Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0209 | 0 | 0.5 | |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0386 | 0.123 | 0.2592 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0894 | 0.4747 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0209 | 0 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0894 | 0.4747 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0386 | 0.123 | 0.2592 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0894 | 0.4747 | 1 |
Onchocerca volvulus | 0.0209 | 0 | 0.5 | |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0386 | 0.123 | 0.123 |
Onchocerca volvulus | 0.0209 | 0 | 0.5 | |
Onchocerca volvulus | 0.0209 | 0 | 0.5 | |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0386 | 0.123 | 0.2592 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0386 | 0.123 | 0.123 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0386 | 0.123 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0894 | 0.4747 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0209 | 0 | 0.5 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0386 | 0.123 | 0.2592 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0894 | 0.4747 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1653 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Emax (binding) | = 4 % | Transactivation activity at glucocorticoid receptor in rat H4II-E cells assessed as induction of tyrosine amino transferase at 1 uM relative to control | ChEMBL. | 21944381 |
Emax (binding) | = 33 % | Transactivation activity at glucocorticoid receptor in human HepG2 cells assessed as induction of tyrosine amino transferase at 1 uM relative to control | ChEMBL. | 21944381 |
Emax (binding) | = 86 % | Transrepression activity at glucocorticoid receptor in human H292 cells assessed as inhibition of TNF-stimulated IL-6 cytokine synthesis at 1 uM relative to control | ChEMBL. | 21944381 |
IC50 (binding) | = 15.9 nM | Transrepression activity at glucocorticoid receptor in human H292 cells assessed as inhibition of TNF-stimulated IL-6 cytokine synthesis | ChEMBL. | 21944381 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.