Detailed information for compound 1580874

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1399.67 | Formula: C70H106N14O16
  • H donors: 14 H acceptors: 16 LogP: -1.45 Rotable bonds: 22
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCC[C@@H]1NC(=O)[C@@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H]2N(C(=O)[C@H](NC(=O)[C@@H](NC1=O)CC(C)C)Cc1ccccc1)CCC2)CCC(=O)O)C(C)C)CCCN)C(C)C
  • InChi: 1S/C70H106N14O16/c1-39(2)35-49-63(93)79-51(37-43-19-11-9-12-20-43)69(99)83-33-17-25-53(83)65(95)73-48(28-30-56(87)88)62(92)82-58(42(7)8)68(98)76-46(24-16-32-72)60(90)78-50(36-40(3)4)64(94)80-52(38-44-21-13-10-14-22-44)70(100)84-34-18-26-54(84)66(96)74-47(27-29-55(85)86)61(91)81-57(41(5)6)67(97)75-45(23-15-31-71)59(89)77-49/h9-14,19-22,39-42,45-54,57-58H,15-18,23-38,71-72H2,1-8H3,(H,73,95)(H,74,96)(H,75,97)(H,76,98)(H,77,89)(H,78,90)(H,79,93)(H,80,94)(H,81,91)(H,82,92)(H,85,86)(H,87,88)/t45-,46-,47+,48+,49-,50-,51+,52+,53-,54-,57-,58-/m0/s1
  • InChiKey: MHNRBVPPGFWCRB-SGHCWUBQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi phosphofructokinase 0.0108 0.2525 0.4772
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0041 0.0041
Schistosoma mansoni cpg binding protein 0.003 0.0575 0.0575
Loa Loa (eye worm) hypothetical protein 0.0062 0.1361 0.2571
Schistosoma mansoni elf1 0.001 0.0081 0.0081
Brugia malayi 6-phosphofructokinase 0.0108 0.2525 0.4772
Schistosoma mansoni cpg binding protein 0.0029 0.0534 0.0534
Echinococcus granulosus amyloid beta A4 protein 0.0069 0.1529 0.1529
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.1055 0.3305
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0041 0.0041
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0012 0.0108 0.0249
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0288 0.0288
Schistosoma mansoni cpg binding protein 0.003 0.0575 0.0575
Trypanosoma brucei DNA polymerase kappa, putative 0.0093 0.2136 0.7271
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.055 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0077
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0096 0.2211 0.4179
Echinococcus granulosus voltage dependent calcium channel 0.002 0.032 0.032
Trypanosoma brucei DNA polymerase kappa, putative 0.0123 0.288 1
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0038 0.0776 0.2182
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.2525 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0041 0.0041
Schistosoma mansoni amyloid beta A4 protein related 0.0069 0.1529 0.1529
Loa Loa (eye worm) RasGEF domain-containing protein 0.0009 0.0044 0.0083
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1336 0.1336
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0096 0.2211 0.2211
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.2525 0.8631
Loa Loa (eye worm) fli-1 protein 0.0219 0.5292 1
Echinococcus multilocularis ets variant gene 4 0.001 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0066 0.1462 0.2763
Echinococcus granulosus ewsr:fli fusion protein type 0.001 0.0081 0.0081
Brugia malayi Ets-domain containing protein 0.0072 0.1622 0.3065
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0041 0.0041
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.055 0.4499
Schistosoma mansoni voltage-gated cation channel 0.0096 0.2211 0.2211
Echinococcus granulosus protein C ets 2 0.001 0.0081 0.0081
Schistosoma mansoni ap endonuclease 0.0019 0.0288 0.0288
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0145 0.3433 0.3433
Brugia malayi polk-prov protein 0.0093 0.2136 0.4036
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.055 0.4499
Trypanosoma brucei DNA polymerase kappa, putative 0.0123 0.288 1
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.0081 0.0153
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.2525 1
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.2525 0.8631
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0898 0.1697
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0041 0.0041
Schistosoma mansoni ets 0.001 0.0081 0.0081
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.055 0.6373
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0041 0.0041
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0058 0.1275 0.411
Trypanosoma cruzi DNA polymerase kappa, putative 0.0123 0.288 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0288 0.0489
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0038 0.0776 0.6488
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.055 0.3206
Echinococcus multilocularis ewsr:fli fusion protein type 0.001 0.0081 0.0081
Leishmania major DNA polymerase kappa, putative 0.0063 0.139 0.5212
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.2525 0.8631
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.018 0.4313 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0123 0.288 1
Schistosoma mansoni dishevelled 0.0012 0.0108 0.0108
Onchocerca volvulus 0.0029 0.0534 0.1239
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.2525 0.8631
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.055 0.5
Schistosoma mansoni ap endonuclease 0.0019 0.0288 0.0288
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0043 0.0898 0.1697
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0038 0.0776 0.2622
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0033 0.0646 0.5342
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0038 0.0072
Schistosoma mansoni terminal deoxycytidyl transferase 0.0043 0.0898 0.0898
Schistosoma mansoni hypothetical protein 0.0408 1 1
Schistosoma mansoni dishevelled 0.0012 0.0108 0.0108
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0041 0.0041
Brugia malayi hypothetical protein 0.0009 0.0041 0.0077
Trypanosoma cruzi DNA polymerase kappa, putative 0.0123 0.288 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0041 0.0077
Echinococcus granulosus dna polymerase eta 0.0043 0.0898 0.0898
Echinococcus multilocularis dna polymerase eta 0.0043 0.0898 0.0898
Trypanosoma brucei DNA polymerase kappa, putative 0.0123 0.288 1
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0038 0.0776 0.2281
