Detailed information for compound 1580704
Basic information
Technical information
- Name: Unnamed compound
- MW: 501.982 | Formula: C24H24ClN3O5S
-
H donors: 2
H acceptors: 3
LogP: 4.17
Rotable bonds: 6
Rule of 5 violations (Lipinski): 2 - SMILES: COc1ccc(cc1OC)C1CC(=NN1c1ccc(cc1)S(=O)(=O)N)c1cc(Cl)c(cc1O)C
- InChi: 1S/C24H24ClN3O5S/c1-14-10-22(29)18(12-19(14)25)20-13-21(15-4-9-23(32-2)24(11-15)33-3)28(27-20)16-5-7-17(8-6-16)34(26,30)31/h4-12,21,29H,13H2,1-3H3,(H2,26,30,31)
- InChiKey: KESFQAMWJBXFEV-UHFFFAOYSA-N
Network
Hover on a compound node to display the structore
Synonyms
No synonyms found for this compound
Targets
Known targets for this compound
No curated genes were found associated with this compound
Predicted pathogen targets for this compound
By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|---|---|---|---|
| Echinococcus multilocularis | acetylcholinesterase | 0.1287 | 0.5 | 0.5 |
| Echinococcus granulosus | acetylcholinesterase | 0.1287 | 0.5 | 0.5 |
| Echinococcus multilocularis | acetylcholinesterase | 0.1287 | 0.5 | 0.5 |
| Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1287 | 0.5 | 0.5 |
| Loa Loa (eye worm) | carboxylesterase | 0.1287 | 0.5 | 0.5 |
| Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1287 | 0.5 | 0.5 |
| Echinococcus multilocularis | carboxylesterase 5A | 0.1287 | 0.5 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.1287 | 0.5 | 0.5 |
| Echinococcus granulosus | carboxylesterase 5A | 0.1287 | 0.5 | 0.5 |
| Brugia malayi | Carboxylesterase family protein | 0.1287 | 0.5 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.1287 | 0.5 | 0.5 |
| Echinococcus granulosus | acetylcholinesterase | 0.1287 | 0.5 | 0.5 |
Activities
| Activity type | Activity value | Assay description | Source | Reference |
|---|---|---|---|---|
| GI50 (functional) | = 1.72 uM | Anticancer activity against human HCT116 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 1.81 uM | Anticancer activity against human HOP92 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 1.93 uM | Anticancer activity against human COLO205 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 2.1 uM | Anticancer activity against human SF539 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 2.24 uM | Anticancer activity against human HT-29 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 2.25 uM | Anticancer activity against human OVCAR5 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 2.34 uM | Anticancer activity against human IGROV1 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 2.37 uM | Anticancer activity against human 786-0 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 2.5 uM | Anticancer activity against human NCI-H460 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 2.58 uM | Anticancer activity against human MDA-MB-468 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 2.61 uM | Anticancer activity against human M14 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 2.61 uM | Anticancer activity against human PC3 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 2.7 uM | Anticancer activity against human SF295 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 2.7 uM | Anticancer activity against human SNB75 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 2.72 uM | Anticancer activity against human HCC2998 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 2.78 uM | Anticancer activity against human Caki1 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 2.82 uM | Anticancer activity against human SR cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 2.88 uM | Anticancer activity against human RXF393 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 2.95 uM | Anticancer activity against human NCI-H522 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 3.03 uM | Anticancer activity against human BT549 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 3.07 uM | Anticancer activity against human KM12 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 3.07 uM | Anticancer activity against human MCF7 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 3.1 uM | Anticancer activity against human T47D cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 3.11 uM | Anticancer activity against human NCI-H23 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 3.13 uM | Anticancer activity against human UACC62 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 3.15 uM | Anticancer activity against human ACHN cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 3.18 uM | Anticancer activity against human K562 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 3.3 uM | Anticancer activity against human UO31 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 3.32 uM | Anticancer activity against human HCT15 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 3.35 uM | Anticancer activity against human LOXIMVI cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 3.37 uM | Anticancer activity against human OVCAR3 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 3.39 uM | Anticancer activity against human OVCAR8 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 3.39 uM | Anticancer activity against human NCI/ADR-RES cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 3.42 uM | Anticancer activity against human HL-60(TB) cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 3.54 uM | Anticancer activity against human A549 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 3.65 uM | Anticancer activity against human MALME-3M cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 3.7 uM | Anticancer activity against human SN12C cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 3.71 uM | Anticancer activity against human U251 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 3.81 uM | Anticancer activity against human MDA-MB-231 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 3.92 uM | Anticancer activity against human HOP62 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 3.97 uM | Anticancer activity against human MDA-MB-435 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 3.97 uM | Anticancer activity against human TK10 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 3.98 uM | Anticancer activity against human A498 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 4.08 uM | Anticancer activity against human SW620 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 4.1 uM | Anticancer activity against human RPMI8226 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 