin	0.0026	0.0083	0.0294
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0314	0.2669	1
Echinococcus granulosus	acetylcholinesterase	0.071	0.6219	1
Brugia malayi	Pre-SET motif family protein	0.0031	0.0121	0.0106
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0121	0.046
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0314	0.2669	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.0381	0.1591
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0191	0.1564	0.2514
Mycobacterium ulcerans	hypothetical protein	0.0168	0.1359	0.3879
Schistosoma mansoni	jumonji domain containing protein	0.0152	0.1211	0.1947
Brugia malayi	PHD-finger family protein	0.0027	0.0086	0.007
Plasmodium vivax	hypothetical protein, conserved	0.0058	0.0371	0.1549
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0048	0.0275	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0186	0.0181
Trypanosoma cruzi	choline/carnitine O-acetyltransferase, putative	0.0024	0.006	0.0044
Schistosoma mansoni	calmodulin	0.0026	0.0083	0.0134
Schistosoma mansoni	hypothetical protein	0.007	0.0474	0.0762
Trichomonas vaginalis	ap endonuclease, putative	0.0037	0.0182	0.0571
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0066	0.0441	0.0709
Mycobacterium tuberculosis	Probable lipase LipD	0.0038	0.0186	0.0135
Onchocerca volvulus		0.012	0.0924	0.4486
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0179	0.0164
Brugia malayi	thymidylate synthase	0.0104	0.0782	0.0767
Echinococcus multilocularis	thymidylate synthase	0.0104	0.0782	0.1133
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0137	0.0198
Echinococcus multilocularis	acetylcholinesterase	0.071	0.6219	0.9007
Trypanosoma cruzi	monoglyceride lipase, putative	0.0168	0.1359	0.1345
Trypanosoma cruzi	hypothetical protein, conserved	0.0024	0.006	0.0044
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0032	0.0046
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0037	0.0182	0.0167
Echinococcus granulosus	peregrin	0.0061	0.0392	0.0631
Leishmania major	calmodulin, putative	0.0026	0.0083	0.0067
Toxoplasma gondii	PHD-finger domain-containing protein	0.0058	0.0371	0.1549
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0037	0.0179	0.056
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0186	0.0585
Trypanosoma brucei	hypothetical protein, conserved	0.0038	0.0186	0.017
Onchocerca volvulus		0.0104	0.0782	0.3752
Leishmania major	calmodulin, putative	0.0026	0.0083	0.0067
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0037	0.0182	0.0264
Brugia malayi	RNA binding protein	0.0061	0.0398	0.0383
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0098	0.0082
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0036	0.0169	0.0245
Schistosoma mansoni	hypothetical protein	0.0019	0.0018	0.0029
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0376	0.3221	1
Echinococcus multilocularis	calmodulin	0.0026	0.0083	0.012
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0058	0.0371	0.0597
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0137	0.0121
Schistosoma mansoni	ap endonuclease	0.0037	0.0182	0.0293
Leishmania major	pteridine reductase 1	0.0191	0.1561	0.1547
Treponema pallidum	fructose-bisphosphate aldolase	0.0314	0.2669	1
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0022	0.0048	0.0078
Mycobacterium ulcerans	beta-lactamase	0.0038	0.0186	0.0022
Toxoplasma gondii	calmodulin, putative	0.0026	0.0083	0.0294
Brugia malayi	beta-lactamase family protein	0.0038	0.0186	0.017
Loa Loa (eye worm)	jmjC domain-containing protein	0.0121	0.0929	0.0924
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.012	0.0924	0.1485
Brugia malayi	beta-lactamase	0.0038	0.0186	0.017
Plasmodium vivax	hypothetical protein, conserved	0.0021	0.0034	0.008
Echinococcus granulosus	dnaJ subfamily B	0.0421	0.3626	0.5831
Brugia malayi	Choline O-acetyltransferase	0.0024	0.006	0.0044
Onchocerca volvulus		0.012	0.0924	0.4486
Plasmodium vivax	calmodulin, putative	0.0026	0.0083	0.0294
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0061	0.0398	0.0576
Loa Loa (eye worm)	carboxylesterase	0.071	0.6219	0.6217
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.1131	1	1
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0274	0.2308	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0394	0.0704
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0032	0.0016
Plasmodium falciparum	lysophospholipase, putative	0.0168	0.1359	0.5861
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0394	0.057
Echinococcus multilocularis	calmodulin	0.0026	0.0083	0.0121
Onchocerca volvulus		0.003	0.0112	0.0272
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0021	0.0034	0.008
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0121	0.0195
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0051	0.0071
Trypanosoma brucei	carnitine O-acetyltransferase, putative	0.0024	0.006	0.0044
Trypanosoma cruzi	carnitine O-palmitoyltransferase II, putative	0.0024	0.006	0.0044
Loa Loa (eye worm)	hypothetical protein	0.071	0.6219	0.6217
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0121	0.0176
Schistosoma mansoni	hypothetical protein	0.0058	0.0371	0.0597
Trichomonas vaginalis	conserved hypothetical protein	0.0168	0.1359	0.5032
Schistosoma mansoni	hypothetical protein	0.0032	0.0137	0.022
Trichomonas vaginalis	ap endonuclease, putative	0.0037	0.0182	0.0571
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0394	0.0378
Loa Loa (eye worm)	jmjC domain-containing protein	0.0019	0.0016	0.0011
Echinococcus multilocularis	BC026374 protein (S09 family)	0.012	0.0924	0.1338
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.0441	0.0426
Brugia malayi	Pre-SET motif family protein	0.0209	0.1726	0.1713
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0098	0.0093
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0314	0.2669	1
Echinococcus granulosus	calmodulin	0.0026	0.0083	0.0134