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0154 0.0154
Trypanosoma brucei DNA polymerase kappa, putative 0.0123 0.288 1
Brugia malayi Ets-domain containing protein 0.001 0.0081 0.0153
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0041 0.0077
Loa Loa (eye worm) hypothetical protein 0.0043 0.0898 0.1697
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0041 0.0041
Toxoplasma gondii transporter, cation channel family protein 0.002 0.032 0.2468
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0038 0.0776 0.0776
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0096 0.2211 0.2211
Echinococcus multilocularis voltage dependent calcium channel 0.0096 0.2211 0.2211
Echinococcus multilocularis protein C ets 2 0.001 0.0081 0.0081
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0288 0.0544
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0288 0.1079
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0041 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0123 0.288 1
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.0898 0.2729
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0288 0.2145
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.2525 0.2525
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0288 0.0489
Toxoplasma gondii exonuclease III APE 0.0019 0.0288 0.2179
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.055 0.6373
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0288 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.139 0.4533
Loa Loa (eye worm) hypothetical protein 0.002 0.032 0.0605
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0288 0.0489
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0096 0.2211 0.2211
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0038 0.0776 0.1466
Brugia malayi Fli-1 protein 0.0219 0.5292 1
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0311 0.0105
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.2525 1
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0038 0.0776 0.2281
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.2525 0.2525
Echinococcus granulosus ETS transcription factor Elf 1 0.001 0.0081 0.0081
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0043 0.0898 0.0898
Schistosoma mansoni hypothetical protein 0.001 0.0081 0.0081
Brugia malayi Ets-domain containing protein 0.0072 0.1622 0.3065
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0038 0.0776 0.1466
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.1622 0.1622
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.1622 0.1622
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0096 0.2211 0.2211
Mycobacterium ulcerans DNA polymerase IV 0.0123 0.288 1
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0041 0.0834 0.0834
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0038 0.0776 0.0776
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0063 0.139 0.5212
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0898 0.2729
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.0061 0.1349 0.2549
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0041 0.0077
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.055 0.1014
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.055 0.1175
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.055 0.4499
Trypanosoma brucei DNA polymerase kappa, putative 0.0123 0.288 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0081 0.0153
Loa Loa (eye worm) hypothetical protein 0.0093 0.2136 0.4036
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0154 0.1003
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.055 0.1014
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0123 0.288 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0123 0.288 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0123 0.288 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0288 0.0288
Trypanosoma brucei unspecified product 0.003 0.0563 0.1501
Loa Loa (eye worm) hypothetical protein 0.0018 0.026 0.0491
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0096 0.2211 0.2211
Brugia malayi N-terminal motif family protein 0.018 0.4313 0.815
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0081 0.0081
Echinococcus multilocularis segment polarity protein dishevelled 0.0012 0.0108 0.0108
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.2525 1
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0038 0.0776 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.1622 0.3065
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.2525 1
Loa Loa (eye worm) voltage-dependent calcium channel 0.002 0.032 0.0605
Trypanosoma brucei unspecified product 0.0103 0.2388 0.8196
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0038 0.0776 0.1884
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.1055 0.3305
Echinococcus granulosus ETS transcription factor Elf 5 0.001 0.0081 0.0081
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0038 0.0776 0.1466
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.1055 0.3305
Echinococcus multilocularis ETS transcription factor Elf 1 0.001 0.0081 0.0081
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0898 0.1697
Schistosoma mansoni dep domain containing protein 0.0009 0.0041 0.0041
Loa Loa (eye worm) X11 protein 0.0069 0.1529 0.289
Loa Loa (eye worm) hypothetical protein 0.018 0.4313 0.815
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0063 0.139 0.4926
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.055 0.1014
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.055 0.1014
Brugia malayi DIX domain containing protein 0.0012 0.0108 0.0203
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0288 0.2145
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0288 0.0562
Echinococcus multilocularis cpg binding protein 0.003 0.0575 0.0575
Trypanosoma brucei DNA polymerase kappa, putative 0.0093 0.2136 0.7271
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0058 0.1275 0.411
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.2525 0.4772
Echinococcus multilocularis voltage dependent calcium channel 0.0096 0.2211 0.2211
