Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | epidermal growth factor receptor | 0.121 | 0.9254 | 0.9254 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0387 | 0.0134 | 0.0134 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1278 | 1 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.065 | 0.3052 | 0.2958 |
Schistosoma mansoni | tyrosine kinase | 0.065 | 0.3052 | 0.2958 |
Schistosoma mansoni | tyrosine kinase | 0.121 | 0.9254 | 0.9243 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1278 | 1 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.121 | 0.9254 | 0.9243 |
Echinococcus multilocularis | insulin receptor | 0.0387 | 0.0134 | 0.0134 |
Echinococcus multilocularis | acetylcholinesterase | 0.1278 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.1278 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1278 | 1 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.065 | 0.3052 | 0.2958 |
Echinococcus granulosus | acetylcholinesterase | 0.1278 | 1 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.121 | 0.9254 | 0.9243 |
Schistosoma mansoni | tyrosine kinase | 0.0643 | 0.2977 | 0.2881 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.121 | 0.9254 | 0.9243 |
Schistosoma mansoni | tyrosine kinase | 0.0643 | 0.2977 | 0.2881 |
Loa Loa (eye worm) | hypothetical protein | 0.1278 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0643 | 0.2977 | 0.2881 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.065 | 0.3052 | 0.3052 |
Echinococcus granulosus | acetylcholinesterase | 0.1278 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.065 | 0.3052 | 0.2958 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1278 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1278 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1278 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1278 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 50 uM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by FACS analysis | ChEMBL. | 21958736 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.