Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 2a (5-HT2a) receptor | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1162 | 1 | 1 |
Onchocerca volvulus | 0.0196 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.1162 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1162 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1162 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1162 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0196 | 0 | 0.5 |
Onchocerca volvulus | 0.0196 | 0 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0196 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0196 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1162 | 1 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0466 | 0.2793 | 0.2793 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.1011 | 0.8442 | 0.8442 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0196 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.1162 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1162 | 1 | 1 |
Onchocerca volvulus | 0.0196 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.1162 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0196 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1162 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.1162 | 1 | 1 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0466 | 0.2793 | 0.2793 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0466 | 0.2793 | 0.2793 |
Onchocerca volvulus | 0.0196 | 0 | 0.5 | |
Onchocerca volvulus | 0.0196 | 0 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0196 | 0 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1011 | 0.8442 | 0.8442 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1162 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 18 nM | Displacement of [3H]-8-OH-DPAT from 5-HT1A receptor in rat hippocampus by liquid scintillation counting | ChEMBL. | 22001327 |
Ki (binding) | = 156 nM | Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting | ChEMBL. | 22001327 |
Ki (binding) | = 825 nM | Displacement of [3H]-LSD from human 5-HT6 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting | ChEMBL. | 22001327 |
Ki (binding) | = 2842 nM | Displacement of [3H]-ketanserin from 5-HT2A receptor in rat cortex by liquid scintillation counting | ChEMBL. | 22001327 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.