Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0631 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0393 | 0.5331 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0393 | 0.5331 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0631 | 1 | 1 |
Onchocerca volvulus | 0.0121 | 0 | 0.5 | |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0631 | 1 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0153 | 0.062 | 0.062 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0393 | 0.5331 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0393 | 0.5331 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0153 | 0.062 | 0.062 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0153 | 0.062 | 0.062 |
Echinococcus granulosus | dihydrofolate reductase | 0.0631 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0631 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.062 | 0.062 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.062 | 0.062 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0631 | 1 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0631 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0631 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0393 | 0.5331 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0393 | 0.5331 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0631 | 1 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0153 | 0.062 | 0.062 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5.97 | Displacement of [3H]ketanserin from 5HT2A receptor | ChEMBL. | 18486277 |
Ki (binding) | = 7.1 | Displacement of [3H]8-OH-DPAT from 5HT1A receptor in rat hippocampal membranes | ChEMBL. | 18486277 |
Ki (binding) | = 80 nM | Displacement of [3H]8-OH-DPAT from 5HT1A receptor in rat hippocampal membranes | ChEMBL. | 18486277 |
Ki (binding) | = 1073 nM | Displacement of [3H]ketanserin from 5HT2A receptor | ChEMBL. | 18486277 |
Time (functional) | = 18.4 s | Antidepressive activity in Albino Swiss mouse assessed as total immobility time at 20 mg/kg, ip after 30 mins measured for 4 mins by forced swimming test | ChEMBL. | 18486277 |
Time (functional) | = 27.5 s | Antidepressive activity in Albino Swiss mouse assessed as total immobility time at 10 mg/kg, ip after 30 mins measured for 4 mins by forced swimming test | ChEMBL. | 18486277 |
Time (functional) | = 48.3 s | Antidepressive activity in Albino Swiss mouse assessed as total immobility time at 5 mg/kg, ip after 30 mins measured for 4 mins by forced swimming test | ChEMBL. | 18486277 |
Time (functional) | = 56.8 s | Antidepressive activity in Albino Swiss mouse assessed as total immobility time at 2.5 mg/kg, ip after 30 mins measured for 4 mins by forced swimming test | ChEMBL. | 18486277 |
Time (functional) | = 114.3 s | Antidepressive activity in Albino Swiss mouse assessed as total immobility time at 1.25 mg/kg, ip after 30 mins measured for 4 mins by forced swimming test | ChEMBL. | 18486277 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.