Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin D2 receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.0334 | 0.0247 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1166 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0154 | 0.1178 | 0.1178 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1166 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.1166 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.1166 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1166 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0851 | 0.725 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1166 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1166 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.0334 | 0.0334 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0323 | 0.2655 | 0.1674 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0323 | 0.2655 | 0.2523 |
Onchocerca volvulus | 0.0323 | 0.2655 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0154 | 0.1178 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0323 | 0.2655 | 0.2589 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1166 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0177 | 0.0089 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0154 | 0.1178 | 0.1521 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0851 | 0.725 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.1166 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.0177 | 0.0177 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0851 | 0.725 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0851 | 0.725 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.0334 | 0.0334 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0334 | 0.0247 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0851 | 0.725 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0851 | 0.725 | 1 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0089 | 0.0089 |
Brugia malayi | thymidylate synthase | 0.0323 | 0.2655 | 0.2655 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Fu (ADMET) | = 0.2 % | Fraction unbound in human plasma | ChEMBL. | 21916510 |
Fu (ADMET) | = 0.6 % | Fraction unbound in mouse plasma | ChEMBL. | 21916510 |
IC50 (functional) | = 1200 nM | Antagonist activity at CRTH2 in human blood cells assessed as inhibition of PGD2-induced eosinophil cell shape change after 10 mins by flow cytometry | ChEMBL. | 21916510 |
Ki (binding) | = 8.6 nM | Displacement of [3H]PGD2 from human CRTH2 expressed in chinese hamster CHO cells by liquid scintillation counting | ChEMBL. | 21916510 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.