4.15 uM | Anticancer activity against human EKVX cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 4.18 uM | Anticancer activity against human OVCAR4 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 4.22 uM | Anticancer activity against human UACC257 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 4.28 uM | Anticancer activity against human SK-MEL-5 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 4.29 uM | Anticancer activity against human SK-MEL-28 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 4.45 uM | Anticancer activity against human NCI-H322M cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 4.49 uM | Anticancer activity against human DU145 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 4.51 uM | Anticancer activity against human SKOV3 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 4.74 uM | Anticancer activity against human SF268 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 5.29 uM | Anticancer activity against human MOLT4 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 5.35 uM | Anticancer activity against human CCRF-CEM cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 5.53 uM | Anticancer activity against human SNB19 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 5.62 uM | Anticancer activity against human NCI-H226 cells after 48 hrs | ChEMBL. | 21664130 |
| GI50 (functional) | = 5.87 uM | Anticancer activity against human SK-MEL-2 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | = 0.34 uM | Anticancer activity against human SF295 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | = 6.02 uM | Anticancer activity against human COLO205 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | = 12 uM | Anticancer activity against human SF539 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | = 12.4 uM | Anticancer activity against human HCT116 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | = 22 uM | Anticancer activity against human NCI-H460 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | = 27.4 uM | Anticancer activity against human HCC2998 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | = 27.8 uM | Anticancer activity against human OVCAR5 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | = 28.8 uM | Anticancer activity against human IGROV1 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | = 31.4 uM | Anticancer activity against human RXF393 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | = 36.9 uM | Anticancer activity against human HT-29 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | = 37.4 uM | Anticancer activity against human LOXIMVI cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | = 38.3 uM | Anticancer activity against human M14 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | = 39.7 uM | Anticancer activity against human SK-MEL-5 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | = 40.4 uM | Anticancer activity against human MDA-MB-231 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | = 43.3 uM | Anticancer activity against human UACC62 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | = 48.2 uM | Anticancer activity against human U251 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | = 49.2 uM | Anticancer activity against human KM12 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | = 52.4 uM | Anticancer activity against human HOP62 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | = 62.7 uM | Anticancer activity against human SK-MEL-28 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | = 69.3 uM | Anticancer activity against human NCI-H522 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | = 77.5 uM | Anticancer activity against human OVCAR3 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | = 86.4 uM | Anticancer activity against human NCI-H226 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | = 95.6 uM | Anticancer activity against human BT549 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human CCRF-CEM cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human HL-60(TB) cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human K562 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human MOLT4 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human RPMI8226 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human SR cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human A549 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human EKVX cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human HOP92 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human NCI-H23 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human NCI-H322M cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human HCT15 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human SW620 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human SF268 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human SNB19 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human SNB75 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human MALME-3M cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human MDA-MB-435 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human SK-MEL-2 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human UACC257 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human OVCAR4 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human OVCAR8 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human NCI/ADR-RES cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human SKOV3 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human 786-0 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human A498 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human ACHN cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human Caki1 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human SN12C cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human TK10 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human UO31 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human PC3 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human DU145 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human MCF7 cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human T47D cells after 48 hrs | ChEMBL. | 21664130 |
