Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APH1B gamma secretase subunit | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K06172 anterior pharynx defective 1, putative | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus granulosus | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Brugia malayi | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1804 | 0.4115 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0331 | 0 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1804 | 0.4115 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0331 | 0 | 0.5 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.1804 | 0.4115 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0331 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0331 | 0 | 0.5 |
Onchocerca volvulus | 0.0331 | 0 | 0.5 | |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0331 | 0 | 0.5 |
Onchocerca volvulus | 0.0331 | 0 | 0.5 | |
Schistosoma mansoni | choline o-acyltransferase | 0.0331 | 0 | 0.5 |
Onchocerca volvulus | 0.0331 | 0 | 0.5 | |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.1804 | 0.4115 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0331 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3911 | 1 | 1 |
Onchocerca volvulus | 0.0331 | 0 | 0.5 | |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.1804 | 0.4115 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.7 | Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta40 level after 48 hrs by AlphaLISA assay | ChEMBL. | 21742495 |
IC50 (binding) | = 6.6 | Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta42 level after 48 hrs by AlphaLISA assay | ChEMBL. | 21742495 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.