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity		Cytotoxicity against mouse RBCs assessed as hemolysis at 0	LITERATURE.	27073054
Activity	<= 20 %	Cytotoxicity against mouse RBCs assessed as hemolysis up to 7	LITERATURE.	27073054
IC50 (binding)	= 59 nM	Inhibition of rat recombinant N-terminal his-tagged MAGL expressed in Escherichia coli DH5alpha assessed as 2-oleoylglycerol hydrolysis after 10 mins by LC/MS analysis	ChEMBL.	22056744
IC50 (binding)	= 0.66 uM	Inhibition of human recombinant MAGL assessed as inhibition of 2-oleoylglycerol hydrolysis preincubated for 10 mins by LC/MS analysis	ChEMBL.	22056744
IC50 (binding)	= 1.66 uM	Inhibition of human recombinant MAGL assessed as [3H]oleoylglycerol hydrolysis after 10 mins by liquid scintillation counting	ChEMBL.	22056744
IC50 (binding)	= 35.2 uM	Inhibition of human recombinant FAAH assessed as conversion of [3H]AEA to [3H]ethanolamine after 10 mins by liquid scintillation counting	ChEMBL.	22056744
Inhibition (binding)		Inhibition of human recombinant MAGL assessed as [3H]oleoylglycerol hydrolysis preincubated for 10 mins at 37 degC by liquid scintillation counting	ChEMBL.	22056744
Inhibition (binding)		Inhibition of human recombinant MAGL assessed as inhibition of [3H]oleoylglycerol hydrolysis preincubated for 30 mins at room temperature by liquid scintillation counting	ChEMBL.	22056744
Inhibition (binding)		Inhibition of human recombinant MAGL assessed as [3H]oleoylglycerol hydrolysis preincubated for 30 mins at 37 degC by liquid scintillation counting	ChEMBL.	22056744
Inhibition (binding)		Inhibition of human recombinant MAGL assessed as [3H]oleoylglycerol hydrolysis preincubated for 10 mins at room temperature by liquid scintillation counting	ChEMBL.	22056744
Inhibition (binding)		Inhibition of human recombinant MAGL assessed as [3H]oleoylglycerol hydrolysis at 10'-5 M preincubated for 5 mins measured after 15 mins by liquid scintillation counting in the presence of dithiothreitol	ChEMBL.	22056744

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1922513

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1580697