Loa Loa (eye worm) hypothetical protein 0.001 0.0081 0.0153
Onchocerca volvulus 0.0009 0.0041 0.0094
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.0081 0.0153
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.2525 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.0145 0.3433 0.3433
Echinococcus multilocularis sodium channel protein 0.0041 0.0834 0.0834
Trypanosoma brucei DNA polymerase kappa, putative 0.0123 0.288 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0898 0.2729
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0038 0.0776 1
Echinococcus multilocularis segment polarity protein dishevelled 0.0012 0.0108 0.0108
Echinococcus multilocularis dna polymerase kappa 0.0123 0.288 0.288
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.2525 0.2525
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0096 0.2211 0.2211
Echinococcus granulosus ETS domain containing protein Elk 1 0.001 0.0081 0.0081
Trypanosoma brucei DNA polymerase IV, putative 0.0123 0.288 1
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.001 0.0081 0.0081
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0041 0.0041
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.055 0.1014
Echinococcus multilocularis ETS domain containing protein Elk 1 0.001 0.0081 0.0081
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0096 0.2211 0.2211
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.2525 0.8698
Echinococcus granulosus segment polarity protein dishevelled 0.0012 0.0108 0.0108
Trypanosoma brucei unspecified product 0.003 0.0563 0.1501
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0288 0.0544
Brugia malayi hypothetical protein 0.0009 0.0041 0.0077
Trypanosoma cruzi DNA polymerase kappa, putative 0.0123 0.288 1
Schistosoma mansoni gabp alpha 0.0072 0.1622 0.1622
Loa Loa (eye worm) calcium channel 0.0096 0.2211 0.4179
Echinococcus multilocularis dnaJ subfamily B 0.0408 1 1
Schistosoma mansoni ets-related 0.001 0.0081 0.0081
Echinococcus granulosus segment polarity protein dishevelled 0.0012 0.0108 0.0108
Giardia lamblia DINP protein human, muc B family 0.0063 0.139 1
Loa Loa (eye worm) D-ets-2 protein 0.001 0.0081 0.0153
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.2525 0.4772
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0043 0.0898 0.0898
Leishmania major DNA polymerase eta, putative 0.0043 0.0898 0.3138
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0038 0.0776 0.2281
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.0081 0.0153
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.2525 0.2525
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0081 0.0081
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0288 0.0489
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.2525 0.5
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.055 0.1014
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0081 0.0081
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0154 0.1003
Brugia malayi CXXC zinc finger family protein 0.0029 0.0534 0.101
Schistosoma mansoni DNA polymerase eta 0.0043 0.0898 0.0898
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0038 0.0776 0.0776
Brugia malayi RasGEF domain containing protein 0.0009 0.0044 0.0083
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0038 0.0776 0.1466
Schistosoma mansoni hypothetical protein 0.001 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0096 0.2211 0.4179
Brugia malayi hypothetical protein 0.0066 0.1462 0.2763
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0096 0.2211 0.2211
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.0081 0.0153
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1174 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.2525 0.8698
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0534 0.101
Trypanosoma brucei DNA polymerase kappa, putative 0.0123 0.288 1
Trypanosoma brucei DNA polymerase IV, putative 0.0103 0.2388 0.8196
Entamoeba histolytica deoxycytidyl transferase, putative 0.0043 0.0898 0.2729
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0041 0.0077
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.055 0.1014
Echinococcus granulosus voltage dependent calcium channel 0.0096 0.2211 0.2211
Loa Loa (eye worm) phosphofructokinase 0.0108 0.2525 0.4772
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.055 0.1175
Loa Loa (eye worm) DIX domain-containing protein 0.0012 0.0108 0.0203
Echinococcus granulosus dna polymerase kappa 0.0123 0.288 0.288
Mycobacterium ulcerans DNA polymerase IV 0.0123 0.288 1
Schistosoma mansoni ets-related 0.0219 0.5292 0.5292
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0012 0.0108 0.0203
Brugia malayi transcription factor E74 isoform 0.001 0.0081 0.0153
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0096 0.2211 0.2211
Echinococcus granulosus cpg binding protein 0.003 0.0575 0.0575
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0038 0.0776 0.1884
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0077
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.055 0.6373
Loa Loa (eye worm) hypothetical protein 0.0018 0.026 0.0491
Toxoplasma gondii hypothetical protein 0.0018 0.026 0.1935
Brugia malayi 6-phosphofructokinase 0.0108 0.2525 0.4772
Loa Loa (eye worm) hypothetical protein 0.0012 0.0108 0.0203
Trypanosoma brucei DNA polymerase IV, putative 0.0123 0.288 1
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0081 0.0081
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0043 0.0898 0.0898
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.055 0.6373
Echinococcus multilocularis amyloid beta A4 protein 0.0069 0.1529 0.1529
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0041 0.0041
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.2525 0.8698
Echinococcus multilocularis ETS transcription factor Elf 5 0.001 0.0081 0.0081

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) > 100 ug ml-1 Antibiotic activity against Escherichia coli NBRC 12734 by microplate dilution assay ChEMBL. 19369073

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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