| LC50 (functional) | > 100 uM | Anticancer activity against human MDA-MB-468 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 3.41 uM | Anticancer activity against human COLO205 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 4.36 uM | Anticancer activity against human HCT116 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 4.75 uM | Anticancer activity against human SF539 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 5.04 uM | Anticancer activity against human 786-0 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 5.46 uM | Anticancer activity against human IGROV1 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 5.85 uM | Anticancer activity against human NCI-H460 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 6.24 uM | Anticancer activity against human SF295 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 6.36 uM | Anticancer activity against human OVCAR5 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 6.48 uM | Anticancer activity against human HT-29 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 7.25 uM | Anticancer activity against human HCC2998 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 7.26 uM | Anticancer activity against human M14 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 7.42 uM | Anticancer activity against human HOP92 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 7.52 uM | Anticancer activity against human RXF393 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 8.77 uM | Anticancer activity against human KM12 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 9.51 uM | Anticancer activity against human MDA-MB-468 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 9.61 uM | Anticancer activity against human NCI-H522 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 9.8 uM | Anticancer activity against human OVCAR3 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 11 uM | Anticancer activity against human LOXIMVI cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 12.2 uM | Anticancer activity against human ACHN cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 12.5 uM | Anticancer activity against human MDA-MB-231 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 12.9 uM | Anticancer activity against human UACC62 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 13.3 uM | Anticancer activity against human T47D cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 13.4 uM | Anticancer activity against human BT549 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 13.6 uM | Anticancer activity against human NCI-H23 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 13.6 uM | Anticancer activity against human MCF7 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 13.7 uM | Anticancer activity against human PC3 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 14 uM | Anticancer activity against human U251 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 14.1 uM | Anticancer activity against human HOP62 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 14.1 uM | Anticancer activity against human NCI/ADR-RES cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 15.2 uM | Anticancer activity against human SK-MEL-5 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 17.7 uM | Anticancer activity against human SK-MEL-28 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 17.9 uM | Anticancer activity against human OVCAR8 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 18.4 uM | Anticancer activity against human TK10 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 19.7 uM | Anticancer activity against human A549 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 19.7 uM | Anticancer activity against human UACC257 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 20.2 uM | Anticancer activity against human HCT15 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 21.7 uM | Anticancer activity against human DU145 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 23.1 uM | Anticancer activity against human NCI-H226 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 24 uM | Anticancer activity against human MDA-MB-435 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 24.6 uM | Anticancer activity against human MALME-3M cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 24.7 uM | Anticancer activity against human A498 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 26.6 uM | Anticancer activity against human SW620 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 30 uM | Anticancer activity against human SN12C cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 32.7 uM | Anticancer activity against human SK-MEL-2 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 38.3 uM | Anticancer activity against human SKOV3 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 39.7 uM | Anticancer activity against human NCI-H322M cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 89.3 uM | Anticancer activity against human SNB19 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 97.2 uM | Anticancer activity against human SNB75 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 100 uM | Anticancer activity against human CCRF-CEM cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 100 uM | Anticancer activity against human HL-60(TB) cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 100 uM | Anticancer activity against human K562 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 100 uM | Anticancer activity against human MOLT4 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 100 uM | Anticancer activity against human RPMI8226 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 100 uM | Anticancer activity against human SR cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 100 uM | Anticancer activity against human EKVX cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 100 uM | Anticancer activity against human SF268 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 100 uM | Anticancer activity against human OVCAR4 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 100 uM | Anticancer activity against human Caki1 cells after 48 hrs | ChEMBL. | 21664130 |
| TGI (functional) | = 100 uM | Anticancer activity against human UO31 cells after 48 hrs | ChEMBL. | 21664130 |
Phenotypes
Whole-cell/tissue/organism interactions
We have no records of whole-cell/tissue assays done with this compound
What does this mean?
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
We have no manually annotated phenotypes for this drug.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
External resources for this compound
- ChEMBL: CHEMBL1914982
Bibliographic References
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