Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0221 | 0.0106 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0221 | 0.0106 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0221 | 0.0106 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0363 | 0.1402 | 0.1402 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1305 | 1 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0675 | 0.4251 | 0.4215 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0221 | 0.0106 | 0.0045 |
Schistosoma mansoni | tyrosine kinase | 0.0363 | 0.1402 | 0.1349 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0363 | 0.1402 | 0.1349 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0221 | 0.0106 | 0.0045 |
Schistosoma mansoni | tyrosine kinase | 0.0359 | 0.1367 | 0.1314 |
Onchocerca volvulus | 0.0221 | 0.0106 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.0106 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.1305 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1305 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1305 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1305 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1305 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0363 | 0.1402 | 0.1349 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0221 | 0.0106 | 0.0106 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0221 | 0.0106 | 0.0045 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0221 | 0.0106 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.1305 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0221 | 0.0106 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.0106 | 0.0045 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0221 | 0.0106 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.0106 | 0.0045 |
Echinococcus multilocularis | neuroligin | 0.0221 | 0.0106 | 0.0106 |
Schistosoma mansoni | tyrosine kinase | 0.0675 | 0.4251 | 0.4215 |
Echinococcus granulosus | neuroligin | 0.0221 | 0.0106 | 0.0045 |
Schistosoma mansoni | tyrosine kinase | 0.0359 | 0.1367 | 0.1314 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0221 | 0.0106 | 0.0045 |
Onchocerca volvulus | 0.0221 | 0.0106 | 0.5 | |
Echinococcus granulosus | epidermal growth factor receptor | 0.0363 | 0.1402 | 0.1349 |
Brugia malayi | Carboxylesterase family protein | 0.0221 | 0.0106 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.0106 | 0.0045 |
Loa Loa (eye worm) | carboxylesterase | 0.0221 | 0.0106 | 0.0045 |
Loa Loa (eye worm) | carboxylesterase | 0.0221 | 0.0106 | 0.0045 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0221 | 0.0106 | 0.0045 |
Schistosoma mansoni | tyrosine kinase | 0.0359 | 0.1367 | 0.1314 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0675 | 0.4251 | 0.4215 |
Onchocerca volvulus | 0.0221 | 0.0106 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.0106 | 0.0045 |
Brugia malayi | hypothetical protein | 0.0221 | 0.0106 | 0.0045 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0221 | 0.0106 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0221 | 0.0106 | 0.0045 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0221 | 0.0106 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0221 | 0.0106 | 0.0045 |
Echinococcus multilocularis | acetylcholinesterase | 0.1305 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0221 | 0.0106 | 0.0045 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0221 | 0.0106 | 0.0106 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.0106 | 0.0045 |
Brugia malayi | Carboxylesterase family protein | 0.0221 | 0.0106 | 0.0045 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0216 | 0.0062 | 0.0062 |
Echinococcus granulosus | carboxylesterase 5A | 0.1305 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0221 | 0.0106 | 0.0045 |
Schistosoma mansoni | acetylcholinesterase | 0.0221 | 0.0106 | 0.0045 |
Onchocerca volvulus | 0.0221 | 0.0106 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.0106 | 0.0045 |
Onchocerca volvulus | 0.0221 | 0.0106 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.1305 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1305 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0675 | 0.4251 | 0.4251 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0221 | 0.0106 | 0.0106 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1305 | 1 | 1 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0675 | 0.4251 | 0.4215 |
Echinococcus multilocularis | insulin receptor | 0.0216 | 0.0062 | 0.0062 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 50 uM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by FACS analysis | ChEMBL. | 21958736 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.