Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | butyrylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 603 aa | 548 aa | 28.6 % |
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | expressed protein | 0.0374 | 0.7519 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0253 | 0.4742 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.4742 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.4742 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0253 | 0.4742 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.4742 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.0282 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0239 | 0.4421 | 0.572 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.4742 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0282 | 0.0282 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.4421 | 0.3471 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.4742 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0175 | 0.2943 | 0.1027 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0253 | 0.4742 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0232 | 0.425 | 0.5484 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0239 | 0.4421 | 0.3471 |
Echinococcus multilocularis | acetylcholinesterase | 0.0239 | 0.4421 | 0.572 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0282 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.4421 | 0.3471 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0175 | 0.2943 | 0.1027 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.0282 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0239 | 0.4421 | 0.572 |
Echinococcus granulosus | expressed protein | 0.0374 | 0.7519 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0239 | 0.4421 | 0.572 |
Brugia malayi | Carboxylesterase family protein | 0.0239 | 0.4421 | 0.9323 |
Brugia malayi | hypothetical protein | 0.0232 | 0.425 | 0.8963 |
Echinococcus multilocularis | acetylcholinesterase | 0.0239 | 0.4421 | 0.572 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0239 | 0.4421 | 0.4421 |
Echinococcus granulosus | carboxylesterase 5A | 0.0239 | 0.4421 | 0.572 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.0282 | 0.5 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0166 | 0.2737 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0239 | 0.4421 | 0.9323 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0282 | 0.0282 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0232 | 0.425 | 0.5484 |
Loa Loa (eye worm) | carboxylesterase | 0.0239 | 0.4421 | 0.3471 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0282 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0282 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.065 uM | Anti-HIV-1 activity tested in human lymphocytic CEM cells | ChEMBL. | 15139762 |
EC50 (functional) | = 0.065 uM | Anti-HIV-1 activity tested in human lymphocytic CEM cells | ChEMBL. | 15139762 |
IC50 (binding) | = 1.2 uM | Inhibitory activity towards human butrylcholinesterase | ChEMBL. | 15139762 |
IC50 (binding) | = 1.2 uM | Inhibitory activity towards human butrylcholinesterase | ChEMBL. | 15139762 |
IC50 (binding) | = 10.5 uM | Inhibitory activity of the compound towards mouse butrylcholinesterase | ChEMBL. | 15139762 |
IC50 (binding) | = 10.5 uM | Inhibitory activity of the compound towards mouse butrylcholinesterase | ChEMBL. | 15139762 |
IC50 (binding) | > 50 uM | Inhibitory activity towards Electrophorus electricus acetylcholinesterase | ChEMBL. | 15139762 |
IC50 (binding) | > 50 uM | Inhibitory activity of the compound towards calf serum acetylcholinesterase | ChEMBL. | 15139762 |
IC50 (binding) | > 50 uM | Inhibitory activity of the compound towards beef erythrocytes acetylcholinesterase | ChEMBL. | 15139762 |
IC50 (binding) | > 50 uM | Inhibitory activity towards Electrophorus electricus acetylcholinesterase | ChEMBL. | 15139762 |
IC50 (binding) | > 50 uM | Inhibitory activity of the compound towards calf serum acetylcholinesterase | ChEMBL. | 15139762 |
IC50 (binding) | > 50 uM | Inhibitory activity of the compound towards beef erythrocytes acetylcholinesterase | ChEMBL. | 15139762 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 15139762 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.